Ccl5 (C-C motif chemokine ligand 5) - Rat Genome Database

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Gene: Ccl5 (C-C motif chemokine ligand 5) Mus musculus
Analyze
Symbol: Ccl5
Name: C-C motif chemokine ligand 5
RGD ID: 69127
MGI Page MGI
Description: Enables CCR1 chemokine receptor binding activity. Involved in negative regulation of macrophage apoptotic process and positive regulation of monocyte chemotaxis. Acts upstream of or within inflammatory response; positive regulation of epithelial cell proliferation; and response to tumor necrosis factor. Located in cytoplasm and extracellular space. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; liver; and retina. Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; liver disease (multiple); pulmonary tuberculosis; and severe acute respiratory syndrome. Orthologous to human CCL5 (C-C motif chemokine ligand 5).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-C motif chemokine 5; chemokine (C-C motif) ligand 5; MuRa; MuRantes; RA; RANTES; S; Scy; Scya5; SIS-delta; SISd; small inducible cytokine A5; small-inducible cytokine A5; T-cell-specific protein RANTES; TCP22; TCP228
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391183,416,604 - 83,421,344 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1183,416,604 - 83,421,344 (-)EnsemblGRCm39 Ensembl
GRCm381183,525,778 - 83,530,518 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1183,525,778 - 83,530,518 (-)EnsemblGRCm38mm10GRCm38
MGSCv371183,339,280 - 83,344,020 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361183,341,974 - 83,346,692 (-)NCBIMGSCv36mm8
Celera1193,127,305 - 93,132,049 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1150.66NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Ccl5Mouseacute kidney failure  IEP 4889990protein:increased secretion:serum (mouse)RGD 
Ccl5MouseAcute Liver Failure  ISOCCL5 (Homo sapiens)14995451protein and mRNA:increased expression:liverRGD 
Ccl5Mousealcoholic hepatitis treatmentISOCcl5 (Rattus norvegicus)14995304 RGD 
Ccl5Mouseallergic conjunctivitis  ISOCcl5 (Rattus norvegicus)2307196mRNA:increased expression:conjunctivaRGD 
Ccl5Mouseallergic contact dermatitis  IEP 1626251protein:increased expression:ear (mouse)RGD 
Ccl5MouseAlzheimer's disease  ISOCCL5 (Homo sapiens)4890025mRNA:increased expression:cerebrum and blood vessels (human)RGD 
Ccl5MouseAnimal Toxoplasmosis  ISOCcl5 (Rattus norvegicus)2307183mRNA and protein:increased expression:blood vessel endothelial cellRGD 
Ccl5Mouseanti-basement membrane glomerulonephritis  ISOCcl5 (Rattus norvegicus)2307059mRNA:increased expression:glomerulusRGD 
Ccl5Mouseantiphospholipid syndrome  ISOCCL5 (Homo sapiens)401794584protein:increased expression:plasmaRGD 
Ccl5Mousearteriosclerosis  IMP 4890030 RGD 
Ccl5Mousearteriosclerosis  IEP 4891452protein:increased secretion:serum (mouse)RGD 
Ccl5Mousearteriosclerosis  ISOCcl5 (Rattus norvegicus)2307165protein:increased expression:plasmaRGD 
Ccl5Mouseasthma susceptibilityISOCCL5 (Homo sapiens)4891381DNA:transition:5' utr:-403G>A (human)RGD 
Ccl5Mouseasthma  IEP 4891430protein:increased expression:lung and secretion (mouse)RGD 
Ccl5Mouseasthma  ISOCcl5 (Rattus norvegicus)2307112protein:increased expression:smooth muscle cellRGD 
Ccl5Mouseatherosclerosis amelioratesIMP 329901820 RGD 
Ccl5MouseBreast Neoplasms  IDA 4891915 RGD 
Ccl5Mousebronchiolitis obliterans  ISOCcl5 (Rattus norvegicus)4889978mRNA:increased expression:lung (rat)RGD 
Ccl5Mousebronchiolitis obliterans  ISOCcl5 (Rattus norvegicus)2307195 RGD 
Ccl5Mousebronchopneumonia  ISOCCL5 (Homo sapiens)4892019protein:increased secretion:serum (human)RGD 
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Ccl5Mousehuman immunodeficiency virus infectious disease  ISOCCL5 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10200305 more ...
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Ccl5Mousealcoholic hepatitis  ISOCCL5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12586603
Ccl5Mouseasthma  ISOCCL5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:8534483
Ccl5Mouseatopic dermatitis  ISOCCL5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18249437
Ccl5Mouseautoimmune hepatitis  ISOCCL5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21227906
Ccl5MouseExperimental Liver Cirrhosis  ISOCCL5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25380136
Ccl5Mouseglomerulonephritis  ISOCCL5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:10385480
Ccl5Mousehuman immunodeficiency virus infectious disease  ISOCCL5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Ccl5MouseHyperoxaluria  ISOCCL5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16284884
Ccl5Mousemalignant mesothelioma  ISOCCL5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25162674
Ccl5MouseNeoplasm Invasiveness  ISOCCL5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18985009
Ccl5Mouseprimary biliary cholangitis  ISOCCL5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12126966
Ccl5Mousepulmonary fibrosis  ISOCCL5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17620002
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Ccl5Mousehuman immunodeficiency virus infectious disease  ISOCCL5 (Homo sapiens)7240710 OMIM 

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Ccl5Mouse(+)-catechin multiple interactionsISOCCL5 (Homo sapiens)6480464[Oxygen deficiency co-treated with Catechin] results in increased expression of CCL5 mRNACTDPMID:35883890
Ccl5Mouse(-)-alpha-phellandrene increases expressionISOCCL5 (Homo sapiens)6480464alpha phellandrene results in increased expression of CCL5 mRNACTDPMID:25075043
Ccl5Mouse(-)-anisomycin decreases expressionISOCCL5 (Homo sapiens)6480464Anisomycin results in decreased expression of CCL5 proteinCTDPMID:20116850
Ccl5Mouse(-)-demecolcine increases expressionISOCCL5 (Homo sapiens)6480464Demecolcine results in increased expression of CCL5 mRNACTDPMID:23649840
Ccl5Mouse(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid multiple interactionsEXP 6480464zopolrestat inhibits the reaction [Antigens and Plant results in increased expression of CCL5 mRNA]CTDPMID:21334316
Ccl5Mouse(R)-noradrenaline increases secretionISOCCL5 (Homo sapiens)6480464Norepinephrine results in increased secretion of CCL5 proteinCTDPMID:16782692
Ccl5Mouse(R)-noradrenaline multiple interactionsISOCCL5 (Homo sapiens)6480464Prazosin inhibits the reaction [Norepinephrine results in increased secretion of CCL5 protein]CTDPMID:16782692
Ccl5Mouse(S)-nicotine increases expressionISOCCL5 (Homo sapiens)6480464Nicotine results in increased expression of CCL5 mRNACTDPMID:18247414
Ccl5Mouse1,4-benzoquinone increases expressionISOCCL5 (Homo sapiens)6480464quinone results in increased expression of CCL5 proteinCTDPMID:17572062
Ccl5Mouse1,4-phenylenediamine increases expressionISOCCL5 (Homo sapiens)64804644-phenylenediamine results in increased expression of CCL5 mRNACTDPMID:27585668
Ccl5Mouse1-Aminopyrene increases expressionISOCCL5 (Homo sapiens)64804641-aminopyrene results in increased expression of CCL5 mRNACTDPMID:19879285
Ccl5Mouse1-chloro-2,4-dinitrobenzene multiple interactionsEXP 6480464diflorasone inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCL5 protein]CTDPMID:15491423
Ccl5Mouse1-chloro-2,4-dinitrobenzene decreases expressionEXP 6480464Dinitrochlorobenzene results in decreased expression of CCL5 mRNACTDPMID:21404309 and PMID:28219650
Ccl5Mouse1-chloro-2,4-dinitrobenzene increases secretionISOCCL5 (Homo sapiens)6480464Dinitrochlorobenzene results in increased secretion of CCL5 proteinCTDPMID:20488241
Ccl5Mouse1-chloro-2,4-dinitrobenzene increases expressionEXP 6480464Dinitrochlorobenzene results in increased expression of CCL5 proteinCTDPMID:15491423
Ccl5Mouse1-fluoro-2,4-dinitrobenzene increases expressionEXP 6480464Dinitrofluorobenzene results in increased expression of CCL5 mRNA and Dinitrofluorobenzene results in increased expression of CCL5 proteinCTDPMID:15719370
Ccl5Mouse1-naphthyl isothiocyanate affects expressionISOCcl5 (Rattus norvegicus)64804641-Naphthylisothiocyanate affects the expression of CCL5 proteinCTDPMID:25051504
Ccl5Mouse1-naphthyl isothiocyanate decreases expressionISOCcl5 (Rattus norvegicus)64804641-Naphthylisothiocyanate results in decreased expression of CCL5 mRNACTDPMID:30723492
Ccl5Mouse1-naphthyl isothiocyanate increases expressionISOCcl5 (Rattus norvegicus)64804641-Naphthylisothiocyanate results in increased expression of CCL5 mRNACTDPMID:25380136
Ccl5Mouse1-nitropyrene increases expressionISOCCL5 (Homo sapiens)64804641-nitropyrene results in increased expression of CCL5 mRNACTDPMID:19879285

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Biological Process
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Ccl5Mouseactivation of phospholipase D activity involved_inISSUniProtKB:P135012290270 BHF-UCLGO_REF:0000024
Ccl5Mouseactivation of phospholipase D activity involved_inISOUniProtKB:P135012290270 GO_CentralGO_REF:0000119
Ccl5Mouseantimicrobial humoral immune response mediated by antimicrobial peptide involved_inIBAPANTHER:PTN000245709 more ...2290270 GO_CentralGO_REF:0000033
Ccl5Mousecalcium ion transport involved_inIEAUniProtKB:P13501 and ensembl:ENSP000004750572290270 EnsemblGO_REF:0000107
Ccl5Mousecalcium ion transport involved_inISOUniProtKB:P135012290270 GO_CentralGO_REF:0000119
Ccl5Mousecell-cell signaling involved_inISSUniProtKB:P135012290270 BHF-UCLGO_REF:0000024
Ccl5Mousecell-cell signaling involved_inISOUniProtKB:P135012290270 GO_CentralGO_REF:0000119
Ccl5Mousecellular response to alkyl hydroperoxide  ISOCcl5 (Rattus norvegicus)9068941 RGDPMID:18478184 and REF_RGD_ID:4890017
Ccl5Mousecellular response to amino acid stimulus  ISOCcl5 (Rattus norvegicus)9068941 RGDPMID:20560880 and REF_RGD_ID:4889887
Ccl5Mousecellular response to cytokine stimulus  ISOCcl5 (Rattus norvegicus)9068941lymphotoxin-beta and LIGHTRGDPMID:19111021 and REF_RGD_ID:4890006
Ccl5Mousecellular response to ethanol  ISOCcl5 (Rattus norvegicus)9068941 RGDPMID:19828633 and REF_RGD_ID:4889979
Ccl5Mousecellular response to fibroblast growth factor stimulus involved_inIEAUniProtKB:P13501 and ensembl:ENSP000004750572290270 EnsemblGO_REF:0000107
Ccl5Mousecellular response to high density lipoprotein particle stimulus  ISOCcl5 (Rattus norvegicus)9068941oxidized HDLRGDPMID:20623482 and REF_RGD_ID:4889888
Ccl5Mousecellular response to interleukin-1 involved_inIEAUniProtKB:P13501 and ensembl:ENSP000004750572290270 EnsemblGO_REF:0000107
Ccl5Mousecellular response to lipid  ISOCcl5 (Rattus norvegicus)9068941lysophosphatidylcholineRGDPMID:20638371 and REF_RGD_ID:4889886
Ccl5Mousecellular response to lipopolysaccharide  ISOCcl5 (Rattus norvegicus)9068941 RGDPMID:20578038 and REF_RGD_ID:4889899
Ccl5Mousecellular response to morphine  ISOCcl5 (Rattus norvegicus)9068941 RGDPMID:20578038 and REF_RGD_ID:4889899
Ccl5Mousecellular response to transforming growth factor beta stimulus  ISOCcl5 (Rattus norvegicus)9068941 RGDPMID:20429874 and REF_RGD_ID:4889909
Ccl5Mousecellular response to tumor necrosis factor involved_inIEAUniProtKB:P13501 and ensembl:ENSP000004750572290270 EnsemblGO_REF:0000107
Ccl5Mousecellular response to tumor necrosis factor  ISOCcl5 (Rattus norvegicus)9068941 RGDPMID:20663893 and REF_RGD_ID:4889885
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Cellular Component

  
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Ccl5Mousecytoplasm located_inIDA 2290270 PMID:1375672MGIPMID:1375672
Ccl5Mouseextracellular space  ISOCcl5 (Rattus norvegicus)9068941 RGDPMID:18208670 and REF_RGD_ID:2307112
Ccl5Mouseextracellular space located_inIDA 2290270 PMID:21148126 more ...MGIPMID:21148126 more ...
Ccl5Mouseextracellular space located_inISOCcl5 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Ccl5Mouseextracellular space is_active_inIBAPANTHER:PTN000245709 more ...2290270 GO_CentralGO_REF:0000033

Molecular Function
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Ccl5MouseCCR chemokine receptor binding enablesIBAPANTHER:PTN000245709 more ...2290270 GO_CentralGO_REF:0000033
Ccl5MouseCCR1 chemokine receptor binding enablesIDA 2290270 PMID:15557190BHF-UCLPMID:15557190
Ccl5MouseCCR1 chemokine receptor binding enablesISOUniProtKB:P135012290270 GO_CentralGO_REF:0000119
Ccl5MouseCCR5 chemokine receptor binding enablesISOUniProtKB:P135012290270 GO_CentralGO_REF:0000119
Ccl5MouseCCR5 chemokine receptor binding enablesISSUniProtKB:P135012290270 BHF-UCLGO_REF:0000024
Ccl5Mousechemoattractant activity enablesISOUniProtKB:P135012290270 GO_CentralGO_REF:0000119
Ccl5Mousechemoattractant activity enablesIEAUniProtKB:P13501 and ensembl:ENSP000004750572290270 EnsemblGO_REF:0000107
Ccl5Mousechemokine activity  ISOCcl5 (Rattus norvegicus)9068941 RGDPMID:11069838 more ...
Ccl5Mousechemokine activity enablesISOCcl5 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Ccl5Mousechemokine activity enablesISOUniProtKB:P135012290270 GO_CentralGO_REF:0000119
Ccl5Mousechemokine activity enablesIBAPANTHER:PTN000245709 more ...2290270 GO_CentralGO_REF:0000033
Ccl5Mousechemokine activity enablesISSUniProtKB:P135012290270 BHF-UCLGO_REF:0000024
Ccl5Mousechemokine receptor antagonist activity enablesISOUniProtKB:P135012290270 GO_CentralGO_REF:0000119
Ccl5Mousechemokine receptor antagonist activity enablesISSUniProtKB:P135012290270 BHF-UCLGO_REF:0000024
Ccl5Mousechemokine receptor binding enablesISOUniProtKB:P135012290270 GO_CentralGO_REF:0000119
Ccl5Mouseheparin binding enablesISOCcl5 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Ccl5Mouseheparin binding  ISOCcl5 (Rattus norvegicus)9068941 RGDPMID:21052646 and REF_RGD_ID:4889872
Ccl5Mouseidentical protein binding enablesISOUniProtKB:P135012290270 GO_CentralGO_REF:0000119
Ccl5Mousephosphatidylinositol-4,5-bisphosphate phospholipase C activity enablesISOUniProtKB:P135012290270 GO_CentralGO_REF:0000119
Ccl5Mousephosphatidylinositol-4,5-bisphosphate phospholipase C activity enablesIEAUniProtKB:P13501 and ensembl:ENSP000004750572290270 EnsemblGO_REF:0000107
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Imported Annotations - KEGG (archival)

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Ccl5MouseChagas disease pathway  IEA 6907045 KEGGmmu:05142
Ccl5Mouseinfluenza A pathway  IEA 6907045 KEGGmmu:05164
Ccl5MouseNOD-like receptor signaling pathway  IEA 6907045 KEGGmmu:04621
Ccl5Mouseprion disease pathway  IEA 6907045 KEGGmmu:05020
Ccl5Mouserheumatoid arthritis pathway  IEA 6907045 KEGGmmu:05323
Ccl5MouseToll-like receptor signaling pathway   IEA 6907045 KEGGmmu:04620

Imported Annotations - PID (archival)

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Ccl5Mousesyndecan signaling pathway  ISOCCL5 (Homo sapiens)6484113 PIDPID:200156
Ccl5Mousesyndecan signaling pathway  ISOCCL5 (Homo sapiens)6484113 PIDPID:200134

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Reference Title
Reference Citation
1. The preventive effect of Met-RANTES on postoperative intraperitoneal adhesion formation in the rat model. Akyildiz H, etal., Surgery. 2008 Sep;144(3):404-9. Epub 2008 Jul 10.
2. RANTES gene polymorphisms (-403G>A and -28C>G) associated with hepatitis B virus infection in a Saudi population. Al-Qahtani A, etal., Genet Mol Res. 2012 Apr 10;11(2):855-62. doi: 10.4238/2012.April.10.1.
3. Polyclonal antibody directed against human RANTES ameliorates disease in the Lewis rat adjuvant-induced arthritis model. Barnes DA, etal., J Clin Invest. 1998 Jun 15;101(12):2910-9.
4. A novel pretherapeutic gene expression-based risk score for treatment guidance in gastric cancer. Bauer L, etal., Ann Oncol. 2018 Jan 1;29(1):127-132. doi: 10.1093/annonc/mdx685.
5. TARC and RANTES, but not CTACK, are induced in two models of allergic contact dermatitis. Effects of cilomilast and diflorasone diacetate on T-cell-attracting chemokines. Baumer W, etal., Br J Dermatol. 2004 Oct;151(4):823-30.
6. Elevated level of the proinflammatory chemokine, RANTES/CCL5, in the periaqueductal grey causes hyperalgesia in rats. Benamar K, etal., Eur J Pharmacol. 2008 Sep 11;592(1-3):93-5. Epub 2008 Jul 11.
7. Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice. Berres ML, etal., J Clin Invest. 2010 Nov;120(11):4129-40. doi: 10.1172/JCI41732. Epub 2010 Oct 18.
8. Delayed functional expression of neuronal chemokine receptors following focal nerve demyelination in the rat: a mechanism for the development of chronic sensitization of peripheral nociceptors. Bhangoo S, etal., Mol Pain. 2007 Dec 12;3:38.
9. Influence of insulin therapy on expression of chemokine receptor CCR5 and selected inflammatory markers in patients with type 2 diabetes mellitus. Bogdanski P, etal., Int J Clin Pharmacol Ther. 2007 Oct;45(10):563-7.
10. CCR3- and CXCR4-mediated interactions regulate migration of CD34+ human bone marrow progenitors to ischemic myocardium and subsequent tissue repair. Bonaros N, etal., J Thorac Cardiovasc Surg. 2008 Oct;136(4):1044-53. Epub 2008 Jul 7.
11. [Urinary excretion of proinflammatory cytokines and transforming growth factor beta at early stages of diabetic nephropathy]. Bondar' IA, etal., Ter Arkh. 2008;80(1):52-6.
12. Endothelial dysfunction and specific inflammation in obesity hypoventilation syndrome. Borel JC, etal., PLoS One. 2009 Aug 24;4(8):e6733.
13. Macrophage inflammatory protein-1alpha (MIP-1alpha), MIP-1beta, and RANTES mRNA semiquantification and protein expression in active demyelinating multiple sclerosis (MS) lesions. Boven LA, etal., Clin Exp Immunol. 2000 Nov;122(2):257-63.
14. The plant extract Isatis tinctoria L. extract (ITE) inhibits allergen-induced airway inflammation and hyperreactivity in mice. Brattstrom A, etal., Phytomedicine. 2010 Jul;17(8-9):551-6. Epub 2010 Jan 22.
15. Protective effect of intravitreal injection of vasoactive intestinal peptide-loaded liposomes on experimental autoimmune uveoretinitis. Camelo S, etal., J Ocul Pharmacol Ther. 2009 Feb;25(1):9-21.
16. IFN regulatory factor 3 contributes to the host response during Pseudomonas aeruginosa lung infection in mice. Carrigan SO, etal., J Immunol. 2010 Sep 15;185(6):3602-9. Epub 2010 Aug 18.
17. Expression and secretion of RANTES (CCL5) in granulomatous calcified tissue before and after lipopolysaccharide treatment in vivo. Castellani ML, etal., Calcif Tissue Int. 2007 Jan;80(1):60-7. Epub 2006 Dec 8.
18. The anti-allergic activity of the acetate fraction of Schinus terebinthifolius leaves in IgE induced mice paw edema and pleurisy. Cavalher-Machado SC, etal., Int Immunopharmacol. 2008 Nov;8(11):1552-60. Epub 2008 Jul 29.
19. SARS Unique Domain (SUD) of Severe Acute Respiratory Syndrome Coronavirus Induces NLRP3 Inflammasome-Dependent CXCL10-Mediated Pulmonary Inflammation. Chang YS, etal., Int J Mol Sci. 2020 Apr 30;21(9). pii: ijms21093179. doi: 10.3390/ijms21093179.
20. Chemokine RANTES promoter dimorphisms and hepatocellular carcinoma occurrence in patients with alcoholic or hepatitis C virus-related cirrhosis. Charni F, etal., Cancer Epidemiol Biomarkers Prev. 2011 Jul;20(7):1439-46. doi: 10.1158/1055-9965.EPI-11-0341. Epub 2011 May 24.
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PMID:1375672   PMID:1376260   PMID:2456327   PMID:7507961   PMID:7513046   PMID:7542490   PMID:7594543   PMID:7594550   PMID:8981365   PMID:9311871   PMID:9365123   PMID:9730682  
PMID:10235110   PMID:10349636   PMID:10438970   PMID:10594742   PMID:10790402   PMID:10995569   PMID:11000125   PMID:11042159   PMID:11076861   PMID:11466387   PMID:11744622   PMID:11801530  
PMID:11818130   PMID:11890717   PMID:11893739   PMID:11911480   PMID:11972057   PMID:11987989   PMID:12077225   PMID:12080938   PMID:12093895   PMID:12112372   PMID:12126650   PMID:12234959  
PMID:12477932   PMID:12850812   PMID:12928419   PMID:14687724   PMID:14761932   PMID:15034013   PMID:15240757   PMID:15271961   PMID:15381731   PMID:15489334   PMID:15546955   PMID:15557190  
PMID:15718270   PMID:15748167   PMID:15860458   PMID:15890969   PMID:15905535   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16707500   PMID:16807117   PMID:16849492   PMID:16873271  
PMID:16940143   PMID:16982880   PMID:16983723   PMID:17220320   PMID:17244892   PMID:17641009   PMID:17641205   PMID:17893273   PMID:17978871   PMID:18287559   PMID:18388327   PMID:18624307  
PMID:18635850   PMID:18700040   PMID:18815890   PMID:18986535   PMID:19006696   PMID:19121387   PMID:19236348   PMID:19421418   PMID:19427874   PMID:19524301   PMID:19665464   PMID:19779041  
PMID:19853894   PMID:19923453   PMID:20038813   PMID:20046229   PMID:20371596   PMID:20442771   PMID:20573836   PMID:20720435   PMID:20864798   PMID:20886281   PMID:21074454   PMID:21148126  
PMID:21267068   PMID:21293018   PMID:21302497   PMID:21335555   PMID:21454528   PMID:21565393   PMID:21680945   PMID:21715689   PMID:21814510   PMID:21873635   PMID:22088941   PMID:22156592  
PMID:22178100   PMID:22205974   PMID:22214846   PMID:22289892   PMID:22297845   PMID:22385043   PMID:22425022   PMID:22447977   PMID:22494696   PMID:22494919   PMID:22679098   PMID:22797700  
1 to 10 of 21 rows



Ccl5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391183,416,604 - 83,421,344 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1183,416,604 - 83,421,344 (-)EnsemblGRCm39 Ensembl
GRCm381183,525,778 - 83,530,518 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1183,525,778 - 83,530,518 (-)EnsemblGRCm38mm10GRCm38
MGSCv371183,339,280 - 83,344,020 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361183,341,974 - 83,346,692 (-)NCBIMGSCv36mm8
Celera1193,127,305 - 93,132,049 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1150.66NCBI
CCL5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381735,871,491 - 35,880,360 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1735,871,491 - 35,880,793 (-)EnsemblGRCh38hg38GRCh38
GRCh371734,198,495 - 34,207,364 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361731,222,608 - 31,231,490 (-)NCBINCBI36Build 36hg18NCBI36
Celera1731,108,052 - 31,116,934 (-)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1730,383,508 - 30,392,390 (-)NCBIHuRef
CHM1_11734,263,060 - 34,271,942 (-)NCBICHM1_1
T2T-CHM13v2.01736,819,399 - 36,828,268 (-)NCBIT2T-CHM13v2.0
Ccl5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81068,820,330 - 68,824,906 (-)NCBIGRCr8
mRatBN7.21068,322,826 - 68,327,380 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1068,322,829 - 68,327,377 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1072,942,820 - 72,947,359 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01072,448,203 - 72,452,742 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01067,912,255 - 67,916,794 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01070,739,764 - 70,744,303 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1070,739,800 - 70,744,315 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01070,373,353 - 70,377,892 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41071,605,791 - 71,610,330 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11071,620,206 - 71,624,712 (-)NCBI
Celera1067,264,203 - 67,268,742 (-)NCBICelera
Cytogenetic Map10q26NCBI
Ccl5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495548110,293,399 - 10,301,143 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495548110,293,758 - 10,301,118 (-)NCBIChiLan1.0ChiLan1.0
CCL5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21928,596,811 - 28,605,632 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11730,476,222 - 30,484,892 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01720,915,198 - 20,923,530 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11721,210,798 - 21,219,172 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1721,210,798 - 21,219,172 (+)Ensemblpanpan1.1panPan2
CCL5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1937,817,409 - 37,823,852 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl937,817,305 - 37,823,852 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha937,039,892 - 37,046,335 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0938,627,353 - 38,633,796 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl938,627,249 - 38,633,796 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1937,410,157 - 37,416,605 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0937,695,725 - 37,702,162 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0937,783,127 - 37,789,578 (+)NCBIUU_Cfam_GSD_1.0
Ccl5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560236,815,103 - 36,821,857 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936490253,034 - 259,965 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936490253,279 - 259,947 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCL5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1239,648,598 - 39,659,118 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11239,652,731 - 39,659,121 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21241,218,074 - 41,228,604 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCL5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11629,351,214 - 29,361,317 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666075615,422 - 624,588 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccl5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248753,334,078 - 3,341,614 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248753,334,136 - 3,342,085 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Ccl5
104 total Variants

Predicted Target Of
Summary Value
Count of predictions:224
Count of miRNA genes:183
Interacting mature miRNAs:203
Transcripts:ENSMUST00000035938, ENSMUST00000125015
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 54 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse

1 to 10 of 54 rows
Ccl5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11CUniSTS
cM Map1147.4UniSTS
cM Map1147.4UniSTS
Ccl5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11CUniSTS
Ccl5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11CUniSTS
cM Map1147.4UniSTS






1 to 19 of 19 rows
RefSeq Transcripts NM_013653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB051897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF065944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF065945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF065946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF065947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF128187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK003101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK158074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL596122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY722103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC033508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE333205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M77747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S37648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U02298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X70675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 19 of 19 rows

Ensembl Acc Id: ENSMUST00000035938   ⟹   ENSMUSP00000039600
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1183,416,604 - 83,421,344 (-)Ensembl
GRCm38.p6 Ensembl1183,525,778 - 83,530,518 (-)Ensembl
Ensembl Acc Id: ENSMUST00000125015
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1183,419,554 - 83,421,339 (-)Ensembl
GRCm38.p6 Ensembl1183,528,728 - 83,530,513 (-)Ensembl
RefSeq Acc Id: NM_013653   ⟹   NP_038681
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391183,416,604 - 83,421,344 (-)NCBI
GRCm381183,525,778 - 83,530,518 (-)ENTREZGENE
MGSCv371183,339,280 - 83,344,020 (-)RGD
Celera1193,127,305 - 93,132,049 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_038681   ⟸   NM_013653
- Peptide Label: precursor
- UniProtKB: P30882 (UniProtKB/Swiss-Prot),   Q5XZF2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000039600   ⟸   ENSMUST00000035938
Chemokine interleukin-8-like

Name Modeler Protein Id AA Range Protein Structure
AF-P30882-F1-model_v2 AlphaFold P30882 1-91 view protein structure

RGD ID:6820571
Promoter ID:MM_KWN:8899
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:OTTMUST00000001951,   OTTMUST00000001952
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361183,343,631 - 83,344,131 (-)MPROMDB
RGD ID:8675908
Promoter ID:EPDNEW_M15985
Type:initiation region
Name:Ccl5_1
Description:Mus musculus chemokine (C-C motif) ligand 5 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381183,530,518 - 83,530,578EPDNEW


1 to 20 of 20 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000035042 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000035938 ENTREZGENE
  ENSMUST00000035938.3 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.40 UniProtKB/Swiss-Prot
InterPro Chemokine_b/g/d UniProtKB/Swiss-Prot
  Chemokine_CC_CS UniProtKB/Swiss-Prot
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot
  Interleukin_8-like_sf UniProtKB/Swiss-Prot
KEGG Report mmu:20304 UniProtKB/Swiss-Prot
MGD MGI:98262 ENTREZGENE
NCBI Gene 20304 ENTREZGENE
PANTHER C-C MOTIF CHEMOKINE 5 UniProtKB/Swiss-Prot
  PTHR12015 UniProtKB/Swiss-Prot
Pfam IL8 UniProtKB/Swiss-Prot
PhenoGen Ccl5 PhenoGen
PROSITE SMALL_CYTOKINES_CC UniProtKB/Swiss-Prot
SMART SCY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot
UniProt CCL5_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q5XZF2 ENTREZGENE, UniProtKB/TrEMBL
1 to 20 of 20 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-07-04 Ccl5  C-C motif chemokine ligand 5  Ccl5  chemokine (C-C motif) ligand 5  Symbol and/or name change 5135510 APPROVED