RGD Reference Report - A novel rat model to determine interaction between reflux oesophagitis and bronchial asthma. - Rat Genome Database

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A novel rat model to determine interaction between reflux oesophagitis and bronchial asthma.

Authors: Sugawa, T  Fujiwara, Y  Yamagami, H  Watanabe, K  Tanigawa, T  Shiba, M  Watanabe, T  Tominaga, K  Oshitani, N  Higuchi, K  Arakawa, T 
Citation: Sugawa T, etal., Gut. 2008 May;57(5):575-81. Epub 2008 Jan 25.
RGD ID: 2307110
Pubmed: PMID:18222984   (View Abstract at PubMed)
DOI: DOI:10.1136/gut.2007.138461   (Journal Full-text)

BACKGROUND: Several studies have shown a strong association between reflux oesophagitis (RO) and bronchial asthma (BA). The precise mechanisms of interaction between RO and BA are uncertain, possibly due to lack of animal models. AIMS: We established a novel rat model and examined pathogenic interaction of RO and BA. METHODS: RO and BA were induced in Brown-Norway rats by ligating the transitional region between the forestomach and the glandular portion and wrapping the duodenum near the pylorus, and by ovalbumin (OVA) sensitisation and challenge with OVA aerosol. Rats were divided into four groups: control, RO, BA, and RO+BA. OVA-induced airway inflammation was assessed by the number of infiltrating cells and cytokine levels in bronchoalveolar lavage fluid (BALF). Oesophageal lesion index, histology and expression of cytokine mRNA, as determined by real-time RT-PCR, were also examined. RESULTS: Significant increases in the number of cells, especially eosinophils, and IL13 but not IFN-gamma concentration in BALF were observed in the RO+BA group compared with the BA group. These enhancements of OVA-induced airway inflammation were prevented by treatment with rabeprazole. Although the oesophagitis lesion index in the RO+BA group did not differ from that in the RO group, eosinophilic infiltration in the oesophageal submucosa and levels of mRNA expression of cytokines such as IL5, IL10, IL13, and RANTES were significantly increased. CONCLUSION: We established a novel rat model of RO and BA, and found significant interactions of the two diseases. This model thus appears to be useful for examining the association between gastro-oesophageal reflux disease and bronchial asthma.



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Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
IL13Humanasthma  ISOIl13 (Rattus norvegicus)mRNA more ...RGD 
Il13Mouseasthma  ISOIl13 (Rattus norvegicus)mRNA more ...RGD 
Il13Ratasthma  IEP mRNA more ...RGD 
CCL5Humanpeptic esophagitis  ISOCcl5 (Rattus norvegicus)associated with Asthma and mRNA:increased expression:esophagusRGD 
Ccl5Ratpeptic esophagitis  IEP associated with Asthma and mRNA:increased expression:esophagusRGD 
Ccl5Mousepeptic esophagitis  ISOCcl5 (Rattus norvegicus)associated with Asthma and mRNA:increased expression:esophagusRGD 
IL13Humanpeptic esophagitis  ISOIl13 (Rattus norvegicus)associated with asthma more ...RGD 
IL5Humanpeptic esophagitis  ISOIl5 (Rattus norvegicus)associated with asthma and mRNA:increased expression:esophagusRGD 
Il13Ratpeptic esophagitis  IEP associated with asthma more ...RGD 
Il13Mousepeptic esophagitis  ISOIl13 (Rattus norvegicus)associated with asthma more ...RGD 
Il5Ratpeptic esophagitis  IEP associated with asthma and mRNA:increased expression:esophagusRGD 
Il5Mousepeptic esophagitis  ISOIl5 (Rattus norvegicus)associated with asthma and mRNA:increased expression:esophagusRGD 
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Genes (Rattus norvegicus)
Ccl5  (C-C motif chemokine ligand 5) Il13  (interleukin 13) Il5  (interleukin 5)

Genes (Mus musculus)
Ccl5  (C-C motif chemokine ligand 5) Il13  (interleukin 13) Il5  (interleukin 5)

Genes (Homo sapiens)
CCL5  (C-C motif chemokine ligand 5) IL13  (interleukin 13) IL5  (interleukin 5)