Imported Disease Annotations - CTDObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Ptprb | Rat | angiosarcoma | | ISO | PTPRB (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:24633157 | |
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Imported Disease Annotations - CTDObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Ptprb | Rat | angiosarcoma | | ISO | PTPRB (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:24633157 | |
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# | Reference Title | Reference Citation |
1. | Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase beta (RPTPbeta) and tyrosine-phosphorylated proteins. | Adamsky K, etal., J Cell Sci 2003 Apr 1;116(Pt 7):1279-89. |
2. | Primary mammary angiosarcomas harbor frequent mutations in KDR and PIK3CA and show evidence of distinct pathogenesis. | Beca F, etal., Mod Pathol. 2020 Aug;33(8):1518-1526. doi: 10.1038/s41379-020-0511-6. Epub 2020 Mar 2. |
3. | Recurrent PTPRB and PLCG1 mutations in angiosarcoma. | Behjati S, etal., Nat Genet. 2014 Apr;46(4):376-379. doi: 10.1038/ng.2921. Epub 2014 Mar 16. |
4. | Oncogenomics of c-Myc transgenic mice reveal novel regulators of extracellular signaling, angiogenesis and invasion with clinical significance for human lung adenocarcinoma. | Ciribilli Y and Borlak J, Oncotarget. 2017 Oct 23;8(60):101808-101831. doi: 10.18632/oncotarget.21981. eCollection 2017 Nov 24. |
5. | Clinical biomarkers of pulmonary carcinoid tumors in never smokers via profiling miRNA and target mRNA. | Deng B, etal., Cell Biosci. 2014 Jul 9;4:35. doi: 10.1186/2045-3701-4-35. eCollection 2014. |
6. | Targeting of the receptor protein tyrosine phosphatase beta with a monoclonal antibody delays tumor growth in a glioblastoma model. | Foehr ED, etal., Cancer Res. 2006 Feb 15;66(4):2271-8. doi: 10.1158/0008-5472.CAN-05-1221. |
7. | Implication of a protein-tyrosine-phosphatase in human lung cancer. | Gaits F, etal., Cell Mol Biol (Noisy-le-grand). 1994 Jul;40(5):677-85. |
8. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
9. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
10. | Effects of vascular-endothelial protein tyrosine phosphatase inhibition on breast cancer vasculature and metastatic progression. | Goel S, etal., J Natl Cancer Inst. 2013 Aug 21;105(16):1188-201. doi: 10.1093/jnci/djt164. Epub 2013 Jul 30. |
11. | VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation. | Hayashi M, etal., Nat Commun. 2013;4:1672. doi: 10.1038/ncomms2683. |
12. | miR-665 promotes hepatocellular carcinoma cell migration, invasion, and proliferation by decreasing Hippo signaling through targeting PTPRB. | Hu Y, etal., Cell Death Dis. 2018 Sep 20;9(10):954. doi: 10.1038/s41419-018-0978-y. |
13. | DCE-MRI in Glioma, Infiltration Zone and Healthy Brain to Assess Angiogenesis: AÂ Biopsy Study. | Keil VC, etal., Clin Neuroradiol. 2021 Dec;31(4):1049-1058. doi: 10.1007/s00062-021-01015-3. Epub 2021 Apr 26. |
14. | The VE-PTP Inhibitor AKB-9778 Improves Antitumor Activity and Diminishes the Toxicity of Interleukin 2 (IL-2) Administration. | Li G, etal., J Immunother. 2019 Sep;42(7):237-243. doi: 10.1097/CJI.0000000000000290. |
15. | Functional comparison of long and short splice forms of RPTPbeta: implications for glioblastoma treatment. | Lorente G, etal., Neuro Oncol. 2005 Apr;7(2):154-63. doi: 10.1215/S1152851704000547. |
16. | miR-624-5p promoted tumorigenesis and metastasis by suppressing hippo signaling through targeting PTPRB in osteosarcoma cells. | Luo Y, etal., J Exp Clin Cancer Res. 2019 Dec 11;38(1):488. doi: 10.1186/s13046-019-1491-6. |
17. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
18. | Targeted massively parallel sequencing of angiosarcomas reveals frequent activation of the mitogen activated protein kinase pathway. | Murali R, etal., Oncotarget. 2015 Nov 3;6(34):36041-52. doi: 10.18632/oncotarget.5936. |
19. | Protein tyrosine phosphatase PTPRB regulates Src phosphorylation and tumour progression in NSCLC. | Qi Y, etal., Clin Exp Pharmacol Physiol. 2016 Oct;43(10):1004-12. doi: 10.1111/1440-1681.12610. |
20. | GOA pipeline | RGD automated data pipeline |
21. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
22. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
23. | PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic cancer progression. | Sahni S, etal., Biochim Biophys Acta Gen Subj. 2020 Nov;1864(11):129682. doi: 10.1016/j.bbagen.2020.129682. Epub 2020 Jul 12. |
24. | Nine Genes Mediate the Therapeutic Effects of Iodine-131 Radiotherapy in Thyroid Carcinoma Patients. | Shuwen H, etal., Dis Markers. 2020 Jun 16;2020:9369341. doi: 10.1155/2020/9369341. eCollection 2020. |
25. | RNA interference targeting protein tyrosine phosphatase zeta/receptor-type protein tyrosine phosphatase beta suppresses glioblastoma growth in vitro and in vivo. | Ulbricht U, etal., J Neurochem. 2006 Sep;98(5):1497-506. doi: 10.1111/j.1471-4159.2006.04022.x. |
26. | Expression and function of the receptor protein tyrosine phosphatase zeta and its ligand pleiotrophin in human astrocytomas. | Ulbricht U, etal., J Neuropathol Exp Neurol. 2003 Dec;62(12):1265-75. doi: 10.1093/jnen/62.12.1265. |
27. | A phase II study of ENMD-2076 in advanced soft tissue sarcoma (STS). | Veitch Z, etal., Sci Rep. 2019 May 14;9(1):7390. doi: 10.1038/s41598-019-43222-6. |
28. | PTPRB promotes metastasis of colorectal carcinoma via inducing epithelial-mesenchymal transition. | Weng X, etal., Cell Death Dis. 2019 Apr 30;10(5):352. doi: 10.1038/s41419-019-1554-9. |
PMID:8889548 | PMID:10557082 | PMID:12234928 | PMID:15708477 | PMID:16028071 | PMID:16514057 | PMID:17360632 | PMID:19116766 | PMID:19136612 | PMID:19451274 | PMID:19751804 | PMID:20014386 |
PMID:21890632 | PMID:23382219 | PMID:26063811 | PMID:28926625 |
Ptprb (Rattus norvegicus - Norway rat) |
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PTPRB (Homo sapiens - human) |
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Ptprb (Mus musculus - house mouse) |
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Ptprb (Chinchilla lanigera - long-tailed chinchilla) |
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PTPRB (Pan paniscus - bonobo/pygmy chimpanzee) |
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PTPRB (Canis lupus familiaris - dog) |
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Ptprb (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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PTPRB (Sus scrofa - pig) |
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PTPRB (Chlorocebus sabaeus - green monkey) |
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Ptprb (Heterocephalus glaber - naked mole-rat) |
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Variants in Ptprb
241 total Variants |
The detailed report is available here: | Full Report | CSV | TAB | Printer | ||||
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | Full Report | CSV | TAB | Printer | Gviewer |
RH131513 |
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RH128899 |
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alimentary part of gastrointestinal system
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appendage
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circulatory system
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ectoderm
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endocrine system
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endoderm
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exocrine system
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hemolymphoid system
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hepatobiliary system
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integumental system
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mesenchyme
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mesoderm
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nervous system
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renal system
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reproductive system
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respiratory system
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9 | 11 | 49 | 113 | 91 | 90 | 59 | 25 | 59 | 6 | 218 | 97 | 93 | 45 | 60 | 31 |
RefSeq Transcripts | NM_001372134 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
NM_001429500 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_003754286 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_008765424 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_008765425 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_008776435 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063263482 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063263483 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AC136025 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
BI276956 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH473960 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JAXUCZ010000007 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
Ensembl Acc Id: | ENSRNOT00000085231 ⟹ ENSRNOP00000072398 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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Ensembl Acc Id: | ENSRNOT00000085334 ⟹ ENSRNOP00000070093 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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Ensembl Acc Id: | ENSRNOT00000094476 ⟹ ENSRNOP00000082351 | ||||||||
Type: | CODING | ||||||||
Position: |
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Ensembl Acc Id: | ENSRNOT00000119174 ⟹ ENSRNOP00000081477 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NM_001372134 ⟹ NP_001359063 | ||||||||||||
RefSeq Status: | VALIDATED | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_063263482 ⟹ XP_063119552 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XM_063263483 ⟹ XP_063119553 | ||||||||
Type: | CODING | ||||||||
Position: |
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Protein RefSeqs | NP_001359063 | (Get FASTA) | NCBI Sequence Viewer |
NP_001416429 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063119552 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063119553 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | EDM16671 | (Get FASTA) | NCBI Sequence Viewer |
EDM16672 | (Get FASTA) | NCBI Sequence Viewer | |
EDM16673 | (Get FASTA) | NCBI Sequence Viewer | |
Ensembl Protein | ENSRNOP00000070093.2 | ||
ENSRNOP00000072398.2 | |||
ENSRNOP00000081477.1 | |||
ENSRNOP00000082351.1 |
Ensembl Acc Id: | ENSRNOP00000072398 ⟸ ENSRNOT00000085231 |
Ensembl Acc Id: | ENSRNOP00000070093 ⟸ ENSRNOT00000085334 |
RefSeq Acc Id: | NP_001359063 ⟸ NM_001372134 |
- Peptide Label: | precursor |
- UniProtKB: | A0A8I5ZV35 (UniProtKB/TrEMBL), A6IGM6 (UniProtKB/TrEMBL), D3ZTG5 (UniProtKB/TrEMBL) |
Ensembl Acc Id: | ENSRNOP00000081477 ⟸ ENSRNOT00000119174 |
Ensembl Acc Id: | ENSRNOP00000082351 ⟸ ENSRNOT00000094476 |
RefSeq Acc Id: | XP_063119552 ⟸ XM_063263482 |
- Peptide Label: | isoform X1 |
RefSeq Acc Id: | XP_063119553 ⟸ XM_063263483 |
- Peptide Label: | isoform X2 |
- UniProtKB: | A6IGM7 (UniProtKB/TrEMBL) |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-A0A0G2K2W0-F1-model_v2 | AlphaFold | A0A0G2K2W0 | 1-2238 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
RGD ID: | 13695203 | ||||||||
Promoter ID: | EPDNEW_R5727 | ||||||||
Type: | multiple initiation site | ||||||||
Name: | Ptprb_2 | ||||||||
Description: | protein tyrosine phosphatase, receptor type, B | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Alternative Promoters: | null; see alsoEPDNEW_R5728 | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
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RGD ID: | 13695206 | ||||||||
Promoter ID: | EPDNEW_R5728 | ||||||||
Type: | single initiation site | ||||||||
Name: | Ptprb_1 | ||||||||
Description: | protein tyrosine phosphatase, receptor type, B | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Alternative Promoters: | null; see alsoEPDNEW_R5727 | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
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Database | Acc Id | Source(s) |
AGR Gene | RGD:1305922 | AgrOrtholog |
BioCyc Gene | G2FUF-34035 | BioCyc |
Ensembl Genes | ENSRNOG00000055293 | Ensembl, UniProtKB/TrEMBL |
Ensembl Transcript | ENSRNOT00000085231.2 | UniProtKB/TrEMBL |
ENSRNOT00000085334.2 | UniProtKB/TrEMBL | |
ENSRNOT00000094476.1 | UniProtKB/TrEMBL | |
ENSRNOT00000119174.1 | UniProtKB/TrEMBL | |
Gene3D-CATH | 2.60.40.10 | UniProtKB/TrEMBL |
2.80.10.50 | UniProtKB/TrEMBL | |
3.90.190.10 | UniProtKB/TrEMBL | |
InterPro | Dual-sp/Tyr_phosphatase | UniProtKB/TrEMBL |
FN3_sf | UniProtKB/TrEMBL | |
FN_III | UniProtKB/TrEMBL | |
Ig-like_fold | UniProtKB/TrEMBL | |
Prot-tyrosine_phosphatase-like | UniProtKB/TrEMBL | |
PTPRJ_TM | UniProtKB/TrEMBL | |
Ricin_B-like_lectins | UniProtKB/TrEMBL | |
Ricin_B_lectin | UniProtKB/TrEMBL | |
RTP_Phos/Ushers | UniProtKB/TrEMBL | |
Tyr_Pase_AS | UniProtKB/TrEMBL | |
Tyr_Pase_cat | UniProtKB/TrEMBL | |
Tyr_Pase_rcpt/non-rcpt | UniProtKB/TrEMBL | |
NCBI Gene | 314843 | ENTREZGENE |
PANTHER | CYTOKINE RECEPTOR | UniProtKB/TrEMBL |
RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE BETA | UniProtKB/TrEMBL | |
Pfam | fn3 | UniProtKB/TrEMBL |
PTP_tm | UniProtKB/TrEMBL | |
Ricin_B_lectin | UniProtKB/TrEMBL | |
Y_phosphatase | UniProtKB/TrEMBL | |
PhenoGen | Ptprb | PhenoGen |
PRINTS | PRTYPHPHTASE | UniProtKB/TrEMBL |
PROSITE | FN3 | UniProtKB/TrEMBL |
RICIN_B_LECTIN | UniProtKB/TrEMBL | |
TYR_PHOSPHATASE_1 | UniProtKB/TrEMBL | |
TYR_PHOSPHATASE_2 | UniProtKB/TrEMBL | |
TYR_PHOSPHATASE_PTP | UniProtKB/TrEMBL | |
RatGTEx | ENSRNOG00000055293 | RatGTEx |
SMART | FN3 | UniProtKB/TrEMBL |
PTPc | UniProtKB/TrEMBL | |
PTPc_motif | UniProtKB/TrEMBL | |
Superfamily-SCOP | FN_III-like | UniProtKB/TrEMBL |
SSF50370 | UniProtKB/TrEMBL | |
SSF52799 | UniProtKB/TrEMBL | |
UniProt | A0A0G2K2W0_RAT | UniProtKB/TrEMBL |
A0A8I5ZV35 | ENTREZGENE, UniProtKB/TrEMBL | |
A0A8I5ZXS1 | ENTREZGENE, UniProtKB/TrEMBL | |
A6IGM6 | ENTREZGENE, UniProtKB/TrEMBL | |
A6IGM7 | ENTREZGENE, UniProtKB/TrEMBL | |
D3ZTG5 | ENTREZGENE, UniProtKB/TrEMBL |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2015-07-29 | Ptprb | protein tyrosine phosphatase, receptor type, B | LOC102546841 | uncharacterized LOC102546841 | Data merged from RGD:7586698 | 737654 | PROVISIONAL |
2015-07-29 | Ptprb | protein tyrosine phosphatase, receptor type, B | LOC688895 | hypothetical protein LOC688895 | Data merged from RGD:1584071 | 737654 | PROVISIONAL |
2013-12-18 | LOC102546841 | uncharacterized LOC102546841 | Symbol and Name status set to provisional | 70820 | PROVISIONAL | ||
2008-04-30 | Ptprb | protein tyrosine phosphatase, receptor type, B | Ptprb_predicted | protein tyrosine phosphatase, receptor type, B (predicted) | 'predicted' is removed | 2292626 | APPROVED |
2006-11-19 | LOC688895 | hypothetical protein LOC688895 | Symbol and Name status set to provisional | 70820 | PROVISIONAL | ||
2005-01-12 | Ptprb_predicted | protein tyrosine phosphatase, receptor type, B (predicted) | Symbol and Name status set to approved | 70820 | APPROVED |