GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Stat3 | affects expression | EXP | | 6480464 | CTD | Nicotine affects the expression of STAT3 mRNA | PMID:29155039 | Stat3 | increases phosphorylation | EXP | | 6480464 | CTD | Nicotine results in increased phosphorylation of STAT3 protein | PMID:34153408 | Stat3 | multiple interactions | EXP | | 6480464 | CTD | [Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of STAT3 protein modified form; Bungarotoxins inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Hexamethonium inhibits the reaction [[Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of STAT3 protein modified form]; methyllycaconitine inhibits the reaction [[Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of STAT3 protein modified form] | PMID:29501575 PMID:34153408 | Stat3 | increases activity | ISO | STAT3 (Homo sapiens) | 6480464 | CTD | Nicotine results in increased activity of STAT3 protein | PMID:18448488 | Stat3 | increases phosphorylation | ISO | Stat3 (Mus musculus) | 6480464 | CTD | Nicotine results in increased phosphorylation of STAT3 protein | PMID:24095726 PMID:25396421 | Stat3 | increases phosphorylation | ISO | STAT3 (Homo sapiens) | 6480464 | CTD | Nicotine results in increased phosphorylation of STAT3 protein | PMID:18448488 PMID:35131329 | Stat3 | increases response to substance | ISO | Stat3 (Mus musculus) | 6480464 | CTD | STAT3 protein results in increased susceptibility to Nicotine | PMID:24095726 | Stat3 | increases response to substance | ISO | STAT3 (Homo sapiens) | 6480464 | CTD | STAT3 results in increased susceptibility to Nicotine | PMID:20943775 | Stat3 | multiple interactions | ISO | Stat3 (Mus musculus) | 6480464 | CTD | HMOX1 protein promotes the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Nicotine inhibits the reaction [Quartz results in decreased phosphorylation of STAT3 protein]; STAT3 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of HMOX1 mRNA]; STAT3 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of ZFP36 mRNA]; STAT3 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; STAT3 protein promotes the reaction [Nicotine results in increased expression of ZFP36 mRNA]; staurosporine aglycone inhibits the reaction [[Nicotine co-treated with Quartz] results in increased phosphorylation of STAT3 protein]; ZFP36 protein promotes the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; zinc protoporphyrin inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein] | PMID:24095726 PMID:36868510 | Stat3 | multiple interactions | ISO | STAT3 (Homo sapiens) | 6480464 | CTD | [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide co-treated with U 0126] inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; [Nicotine co-treated with Lipopolysaccharides] results in increased phosphorylation of STAT3 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]]; CHRNA5 protein affects the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Hexamethonium inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Lobeline inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Nicotine inhibits the reaction [Cisplatin results in decreased activity of STAT3 protein]; Nicotine inhibits the reaction [Paclitaxel results in decreased activity of STAT3 protein]; Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]; Nicotine promotes the reaction [STAT3 protein binds to ZFP36 promoter]; Nicotine results in increased phosphorylation of and results in increased activity of STAT3 protein; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Staurosporine inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; U 0126 inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]]; U 0126 inhibits the reaction [Nicotine results in increased activity of STAT3 protein]; U 0126 inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein] | PMID:18448488 PMID:20106947 PMID:21606497 PMID:35131329 | | ||||||||||||||||||||||
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