Ccr5 (chemokine (C-C motif) receptor 5) - Rat Genome Database

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Gene: Ccr5 (chemokine (C-C motif) receptor 5) Mus musculus
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Symbol: Ccr5
Name: chemokine (C-C motif) receptor 5
RGD ID: 733487
MGI Page MGI
Description: Enables C-C chemokine binding activity and C-C chemokine receptor activity. Involved in negative regulation of macrophage apoptotic process. Acts upstream of or within defense response. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study Coronavirus infectious disease. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; West Nile fever; autoimmune disease (multiple); berylliosis; and sarcoidosis (multiple). Orthologous to human CCR5 (C-C motif chemokine receptor 5); PARTICIPATES IN interleukin-12 signaling pathway; endocytosis pathway; toxoplasmosis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AM4-7; C-C chemokine receptor type 5; C-C CKR-5; CC-CKR-5; CCR-5; CD195; chemokine (C-C) receptor 5; Cmkbr; Cmkbr5; MIP-1 alpha receptor
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399123,921,557 - 123,934,153 (+)NCBIGRCm39mm39
GRCm39 Ensembl9123,921,580 - 123,947,736 (+)Ensembl
GRCm389124,121,543 - 124,127,183 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9124,121,543 - 124,147,699 (+)EnsemblGRCm38mm10GRCm38
MGSCv379124,036,282 - 124,041,922 (+)NCBIGRCm37mm9NCBIm37
Celera9124,872,533 - 124,878,180 (-)NCBICelera
Cytogenetic Map9F4NCBI
cM Map975.05NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acquired immunodeficiency syndrome  (ISO)
Acute Hepatitis  (IMP)
acute kidney failure  (ISO)
Alcoholic Fatty Liver  (IMP)
allergic contact dermatitis  (ISO)
Alzheimer's disease  (ISO)
anterior uveitis  (ISO)
Arterial Injury  (ISO)
arteriosclerosis  (IMP)
asthma  (IEP,IMP,ISO)
atherosclerosis  (IMP)
atopic dermatitis  (ISO)
Behcet's disease  (ISO)
berylliosis  (ISO)
Birth Injuries  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
cerebral infarction  (IEP)
Chemical and Drug Induced Liver Injury  (IMP)
chlamydia  (IMP)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
corneal neovascularization  (IMP)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
Coronavirus infectious disease  (IEA,IEP,IMP)
cutaneous leishmaniasis  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (IEP)
dry eye syndrome  (ISO)
end stage renal disease  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (IEP,IMP)
fallopian tube disease  (ISO)
Fever  (IDA,ISO)
Flaviviridae Infections  (ISO)
gallbladder cancer  (ISO)
glaucoma  (ISO)
Graft vs Host Disease  (IEP)
granulomatosis with polyangiitis  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
Herpes Simplex Encephalitis  (IMP)
herpes simplex virus keratitis  (IMP)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (IMP,ISO)
Hyperalgesia  (IMP,ISO)
hypertension  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
Inflammation  (ISO)
interstitial lung disease  (ISO)
juvenile rheumatoid arthritis  (ISO)
Kawasaki disease  (ISO)
keratoconjunctivitis sicca  (ISO)
leishmaniasis  (IMP,ISO)
Liver Injury  (ISO)
Lymphatic Metastasis  (ISO)
Mammary Neoplasms, Experimental  (ISO)
multiple sclerosis  (ISO)
Mycoplasma Infections  (ISO)
Mycoplasma pneumoniae pneumonia  (IEP)
Myocardial Reperfusion Injury  (ISO)
nephritis  (ISO)
optic neuritis  (ISO)
Oral Lichen Planus  (ISO)
orchitis  (ISO)
ovarian carcinoma  (ISO)
pancreatic cancer  (IMP)
paracoccidioidomycosis  (IMP)
Perennial Allergic Rhinitis  (ISO)
plague  (ISO)
pleural tuberculosis  (ISO)
pneumonia  (IEP)
posterior uveitis  (ISO)
psoriasis  (ISO)
pulmonary emphysema  (IEP,IMP,ISO)
pulmonary fibrosis  (IEP,ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
respiratory syncytial virus infectious disease  (ISO)
Respirovirus Infections  (IMP)
rheumatoid arthritis  (ISO)
sarcoidosis  (ISO)
Sjogren's syndrome  (ISO)
status epilepticus  (ISO)
syphilis  (ISO)
systemic lupus erythematosus  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (ISO)
type 1 diabetes mellitus 22  (ISO)
type 2 diabetes mellitus  (ISO)
Ulcer  (ISO)
urticaria  (ISO)
uveitis  (ISO)
visceral leishmaniasis  (IMP)
visual epilepsy  (ISO)
West Nile fever  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-mevalonic acid  (ISO)
(S)-nicotine  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-naphthylamine  (ISO)
3-chlorophenol  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxyphenyl retinamide  (EXP)
acetamide  (ISO)
aflatoxin B1  (EXP,ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
Ancriviroc  (ISO)
antirheumatic drug  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
Bardoxolone methyl  (ISO)
benzalkonium chloride  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (ISO)
bisphenol F  (EXP)
bleomycin A2  (EXP)
buta-1,3-diene  (EXP)
carbon nanotube  (EXP)
celecoxib  (EXP)
chloroprene  (EXP)
cisplatin  (EXP)
clofibrate  (EXP)
cocaine  (ISO)
crocidolite asbestos  (EXP)
Cuprizon  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP)
cyproterone acetate  (ISO)
D-penicillamine  (ISO)
dextran sulfate  (EXP)
diclofenac  (EXP)
dioxygen  (EXP)
disulfiram  (EXP)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
formaldehyde  (ISO)
graphene oxide  (EXP)
indole-3-methanol  (ISO)
isopentenyl diphosphate  (ISO)
ketamine  (ISO)
lipopolysaccharide  (EXP,ISO)
maraviroc  (ISO)
mechlorethamine  (ISO)
mercury dichloride  (ISO)
methamphetamine  (ISO)
methyl methanesulfonate  (ISO)
mycotoxin  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
nitric oxide  (EXP)
oxaliplatin  (ISO)
paracetamol  (EXP)
pentachlorophenol  (ISO)
phenobarbital  (EXP)
pirinixic acid  (EXP)
proanthocyanidin  (ISO)
prostaglandin E2  (ISO)
protein kinase inhibitor  (ISO)
reactive oxygen species  (EXP)
resveratrol  (EXP)
SCH 23390  (ISO)
silicon dioxide  (EXP)
simvastatin  (ISO)
sodium arsenite  (EXP)
sodium dodecyl sulfate  (ISO)
Soman  (ISO)
staurosporine  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (EXP)
topotecan  (ISO)
tremolite asbestos  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
troglitazone  (EXP)
vinclozolin  (ISO)
wortmannin  (EXP)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
calcium ion transport  (ISO)
calcium-mediated signaling  (IBA,ISO)
cell chemotaxis  (IBA)
cell-cell signaling  (ISO)
cellular response to lipopolysaccharide  (ISO)
chemotaxis  (IEA)
defense response  (IMP)
defense response to bacterium  (ISO)
fat cell differentiation  (ISO)
forebrain development  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
immune response  (IBA)
inflammatory response  (IBA,ISO)
inflammatory response to antigenic stimulus  (ISO)
MAPK cascade  (ISO)
negative regulation of axon extension  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of macrophage apoptotic process  (IDA)
negative regulation of neural precursor cell proliferation  (ISO)
neuron death  (ISO)
positive regulation of apoptotic process by virus  (ISO)
positive regulation of cell-cell adhesion  (ISO)
positive regulation of cytosolic calcium ion concentration  (IBA,ISO)
positive regulation of fever generation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (ISO)
response to cholesterol  (ISO)
response to ionizing radiation  (ISO)
response to lipopolysaccharide  (ISO)
signal transduction  (IEA)
signaling  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal astrocyte physiology  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal CD4-positive, alpha beta T cell morphology  (IAGP)
abnormal CD8-positive, alpha beta T cell morphology  (IAGP)
abnormal cellular extravasation  (IAGP)
abnormal conditioned taste aversion behavior  (IAGP)
abnormal cytokine level  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal glial cell physiology  (IAGP)
abnormal heart size  (IAGP)
abnormal hepatocyte physiology  (IAGP)
abnormal Ito cell morphology  (IAGP)
abnormal Kupffer cell morphology  (IAGP)
abnormal leukocyte adhesion  (IAGP)
abnormal leukocyte physiology  (IAGP)
abnormal locomotor behavior  (IAGP)
abnormal long term spatial reference memory  (IAGP)
abnormal lymphocyte physiology  (IAGP)
abnormal mononuclear phagocyte morphology  (IAGP)
abnormal nervous system physiology  (IAGP)
abnormal NK T cell physiology  (IAGP)
abnormal response to cardiac infarction  (IAGP)
abnormal spatial learning  (IAGP)
abnormal vascular smooth muscle morphology  (IAGP)
atherosclerotic lesions  (IAGP)
bronchiolitis  (IAGP)
corneal vascularization  (IAGP)
decreased inflammatory response  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased interleukin-1 beta secretion  (IAGP)
decreased interleukin-6 secretion  (IAGP)
decreased metastatic potential  (IAGP)
decreased microglial cell activation  (IAGP)
decreased NK cell number  (IAGP)
decreased right ventricle systolic pressure  (IAGP)
decreased skeletal muscle glycogen level  (IAGP)
decreased susceptibility to endotoxin shock  (IAGP)
decreased susceptibility to induced colitis  (IAGP)
decreased susceptibility to injury  (IAGP)
decreased susceptibility to Retroviridae infection  (IAGP)
decreased T cell number  (IAGP)
decreased T cell proliferation  (IAGP)
impaired exercise endurance  (IAGP)
impaired macrophage chemotaxis  (IAGP)
increased alcohol consumption  (IAGP)
increased fluid intake  (IAGP)
increased IgG1 level  (IAGP)
increased interferon-gamma secretion  (IAGP)
increased interleukin-10 secretion  (IAGP)
increased interleukin-4 secretion  (IAGP)
increased length of allograft survival  (IAGP)
increased NK T cell number  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to Coronaviridae infection  (IAGP)
increased susceptibility to fungal infection  (IAGP)
increased susceptibility to type IV hypersensitivity reaction  (IAGP)
liver failure  (IAGP)
References

References - curated
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Additional References at PubMed
PMID:8631787   PMID:8662890   PMID:9139699   PMID:9184207   PMID:9261347   PMID:9343222   PMID:9558111   PMID:10349636   PMID:10479460   PMID:10528159   PMID:10843684   PMID:10854218  
PMID:10899907   PMID:10940868   PMID:10969070   PMID:11042159   PMID:11067740   PMID:11076861   PMID:11137111   PMID:11217851   PMID:11278962   PMID:11466387   PMID:11591761   PMID:11700073  
PMID:11744622   PMID:11830471   PMID:12050188   PMID:12055206   PMID:12145162   PMID:12154092   PMID:12461651   PMID:12477932   PMID:12524535   PMID:12560237   PMID:12618265   PMID:12665855  
PMID:12682253   PMID:12807425   PMID:12829028   PMID:12919745   PMID:12960300   PMID:14597223   PMID:14607889   PMID:14656931   PMID:14742553   PMID:14747380   PMID:14757698   PMID:14961112  
PMID:15003318   PMID:15030585   PMID:15067318   PMID:15075201   PMID:15163738   PMID:15178708   PMID:15210789   PMID:15213273   PMID:15240672   PMID:15262275   PMID:15272490   PMID:15307189  
PMID:15322191   PMID:15466386   PMID:15517609   PMID:15591779   PMID:15655788   PMID:15660419   PMID:15705791   PMID:15708587   PMID:15730850   PMID:15790880   PMID:15831559   PMID:15833871  
PMID:15843579   PMID:15879153   PMID:15944310   PMID:15944326   PMID:15967376   PMID:16002422   PMID:16014944   PMID:16034118   PMID:16049180   PMID:16105698   PMID:16129397   PMID:16141072  
PMID:16141073   PMID:16186359   PMID:16208318   PMID:16230476   PMID:16275892   PMID:16301745   PMID:16316965   PMID:16365158   PMID:16368966   PMID:16455991   PMID:16467202   PMID:16543065  
PMID:16585593   PMID:16602821   PMID:16612374   PMID:16789839   PMID:16841089   PMID:16849492   PMID:16891300   PMID:17013391   PMID:17015634   PMID:17086356   PMID:17098215   PMID:17175228  
PMID:17197426   PMID:17200718   PMID:17267483   PMID:17275502   PMID:17322370   PMID:17325167   PMID:17404315   PMID:17466311   PMID:17525265   PMID:17548518   PMID:17548597   PMID:17626099  
PMID:17660821   PMID:17689697   PMID:17893273   PMID:17911609   PMID:18077323   PMID:18259609   PMID:18285404   PMID:18347211   PMID:18354191   PMID:18354195   PMID:18375791   PMID:18403229  
PMID:18453619   PMID:18535183   PMID:18551072   PMID:18559949   PMID:18566004   PMID:18588860   PMID:18644849   PMID:18776949   PMID:18791167   PMID:18941229   PMID:18941245   PMID:19005063  
PMID:19006696   PMID:19008373   PMID:19050266   PMID:19073715   PMID:19079579   PMID:19109148   PMID:19302742   PMID:19303390   PMID:19394434   PMID:19421418   PMID:19494319   PMID:19517561  
PMID:19564392   PMID:19656127   PMID:19675159   PMID:19729478   PMID:19734208   PMID:19758998   PMID:19790057   PMID:19824873   PMID:19830734   PMID:20046229   PMID:20050195   PMID:20053385  
PMID:20083664   PMID:20083666   PMID:20335531   PMID:20382703   PMID:20400704   PMID:20436484   PMID:20501509   PMID:20639487   PMID:20663902   PMID:20844481   PMID:21029863   PMID:21165786  
PMID:21206747   PMID:21217759   PMID:21245464   PMID:21248750   PMID:21263020   PMID:21267068   PMID:21276984   PMID:21297029   PMID:21376626   PMID:21454526   PMID:21478401   PMID:21533529  
PMID:21677750   PMID:21715565   PMID:21757680   PMID:21788406   PMID:21788409   PMID:21814510   PMID:21873635   PMID:21963866   PMID:22001348   PMID:22042976   PMID:22154893   PMID:22160774  
PMID:22203055   PMID:22214846   PMID:22271672   PMID:22282655   PMID:22421969   PMID:22425022   PMID:22430509   PMID:22438032   PMID:22442210   PMID:22474027   PMID:22526024   PMID:22528550  
PMID:22567084   PMID:22664873   PMID:22674804   PMID:22729248   PMID:22811524   PMID:22906987   PMID:22907530   PMID:22922220   PMID:23028638   PMID:23152559   PMID:23235831   PMID:23248310  
PMID:23326300   PMID:23352234   PMID:23526353   PMID:23536638   PMID:23565250   PMID:23610400   PMID:23620790   PMID:23708969   PMID:23860188   PMID:23941876   PMID:24030499   PMID:24080631  
PMID:24101375   PMID:24166712   PMID:24197118   PMID:24227783   PMID:24366614   PMID:24370436   PMID:24510316   PMID:24695099   PMID:24713702   PMID:24993099   PMID:25031461   PMID:25119429  
PMID:25172484   PMID:25212047   PMID:25264308   PMID:25498590   PMID:25558986   PMID:25582888   PMID:25838430   PMID:25889019   PMID:25939314   PMID:25999468   PMID:26047948   PMID:26055553  
PMID:26056232   PMID:26109379   PMID:26116901   PMID:26408666   PMID:26590316   PMID:26667390   PMID:26740279   PMID:26854929   PMID:26910914   PMID:26985768   PMID:26994221   PMID:27006388  
PMID:27021296   PMID:27177471   PMID:27183602   PMID:27216980   PMID:27439902   PMID:27456129   PMID:27480124   PMID:27569912   PMID:27680685   PMID:27886644   PMID:27888192   PMID:27996938  
PMID:28082402   PMID:28294064   PMID:28382399   PMID:28486109   PMID:28550204   PMID:28630065   PMID:28650342   PMID:29052263   PMID:29166611   PMID:29216863   PMID:29263385   PMID:29288198  
PMID:29303012   PMID:29469612   PMID:29593265   PMID:30305110   PMID:30664764   PMID:30784579   PMID:30799265   PMID:30811246   PMID:30835201   PMID:31320454   PMID:31506064   PMID:31644426  
PMID:31809737   PMID:31995405   PMID:32001710   PMID:32089258   PMID:32111837   PMID:32174921   PMID:32410846   PMID:32525588   PMID:33046212   PMID:33200795   PMID:33591187   PMID:33613516  
PMID:33805933  


Genomics

Comparative Map Data
Ccr5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399123,921,557 - 123,934,153 (+)NCBIGRCm39mm39
GRCm39 Ensembl9123,921,580 - 123,947,736 (+)Ensembl
GRCm389124,121,543 - 124,127,183 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9124,121,543 - 124,147,699 (+)EnsemblGRCm38mm10GRCm38
MGSCv379124,036,282 - 124,041,922 (+)NCBIGRCm37mm9NCBIm37
Celera9124,872,533 - 124,878,180 (-)NCBICelera
Cytogenetic Map9F4NCBI
cM Map975.05NCBI
CCR5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl346,370,854 - 46,376,206 (+)EnsemblGRCh38hg38GRCh38
GRCh38346,370,142 - 46,376,206 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37346,411,633 - 46,417,697 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,386,637 - 46,392,701 (+)NCBINCBI36hg18NCBI36
Celera346,348,960 - 46,355,024 (+)NCBI
Cytogenetic Map3p21.31NCBI
HuRef346,455,276 - 46,461,340 (+)NCBIHuRef
CHM1_1346,361,630 - 46,367,689 (+)NCBICHM1_1
Ccr5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28123,752,423 - 123,757,538 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl8123,752,325 - 123,759,260 (+)Ensembl
Rnor_6.08133,192,398 - 133,215,599 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8133,197,032 - 133,215,614 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08132,362,664 - 132,367,779 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48128,907,157 - 128,912,272 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18128,929,594 - 128,932,000 (+)NCBI
Celera8122,847,673 - 122,852,786 (+)NCBICelera
Cytogenetic Map8q32NCBI
CCR5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1347,377,564 - 47,383,625 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl347,380,321 - 47,381,379 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0346,273,096 - 46,278,471 (+)NCBIMhudiblu_PPA_v0panPan3
CCR5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12042,293,288 - 42,297,952 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2042,294,996 - 42,297,952 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2042,210,909 - 42,213,866 (-)NCBI
ROS_Cfam_1.02042,775,514 - 42,780,183 (-)NCBI
UMICH_Zoey_3.12042,018,434 - 42,021,393 (-)NCBI
UNSW_CanFamBas_1.02042,419,865 - 42,422,824 (-)NCBI
UU_Cfam_GSD_1.02042,700,801 - 42,703,760 (-)NCBI
CCR5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1329,383,303 - 29,387,902 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11329,382,383 - 29,387,902 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,546,545 - 32,551,732 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCR5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1227,803,794 - 7,818,112 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041159,335,032 - 159,341,705 (-)NCBIVero_WHO_p1.0

Position Markers
D83648  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389124,125,700 - 124,125,829UniSTSGRCm38
MGSCv379124,040,439 - 124,040,568UniSTSGRCm37
Celera9124,873,887 - 124,874,016UniSTS
Cytogenetic Map9FUniSTS
cM Map972.0UniSTS
Whitehead/MRC_RH91209.38UniSTS
PMC122923P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389124,124,358 - 124,124,603UniSTSGRCm38
MGSCv379124,039,097 - 124,039,342UniSTSGRCm37
Celera9124,875,113 - 124,875,358UniSTS
Cytogenetic Map9FUniSTS
cM Map972.0UniSTS
PMC151896P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389124,125,200 - 124,125,274UniSTSGRCm38
MGSCv379124,039,939 - 124,040,013UniSTSGRCm37
Celera9124,874,442 - 124,874,516UniSTS
Cytogenetic Map9FUniSTS
cM Map972.0UniSTS
UniSTS:224352  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389124,125,512 - 124,125,684UniSTSGRCm38
MGSCv379124,040,251 - 124,040,423UniSTSGRCm37
Celera9124,874,032 - 124,874,204UniSTS
Cytogenetic Map9FUniSTS
cM Map972.0UniSTS
PMC24402P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389124,124,869 - 124,125,324UniSTSGRCm38
MGSCv379124,039,608 - 124,040,063UniSTSGRCm37
Celera9124,874,392 - 124,874,847UniSTS
Cytogenetic Map9FUniSTS
cM Map972.0UniSTS
PMC228408P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389124,105,966 - 124,106,045UniSTSGRCm38
GRCm389124,124,574 - 124,124,653UniSTSGRCm38
MGSCv379124,020,705 - 124,020,784UniSTSGRCm37
MGSCv379124,039,313 - 124,039,392UniSTSGRCm37
Celera9124,893,597 - 124,893,676UniSTS
Celera9124,875,063 - 124,875,142UniSTS
Cytogenetic Map9FUniSTS
cM Map971.9UniSTS
cM Map972.0UniSTS
Cmkbr5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389124,125,239 - 124,125,395UniSTSGRCm38
MGSCv379124,039,978 - 124,040,134UniSTSGRCm37
Celera9124,874,321 - 124,874,477UniSTS
Cytogenetic Map9FUniSTS
cM Map972.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:911
Count of miRNA genes:561
Interacting mature miRNAs:659
Transcripts:ENSMUST00000097855, ENSMUST00000111442, ENSMUST00000168179, ENSMUST00000169553, ENSMUST00000171499, ENSMUST00000171579
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_009917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC168021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF019772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF022990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK141906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC103574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC103586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC103587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC105643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG091923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY198155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D83648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U47036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U68565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U83327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X94151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000097855   ⟹   ENSMUSP00000149719
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9123,928,785 - 123,947,736 (+)Ensembl
GRCm38.p6 Ensembl9124,128,748 - 124,147,699 (+)Ensembl
RefSeq Acc Id: ENSMUST00000111442   ⟹   ENSMUSP00000107069
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9123,921,580 - 123,932,521 (+)Ensembl
GRCm38.p6 Ensembl9124,121,543 - 124,132,484 (+)Ensembl
RefSeq Acc Id: ENSMUST00000168179   ⟹   ENSMUSP00000129848
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9123,921,610 - 123,931,938 (+)Ensembl
GRCm38.p6 Ensembl9124,121,573 - 124,131,901 (+)Ensembl
RefSeq Acc Id: ENSMUST00000169553
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9123,921,610 - 123,925,304 (+)Ensembl
GRCm38.p6 Ensembl9124,121,573 - 124,125,267 (+)Ensembl
RefSeq Acc Id: ENSMUST00000171499   ⟹   ENSMUSP00000127328
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9123,921,618 - 123,924,768 (+)Ensembl
GRCm38.p6 Ensembl9124,121,581 - 124,124,731 (+)Ensembl
RefSeq Acc Id: ENSMUST00000171579
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9123,926,721 - 123,930,287 (+)Ensembl
GRCm38.p6 Ensembl9124,126,684 - 124,130,250 (+)Ensembl
RefSeq Acc Id: NM_009917   ⟹   NP_034047
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399123,921,580 - 123,927,220 (+)NCBI
GRCm389124,121,543 - 124,127,183 (+)ENTREZGENE
MGSCv379124,036,282 - 124,041,922 (+)RGD
Celera9124,872,533 - 124,878,180 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036154589   ⟹   XP_036010482
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399123,921,557 - 123,934,153 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_034047   ⟸   NM_009917
- UniProtKB: P51682 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000107069   ⟸   ENSMUST00000111442
RefSeq Acc Id: ENSMUSP00000127328   ⟸   ENSMUST00000171499
RefSeq Acc Id: ENSMUSP00000129848   ⟸   ENSMUST00000168179
RefSeq Acc Id: ENSMUSP00000149719   ⟸   ENSMUST00000097855
RefSeq Acc Id: XP_036010482   ⟸   XM_036154589
- Peptide Label: isoform X1
Protein Domains
G_PROTEIN_RECEP_F1_2

Promoters
RGD ID:6844300
Promoter ID:MM_KWN:59292
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour
Transcripts:NM_009917
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369124,036,206 - 124,036,706 (+)MPROMDB
RGD ID:8671372
Promoter ID:EPDNEW_M13717
Type:initiation region
Name:Ccr5_1
Description:Mus musculus chemokine (C-C motif) receptor 5 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389124,121,573 - 124,121,633EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107182 AgrOrtholog
Ensembl Genes ENSMUSG00000079227 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000107069 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000127328 UniProtKB/TrEMBL
  ENSMUSP00000129848 UniProtKB/TrEMBL
  ENSMUSP00000149719 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000097855 UniProtKB/TrEMBL
  ENSMUST00000111442 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000168179 UniProtKB/TrEMBL
  ENSMUST00000171499 UniProtKB/TrEMBL
InterPro Chemokine_CCR5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12774 UniProtKB/Swiss-Prot
MGD MGI:107182 ENTREZGENE
NCBI Gene 12774 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CCR5 RGD
PhenoGen Ccr5 PhenoGen
PRINTS CCCHEMOKINER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CHEMOKINER5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1L1SS26_MOUSE UniProtKB/TrEMBL
  CCR5_MOUSE UniProtKB/Swiss-Prot
  E9Q351_MOUSE UniProtKB/TrEMBL
  E9Q3E5_MOUSE UniProtKB/TrEMBL
  P51682 ENTREZGENE
  Q3TDA4_MOUSE UniProtKB/TrEMBL
UniProt Secondary O35313 UniProtKB/Swiss-Prot
  O35891 UniProtKB/Swiss-Prot
  P97308 UniProtKB/Swiss-Prot
  P97405 UniProtKB/Swiss-Prot
  Q3ZAZ8 UniProtKB/Swiss-Prot
  Q61867 UniProtKB/Swiss-Prot