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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10799
Species: Mus musculus
RGD Object: Gene
Symbol: Il5
Name: interleukin 5
Acc ID: CHEBI:34795
Term: 3-isobutyl-1-methyl-7H-xanthine
Definition: A 3-isobutyl-1-methylxanthine that has formula C10H14N4O2.
Chemical ID: MESH:D015056
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il5multiple interactionsISOIL5 (Homo sapiens)6480464CTD1-Methyl-3-isobutylxanthine inhibits the reaction [Itraconazole results in decreased expression of IL5 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Itraconazole results in decreased secretion of IL5 protein]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Ketoconazole results in decreased expression of IL5 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Ketoconazole results in decreased secretion of IL5 protein]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Miconazole results in decreased expression of IL5 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Miconazole results in decreased secretion of IL5 protein]; 1-Methyl-3-isobutylxanthine inhibits the reaction [terbinafine results in decreased expression of IL5 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [terbinafine results in decreased secretion of IL5 protein]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Tolnaftate results in decreased expression of IL5 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Tolnaftate results in decreased secretion of IL5 protein]; 1-Methyl-3-isobutylxanthine promotes the reaction [Albuterol inhibits the reaction [IL5 protein results in increased abundance of Superoxides]]PMID:11886533 PMID:16238794
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