RGD Reference Report - Chemokine RANTES promoter dimorphisms and hepatocellular carcinoma occurrence in patients with alcoholic or hepatitis C virus-related cirrhosis. - Rat Genome Database

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Chemokine RANTES promoter dimorphisms and hepatocellular carcinoma occurrence in patients with alcoholic or hepatitis C virus-related cirrhosis.

Authors: Charni, Faten  Sutton, Angela  Rufat, Pierre  Laguillier, Christelle  Mansouri, Abdellah  Moreau, Richard  Ganne-Carrié, Nathalie  Trinchet, Jean-Claude  Beaugrand, Michel  Charnaux, Nathalie  Nahon, Pierre 
Citation: Charni F, etal., Cancer Epidemiol Biomarkers Prev. 2011 Jul;20(7):1439-46. doi: 10.1158/1055-9965.EPI-11-0341. Epub 2011 May 24.
RGD ID: 14995338
Pubmed: PMID:21610221   (View Abstract at PubMed)
DOI: DOI:10.1158/1055-9965.EPI-11-0341   (Journal Full-text)


BACKGROUND: This study explores the influence of two functional genetic polymorphisms in the regulated on activation in normal T-cell expressed and secreted(RANTES) promoter on the risk of hepatocellular carcinoma (HCC) occurrence in patients with alcoholic or Hepatitis C Virus (HCV)-related cirrhosis.
METHODS: RANTES C-28G and G-403A promoter dimorphisms and RANTES serum levels were assessed in 243 HCV-infected patients and 253 alcoholic patients, included at the time of diagnosis of cirrhosis and prospectively followed-up.
RESULTS: During a mean follow-up time of 76 months, 137 (27.6%) patients developed HCC and 170 (34.2%) died or were transplanted. During follow-up, patients with alcoholic cirrhosis and bearing two copies of the RANTES G-403 variant (2G-403 genotype, n = 156/253) had a higher rate of HCC occurrence compared with patients carrying at least one RANTES A-403 allele (26.3% vs. 8.2%, P = 0.0004). The RANTES 2G-403 genotype was a risk factor for HCC occurrence [HR = 3.0 (1.3-5.8); first quartile time to HCC occurrence: 60 vs. 120 months; LogRank = 0.007] and death [HR = 1.4 (1.0-2.0); median time to death: 55 vs. 79 months; LogRank = 0.01] in this subgroup. Carriage of the RANTES 2G-403 genotype was not associated with HCC development or death in patients with HCV-related cirrhosis. The RANTES C-28G dimorphism did not influence the occurrence of death or HCC in either cohort of patients.
CONCLUSION: This study suggests an influence of the chemokine RANTES G-403A dimorphism on the occurrence of HCC in patients with alcoholic cirrhosis.
IMPACT: Our findings provide clues for future studies on RANTES gene in relation to HCC susceptibility.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CCL5Humanhepatocellular carcinoma susceptibilityIAGP associated with alcoholic liver cirrhosis and DNA:SNP:promoter:-403G>A(human)RGD 
Ccl5Rathepatocellular carcinoma susceptibilityISOCCL5 (Homo sapiens)associated with alcoholic liver cirrhosis and DNA:SNP:promoter:-403G>A(human)RGD 
Ccl5Mousehepatocellular carcinoma susceptibilityISOCCL5 (Homo sapiens)associated with alcoholic liver cirrhosis and DNA:SNP:promoter:-403G>A(human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccl5  (C-C motif chemokine ligand 5)

Genes (Mus musculus)
Ccl5  (C-C motif chemokine ligand 5)

Genes (Homo sapiens)
CCL5  (C-C motif chemokine ligand 5)


Additional Information