RGD Reference Report - Role of unphosphorylated transcription factor STAT3 in late cerebral ischemia after subarachnoid hemorrhage. - Rat Genome Database

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Role of unphosphorylated transcription factor STAT3 in late cerebral ischemia after subarachnoid hemorrhage.

Authors: Samraj, AK  Muller, AH  Grell, AS  Edvinsson, L 
Citation: Samraj AK, etal., J Cereb Blood Flow Metab. 2014 May;34(5):759-63. doi: 10.1038/jcbfm.2014.15. Epub 2014 Feb 12.
RGD ID: 8694356
Pubmed: PMID:24517975   (View Abstract at PubMed)
PMCID: PMC4013756   (View Article at PubMed Central)
DOI: DOI:10.1038/jcbfm.2014.15   (Journal Full-text)

Molecular mechanisms behind increased cerebral vasospasm and local inflammation in late cerebral ischemia after subarachnoid hemorrhage (SAH) are poorly elucidated. Using system biology tools and experimental SAH models, we have identified signal transducer and activator of transcription 3 (STAT3) transcription factor as a possible major regulatory molecule. On the basis of the presence of transcription factor binding sequence in the promoters of differentially regulated genes (significant enrichment PE: 6 x 10(5)) and the consistent expression of STAT3 (mRNA, P=0.0159 and Protein, P=0.0467), we hypothesize that unphosphorylated STAT3 may directly DNA bind and probably affect the genes that are involved in inflammation and late cerebral ischemia to influence the pathologic progression of SAH.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
STAT3HumanSubarachnoid Hemorrhage  ISOStat3 (Rattus norvegicus)mRNA more ...RGD 
Stat3RatSubarachnoid Hemorrhage  IEP mRNA more ...RGD 
Stat3MouseSubarachnoid Hemorrhage  ISOStat3 (Rattus norvegicus)mRNA more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Stat3  (signal transducer and activator of transcription 3)

Genes (Mus musculus)
Stat3  (signal transducer and activator of transcription 3)

Genes (Homo sapiens)
STAT3  (signal transducer and activator of transcription 3)


Additional Information