Tph2 (tryptophan hydroxylase 2) - Rat Genome Database

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Gene: Tph2 (tryptophan hydroxylase 2) Rattus norvegicus
Symbol: Tph2
Name: tryptophan hydroxylase 2
RGD ID: 631332
Description: Predicted to enable tryptophan 5-monooxygenase activity. Involved in several processes, including cellular response to lithium ion; response to activity; and response to estrogen. Predicted to be active in neuron projection. Human ortholog(s) of this gene implicated in autistic disorder; major depressive disorder; and panic disorder. Orthologous to human TPH2 (tryptophan hydroxylase 2); PARTICIPATES IN tryptophan metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3-bis(4-hydroxyphenyl)propionitrile.
Type: protein-coding
Previously known as: neuronal tryptophan hydroxylase; Ntph; tryptophan 5-hydroxylase 2; tryptophan 5-monooxygenase 2
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Tph2em2Mcwi   Tph2em3Mcwi  
Genetic Models: DA-Tph2em2Mcwi DA-Tph2em3Mcwi DA-Tph2em3Mcwi+/+ DA-Tph2em2Mcwi-/- DA-Tph2em3Mcwi-/- DA-Tph2em2Mcwi+/- DA-Tph2em3Mcwi+/-
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2750,685,694 - 50,789,424 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl750,685,694 - 50,789,424 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx752,592,588 - 52,696,312 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0754,795,694 - 54,899,410 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0754,573,629 - 54,677,371 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0758,042,279 - 58,149,220 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl758,042,281 - 58,149,061 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0758,053,268 - 58,157,949 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4754,321,033 - 54,430,706 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1754,341,665 - 54,451,339 (-)NCBI
Celera747,478,282 - 47,582,240 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
neuron projection  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Possible association between autism and variants in the brain-expressed tryptophan hydroxylase gene (TPH2). Coon H, etal., Am J Med Genet B Neuropsychiatr Genet. 2005 May 5;135B(1):42-6.
2. Tryptophan hydroxylase 2 gene expression and promoter polymorphisms in bipolar disorder and schizophrenia. De Luca V, etal., Psychopharmacology (Berl). 2005 Dec;183(3):378-82. Epub 2005 Oct 21.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Estrogen selectively increases tryptophan hydroxylase-2 mRNA expression in distinct subregions of rat midbrain raphe nucleus: association between gene expression and anxiety behavior in the open field. Hiroi R, etal., Biol Psychiatry. 2006 Aug 1;60(3):288-95. Epub 2006 Feb 3.
5. Tryptophan hydroxylase 1 knockout and tryptophan hydroxylase 2 polymorphism: effects on hypoxic pulmonary hypertension in mice. Izikki M, etal., Am J Physiol Lung Cell Mol Physiol. 2007 Oct;293(4):L1045-52. Epub 2007 Aug 3.
6. Cell-type specific induction of tryptophan hydroxylase-2 transcription by calcium mobilization. Lenicov FR, etal., J Neurochem. 2007 Dec;103(5):2047-57. Epub 2007 Sep 14.
7. Diurnal rhythms of tryptophan hydroxylase 1 and 2 mRNA expression in the rat retina. Liang J, etal., Neuroreport. 2004 Jun 28;15(9):1497-500.
8. Daily rhythm of tryptophan hydroxylase-2 messenger ribonucleic acid within raphe neurons is induced by corticoid daily surge and modulated by enhanced locomotor activity. Malek ZS, etal., Endocrinology. 2007 Nov;148(11):5165-72. Epub 2007 Jun 26.
9. Association study of tryptophan hydroxylase 2 gene polymorphisms in panic disorder. Maron E, etal., Neurosci Lett. 2007 Jan 16;411(3):180-4. Epub 2006 Nov 22.
10. Omega-3 fatty acid deficiency during perinatal development increases serotonin turnover in the prefrontal cortex and decreases midbrain tryptophan hydroxylase-2 expression in adult female rats: dissociation from estrogenic effects. McNamara RK, etal., J Psychiatr Res. 2009 Mar;43(6):656-63. Epub 2008 Nov 4.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. Family-based association study of TPH1 and TPH2 polymorphisms in autism. Ramoz N, etal., Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 5;141B(8):861-7.
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
19. Lithium modulates tryptophan hydroxylase 2 gene expression and serotonin release in primary cultures of serotonergic raphe neurons. Scheuch K, etal., Brain Res. 2010 Jan 11;1307:14-21. Epub 2009 Oct 17.
20. Serotonergic changes produced by repeated exposure to forced swimming: correlation with behavior. Shishkina GT, etal., Ann N Y Acad Sci. 2008 Dec;1148:148-53.
21. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Walther DJ, etal., Science 2003 Jan 3;299(5603):76.
Additional References at PubMed
PMID:12911638   PMID:16115212   PMID:16917826   PMID:17950541   PMID:18197473   PMID:19559077   PMID:19588223   PMID:19647049   PMID:19906978   PMID:20127812   PMID:21182901   PMID:21272616  
PMID:21924839   PMID:22511363   PMID:31078489   PMID:31415826   PMID:31505169   PMID:34874128   PMID:36868221  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2750,685,694 - 50,789,424 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl750,685,694 - 50,789,424 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx752,592,588 - 52,696,312 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0754,795,694 - 54,899,410 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0754,573,629 - 54,677,371 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0758,042,279 - 58,149,220 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl758,042,281 - 58,149,061 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0758,053,268 - 58,157,949 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4754,321,033 - 54,430,706 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1754,341,665 - 54,451,339 (-)NCBI
Celera747,478,282 - 47,582,240 (-)NCBICelera
Cytogenetic Map7q22NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381271,938,845 - 72,032,440 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1271,938,845 - 72,186,618 (+)EnsemblGRCh38hg38GRCh38
GRCh371272,332,625 - 72,426,220 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361270,618,893 - 70,712,488 (+)NCBINCBI36Build 36hg18NCBI36
Build 341270,618,892 - 70,712,488NCBI
Celera1271,995,911 - 72,089,543 (+)NCBICelera
Cytogenetic Map12q21.1NCBI
HuRef1269,382,235 - 69,474,238 (+)NCBIHuRef
CHM1_11272,299,779 - 72,391,813 (+)NCBICHM1_1
T2T-CHM13v2.01271,916,323 - 72,008,338 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3910114,914,546 - 115,020,927 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10114,914,546 - 115,020,927 (-)EnsemblGRCm39 Ensembl
GRCm3810115,078,641 - 115,185,022 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10115,078,641 - 115,185,022 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710114,515,697 - 114,622,078 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610114,482,751 - 114,589,132 (-)NCBIMGSCv36mm8
Celera10117,006,698 - 117,113,837 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1063.51NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495540511,886,206 - 11,982,550 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540511,877,474 - 11,981,035 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11279,962,807 - 80,059,170 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01269,460,883 - 69,557,329 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11272,318,908 - 72,412,557 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1272,318,908 - 72,412,557 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11013,442,611 - 13,526,537 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1013,442,611 - 13,527,243 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1013,381,425 - 13,464,836 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01013,578,664 - 13,662,404 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1013,578,143 - 13,663,110 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11013,440,095 - 13,523,686 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01013,688,920 - 13,772,483 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01013,812,858 - 13,896,308 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494544,662,510 - 44,753,680 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936568974,767 - 1,065,804 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936568974,575 - 1,065,800 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl535,918,370 - 36,017,509 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1535,917,159 - 36,016,981 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2538,620,459 - 38,716,640 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11167,568,744 - 67,664,911 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037177,991,214 - 178,084,445 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462475025,702,630 - 25,801,618 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475025,702,597 - 25,801,938 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Tph2
204 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:308
Count of miRNA genes:199
Interacting mature miRNAs:236
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)71965431752888450Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)72940968353612950Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
2303629Vencon3Ventilatory control QTL 37.25respiration trait (VT:0001943)respiration rate (CMO:0000289)74110969256793354Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2750,685,695 - 50,685,852 (+)MAPPERmRatBN7.2
Rnor_6.0758,042,283 - 58,042,439NCBIRnor6.0
Rnor_5.0758,053,272 - 58,053,428UniSTSRnor5.0
RGSC_v3.4754,321,035 - 54,321,191UniSTSRGSC3.4
Celera747,478,284 - 47,478,440UniSTS
RH 3.4 Map7442.0UniSTS
Cytogenetic Map7q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2750,686,685 - 50,686,866 (+)MAPPERmRatBN7.2
Rnor_6.0758,043,273 - 58,043,453NCBIRnor6.0
Rnor_5.0758,054,262 - 58,054,442UniSTSRnor5.0
RGSC_v3.4754,322,025 - 54,322,205UniSTSRGSC3.4
Celera747,479,274 - 47,479,454UniSTS
RH 3.4 Map7442.6UniSTS
Cytogenetic Map7q22UniSTS

Genetic Models


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system appendage
Medium 5
Low 8 47 14 21
Below cutoff 3 2 7 3 4 3 1 1 16 13 15 1


RefSeq Acc Id: ENSRNOT00000005157   ⟹   ENSRNOP00000005157
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl750,685,694 - 50,789,424 (-)Ensembl
Rnor_6.0 Ensembl758,042,281 - 58,149,061 (-)Ensembl
RefSeq Acc Id: NM_173839   ⟹   NP_776211
Rat AssemblyChrPosition (strand)Source
mRatBN7.2750,685,694 - 50,789,424 (-)NCBI
Rnor_6.0758,042,281 - 58,149,061 (-)NCBI
Rnor_5.0758,053,268 - 58,157,949 (-)NCBI
RGSC_v3.4754,321,033 - 54,430,706 (-)RGD
Celera747,478,282 - 47,582,240 (-)RGD
Protein Sequences
Protein RefSeqs NP_776211 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAM28947 (Get FASTA)   NCBI Sequence Viewer  
  EDM16695 (Get FASTA)   NCBI Sequence Viewer  
  EDM16696 (Get FASTA)   NCBI Sequence Viewer  
  Q8CGU9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_776211   ⟸   NM_173839
- UniProtKB: Q8CGU9 (UniProtKB/Swiss-Prot),   A6IGK2 (UniProtKB/TrEMBL),   A0A8L2Q1S6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000005157   ⟸   ENSRNOT00000005157
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CGU9-F1-model_v2 AlphaFold Q8CGU9 1-485 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631332 AgrOrtholog
BioCyc Gene G2FUF-34069 BioCyc
BioCyc Pathway PWY-6030 [serotonin and melatonin biosynthesis] BioCyc
Ensembl Genes ENSRNOG00000003880 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000005157 ENTREZGENE
  ENSRNOP00000005157.5 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005157 ENTREZGENE
  ENSRNOT00000005157.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.800.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ACT-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACT_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArAA_hydroxylase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArAA_hydroxylase_Fe/CU_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArAA_hydroxylase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aro-AA_hydroxylase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aromatic-AA_hydroxylase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trp_5_mOase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TrpOH_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyrosine_3-monooxygenase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:317675 UniProtKB/Swiss-Prot
PANTHER PTHR11473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Biopterin_H UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tph2 PhenoGen
PIRSF PIRSF000336 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ACT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BH4_AAA_HYDROXYL_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BH4_AAA_HYDROXYL_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55021 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56534 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Q8CGU9 ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-11 Tph2  tryptophan hydroxylase 2  Ntph  neuronal tryptophan hydroxylase  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in brain 633509