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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10799
Species: Mus musculus
RGD Object: Gene
Symbol: Il5
Name: interleukin 5
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il5decreases activityISOIL5 (Homo sapiens)6480464CTDIL5 protein results in decreased activity of TretinoinPMID:11171635
Il5increases expressionISOIL5 (Homo sapiens)6480464CTDTretinoin results in increased expression of IL5 mRNA; Tretinoin results in increased expression of IL5 proteinPMID:17118196
Il5multiple interactionsISOIL5 (Homo sapiens)6480464CTDTretinoin inhibits the reaction [IL5 protein results in increased expression of IL5RA protein]PMID:10224351
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