RGD Reference Report - [Expression and its significance of STAT3, STAT5, Survivin and Ki67 in nasal NK/T cell lymphoma]. - Rat Genome Database

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[Expression and its significance of STAT3, STAT5, Survivin and Ki67 in nasal NK/T cell lymphoma].

Authors: Yue, Lihua  Cheng, Jinmei  Zhang, Peng fei  Lin, Gongbiao  Yi, Zixiang  Zhang, Rong 
Citation: Yue L, etal., Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2006 Oct;20(20):931-3, 936.
RGD ID: 153298933
Pubmed: PMID:17225522   (View Abstract at PubMed)


OBJECTIVE: To study the expression and its significance of STAT3, STAT5, Survivin and Ki67 in the Epstein-Barr virus associated nasal NK/T cell lymphoma.
METHOD: The expression of STAT3, STAT5, Survivin and Ki67 were detected with immunohistochemistry in 25 cases of nasal NK/T cell lymphoma, and their relationship was analyzed. Nasal cavity tissues from 20 cases of chronic sinusitis were as the control group.
RESULT: The positive rates of STAT3 in the lymphoma and in control group were 56% and 10%, respectively (P <0.01). The positive rates of STAT5 in the lymphoma and in control group were 68% and 15%, respectively (P <0.01). The positive rates of Survivin and Ki67 of nasal NK/T cell-lymphoma were 68% and 72%, respectively; but it in the control group was 0% and 20%, respectively, P <0.01. The expression of STAT3 was positively related to that of Survivin and Ki67(r =0. 428, P <0. 05 and r =0. 704, P <0. 01); The expression of STAT5 was not related to that of Survivin and Ki67.
CONCLUSION: The pathway of STAT may play a role in the development of nasal NK/T cell lymphoma. STAT maybe take part in the formation of nasal NK/T cell lymphoma through induction of Survivin and Ki67.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
STAT3Humannasal type extranodal NK/T-cell lymphoma  IEP protein:increased expression:nasal cavity (human)RGD 
Stat3Ratnasal type extranodal NK/T-cell lymphoma  ISOSTAT3 (Homo sapiens)protein:increased expression:nasal cavity (human)RGD 
Stat3Mousenasal type extranodal NK/T-cell lymphoma  ISOSTAT3 (Homo sapiens)protein:increased expression:nasal cavity (human)RGD 


Genes (Rattus norvegicus)
Stat3  (signal transducer and activator of transcription 3)

Genes (Mus musculus)
Stat3  (signal transducer and activator of transcription 3)

Genes (Homo sapiens)
STAT3  (signal transducer and activator of transcription 3)