Phlda1 (pleckstrin homology-like domain, family A, member 1) - Rat Genome Database

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Gene: Phlda1 (pleckstrin homology-like domain, family A, member 1) Rattus norvegicus
Analyze
Symbol: Phlda1
Name: pleckstrin homology-like domain, family A, member 1
RGD ID: 3836
Description: Predicted to enable phosphatidylinositol phosphate binding activity. Involved in forebrain neuron differentiation; positive regulation of apoptotic process; and response to aldosterone. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus. Biomarker of retinal degeneration. Orthologous to human PHLDA1 (pleckstrin homology like domain family A member 1); INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: pleckstrin homology-like domain family A member 1; PQ-rich protein; PQR protein; proline- and glutamine-rich protein; T-cell death associated; T-cell death associated gene; Tdag
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8748,853,690 - 48,855,894 (+)NCBIGRCr8
mRatBN7.2746,967,433 - 46,969,637 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl746,967,409 - 46,969,861 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx748,867,211 - 48,869,432 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0751,070,266 - 51,072,487 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0750,848,128 - 50,850,349 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0754,247,460 - 54,249,664 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl754,247,460 - 54,249,664 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0754,272,090 - 54,274,294 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4750,541,011 - 50,543,215 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1750,561,474 - 50,563,217 (+)NCBI
Celera743,765,108 - 43,767,312 (+)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
belinostat  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzoates  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
bromobenzene  (EXP)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
ciprofibrate  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
deoxynivalenol  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dieldrin  (EXP,ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP,ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (ISO)
fenpyroximate  (ISO)
fenvalerate  (EXP)
ferric oxide  (ISO)
ferroheme b  (ISO)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
fumonisin B1  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
heme b  (ISO)
hexane  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
irinotecan  (ISO)
isoflavones  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
melphalan  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
rotenone  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
succimer  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triacsin C  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytoplasmic vesicle  (IEA)
nucleolus  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. A proline- and glutamine-rich protein promotes apoptosis in neuronal cells. Gomes I, etal., J Neurochem 1999 Aug;73(2):612-22.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. Gene expression changes in the retina after systemic administration of aldosterone. Ono A, etal., Jpn J Ophthalmol. 2018 Jul;62(4):499-507. doi: 10.1007/s10384-018-0595-4. Epub 2018 Apr 30.
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:8673705   PMID:21480429   PMID:29736818   PMID:31981628   PMID:36881362  


Genomics

Comparative Map Data
Phlda1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8748,853,690 - 48,855,894 (+)NCBIGRCr8
mRatBN7.2746,967,433 - 46,969,637 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl746,967,409 - 46,969,861 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx748,867,211 - 48,869,432 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0751,070,266 - 51,072,487 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0750,848,128 - 50,850,349 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0754,247,460 - 54,249,664 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl754,247,460 - 54,249,664 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0754,272,090 - 54,274,294 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4750,541,011 - 50,543,215 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1750,561,474 - 50,563,217 (+)NCBI
Celera743,765,108 - 43,767,312 (+)NCBICelera
Cytogenetic Map7q22NCBI
PHLDA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381276,025,447 - 76,031,776 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1276,025,447 - 76,031,776 (-)EnsemblGRCh38hg38GRCh38
GRCh371276,419,227 - 76,425,556 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361274,705,494 - 74,711,823 (-)NCBINCBI36Build 36hg18NCBI36
Build 341274,709,366 - 74,711,784NCBI
Celera1276,086,396 - 76,092,722 (-)NCBICelera
Cytogenetic Map12q21.2NCBI
HuRef1273,469,274 - 73,475,600 (-)NCBIHuRef
CHM1_11276,385,168 - 76,391,494 (-)NCBICHM1_1
T2T-CHM13v2.01276,000,528 - 76,006,853 (-)NCBIT2T-CHM13v2.0
Phlda1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910111,342,147 - 111,344,510 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10111,342,147 - 111,344,506 (+)EnsemblGRCm39 Ensembl
GRCm3810111,506,286 - 111,508,649 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10111,506,286 - 111,508,645 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710110,943,342 - 110,945,705 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610110,910,396 - 110,912,758 (+)NCBIMGSCv36mm8
Celera10113,449,506 - 113,451,890 (+)NCBICelera
Cytogenetic Map10D1NCBI
cM Map1058.7NCBI
Phlda1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540515,320,005 - 15,321,301 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540515,318,785 - 15,321,316 (-)NCBIChiLan1.0ChiLan1.0
PHLDA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21084,049,740 - 84,064,959 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11284,043,050 - 84,056,634 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01273,530,456 - 73,543,951 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11276,382,220 - 76,390,462 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1276,387,313 - 76,388,502 (-)Ensemblpanpan1.1panPan2
PHLDA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11519,127,371 - 19,128,912 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1519,128,035 - 19,128,779 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1519,607,951 - 19,613,002 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01519,461,956 - 19,467,007 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11519,064,440 - 19,069,483 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01519,121,020 - 19,126,065 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01519,249,937 - 19,254,988 (-)NCBIUU_Cfam_GSD_1.0
Phlda1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494541,321,461 - 41,327,462 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365684,404,818 - 4,406,006 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365684,400,094 - 4,407,900 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PHLDA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl539,291,560 - 39,315,615 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1539,309,701 - 39,319,313 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2542,872,318 - 42,878,707 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PHLDA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11171,621,536 - 71,630,051 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037173,916,976 - 173,928,423 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Phlda1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475022,012,245 - 22,018,338 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Phlda1
9 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:466
Count of miRNA genes:234
Interacting mature miRNAs:283
Transcripts:ENSRNOT00000005361
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)71965431749753746Rat
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)71965431749753746Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)71965431752888450Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)72940968353612950Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
2303629Vencon3Ventilatory control QTL 37.25respiration trait (VT:0001943)respiration rate (CMO:0000289)74110969256793354Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 29 11 4 7 4 66 25 22 11
Low 14 46 37 12 37 8 11 8 10 15 8
Below cutoff 4

Sequence


RefSeq Acc Id: ENSRNOT00000005361   ⟹   ENSRNOP00000005361
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl746,967,409 - 46,969,861 (+)Ensembl
Rnor_6.0 Ensembl754,247,460 - 54,249,664 (+)Ensembl
RefSeq Acc Id: NM_017180   ⟹   NP_058876
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8748,853,690 - 48,855,894 (+)NCBI
mRatBN7.2746,967,433 - 46,969,637 (+)NCBI
Rnor_6.0754,247,460 - 54,249,664 (+)NCBI
Rnor_5.0754,272,090 - 54,274,294 (+)NCBI
RGSC_v3.4750,541,011 - 50,543,215 (+)RGD
Celera743,765,108 - 43,767,312 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058876 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF07181 (Get FASTA)   NCBI Sequence Viewer  
  EDM16726 (Get FASTA)   NCBI Sequence Viewer  
  EDM16727 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005361
  ENSRNOP00000005361.3
GenBank Protein Q9QZA1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058876   ⟸   NM_017180
- UniProtKB: Q9QZA1 (UniProtKB/Swiss-Prot),   F1LNT5 (UniProtKB/TrEMBL),   A6IGH2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000005361   ⟸   ENSRNOT00000005361
Protein Domains
PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QZA1-F1-model_v2 AlphaFold Q9QZA1 1-407 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3836 AgrOrtholog
BioCyc Gene G2FUF-34120 BioCyc
Ensembl Genes ENSRNOG00000004019 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005361 ENTREZGENE
  ENSRNOT00000005361.4 UniProtKB/TrEMBL
InterPro PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PHLA1/2/3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29380 UniProtKB/TrEMBL
NCBI Gene 29380 ENTREZGENE
PANTHER PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY A MEMBER 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15478 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Phlda1 PhenoGen
RatGTEx ENSRNOG00000004019 RatGTEx
SMART SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC229916
UniProt A6IGH1_RAT UniProtKB/TrEMBL
  A6IGH2 ENTREZGENE, UniProtKB/TrEMBL
  F1LNT5 ENTREZGENE, UniProtKB/TrEMBL
  PHLA1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Phlda1  pleckstrin homology-like domain, family A, member 1  Tdag  T-cell death associated gene  Symbol and Name updated 1299863 APPROVED
2002-06-10 Tdag  T-cell death associated gene      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein proline- and glutamine-rich; 44 kDa 70034