RGD Reference Report - RANTES gene polymorphisms and asthma risk: A meta-analysis. - Rat Genome Database

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RANTES gene polymorphisms and asthma risk: A meta-analysis.

Authors: Zhang, YG  Huang, J  Zhang, J  Li, XB  He, C  Xiao, YL  Tian, C  Wan, H  Zhao, YL  Tsewang, YG  Fan, H 
Citation: Zhang YG, etal., Arch Med Res. 2010 Jan;41(1):50-8.
RGD ID: 4891381
Pubmed: PMID:20430255   (View Abstract at PubMed)
DOI: DOI:10.1016/j.arcmed.2010.01.002   (Journal Full-text)

BACKGROUND AND AIMS: RANTES is a chemokine that assists the recruitment of inflammatory cells including eosinophils. Previous studies revealed that polymorphisms of RANTES were implicated in susceptibility to asthma, but a large number of studies reported apparently conflicting results. We performed a meta-analysis to investigate the association of these polymorphisms and asthma risk. METHODS: Literature-based meta-analysis was supplemented by tabular data from investigation of all relevant studies regarding all polymorphisms of RANTES available before November 30, 2009, with investigation on potential sources of heterogeneity. RESULTS: Ten case/control studies were included in the meta-analysis, involving a total of 1706 cases and 1685 controls. In a combined analysis, no significant associations with asthma risk were found on these two polymorphisms (-403G/A and -28C/G) without any publication bias. For the -403G/A polymorphism, in subgroup analysis by ethnicity, no significant associations were found in Asians, Europeans or African-Americans; in subgroup analysis by age, no significant associations were found in adults or children. In subgroup analysis by atopic status, the -403G/A polymorphism was significantly associated with asthma risk in atopic asthma (dominant model [OR = 1.38, 95% CI = 1.09-1.76, p = 0.009; P(het) = 0.10]; A vs. G model [OR = 1.25, 95% CI = 1.04-1.51, p = 0.02; P(het) = 0.11] and AG vs. GG model [OR = 1.37, 95% CI = 1.06-1.77, p = 0.02; P(het) = 0.14]). CONCLUSIONS: This meta-analysis suggested that RANTES gene -403G/A polymorphism would be a risk factor among atopic asthma patients. To further evaluate gene-to-gene and gene-to-environment interactions on RANTES polymorphisms and asthma risk, more studies with thousands of patients are required.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
asthma susceptibilityIAGP 4891381DNA:transition:5' utr:-403G>A (human)RGD 
asthma susceptibilityISOCCL5 (Homo sapiens)4891381; 4891381DNA:transition:5' utr:-403G>A (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccl5  (C-C motif chemokine ligand 5)

Genes (Mus musculus)
Ccl5  (C-C motif chemokine ligand 5)

Genes (Homo sapiens)
CCL5  (C-C motif chemokine ligand 5)


Additional Information