RGD Reference Report - Role of FTY720 on M1 and M2 macrophages, lymphocytes, and chemokines in 5/6 nephrectomized rats. - Rat Genome Database

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Role of FTY720 on M1 and M2 macrophages, lymphocytes, and chemokines in 5/6 nephrectomized rats.

Authors: Schaier, M  Vorwalder, S  Sommerer, C  Dikow, R  Hug, F  Gross, ML  Waldherr, R  Zeier, M 
Citation: Schaier M, etal., Am J Physiol Renal Physiol. 2009 Sep;297(3):F769-80. Epub 2009 Jun 17.
RGD ID: 4889989
Pubmed: PMID:19535570   (View Abstract at PubMed)
DOI: DOI:10.1152/ajprenal.90530.2008   (Journal Full-text)

Renal injury is accompanied by the presence of infiltrating inflammatory cells in the glomerulus and tubulointerstitium. FTY720 modifies lymphocyte migration into injured tissues by lymphocyte sequestration to secondary lymphoid organs. The purpose of this study was to examine the potential of FTY720 to influence the inflammatory response in a nonimmunological model of renal failure. Sham-operated and 5/6 nephrectomized (SNX) Sprague-Dawley rats received two different doses of FTY720 or vehicle orally for 14 wk. Treatment with FTY720 reduced glomerular and tubulointerstitial damage in SNX rats but failed to stabilize creatinine clearance. The increase in gene expression of chemokine receptors CCR1, CCR2, and CCR5 in kidneys of vehicle-treated SNX rats was significantly attenuated by high-dose FTY720. Treatment with high-dose FTY720 tended to normalize RANTES and MCP-1 renal gene expression. FTY720 affected not only glomerular and tubulointerstitial lymphocytes, but M1 and M2 phenotype macrophages were also reduced. FTY720 significantly reduced key mediators of renal inflammation and fibrosis. FTY720 also decreased immunoregulation of M2 macrophages, which are beneficial for tissue remodeling and repair.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CCL5Humanend stage renal disease  ISOCcl5 (Rattus norvegicus)mRNA:increased expression:kidney cortex (rat)RGD 
CCR5Humanend stage renal disease  ISOCcr5 (Rattus norvegicus)mRNA:increased expression:kidney cortex (rat)RGD 
Ccl5Ratend stage renal disease  IEP mRNA:increased expression:kidney cortex (rat)RGD 
Ccl5Mouseend stage renal disease  ISOCcl5 (Rattus norvegicus)mRNA:increased expression:kidney cortex (rat)RGD 
Ccr5Ratend stage renal disease  IEP mRNA:increased expression:kidney cortex (rat)RGD 
Ccr5Mouseend stage renal disease  ISOCcr5 (Rattus norvegicus)mRNA:increased expression:kidney cortex (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccl5  (C-C motif chemokine ligand 5)
Ccr5  (C-C motif chemokine receptor 5)

Genes (Mus musculus)
Ccl5  (C-C motif chemokine ligand 5)
Ccr5  (C-C motif chemokine receptor 5)

Genes (Homo sapiens)
CCL5  (C-C motif chemokine ligand 5)
CCR5  (C-C motif chemokine receptor 5)


Additional Information