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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3772
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:23414
Term: copper(II) sulfate
Definition: A metal sulfate compound having copper(2+) as the metal ion.
Chemical ID: MESH:D019327
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat3increases expressionEXP 6480464CTDCopper Sulfate results in increased expression of STAT3 proteinPMID:30431687
Stat3multiple interactionsEXP 6480464CTDCurcumin analog inhibits the reaction [Copper Sulfate results in increased expression of STAT3 protein]; Curcumin inhibits the reaction [Copper Sulfate results in increased expression of STAT3 protein]; Deferoxamine inhibits the reaction [Copper Sulfate results in increased expression of STAT3 protein]PMID:30431687
Stat3increases expressionISOSTAT3 (Homo sapiens)6480464CTDCopper Sulfate results in increased expression of STAT3 mRNAPMID:19549813
Stat3multiple interactionsISOSTAT3 (Homo sapiens)6480464CTD[ferrous sulfate co-treated with Copper Sulfate] promotes the reaction [Hydrogen Peroxide affects the localization of STAT3 protein]; Copper Sulfate inhibits the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]PMID:10364193 PMID:16896058
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