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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10799
Species: Mus musculus
RGD Object: Gene
Symbol: Il5
Name: interleukin 5
Acc ID: CHEBI:9620
Term: tolnaftate
Definition: A monothiocarbamic ester that is the methyl(3-tolyl)carbamothioate ester of 2-naphthol. A synthetic anti-fungal agent used to treat jock itch, athlete's foot and ringworm.
Chemical ID: MESH:D014047
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il5decreases expressionISOIL5 (Homo sapiens)6480464CTDTolnaftate results in decreased expression of IL5 mRNAPMID:11886533 PMID:15284827
Il5decreases secretionISOIL5 (Homo sapiens)6480464CTDTolnaftate results in decreased secretion of IL5 proteinPMID:11886533 PMID:15284827
Il5multiple interactionsISOIL5 (Homo sapiens)6480464CTD1-Methyl-3-isobutylxanthine inhibits the reaction [Tolnaftate results in decreased expression of IL5 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Tolnaftate results in decreased secretion of IL5 protein]; Bucladesine inhibits the reaction [Tolnaftate results in decreased expression of IL5 mRNA]; Bucladesine inhibits the reaction [Tolnaftate results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [Tolnaftate results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Tolnaftate results in decreased secretion of IL5 protein]PMID:11886533
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