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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | decreases expression | ISO | RGD:1558525 | 6480464 | 1, 2-Dimethylhydrazine results in decreased expression of OSBPL8 mRNA | CTD | PMID:22206623 | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | RGD:1348483 | 6480464 | 2 more ... | CTD | PMID:31675489 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1348483 | 6480464 | Tetrachlorodibenzodioxin affects the expression of OSBPL8 mRNA | CTD | PMID:22574217 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of OSBPL8 mRNA | CTD | PMID:32109520, PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1558525 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of OSBPL8 mRNA | CTD | PMID:20819909 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1558525 | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to OSBPL8 gene] | CTD | PMID:20819909 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1558525 | 6480464 | Tetrachlorodibenzodioxin affects the expression of OSBPL8 mRNA | CTD | PMID:21570461 | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | RGD:1348483 | 6480464 | tetrabromobisphenol A results in decreased expression of OSBPL8 protein | CTD | PMID:31675489 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | RGD:1348483 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of OSBPL8 mRNA | CTD | PMID:28628672 | 4,4'-sulfonyldiphenol | multiple interactions | ISO | RGD:1348483 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of OSBPL8 mRNA | CTD | PMID:28628672 | 4,4'-sulfonyldiphenol | decreases methylation | ISO | RGD:1348483 | 6480464 | bis(4-hydroxyphenyl)sulfone results in decreased methylation of OSBPL8 gene | CTD | PMID:31601247 | acetamide | decreases expression | EXP | | 6480464 | acetamide results in decreased expression of OSBPL8 mRNA | CTD | PMID:31881176 | acrolein | multiple interactions | ISO | RGD:1348483 | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of OSBPL8 mRNA, [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of OSBPL8 mRNA | CTD | PMID:32699268 | all-trans-retinoic acid | decreases expression | ISO | RGD:1348483 | 6480464 | Tretinoin results in decreased expression of OSBPL8 mRNA | CTD | PMID:21934132 | alpha-pinene | multiple interactions | ISO | RGD:1348483 | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of OSBPL8 mRNA, [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of OSBPL8 mRNA | CTD | PMID:32699268 | aristolochic acid A | decreases expression | ISO | RGD:1348483 | 6480464 | aristolochic acid I results in decreased expression of OSBPL8 mRNA | CTD | PMID:33212167 | arsane | multiple interactions | ISO | RGD:1348483 | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of OSBPL8 mRNA | CTD | PMID:32525701 | arsenic atom | multiple interactions | ISO | RGD:1348483 | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of OSBPL8 mRNA | CTD | PMID:32525701 | arsenite(3-) | multiple interactions | ISO | RGD:1348483 | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to OSBPL8 mRNA] | CTD | PMID:32406909 | arsenous acid | increases expression | ISO | RGD:1348483 | 6480464 | Arsenic Trioxide results in increased expression of OSBPL8 mRNA | CTD | PMID:20458559 | benzo[a]pyrene | decreases expression | ISO | RGD:1348483 | 6480464 | Benzo(a)pyrene results in decreased expression of OSBPL8 mRNA | CTD | PMID:20064835, PMID:22316170 | benzo[a]pyrene | increases methylation | ISO | RGD:1348483 | 6480464 | Benzo(a)pyrene results in increased methylation of OSBPL8 5' UTR | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | RGD:1558525 | 6480464 | Benzo(a)pyrene results in increased expression of OSBPL8 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | decreases expression | ISO | RGD:1558525 | 6480464 | Benzo(a)pyrene results in decreased expression of OSBPL8 mRNA | CTD | PMID:19770486 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | RGD:1348483 | 6480464 | 7 more ... | CTD | PMID:19150397, PMID:20018196 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of OSBPL8 mRNA | CTD | PMID:25181051 | bisphenol A | decreases methylation | ISO | RGD:1348483 | 6480464 | bisphenol A results in decreased methylation of OSBPL8 gene | CTD | PMID:31601247 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of OSBPL8 mRNA | CTD | PMID:30816183 | bisphenol A | increases expression | ISO | RGD:1558525 | 6480464 | bisphenol A results in increased expression of OSBPL8 mRNA | CTD | PMID:21932408 | bromobenzene | decreases expression | EXP | | 6480464 | bromobenzene results in decreased expression of OSBPL8 mRNA | CTD | PMID:32479839 | cadmium dichloride | decreases expression | ISO | RGD:1348483 | 6480464 | Cadmium Chloride results in decreased expression of OSBPL8 mRNA | CTD | PMID:18560533 | caffeine | affects phosphorylation | ISO | RGD:1348483 | 6480464 | Caffeine affects the phosphorylation of OSBPL8 protein | CTD | PMID:35688186 | cefaloridine | decreases expression | EXP | | 6480464 | Cephaloridine results in decreased expression of OSBPL8 mRNA | CTD | PMID:18500788 | cisplatin | decreases expression | ISO | RGD:1348483 | 6480464 | Cisplatin results in decreased expression of OSBPL8 mRNA | CTD | PMID:27392435 | clozapine | increases expression | ISO | RGD:1558525 | 6480464 | Clozapine results in increased expression of OSBPL8 mRNA | CTD | PMID:14647396 | copper(II) sulfate | increases expression | ISO | RGD:1348483 | 6480464 | Copper Sulfate results in increased expression of OSBPL8 mRNA | CTD | PMID:19549813 | coumarin | decreases phosphorylation | ISO | RGD:1348483 | 6480464 | coumarin results in decreased phosphorylation of OSBPL8 protein | CTD | PMID:35688186 | cyclosporin A | decreases expression | ISO | RGD:1558525 | 6480464 | Cyclosporine results in decreased expression of OSBPL8 mRNA | CTD | PMID:19770486 | dexamethasone | multiple interactions | ISO | RGD:1348483 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of OSBPL8 mRNA | CTD | PMID:28628672 | diarsenic trioxide | increases expression | ISO | RGD:1348483 | 6480464 | Arsenic Trioxide results in increased expression of OSBPL8 mRNA | CTD | PMID:20458559 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of OSBPL8 mRNA | CTD | PMID:21266533 | epoxiconazole | decreases expression | ISO | RGD:1558525 | 6480464 | epoxiconazole results in decreased expression of OSBPL8 mRNA | CTD | PMID:35436446 | ethanol | affects splicing | ISO | RGD:1558525 | 6480464 | Ethanol affects the splicing of OSBPL8 mRNA | CTD | PMID:30319688 | geldanamycin | increases expression | ISO | RGD:1348483 | 6480464 | geldanamycin results in increased expression of OSBPL8 mRNA | CTD | PMID:26705709 | glafenine | decreases expression | EXP | | 6480464 | Glafenine results in decreased expression of OSBPL8 mRNA | CTD | PMID:24136188 | haloperidol | increases expression | ISO | RGD:1558525 | 6480464 | Haloperidol results in increased expression of OSBPL8 mRNA | CTD | PMID:14647396 | hydrogen peroxide | affects expression | ISO | RGD:1348483 | 6480464 | Hydrogen Peroxide affects the expression of OSBPL8 mRNA | CTD | PMID:21179406 | indometacin | multiple interactions | ISO | RGD:1348483 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of OSBPL8 mRNA | CTD | PMID:28628672 | methotrexate | affects expression | ISO | RGD:1558525 | 6480464 | Methotrexate affects the expression of OSBPL8 mRNA | CTD | PMID:18502557 | methyl methanesulfonate | increases expression | ISO | RGD:1348483 | 6480464 | Methyl Methanesulfonate results in increased expression of OSBPL8 mRNA | CTD | PMID:23649840 | methylmercury chloride | increases expression | ISO | RGD:1348483 | 6480464 | methylmercuric chloride results in increased expression of OSBPL8 mRNA | CTD | PMID:23179753, PMID:26272509 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of OSBPL8 mRNA | CTD | PMID:25729387 | ozone | multiple interactions | ISO | RGD:1348483 | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of OSBPL8 mRNA more ... | CTD | PMID:32699268 | paracetamol | affects expression | ISO | RGD:1348483 | 6480464 | Acetaminophen affects the expression of OSBPL8 mRNA | CTD | PMID:25458485 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of OSBPL8 mRNA | CTD | PMID:33387578 | paracetamol | increases expression | ISO | RGD:1348483 | 6480464 | Acetaminophen results in increased expression of OSBPL8 mRNA | CTD | PMID:26497421 | paracetamol | affects expression | ISO | RGD:1558525 | 6480464 | Acetaminophen affects the expression of OSBPL8 mRNA | CTD | PMID:17562736 | perfluorooctane-1-sulfonic acid | decreases expression | ISO | RGD:1348483 | 6480464 | perfluorooctane sulfonic acid results in decreased expression of OSBPL8 mRNA | CTD | PMID:27153767 | phenobarbital | affects expression | ISO | RGD:1558525 | 6480464 | Phenobarbital affects the expression of OSBPL8 mRNA | CTD | PMID:23091169 | pirinixic acid | decreases expression | ISO | RGD:1558525 | 6480464 | pirinixic acid results in decreased expression of OSBPL8 mRNA | CTD | PMID:20813756 | potassium dichromate | decreases expression | ISO | RGD:1558525 | 6480464 | Potassium Dichromate results in decreased expression of OSBPL8 mRNA | CTD | PMID:23608068 | pregnenolone 16alpha-carbonitrile | decreases expression | ISO | RGD:1558525 | 6480464 | Pregnenolone Carbonitrile results in decreased expression of OSBPL8 mRNA | CTD | PMID:28903501 | quercetin | decreases expression | ISO | RGD:1348483 | 6480464 | Quercetin results in decreased expression of OSBPL8 mRNA | CTD | PMID:21632981 | quercetin | increases phosphorylation | ISO | RGD:1348483 | 6480464 | Quercetin results in increased phosphorylation of OSBPL8 protein | CTD | PMID:35688186 | rimonabant | affects expression | ISO | RGD:1558525 | 6480464 | Rimonabant affects the expression of OSBPL8 mRNA | CTD | PMID:19030233 | rimonabant | multiple interactions | ISO | RGD:1558525 | 6480464 | Rimonabant inhibits the reaction [Dietary Fats results in increased expression of OSBPL8 mRNA] | CTD | PMID:19030233 | silicon dioxide | increases methylation | ISO | RGD:1348483 | 6480464 | Silicon Dioxide results in increased methylation of OSBPL8 gene | CTD | PMID:34973136 | sodium arsenate | multiple interactions | ISO | RGD:1348483 | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of OSBPL8 mRNA | CTD | PMID:32525701 | temozolomide | increases expression | ISO | RGD:1348483 | 6480464 | Temozolomide results in increased expression of OSBPL8 mRNA | CTD | PMID:31758290 | testosterone enanthate | affects expression | ISO | RGD:1348483 | 6480464 | testosterone enanthate affects the expression of OSBPL8 mRNA | CTD | PMID:17440010 | tetracycline | decreases expression | ISO | RGD:1558525 | 6480464 | Tetracycline results in decreased expression of OSBPL8 mRNA | CTD | PMID:16917069 | thimerosal | decreases expression | ISO | RGD:1348483 | 6480464 | Thimerosal results in decreased expression of OSBPL8 mRNA | CTD | PMID:27188386 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of OSBPL8 mRNA | CTD | PMID:25729387 | trichostatin A | decreases expression | ISO | RGD:1348483 | 6480464 | trichostatin A results in decreased expression of OSBPL8 mRNA | CTD | PMID:26272509 | trichostatin A | affects expression | ISO | RGD:1348483 | 6480464 | trichostatin A affects the expression of OSBPL8 mRNA | CTD | PMID:28542535 | tungsten | decreases expression | ISO | RGD:1558525 | 6480464 | Tungsten results in decreased expression of OSBPL8 mRNA | CTD | PMID:30912803 | urethane | increases expression | ISO | RGD:1348483 | 6480464 | Urethane results in increased expression of OSBPL8 mRNA | CTD | PMID:28818685 | valproic acid | increases expression | ISO | RGD:1348483 | 6480464 | Valproic Acid results in increased expression of OSBPL8 mRNA | CTD | PMID:19101580 | valproic acid | affects expression | ISO | RGD:1558525 | 6480464 | Valproic Acid affects the expression of OSBPL8 mRNA | CTD | PMID:17292431 | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of OSBPL8 mRNA | CTD | PMID:23034163 | vorinostat | decreases expression | ISO | RGD:1348483 | 6480464 | vorinostat results in decreased expression of OSBPL8 mRNA | CTD | PMID:27188386 | |