Il5 (interleukin 5) - Rat Genome Database

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Gene: Il5 (interleukin 5) Ictidomys tridecemlineatus
Analyze
Symbol: Il5
Name: interleukin 5
RGD ID: 12595396
Description: ENCODES a protein that exhibits cytokine activity (ortholog); interleukin-5 receptor binding (ortholog); INVOLVED IN cytokine-mediated signaling pathway (ortholog); peptidyl-tyrosine phosphorylation (ortholog); positive regulation of B cell proliferation (ortholog); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; interleukin-4 signaling pathway; interleukin-5 signaling pathway; ASSOCIATED WITH adult T-cell leukemia/lymphoma (ortholog); allergic contact dermatitis (ortholog); allergic rhinitis (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: interleukin 5 (colony-stimulating factor, eosinophil); interleukin-5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213115,645,479 - 115,648,668 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366472,648,241 - 2,651,430 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366472,647,982 - 2,651,477 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adult T-cell leukemia/lymphoma  (ISO)
allergic contact dermatitis  (ISO)
allergic rhinitis  (ISO)
angiostrongyliasis  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
autistic disorder  (ISO)
autoimmune hepatitis  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
Brain Injuries  (ISO)
Bronchial Hyperreactivity  (ISO)
chronic lymphocytic leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
Churg-Strauss syndrome  (ISO)
colitis  (ISO)
Coronavirus infectious disease  (ISO)
Cough  (ISO)
Cytomegalovirus Infections  (ISO)
echinococcosis  (ISO)
Entamoebiasis  (ISO)
Eosinophilia  (ISO)
eosinophilic esophagitis  (ISO)
eosinophilic gastroenteritis  (ISO)
esophageal cancer  (ISO)
Experimental Autoimmune Neuritis  (ISO)
extrinsic allergic alveolitis  (ISO)
familial adenomatous polyposis 1  (ISO)
food allergy  (ISO)
Henoch-Schoenlein purpura  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
inflammatory bowel disease  (ISO)
major depressive disorder  (ISO)
middle cerebral artery infarction  (ISO)
nephrotic syndrome  (ISO)
Neurodevelopmental Disorders  (ISO)
osteoarthritis  (ISO)
Parasitic Intestinal Diseases  (ISO)
peptic esophagitis  (ISO)
Perennial Allergic Rhinitis  (ISO)
prostatic hypertrophy  (ISO)
pulmonary eosinophilia  (ISO)
pulmonary fibrosis  (ISO)
respiratory syncytial virus infectious disease  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
sickle cell anemia  (ISO)
status asthmaticus  (ISO)
stomach cancer  (ISO)
strongyloidiasis  (ISO)
systemic lupus erythematosus  (ISO)
Transplant Rejection  (ISO)
urinary schistosomiasis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Il5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213115,645,479 - 115,648,668 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366472,648,241 - 2,651,430 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366472,647,982 - 2,651,477 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385132,541,445 - 132,556,815 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5132,541,445 - 132,556,838 (-)EnsemblGRCh38hg38GRCh38
GRCh375131,877,137 - 131,879,214 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365131,905,035 - 131,907,113 (-)NCBINCBI36Build 36hg18NCBI36
Build 345131,905,034 - 131,907,113NCBI
Celera5128,007,258 - 128,009,336 (-)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5127,069,401 - 127,071,479 (-)NCBIHuRef
CHM1_15131,310,410 - 131,312,488 (-)NCBICHM1_1
T2T-CHM13v2.05133,061,254 - 133,076,701 (-)NCBIT2T-CHM13v2.0
Il5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,611,621 - 53,615,930 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,611,621 - 53,615,933 (+)EnsemblGRCm39 Ensembl
GRCm381153,720,794 - 53,725,103 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,720,794 - 53,725,106 (+)EnsemblGRCm38mm10GRCm38
MGSCv371153,534,296 - 53,538,605 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361153,564,217 - 53,568,526 (+)NCBIMGSCv36mm8
Celera1158,300,334 - 58,304,644 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.99NCBI
Il5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81038,375,132 - 38,378,003 (+)NCBIGRCr8
mRatBN7.21037,874,342 - 37,877,213 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1037,874,342 - 37,877,213 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1042,566,241 - 42,569,117 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01042,056,311 - 42,059,187 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01037,560,033 - 37,562,909 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01039,066,716 - 39,069,587 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1039,066,716 - 39,069,587 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01038,848,654 - 38,851,525 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,177,786 - 39,180,657 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11039,187,032 - 39,189,904 (+)NCBI
Celera1037,217,913 - 37,220,782 (+)NCBICelera
RH 3.4 Map10405.8RGD
Cytogenetic Map10q22NCBI
Il5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554083,937,894 - 3,939,358 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554083,937,128 - 3,951,784 (-)NCBIChiLan1.0ChiLan1.0
IL5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24127,852,984 - 127,868,373 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15125,985,380 - 126,007,938 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05127,955,377 - 127,961,726 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15134,119,608 - 134,121,682 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5134,119,608 - 134,121,675 (-)Ensemblpanpan1.1panPan2
IL5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11120,825,469 - 20,827,269 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1120,825,469 - 20,827,269 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1119,627,141 - 19,628,942 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01121,611,416 - 21,613,216 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1121,611,416 - 21,613,216 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11120,329,893 - 20,331,692 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01120,177,516 - 20,179,316 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01120,819,966 - 20,821,765 (-)NCBIUU_Cfam_GSD_1.0
IL5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2134,832,147 - 134,835,212 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12134,832,143 - 134,846,141 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140,301,702 - 140,315,329 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12335,360,143 - 35,375,169 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2335,360,506 - 35,362,178 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603442,568,292 - 42,583,307 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473339,556,797 - 39,559,119 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473339,544,487 - 39,558,943 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005335777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010002273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSTOT00000009580   ⟹   ENSSTOP00000008594
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366472,648,241 - 2,651,430 (+)Ensembl
RefSeq Acc Id: XM_005335777   ⟹   XP_005335834
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213115,645,479 - 115,648,668 (+)NCBI
SpeTri2.0NW_0049366472,647,982 - 2,651,477 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005335834 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000008594.3
GenBank Protein KAG3265523 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005335834   ⟸   XM_005335777
- UniProtKB: I3MDT8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSTOP00000008594   ⟸   ENSSTOT00000009580


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000009588 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000009580.3 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/TrEMBL
  IL-5 UniProtKB/TrEMBL
  IL-5_Cytokine UniProtKB/TrEMBL
NCBI Gene Il5 ENTREZGENE
PANTHER INTERLEUKIN-5 UniProtKB/TrEMBL
  INTERLEUKIN-5 UniProtKB/TrEMBL
Pfam IL5 UniProtKB/TrEMBL
PRINTS INTERLEUKIN5 UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/TrEMBL
UniProt I3MDT8 ENTREZGENE, UniProtKB/TrEMBL