Gene: Lgr5 (leucine rich repeat containing G protein coupled receptor 5) Rattus norvegicus
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Symbol: Lgr5
Name: leucine rich repeat containing G protein coupled receptor 5
Description: Predicted to have G protein-coupled peptide receptor activity. Predicted to be involved in several processes, including activation of adenylate cyclase activity; animal organ development; and epithelial cell proliferation involved in renal tubule morphogenesis. Predicted to localize to the integral component of plasma membrane and trans-Golgi network membrane. Orthologous to human LGR5 (leucine rich repeat containing G protein-coupled receptor 5); PARTICIPATES IN Wnt signaling, canonical pathway; INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: G protein-coupled receptor 49; Gpr49; leucine-rich repeat-containing G-protein coupled receptor 5; LOC299802
Orthologs:
Homo sapiens (human) : LGR5 (leucine rich repeat containing G protein-coupled receptor 5)  HGNC  Alliance
Mus musculus (house mouse) : Lgr5 (leucine rich repeat containing G protein coupled receptor 5)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lgr5 (leucine rich repeat containing G protein-coupled receptor 5)
Pan paniscus (bonobo/pygmy chimpanzee) : LGR5 (leucine rich repeat containing G protein-coupled receptor 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lgr5 (leucine rich repeat containing G protein-coupled receptor 5)
Sus scrofa (pig) : LGR5 (leucine rich repeat containing G protein-coupled receptor 5)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0758,447,097 - 58,587,787 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0758,458,486 - 58,596,253 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4754,737,745 - 54,876,664 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1754,758,873 - 54,897,394 (-)NCBI
Celera747,880,362 - 48,010,031 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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References - curated
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RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
  
More on Lgr5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1307733
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.