CCL5 (C-C motif chemokine ligand 5) - Rat Genome Database

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Advanced Search (OLGA)
Gene: CCL5 (C-C motif chemokine ligand 5) Chlorocebus sabaeus
Analyze
Symbol: CCL5
Name: C-C motif chemokine ligand 5
RGD ID: 18603395
Description: ENCODES a protein that exhibits CCR1 chemokine receptor binding (ortholog); CCR5 chemokine receptor binding (ortholog); chemoattractant activity (ortholog); INVOLVED IN calcium ion transport (ortholog); cell-cell signaling (ortholog); cellular response to alkyl hydroperoxide (ortholog); PARTICIPATES IN syndecan signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Liver Failure (ortholog); alcoholic hepatitis (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: C-C motif chemokine 5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11629,351,214 - 29,361,317 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666075615,422 - 624,588 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Liver Failure  (ISO)
alcoholic hepatitis  (ISO)
allergic conjunctivitis  (ISO)
allergic contact dermatitis  (ISO)
Alzheimer's disease  (ISO)
Animal Toxoplasmosis  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
antiphospholipid syndrome  (ISO)
arteriosclerosis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
autoimmune hepatitis  (ISO)
Breast Neoplasms  (ISO)
bronchiolitis obliterans  (ISO)
bronchopneumonia  (ISO)
cardiac arrest  (ISO)
Chagas disease  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic inflammatory demyelinating polyradiculoneuropathy  (ISO)
chronic obstructive pulmonary disease  (ISO)
cocaine abuse  (ISO)
COVID-19  (ISO)
Cytomegalovirus Infections  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
end stage renal disease  (ISO)
endometriosis  (ISO)
Endotoxemia  (ISO)
exercise-induced bronchoconstriction  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Seizures  (ISO)
extrinsic allergic alveolitis  (ISO)
Fever  (ISO)
genital herpes  (ISO)
glomerulonephritis  (ISO)
glucose intolerance  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
Hermansky-Pudlak syndrome  (ISO)
Herpesviridae Infections  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
Hyperoxaluria  (ISO)
hypertension  (ISO)
Hypoventilation  (ISO)
Immediate Hypersensitivity  (ISO)
Inflammation  (ISO)
interstitial lung disease  (ISO)
invasive ductal carcinoma  (ISO)
kidney disease  (ISO)
liver cirrhosis  (ISO)
Liver Metastasis  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (ISO)
Lung Injury  (ISO)
malignant mesothelioma  (ISO)
metabolic dysfunction-associated steatohepatitis  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
multiple sclerosis  (ISO)
Mycoplasma pneumoniae pneumonia  (ISO)
myocardial infarction  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
orchitis  (ISO)
Ovarian Neoplasms  (ISO)
Pain  (ISO)
pancreatic cancer  (ISO)
pancreatitis  (ISO)
Paramyxoviridae Infections  (ISO)
peptic esophagitis  (ISO)
pleurisy  (ISO)
Pneumococcal Pneumonia  (ISO)
posterior uveitis  (ISO)
pre-eclampsia  (ISO)
primary biliary cholangitis  (ISO)
Pseudomonas Infections  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
Reperfusion Injury  (ISO)
Respiration Disorders  (ISO)
respiratory syncytial virus infectious disease  (ISO)
sciatic neuropathy  (ISO)
scrapie  (ISO)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
Spinal Cord Injuries  (ISO)
Spontaneous Abortions  (ISO)
steatotic liver disease  (ISO)
stomach cancer  (ISO)
Tissue Adhesions  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
uveitis  (ISO)
Viral Bronchiolitis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
calcium ion transport  (ISO)
cell-cell signaling  (ISO)
cellular response to alkyl hydroperoxide  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to ethanol  (ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to high density lipoprotein particle stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to lipid  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to morphine  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to type II interferon  (ISO)
cellular response to vitamin K  (ISO)
chemokine (C-C motif) ligand 5 signaling pathway  (ISO)
chemokine-mediated signaling pathway  (ISO)
chronic inflammatory response  (ISO)
dibenzo-p-dioxin metabolic process  (ISO)
eosinophil chemotaxis  (ISO)
epithelial cell proliferation  (ISO)
ERK1 and ERK2 cascade  (ISO)
exocytosis  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
inflammatory response  (ISO)
intracellular calcium ion homeostasis  (ISO)
leukocyte cell-cell adhesion  (ISO)
lymphocyte chemotaxis  (ISO)
negative regulation of cellular process  (ISO)
negative regulation of G protein-coupled receptor signaling pathway  (ISO)
negative regulation of macrophage apoptotic process  (ISO)
negative regulation of T cell apoptotic process  (ISO)
negative regulation of viral genome replication  (ISO)
neutrophil activation  (ISO)
phospholipase D-activating G protein-coupled receptor signaling pathway  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of calcium ion transport  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell-cell adhesion mediated by integrin  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of fever generation  (ISO)
positive regulation of G protein-coupled receptor signaling pathway  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of homotypic cell-cell adhesion  (ISO)
positive regulation of macrophage chemotaxis  (ISO)
positive regulation of mast cell chemotaxis  (ISO)
positive regulation of monocyte chemotaxis  (ISO)
positive regulation of natural killer cell chemotaxis  (ISO)
positive regulation of neuroinflammatory response  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of osteoclast differentiation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of receptor signaling pathway via STAT  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of T cell apoptotic process  (ISO)
positive regulation of T cell chemotaxis  (ISO)
positive regulation of T cell migration  (ISO)
positive regulation of T cell proliferation  (ISO)
positive regulation of TOR signaling  (ISO)
pseudopodium assembly  (ISO)
regulation of insulin secretion  (ISO)
regulation of programmed cell death  (ISO)
regulation of T cell activation  (ISO)
response to activity  (ISO)
response to alcohol  (ISO)
response to bacterium  (ISO)
response to cholesterol  (ISO)
response to cyclophosphamide  (ISO)
response to cytokine  (ISO)
response to estrogen  (ISO)
response to glucocorticoid  (ISO)
response to insulin  (ISO)
response to lipopolysaccharide  (ISO)
response to nutrient levels  (ISO)
response to salt stress  (ISO)
response to toxic substance  (ISO)
response to tumor necrosis factor  (ISO)
response to type II interferon  (ISO)
response to xenobiotic stimulus  (ISO)
T-helper 1 cell diapedesis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CCL5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11629,351,214 - 29,361,317 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666075615,422 - 624,588 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CCL5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381735,871,491 - 35,880,360 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1735,871,491 - 35,880,793 (-)Ensemblhg38GRCh38
GRCh371734,198,495 - 34,207,364 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361731,222,608 - 31,231,490 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1731,108,052 - 31,116,934 (-)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1730,383,508 - 30,392,390 (-)NCBIHuRef
CHM1_11734,263,060 - 34,271,942 (-)NCBICHM1_1
T2T-CHM13v2.01736,819,399 - 36,828,268 (-)NCBIT2T-CHM13v2.0
Ccl5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391183,416,604 - 83,421,344 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1183,416,604 - 83,421,344 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381183,525,778 - 83,530,518 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1183,525,778 - 83,530,518 (-)Ensemblmm10GRCm38
MGSCv371183,339,280 - 83,344,020 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361183,341,974 - 83,346,692 (-)NCBIMGSCv36mm8
Celera1193,127,305 - 93,132,049 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1150.66NCBI
Ccl5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81068,820,330 - 68,824,906 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1068,738,651 - 68,824,884 (-)EnsemblGRCr8
mRatBN7.21068,322,826 - 68,327,380 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1068,322,829 - 68,327,377 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1072,942,820 - 72,947,359 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01072,448,203 - 72,452,742 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01067,912,255 - 67,916,794 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01070,739,764 - 70,744,303 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1070,739,800 - 70,744,315 (-)Ensemblrn6Rnor6.0
Rnor_5.01070,373,353 - 70,377,892 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41071,605,791 - 71,610,330 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1067,264,203 - 67,268,742 (-)NCBICelera
RGSC_v3.11071,620,206 - 71,624,712 (-)NCBI
Cytogenetic Map10q26NCBI
Ccl5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495548110,293,399 - 10,301,143 (-)Ensembl
ChiLan1.0NW_00495548110,293,758 - 10,301,118 (-)NCBIChiLan1.0ChiLan1.0
CCL5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21928,596,811 - 28,605,632 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11730,476,222 - 30,484,892 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01720,915,198 - 20,923,530 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11721,210,798 - 21,219,172 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1721,210,798 - 21,219,172 (+)EnsemblpanPan2panpan1.1
CCL5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1937,817,409 - 37,823,852 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl937,817,305 - 37,823,852 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha937,039,892 - 37,046,335 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0938,627,353 - 38,633,796 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl938,627,249 - 38,633,796 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1937,410,157 - 37,416,605 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0937,695,725 - 37,702,162 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0937,783,127 - 37,789,578 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ccl5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560236,815,103 - 36,821,857 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936490253,034 - 259,965 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936490253,279 - 259,947 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCL5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1239,648,598 - 39,659,118 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11239,652,731 - 39,659,121 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21241,218,074 - 41,228,604 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Ccl5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248753,334,078 - 3,341,614 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248753,334,136 - 3,342,085 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in CCL5
202 total Variants

Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_008011081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JBLKOC010000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: XM_008011081   ⟹   XP_008009272
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11629,351,214 - 29,361,317 (-)NCBI
Vero_WHO_p1.0NW_023666075615,422 - 624,588 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008009272 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_008009272   ⟸   XM_008011081


Additional Information

Database Acc Id Source(s)
NCBI Gene CCL5 ENTREZGENE