1,2-dimethylhydrazine increases expression ISO RGD:1550798 6480464 1, 2-Dimethylhydrazine results in increased expression of LGR5 mRNA CTD PMID:22206623 17beta-estradiol decreases expression EXP 6480464 Estradiol results in decreased expression of LGR5 mRNA CTD PMID:26945725 17beta-estradiol increases expression ISO RGD:1605118 6480464 Estradiol results in increased expression of LGR5 mRNA CTD PMID:25878060 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1550798 6480464 Tetrachlorodibenzodioxin affects the expression of LGR5 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of LGR5 mRNA CTD PMID:32109520 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1550798 6480464 Tetrachlorodibenzodioxin results in decreased expression of LGR5 mRNA CTD PMID:25975270 , PMID:26290441 2-butoxyethanol decreases expression ISO RGD:1550798 6480464 n-butoxyethanol results in decreased expression of LGR5 mRNA CTD PMID:19812364 3,3',5,5'-tetrabromobisphenol A multiple interactions EXP 6480464 N-(N-(3, 5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [tetrabromobisphenol A results in increased expression of LGR5 mRNA] CTD PMID:32041402 3,3',5,5'-tetrabromobisphenol A increases expression EXP 6480464 tetrabromobisphenol A results in increased expression of LGR5 mRNA CTD PMID:32041402 4,4'-sulfonyldiphenol affects expression ISO RGD:1550798 6480464 bis(4-hydroxyphenyl)sulfone affects the expression of LGR5 mRNA CTD PMID:30951980 5-fluorouracil decreases expression ISO RGD:1605118 6480464 Fluorouracil results in decreased expression of LGR5 mRNA CTD PMID:24737281 6-bromoindirubin-3'-oxime increases expression ISO RGD:1605118 6480464 6-bromoindirubin-3'-oxime results in increased expression of LGR5 mRNA CTD PMID:26259606 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of LGR5 mRNA CTD PMID:24780913 acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of LGR5 mRNA CTD PMID:28959563 aflatoxin B1 increases methylation ISO RGD:1605118 6480464 Aflatoxin B1 results in increased methylation of LGR5 intron CTD PMID:30157460 antirheumatic drug increases expression ISO RGD:1605118 6480464 Antirheumatic Agents results in increased expression of LGR5 mRNA CTD PMID:24449571 arsane affects expression ISO RGD:1605118 6480464 Arsenic affects the expression of LGR5 mRNA CTD PMID:28615018 arsenic atom affects expression ISO RGD:1605118 6480464 Arsenic affects the expression of LGR5 mRNA CTD PMID:28615018 arsenous acid decreases expression ISO RGD:1605118 6480464 Arsenic Trioxide results in decreased expression of LGR5 mRNA CTD PMID:26705709 benzo[a]pyrene decreases expression ISO RGD:1605118 6480464 Benzo(a)pyrene results in decreased expression of LGR5 mRNA CTD PMID:20106945 , PMID:21632981 benzo[a]pyrene affects methylation ISO RGD:1605118 6480464 Benzo(a)pyrene affects the methylation of LGR5 intron CTD PMID:30157460 benzo[a]pyrene increases methylation ISO RGD:1605118 6480464 Benzo(a)pyrene results in increased methylation of LGR5 exon, Benzo(a)pyrene results in increased methylation of LGR5 promoter CTD PMID:27901495 benzo[a]pyrene decreases methylation ISO RGD:1550798 6480464 Benzo(a)pyrene results in decreased methylation of LGR5 intron CTD PMID:27901495 benzo[b]fluoranthene increases expression ISO RGD:1550798 6480464 benzo(b)fluoranthene results in increased expression of LGR5 mRNA CTD PMID:26377693 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:1605118 6480464 Diethylhexyl Phthalate results in decreased expression of LGR5 mRNA CTD PMID:31163220 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of LGR5 mRNA CTD PMID:25181051 , PMID:34947998 bisphenol A increases expression ISO RGD:1550798 6480464 bisphenol A results in increased expression of LGR5 mRNA CTD PMID:30951980 , PMID:34585602 bisphenol A affects expression ISO RGD:1605118 6480464 bisphenol A affects the expression of LGR5 mRNA CTD PMID:30903817 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of LGR5 mRNA CTD PMID:30816183 , PMID:32528016 bisphenol F increases expression ISO RGD:1550798 6480464 bisphenol F results in increased expression of LGR5 mRNA CTD PMID:30951980 bromobenzene decreases expression EXP 6480464 bromobenzene results in decreased expression of LGR5 mRNA CTD PMID:32479839 buta-1,3-diene decreases expression ISO RGD:1550798 6480464 1, 3-butadiene results in decreased expression of LGR5 mRNA CTD PMID:21147608 cannabidiol decreases expression ISO RGD:1550798 6480464 Cannabidiol results in decreased expression of LGR5 mRNA CTD PMID:31052254 carbon nanotube decreases expression ISO RGD:1550798 6480464 Nanotubes more ... CTD PMID:25620056 CHIR 99021 increases expression ISO RGD:1605118 6480464 Chir 99021 results in increased expression of LGR5 mRNA CTD PMID:26259606 choline multiple interactions ISO RGD:1550798 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LGR5 gene CTD PMID:20938992 ciguatoxin CTX1B affects expression ISO RGD:1550798 6480464 Ciguatoxins affects the expression of LGR5 mRNA CTD PMID:18353800 clofibrate increases expression ISO RGD:1550798 6480464 Clofibrate results in increased expression of LGR5 mRNA CTD PMID:17585979 cocaine decreases expression EXP 6480464 Cocaine results in decreased expression of LGR5 mRNA CTD PMID:27899881 copper atom multiple interactions ISO RGD:1605118 6480464 [NSC 689534 binds to Copper] which results in decreased expression of LGR5 mRNA CTD PMID:20971185 copper atom increases expression EXP 6480464 Copper results in increased expression of LGR5 mRNA CTD PMID:30556269 copper(0) multiple interactions ISO RGD:1605118 6480464 [NSC 689534 binds to Copper] which results in decreased expression of LGR5 mRNA CTD PMID:20971185 copper(0) increases expression EXP 6480464 Copper results in increased expression of LGR5 mRNA CTD PMID:30556269 cyclosporin A decreases expression ISO RGD:1605118 6480464 Cyclosporine results in decreased expression of LGR5 mRNA CTD PMID:25562108 DAPT multiple interactions EXP 6480464 N-(N-(3, 5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [tetrabromobisphenol A results in increased expression of LGR5 mRNA] CTD PMID:32041402 deoxynivalenol decreases expression ISO RGD:1550798 6480464 deoxynivalenol results in decreased expression of LGR5 protein CTD PMID:34506767 deoxynivalenol multiple interactions ISO RGD:1550798 6480464 lauric acid inhibits the reaction [deoxynivalenol results in decreased expression of LGR5 protein] CTD PMID:34506767 diarsenic trioxide decreases expression ISO RGD:1605118 6480464 Arsenic Trioxide results in decreased expression of LGR5 mRNA CTD PMID:26705709 dioxygen decreases expression ISO RGD:1605118 6480464 Oxygen deficiency results in decreased expression of LGR5 mRNA CTD PMID:24236059 dodecanoic acid multiple interactions ISO RGD:1550798 6480464 lauric acid inhibits the reaction [deoxynivalenol results in decreased expression of LGR5 protein] CTD PMID:34506767 dorsomorphin multiple interactions ISO RGD:1605118 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 entinostat decreases expression ISO RGD:1605118 6480464 entinostat results in decreased expression of LGR5 mRNA CTD PMID:26272509 entinostat multiple interactions ISO RGD:1605118 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LGR5 mRNA CTD PMID:27188386 ethanol affects expression ISO RGD:1550798 6480464 Ethanol affects the expression of LGR5 mRNA CTD PMID:30319688 flutamide increases expression EXP 6480464 Flutamide results in increased expression of LGR5 mRNA CTD PMID:24793618 folic acid multiple interactions ISO RGD:1550798 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LGR5 gene CTD PMID:20938992 folic acid decreases expression ISO RGD:1550798 6480464 Folic Acid results in decreased expression of LGR5 mRNA CTD PMID:25629700 fonofos increases methylation ISO RGD:1605118 6480464 Fonofos results in increased methylation of LGR5 promoter CTD PMID:22847954 genistein decreases expression ISO RGD:1550798 6480464 Genistein results in decreased expression of LGR5 mRNA CTD PMID:32186404 hydrogen peroxide affects expression ISO RGD:1605118 6480464 Hydrogen Peroxide affects the expression of LGR5 mRNA CTD PMID:23410634 L-methionine multiple interactions ISO RGD:1550798 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LGR5 gene CTD PMID:20938992 lead diacetate decreases expression ISO RGD:1550798 6480464 lead acetate results in decreased expression of LGR5 mRNA CTD PMID:22613225 leflunomide increases expression ISO RGD:1605118 6480464 leflunomide results in increased expression of LGR5 mRNA CTD PMID:28988120 lithium chloride increases expression ISO RGD:1550798 6480464 Lithium Chloride results in increased expression of LGR5 mRNA CTD PMID:33901603 menadione affects expression ISO RGD:1605118 6480464 Vitamin K 3 affects the expression of LGR5 mRNA CTD PMID:23410634 methotrexate decreases expression ISO RGD:1605118 6480464 Methotrexate results in decreased expression of LGR5 mRNA CTD PMID:17400583 methylmercury chloride decreases expression ISO RGD:1605118 6480464 methylmercuric chloride results in decreased expression of LGR5 mRNA CTD PMID:28001369 mono(2-ethylhexyl) phthalate affects expression ISO RGD:1550798 6480464 mono-(2-ethylhexyl)phthalate affects the expression of LGR5 mRNA CTD PMID:21195148 Monobutylphthalate affects expression ISO RGD:1550798 6480464 monobutyl phthalate affects the expression of LGR5 mRNA CTD PMID:21195148 N-nitrosodiethylamine decreases expression ISO RGD:1550798 6480464 Diethylnitrosamine results in decreased expression of LGR5 mRNA CTD PMID:24535843 N-nitrosodiethylamine multiple interactions ISO RGD:1550798 6480464 [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of LGR5 mRNA CTD PMID:24535843 nickel atom decreases expression ISO RGD:1605118 6480464 Nickel results in decreased expression of LGR5 mRNA CTD PMID:24768652 , PMID:25583101 okadaic acid increases expression ISO RGD:1605118 6480464 Okadaic Acid results in increased expression of LGR5 mRNA CTD PMID:31115591 paracetamol affects expression ISO RGD:1550798 6480464 Acetaminophen affects the expression of LGR5 mRNA CTD PMID:17562736 paracetamol decreases expression ISO RGD:1550798 6480464 Acetaminophen results in decreased expression of LGR5 mRNA CTD PMID:19420014 parathion increases methylation ISO RGD:1605118 6480464 Parathion results in increased methylation of LGR5 promoter CTD PMID:22847954 pentachlorophenol increases expression ISO RGD:1550798 6480464 Pentachlorophenol results in increased expression of LGR5 mRNA CTD PMID:23892564 phenobarbital multiple interactions ISO RGD:1550798 6480464 [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of LGR5 mRNA, NR1I3 protein affects the reaction [Phenobarbital results in increased expression of LGR5 mRNA] CTD PMID:19482888 , PMID:24535843 phenobarbital decreases expression ISO RGD:1550798 6480464 Phenobarbital results in decreased expression of LGR5 mRNA CTD PMID:19270015 , PMID:23091169 phenobarbital increases expression ISO RGD:1550798 6480464 Phenobarbital results in increased expression of LGR5 mRNA CTD PMID:19482888 pirinixic acid decreases expression ISO RGD:1550798 6480464 pirinixic acid results in decreased expression of LGR5 mRNA CTD PMID:23811191 progesterone decreases expression ISO RGD:1550798 6480464 Progesterone results in decreased expression of LGR5 mRNA CTD PMID:22238285 quercetin decreases expression ISO RGD:1605118 6480464 Quercetin results in decreased expression of LGR5 mRNA CTD PMID:21632981 , PMID:30152185 resveratrol decreases expression ISO RGD:1605118 6480464 resveratrol results in decreased expression of LGR5 mRNA CTD PMID:21291235 resveratrol decreases expression ISO RGD:1550798 6480464 resveratrol results in decreased expression of LGR5 protein CTD PMID:25280562 SB 431542 multiple interactions ISO RGD:1605118 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 senecionine decreases expression ISO RGD:1550798 6480464 senecionine results in decreased expression of LGR5 mRNA CTD PMID:31606820 silicon dioxide decreases expression ISO RGD:1550798 6480464 Silicon Dioxide results in decreased expression of LGR5 mRNA CTD PMID:23221170 sodium arsenite decreases expression ISO RGD:1605118 6480464 sodium arsenite results in decreased expression of LGR5 mRNA CTD PMID:34032870 sodium arsenite decreases expression ISO RGD:1550798 6480464 sodium arsenite results in decreased expression of LGR5 mRNA CTD PMID:33957193 T-2 toxin decreases expression ISO RGD:1605118 6480464 T-2 Toxin results in decreased expression of LGR5 mRNA CTD PMID:31863870 tamoxifen multiple interactions ISO RGD:1605118 6480464 ESR1 protein affects the reaction [Tamoxifen results in decreased expression of LGR5 mRNA] CTD PMID:14699072 tamoxifen affects expression ISO RGD:1605118 6480464 Tamoxifen affects the expression of LGR5 mRNA CTD PMID:14699072 terbufos increases methylation ISO RGD:1605118 6480464 terbufos results in increased methylation of LGR5 promoter CTD PMID:22847954 tert-butyl hydroperoxide affects expression ISO RGD:1605118 6480464 tert-Butylhydroperoxide affects the expression of LGR5 mRNA CTD PMID:23410634 tetrachloromethane decreases expression ISO RGD:1550798 6480464 Carbon Tetrachloride results in decreased expression of LGR5 mRNA CTD PMID:31919559 thimerosal increases expression ISO RGD:1550798 6480464 Thimerosal results in increased expression of LGR5 mRNA CTD PMID:24675092 thioacetamide decreases expression EXP 6480464 Thioacetamide results in decreased expression of LGR5 mRNA CTD PMID:34492290 trichloroethene decreases expression ISO RGD:1550798 6480464 Trichloroethylene results in decreased expression of LGR5 mRNA CTD PMID:25549359 trichloroethene decreases expression EXP 6480464 Trichloroethylene results in decreased expression of LGR5 mRNA CTD PMID:33387578 trichostatin A increases expression ISO RGD:1605118 6480464 trichostatin A results in increased expression of LGR5 mRNA CTD PMID:24935251 trichostatin A decreases expression ISO RGD:1605118 6480464 trichostatin A results in decreased expression of LGR5 mRNA CTD PMID:24935251 triclosan increases expression ISO RGD:1605118 6480464 Triclosan results in increased expression of LGR5 mRNA CTD PMID:30510588 trimellitic anhydride increases expression ISO RGD:1550798 6480464 trimellitic anhydride results in increased expression of LGR5 mRNA CTD PMID:19042947 triptonide increases expression ISO RGD:1550798 6480464 triptonide results in increased expression of LGR5 mRNA CTD PMID:33045310 urethane decreases expression ISO RGD:1605118 6480464 Urethane results in decreased expression of LGR5 mRNA CTD PMID:28818685 valproic acid affects expression ISO RGD:1550798 6480464 Valproic Acid affects the expression of LGR5 mRNA CTD PMID:17292431 valproic acid increases expression ISO RGD:1605118 6480464 Valproic Acid results in increased expression of LGR5 mRNA CTD PMID:24383497 , PMID:28001369 valproic acid affects expression ISO RGD:1605118 6480464 Valproic Acid affects the expression of LGR5 mRNA CTD PMID:25979313 valproic acid multiple interactions ISO RGD:1605118 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LGR5 mRNA CTD PMID:27188386 valproic acid decreases expression ISO RGD:1605118 6480464 Valproic Acid results in decreased expression of LGR5 mRNA CTD PMID:23179753 more ... vorinostat increases expression ISO RGD:1605118 6480464 vorinostat results in increased expression of LGR5 mRNA CTD PMID:26272509