Stat6 (signal transducer and activator of transcription 6) - Rat Genome Database

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Gene: Stat6 (signal transducer and activator of transcription 6) Mus musculus
Analyze
Symbol: Stat6
Name: signal transducer and activator of transcription 6
RGD ID: 1319195
MGI Page MGI
Description: Exhibits RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including T-helper 1 cell lineage commitment; mammary gland development; and regulation of nucleobase-containing compound metabolic process. Localizes to chromatin; cytoplasm; and nucleus. Is expressed in several structures, including 2-cell stage embryo; alimentary system; lower urinary tract; male reproductive system; and olfactory epithelium. Human ortholog(s) of this gene implicated in lipoid nephrosis; prostate carcinoma; and urinary schistosomiasis. Orthologous to human STAT6 (signal transducer and activator of transcription 6); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-4 signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1,4-dithiothreitol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: signal transducer and transcription activator 6
RGD Orthologs
Human
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,478,855 - 127,496,856 (+)NCBIGRCm39mm39
GRCm39 Ensembl10127,478,855 - 127,496,826 (+)Ensembl
GRCm3810127,642,955 - 127,660,987 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,642,986 - 127,660,957 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710127,080,042 - 127,098,043 (+)NCBIGRCm37mm9NCBIm37
MGSCv3610127,046,120 - 127,063,352 (+)NCBImm8
Celera10130,035,284 - 130,053,348 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1074.59NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
1,4-dithiothreitol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpinumisoflavone  (ISO)
ammonium chloride  (ISO)
Aroclor 1254  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (EXP)
calcitriol  (ISO)
calcium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP,ISO)
carboplatin  (EXP)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyfluthrin  (ISO)
Deguelin  (ISO)
diclofenac  (ISO)
Diisodecyl phthalate  (EXP)
donepezil hydrochloride  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
Fidarestat  (EXP,ISO)
flavonoids  (ISO)
fluorescein 5-isothiocyanate  (EXP)
flutamide  (EXP,ISO)
geraniol  (ISO)
glycidol  (ISO)
histamine  (ISO)
hydrogen peroxide  (EXP,ISO)
ketorolac  (ISO)
L-1,4-dithiothreitol  (EXP)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
melatonin  (EXP)
mercury dichloride  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
morphine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nicotine  (ISO)
oxaliplatin  (EXP,ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rimonabant  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
serpentine asbestos  (EXP)
simvastatin  (EXP)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
Sodium salicylate  (ISO)
sunitinib  (ISO)
synephrine  (EXP)
tamoxifen  (EXP)
tert-butyl hydroperoxide  (ISO)
thioacetamide  (ISO)
thymoquinone  (EXP)
tofacitinib  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
triptonide  (EXP)
tungsten  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IDA)
cytoplasm  (IDA)
cytosol  (ISO)
membrane raft  (ISO)
nucleoplasm  (ISO)
nucleus  (IDA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal acute inflammation  (IAGP)
abnormal airway responsiveness  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal B cell proliferation  (IAGP)
abnormal CD4-positive T cell differentiation  (IAGP)
abnormal CD8-positive, alpha beta T cell morphology  (IAGP)
abnormal circulating alanine transaminase level  (IAGP)
abnormal circulating histamine level  (IAGP)
abnormal circulating interleukin level  (IAGP)
abnormal circulating interleukin-4 level  (IAGP)
abnormal circulating interleukin-5 level  (IAGP)
abnormal class switch recombination  (IAGP)
abnormal conjunctival epithelium morphology  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal cytotoxic T cell physiology  (IAGP)
abnormal granulocyte physiology  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal immune serum protein physiology  (IAGP)
abnormal immunoglobulin level  (IAGP)
abnormal interleukin secretion  (IAGP)
abnormal leukocyte migration  (IAGP)
abnormal leukocyte physiology  (IAGP)
abnormal level of surface class II molecules  (IAGP)
abnormal lung morphology  (IAGP)
abnormal lung size  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal mammary gland epithelium morphology  (IAGP)
abnormal mammary gland growth during pregnancy  (IAGP)
abnormal mammary gland morphology  (IAGP)
abnormal mast cell morphology  (IAGP)
abnormal noradrenaline level  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal renal tubule morphology  (IAGP)
abnormal respiratory epithelium morphology  (IAGP)
abnormal respiratory system morphology  (IAGP)
abnormal respiratory system physiology  (IAGP)
abnormal T-helper 1 cell differentiation  (IAGP)
abnormal T-helper 2 cell differentiation  (IAGP)
abnormal T-helper 2 physiology  (IAGP)
abnormal tumor susceptibility  (IAGP)
acanthosis  (IAGP)
blepharitis  (IAGP)
decreased B cell proliferation  (IAGP)
decreased body size  (IAGP)
decreased core body temperature  (IAGP)
decreased fatty acids level  (IAGP)
decreased IgA level  (IAGP)
decreased IgE level  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG3 level  (IAGP)
decreased IgM level  (IAGP)
decreased interleukin-4 secretion  (IAGP)
decreased interleukin-5 secretion  (IAGP)
decreased mammary gland epithelial cell proliferation  (IAGP)
decreased metastatic potential  (IAGP)
decreased susceptibility to autoimmune diabetes  (IAGP)
decreased susceptibility to Herpesvirales infection  (IAGP)
decreased T cell proliferation  (IAGP)
decreased T-helper 2 cell number  (IAGP)
dermatitis  (IAGP)
emphysema  (IAGP)
enlarged liver  (IAGP)
epidermal hyperplasia  (IAGP)
excessive scratching  (IAGP)
eye inflammation  (IAGP)
hyperkeratosis  (IAGP)
impaired eosinophil chemotaxis  (IAGP)
impaired eosinophil recruitment  (IAGP)
impaired neutrophil chemotaxis  (IAGP)
increased activated T cell number  (IAGP)
increased B cell apoptosis  (IAGP)
increased cellular sensitivity to gamma-irradiation  (IAGP)
increased circulating creatine level  (IAGP)
increased circulating interferon-gamma level  (IAGP)
increased circulating interleukin-18 level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased eosinophil cell number  (IAGP)
increased IgA level  (IAGP)
increased IgE level  (IAGP)
increased IgG level  (IAGP)
increased IgG1 level  (IAGP)
increased IgG2a level  (IAGP)
increased interferon-gamma secretion  (IAGP)
increased interleukin-12 secretion  (IAGP)
increased interleukin-2 secretion  (IAGP)
increased susceptibility to autoimmune diabetes  (IAGP)
increased susceptibility to parasitic infection  (IAGP)
lethality at weaning, complete penetrance  (IAGP)
liver inflammation  (IAGP)
overexpanded pulmonary alveoli  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
respiratory system inflammation  (IAGP)
skin edema  (IAGP)
skin inflammation  (IAGP)
skin lesions  (IAGP)
thymus atrophy  (IAGP)
References

References - curated
1. Acharya B, etal., Am J Nephrol. 2005 Jan-Feb;25(1):30-5. Epub 2005 Feb 1.
2. Das S, etal., Prostate. 2007 Oct 1;67(14):1550-64.
3. He H, etal., Genes Immun. 2008 Apr;9(3):195-206. doi: 10.1038/gene.2008.2. Epub 2008 Feb 14.
4. Ikeuchi Y, etal., Pediatr Nephrol. 2009 Mar;24(3):489-95. doi: 10.1007/s00467-008-1003-y. Epub 2008 Nov 15.
5. Jacob CO, etal., J Immunol. 2003 Aug 1;171(3):1564-71.
6. Kobayashi Y, etal., Am J Kidney Dis. 2003 Aug;42(2):271-6.
7. Land KJ, etal., Endocrinology. 2004 Aug;145(8):3724-30. Epub 2004 Apr 29.
8. Lau M, etal., J Autoimmun. 2012 Dec;39(4):388-97. doi: 10.1016/j.jaut.2012.06.003. Epub 2012 Aug 4.
9. Li CC, etal., Zhonghua Er Ke Za Zhi. 2005 Jul;43(7):521-5.
10. Liu ZC, etal., Zhonghua Yi Xue Za Zhi. 2008 Sep 9;88(34):2432-6.
11. Low SH, etal., Dev Cell. 2006 Jan;10(1):57-69.
12. Matsukawa A, etal., J Exp Med. 2001 Mar 19;193(6):679-88.
13. MGD data from the GO Consortium
14. MGD IEA
15. Murray PJ J Immunol. 2007 Mar 1;178(5):2623-9.
16. Ni Z, etal., J Urol. 2002 Apr;167(4):1859-62.
17. Olsan EE, etal., Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18067-72. doi: 10.1073/pnas.1111966108. Epub 2011 Oct 24.
18. Ong CJ, etal., Cell Immunol. 1999 Aug 25;196(1):60-8.
19. Ostrand-Rosenberg S, etal., J Immunol. 2000 Dec 1;165(11):6015-9.
20. Pipeline to import KEGG annotations from KEGG into RGD
21. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. RGD automated import pipeline
23. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. RGD automated import pipeline for gene-chemical interactions
25. Summers SA, etal., Clin Exp Immunol. 2011 Nov;166(2):227-34. doi: 10.1111/j.1365-2249.2011.04437.x.
26. Sun SL, etal., Clin Exp Pharmacol Physiol. 2007 Nov;34(11):1097-101.
27. Yokota N, etal., Am J Physiol Renal Physiol. 2003 Aug;285(2):F319-25. Epub 2003 Apr 22.
28. Yukawa K, etal., Int J Mol Med. 2005 Feb;15(2):225-30.
29. Zhao J, etal., Toxicol Lett. 2012 Feb 5;208(3):225-31. doi: 10.1016/j.toxlet.2011.11.012. Epub 2011 Nov 23.
Additional References at PubMed
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PMID:9175833   PMID:9379007   PMID:9469446   PMID:9492006   PMID:9500796   PMID:9531287   PMID:9548487   PMID:9565645   PMID:9647237   PMID:9743537   PMID:9811885   PMID:9834104  
PMID:9846495   PMID:9881967   PMID:10051710   PMID:10200816   PMID:10227985   PMID:10227996   PMID:10349636   PMID:10400816   PMID:10438949   PMID:10452990   PMID:10490661   PMID:10508820  
PMID:10526573   PMID:10553062   PMID:10586035   PMID:10586046   PMID:10602484   PMID:10675904   PMID:10679064   PMID:10706693   PMID:10727445   PMID:10727461   PMID:10781830   PMID:10792004  
PMID:10851056   PMID:10880049   PMID:10880399   PMID:10882411   PMID:10903759   PMID:10922068   PMID:11042159   PMID:11067913   PMID:11076861   PMID:11086033   PMID:11086062   PMID:11207314  
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PMID:16237058   PMID:16237061   PMID:16237106   PMID:16251181   PMID:16272308   PMID:16275384   PMID:16298365   PMID:16352646   PMID:16357187   PMID:16365403   PMID:16365442   PMID:16374521  
PMID:16393972   PMID:16413227   PMID:16461458   PMID:16462603   PMID:16517724   PMID:16537510   PMID:16546102   PMID:16547273   PMID:16568497   PMID:16585215   PMID:16585592   PMID:16594735  
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PMID:17855502   PMID:17873878   PMID:17878371   PMID:17878403   PMID:17892853   PMID:17911579   PMID:17982031   PMID:17982094   PMID:18056268   PMID:18166499   PMID:18172549   PMID:18178813  
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PMID:21751242   PMID:21765211   PMID:21826890   PMID:21873635   PMID:21911376   PMID:21931552   PMID:21945076   PMID:21949021   PMID:21949024   PMID:21959772   PMID:21960549   PMID:21980379  
PMID:22000020   PMID:22005305   PMID:22014099   PMID:22039015   PMID:22078635   PMID:22100973   PMID:22101429   PMID:22130674   PMID:22164377   PMID:22174793   PMID:22180613   PMID:22195747  
PMID:22210911   PMID:22327070   PMID:22504655   PMID:22544395   PMID:22588720   PMID:22675208   PMID:22684102   PMID:22684943   PMID:22732589   PMID:22740092   PMID:22865229   PMID:22865552  
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PMID:24216482   PMID:24280725   PMID:24314139   PMID:24361497   PMID:24489947   PMID:24508458   PMID:24534206   PMID:24586307   PMID:24620029   PMID:24631157   PMID:24634488   PMID:24646742  
PMID:24647735   PMID:24695852   PMID:24717539   PMID:24751726   PMID:24777733   PMID:24792964   PMID:24828142   PMID:24845637   PMID:24906147   PMID:24906148   PMID:25108223   PMID:25145352  
PMID:25207963   PMID:25307347   PMID:25332236   PMID:25646481   PMID:25681342   PMID:25751266   PMID:25769044   PMID:25769611   PMID:25780046   PMID:25862819   PMID:25873311   PMID:25912172  
PMID:25934862   PMID:26048978   PMID:26185131   PMID:26278622   PMID:26365184   PMID:26410628   PMID:26423151   PMID:26519105   PMID:26595887   PMID:26601901   PMID:26669445   PMID:26690703  
PMID:26699812   PMID:26764350   PMID:26847546   PMID:26895644   PMID:26899911   PMID:26953325   PMID:27034374   PMID:27080105   PMID:27216180   PMID:27273006   PMID:27336716   PMID:27417023  
PMID:27417725   PMID:27510401   PMID:27568549   PMID:27581382   PMID:27605008   PMID:27626662   PMID:27653687   PMID:27760338   PMID:27783989   PMID:27815425   PMID:27836432   PMID:27906181  
PMID:28003382   PMID:28069805   PMID:28096407   PMID:28129374   PMID:28199385   PMID:28327619   PMID:28348271   PMID:28355561   PMID:28374774   PMID:28375154   PMID:28385737   PMID:28399411  
PMID:28420758   PMID:28600950   PMID:28615615   PMID:28650342   PMID:28654863   PMID:28670633   PMID:28739140   PMID:28765368   PMID:28783681   PMID:28790455   PMID:28874416   PMID:28877454  
PMID:28917204   PMID:29022575   PMID:29066614   PMID:29215829   PMID:29275858   PMID:29304229   PMID:29343442   PMID:29436412   PMID:29513071   PMID:29518091   PMID:29587269   PMID:29590614  
PMID:29593739   PMID:29674655   PMID:29688375   PMID:29728568   PMID:29738764   PMID:29894691   PMID:29915289   PMID:29925696   PMID:30098864   PMID:30122557   PMID:30127086   PMID:30194773  
PMID:30209189   PMID:30216839   PMID:30266770   PMID:30291131   PMID:30353167   PMID:30446568   PMID:30446727   PMID:30449686   PMID:30555556   PMID:30575951   PMID:30610060   PMID:30617301  
PMID:30623726   PMID:30930171   PMID:31125592   PMID:31144294   PMID:31178059   PMID:31196774   PMID:31207335   PMID:31363052   PMID:31534167   PMID:31554795   PMID:31619589   PMID:31957000  
PMID:31980480   PMID:32397290   PMID:32471168   PMID:33017719   PMID:33153718   PMID:33220232   PMID:33293423  


Genomics

Comparative Map Data
Stat6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,478,855 - 127,496,856 (+)NCBIGRCm39mm39
GRCm39 Ensembl10127,478,855 - 127,496,826 (+)Ensembl
GRCm3810127,642,955 - 127,660,987 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,642,986 - 127,660,957 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710127,080,042 - 127,098,043 (+)NCBIGRCm37mm9NCBIm37
MGSCv3610127,046,120 - 127,063,352 (+)NCBImm8
Celera10130,035,284 - 130,053,348 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1074.59NCBI
STAT6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1257,095,408 - 57,132,139 (-)EnsemblGRCh38hg38GRCh38
GRCh381257,095,408 - 57,111,413 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371257,489,191 - 57,505,145 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,775,458 - 55,791,428 (-)NCBINCBI36hg18NCBI36
Build 341255,775,461 - 55,791,428NCBI
Celera1257,143,115 - 57,159,124 (-)NCBI
Cytogenetic Map12q13.3NCBI
HuRef1254,527,593 - 54,543,593 (-)NCBIHuRef
CHM1_11257,456,871 - 57,472,880 (-)NCBICHM1_1
Stat6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2763,480,229 - 63,497,551 (+)NCBI
Rnor_6.0 Ensembl770,946,228 - 70,964,484 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0770,946,228 - 70,963,542 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0771,118,725 - 71,135,848 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,623,534 - 67,642,283 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1767,622,590 - 67,662,987 (+)NCBI
Celera760,619,697 - 60,637,001 (+)NCBICelera
Cytogenetic Map7q22NCBI
Stat6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554584,833,515 - 4,843,273 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554584,833,417 - 4,847,956 (-)NCBIChiLan1.0ChiLan1.0
STAT6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1101,232,515 - 1,247,011 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl101,233,691 - 1,247,075 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha101,297,560 - 1,307,021 (-)NCBI
ROS_Cfam_1.0101,243,003 - 1,257,485 (-)NCBI
UMICH_Zoey_3.1101,220,880 - 1,230,352 (-)NCBI
UNSW_CanFamBas_1.0101,462,887 - 1,472,341 (-)NCBI
UU_Cfam_GSD_1.0101,587,736 - 1,597,208 (-)NCBI
Stat6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494557,557,740 - 57,572,832 (+)NCBI
SpeTri2.0NW_0049366461,297,530 - 1,312,508 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STAT6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl522,406,364 - 22,421,990 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1522,406,356 - 22,422,412 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2524,206,059 - 24,221,697 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STAT6
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11153,005,378 - 53,020,899 (-)NCBI
ChlSab1.1 Ensembl1153,006,145 - 53,021,203 (-)Ensembl
Stat6
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480210,809,234 - 10,847,762 (+)NCBI

Position Markers
RH128335  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810127,660,991 - 127,661,171UniSTSGRCm38
MGSCv3710127,098,047 - 127,098,227UniSTSGRCm37
Celera10130,053,352 - 130,053,532UniSTS
Cytogenetic Map10D3UniSTS
cM Map1070.0UniSTS
cM Map1070.0UniSTS
AI451907  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810127,661,217 - 127,661,334UniSTSGRCm38
MGSCv3710127,098,273 - 127,098,390UniSTSGRCm37
Celera10130,053,578 - 130,053,695UniSTS
Cytogenetic Map10D3UniSTS
cM Map1070.0UniSTS
cM Map1070.0UniSTS
Whitehead/MRC_RH101381.69UniSTS
UniSTS:224451  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810127,660,120 - 127,660,282UniSTSGRCm38
MGSCv3710127,097,176 - 127,097,338UniSTSGRCm37
Celera10130,052,481 - 130,052,643UniSTS
Cytogenetic Map10D3UniSTS
cM Map1070.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226772Tibl13_mtibia length 13, 10 week (mouse)1019000000129800000Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039300000129800000Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039300000129800000Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069900000132500000Mouse
4142461Bmd25_mbone mineral density 25 (mouse)Not determined1097381196130694993Mouse
1357544Vtbt10_mvertebral trabecular bone trait 10 (mouse)Not determined1097381196130694993Mouse
11533919Mvb4_mmodifier of vibrator 4 (mouse)397381196130694993Mouse
11533921Mvb2_mmodifier of vibrator 2 (mouse)1097381196130694993Mouse
12880413V125Dq9_mvitamin D active form serum level QTL 9 (mouse)1097700000130694993Mouse
4141402T2dm1sa_mtype 2 diabetes mellitus 1 in SMXA RI mice (mouse)Not determined97922739130694993Mouse
11040593Lmr5e_mleishmaniasis resistance 5e (mouse)1099384730130694993Mouse
11040595Lmr5c_mleishmaniasis resistance 5c (mouse)1099384730130694993Mouse
11040597Lmr5a_mleishmaniasis resistance 5a (mouse)1099384730130694993Mouse
1301968Estq4_mestradiol regulated response QTL 4 (mouse)Not determined10101150611130694993Mouse
1357744Cfbw4_mcystic fibrosis body weight 4 (mouse)Not determined10101150611130694993Mouse
1301901Im5_mimmunoregulatory 5 (mouse)Not determined10101661259130694993Mouse
4141361Cfmq3_mcystic fibrosis modifier QTL 3 (mouse)Not determined10101661259130694993Mouse
1300678Leg2_mlongevity extending gene 2 (mouse)Not determined10102671003130694993Mouse
1301895Exq1_mexploratory and excitability QTL 1 (mouse)Not determined10103011947130694993Mouse
14696727Kidrq2_mkidney weight, right QTL 2 (mouse)10103066603130694993Mouse
4141007Obrq10_mobesity resistance QTL 10 (mouse)Not determined103407822130694993Mouse
4141487Tgq21_mtriglyceride QTL 21 (mouse)Not determined104274116130694993Mouse
14746996Manh69_mmandible shape 69 (mouse)10104927733130694993Mouse
1357482Nhdlq4_mnon-HDL QTL 4 (mouse)Not determined10105205399130694993Mouse
1300679Nociq2_mnociceptive sensitivity inflammatory QTL 2 (mouse)Not determined10105205399130694993Mouse
1302200Sle12_msystematic lupus erythematosus susceptibility 12 (mouse)Not determined10105205399130694993Mouse
11040594Lmr5f_mleishmaniasis resistance 5f (mouse)10105343808130694993Mouse
11040596Lmr5d_mleishmaniasis resistance 5d (mouse)10105343808130694993Mouse
11040598Lmr5b_mleishmaniasis resistance 5b (mouse)10105343808130694993Mouse
4142089Obrq9_mobesity resistance QTL 9 (mouse)Not determined108680038130694993Mouse
4141153Ltgq2_mliver triglyceride QTL 2 (mouse)Not determined108680038130694993Mouse
11039496Ltpr5b_mLeishmania tropica response 5b (mouse)10108739225130694993Mouse
11041664Lmr25_mleishmaniasis resistance 25 (mouse)10108739225130694993Mouse
11049563Lmr25a_mleishmaniasis resistance 25a (mouse)10108739225130694993Mouse
11049570Lmr25b_mleishmaniasis resistance 25b (mouse)10108739225130694993Mouse
12911218Frct3a_mfear conditioning traits 3a (mouse)10122950065129631127Mouse
12911220Frct3c_mfear conditioning traits 3c (mouse)10122950065129631127Mouse
12879490Frct3_mfear conditioning traits 3 (mouse)10122950065129631127Mouse
12904001Opfaq10_mopen field activity QTL 10 (mouse)10125797802129630506Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir135a-2mmu-miR-135a-5pOncomiRDBexternal_infoNANA22139076
Mir135a-1mmu-miR-135a-5pOncomiRDBexternal_infoNANA22139076

Predicted Target Of
Summary Value
Count of predictions:1005
Count of miRNA genes:521
Interacting mature miRNAs:633
Transcripts:ENSMUST00000092074, ENSMUST00000120279, ENSMUST00000128072, ENSMUST00000145470, ENSMUST00000156231
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_009284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC160970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF481808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF481809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK135911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC029318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC127054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM122652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U66575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000092074   ⟹   ENSMUSP00000089708
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl10127,642,986 - 127,660,957 (+)Ensembl
RefSeq Acc Id: ENSMUST00000120279   ⟹   ENSMUSP00000112722
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl10127,643,002 - 127,650,780 (+)Ensembl
RefSeq Acc Id: ENSMUST00000128072
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl10127,653,079 - 127,655,015 (+)Ensembl
RefSeq Acc Id: ENSMUST00000145470
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl10127,659,400 - 127,660,187 (+)Ensembl
RefSeq Acc Id: ENSMUST00000156231
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl10127,656,761 - 127,657,928 (+)Ensembl
RefSeq Acc Id: NM_009284   ⟹   NP_033310
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910127,478,855 - 127,496,856 (+)NCBI
GRCm3810127,642,986 - 127,660,987 (+)NCBI
MGSCv3710127,080,042 - 127,098,043 (+)RGD
Celera10130,035,284 - 130,053,348 (+)RGD
cM Map10 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033310   ⟸   NM_009284
- UniProtKB: P52633 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000089708   ⟸   ENSMUST00000092074
RefSeq Acc Id: ENSMUSP00000112722   ⟸   ENSMUST00000120279
Protein Domains
SH2   STAT6_C   STAT_int

Promoters
RGD ID:6819967
Promoter ID:MM_KWN:5916
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000120279,   NM_009284
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610127,079,311 - 127,080,167 (+)MPROMDB
RGD ID:6819970
Promoter ID:MM_KWN:5917
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   ES_Cell,   Kidney,   Lung,   Spleen
Transcripts:OTTMUST00000078899
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610127,089,196 - 127,090,582 (+)MPROMDB
RGD ID:6819971
Promoter ID:MM_KWN:5918
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour
Transcripts:OTTMUST00000078900
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610127,093,411 - 127,094,112 (+)MPROMDB
RGD ID:6819968
Promoter ID:MM_KWN:5919
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   ES_Cell,   Kidney,   Lung
Transcripts:ENSMUST00000099159
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610127,094,711 - 127,095,367 (+)MPROMDB
RGD ID:6819972
Promoter ID:MM_KWN:5920
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000078901
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610127,095,791 - 127,096,862 (+)MPROMDB
RGD ID:8673524
Promoter ID:EPDNEW_M14792
Type:initiation region
Name:Stat6_1
Description:Mus musculus signal transducer and activator of transcription6 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3810127,643,024 - 127,643,084EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:103034 AgrOrtholog
Ensembl Genes ENSMUSG00000002147 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000089708 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000112722 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000092074 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000120279 UniProtKB/TrEMBL
Gene3D-CATH 1.10.532.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.630 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro p53-like_TF_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT6_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT6_SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_TF_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_TF_coiled-coil UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_TF_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_TF_DNA-bd_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_TF_prot_interaction UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20852 UniProtKB/Swiss-Prot
MGD MGI:103034 ENTREZGENE
NCBI Gene 20852 ENTREZGENE
PANTHER PTHR11801 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT6_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_int UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Stat6 PhenoGen
PROSITE SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAT_int UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47655 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48092 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49417 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3YU28_MOUSE UniProtKB/TrEMBL
  P52633 ENTREZGENE
  P70383_MOUSE UniProtKB/TrEMBL
  Q3UX41_MOUSE UniProtKB/TrEMBL
  Q8R4D4_MOUSE UniProtKB/TrEMBL
  STAT6_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q8R2F1 UniProtKB/Swiss-Prot