Kcnc2 (potassium voltage-gated channel subfamily C member 2) - Rat Genome Database

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Gene: Kcnc2 (potassium voltage-gated channel subfamily C member 2) Rattus norvegicus
Analyze
Symbol: Kcnc2
Name: potassium voltage-gated channel subfamily C member 2
RGD ID: 628829
Description: Enables delayed rectifier potassium channel activity; transmembrane transporter binding activity; and voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Involved in several processes, including cellular response to nitric oxide; nervous system development; and protein complex oligomerization. Located in several cellular components, including axon; basolateral plasma membrane; and neuronal cell body membrane. Part of voltage-gated potassium channel complex. Is active in GABA-ergic synapse and presynaptic membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 103. Orthologous to human KCNC2 (potassium voltage-gated channel subfamily C member 2); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-Tetrachlorodibenzofuran; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: KShIIIA; Kv3.2; potassium channel voltage-gated Shaw-related subfamily C member 2; potassium channel, voltage gated Shaw-related subfamily C, member 2; potassium voltage gated channel, Shaw-related subfamily, member 2; shaw-like potassium channel; voltage-gated potassium channel subunit Kv3.2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8749,586,274 - 49,770,212 (+)NCBIGRCr8
mRatBN7.2747,700,035 - 47,883,979 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl747,700,288 - 47,883,968 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx749,609,550 - 49,792,283 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0751,812,632 - 51,995,385 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0751,590,463 - 51,773,199 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0754,978,453 - 55,159,362 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl754,980,120 - 55,159,351 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0754,998,077 - 55,177,456 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4751,326,602 - 51,487,958 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1751,347,043 - 51,508,400 (+)NCBI
Celera744,495,328 - 44,675,986 (+)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Potassium channel subunit Kv3.2 and the water channel aquaporin-4 are selectively localized to cerebellar pinceau. Bobik M, etal., Brain Res. 2004 Nov 12;1026(2):168-78.
2. Global analysis of aberrant pre-mRNA splicing in glioblastoma using exon expression arrays. Cheung HC, etal., BMC Genomics. 2008 May 12;9:216. doi: 10.1186/1471-2164-9-216.
3. K(+) channel expression distinguishes subpopulations of parvalbumin- and somatostatin-containing neocortical interneurons. Chow A, etal., J Neurosci. 1999 Nov 1;19(21):9332-45.
4. Kv3.1b is a novel component of CNS nodes. Devaux J, etal., J Neurosci. 2003 Jun 1;23(11):4509-18.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Neuronal activity and TrkB ligands influence Kv3.1b and Kv3.2 expression in developing cortical interneurons. Grabert J and Wahle P, Neuroscience. 2008 Oct 15;156(3):618-29. doi: 10.1016/j.neuroscience.2008.08.008. Epub 2008 Aug 12.
7. Visual experience regulates Kv3.1b and Kv3.2 expression in developing rat visual cortex. Grabert J and Wahle P, Neuroscience. 2009 Jan 23;158(2):654-64. doi: 10.1016/j.neuroscience.2008.07.035. Epub 2008 Jul 25.
8. Kv3.1-Kv3.2 channels underlie a high-voltage-activating component of the delayed rectifier K+ current in projecting neurons from the globus pallidus. Hernandez-Pineda R, etal., J Neurophysiol. 1999 Sep;82(3):1512-28.
9. Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain. Huang CY, etal., J Comp Neurol. 2012 Nov 1;520(16):3650-72. doi: 10.1002/cne.23119.
10. KCNE1 and KCNE2 provide a checkpoint governing voltage-gated potassium channel a-subunit composition. Kanda VA, etal., Biophys J. 2011 Sep 21;101(6):1364-75. doi: 10.1016/j.bpj.2011.08.014. Epub 2011 Sep 20.
11. Impaired fast-spiking, suppressed cortical inhibition, and increased susceptibility to seizures in mice lacking Kv3.2 K+ channel proteins. Lau D, etal., J Neurosci. 2000 Dec 15;20(24):9071-85.
12. Shaw-like rat brain potassium channel cDNA's with divergent 3' ends. Luneau C, etal., FEBS Lett 1991 Aug 19;288(1-2):163-7.
13. Molecular cloning of a member of a third class of Shaker-family K+ channel genes in mammals. McCormack T, etal., Proc Natl Acad Sci U S A 1990 Jul;87(13):5227-31.
14. Molecular cloning of a member of a third class of Shaker-family K+ channel genes in mammals. McCormack T, etal., Proc Natl Acad Sci U S A 1991 May 1;88(9):4060.
15. Differential expression of Kv3.1b and Kv3.2 potassium channel subunits in interneurons of the basolateral amygdala. McDonald AJ and Mascagni F, Neuroscience. 2006;138(2):537-47. Epub 2006 Jan 18.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Thalamocortical projections have a K+ channel that is phosphorylated and modulated by cAMP-dependent protein kinase. Moreno H, etal., J Neurosci. 1995 Aug;15(8):5486-501.
18. Modulation of Kv3 potassium channels expressed in CHO cells by a nitric oxide-activated phosphatase. Moreno H, etal., J Physiol. 2001 Feb 1;530(Pt 3):345-58.
19. K+ channel subunit isoforms with divergent carboxy-terminal sequences carry distinct membrane targeting signals. Ponce A, etal., J Membr Biol. 1997 Sep 15;159(2):149-59.
20. Characterization of a Shaw-related potassium channel family in rat brain. Rettig J, etal., EMBO J 1992 Jul;11(7):2473-86.
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Region-specific expression of a K+ channel gene in brain. Rudy B, etal., Proc Natl Acad Sci U S A 1992 May 15;89(10):4603-7.
24. Selective underexpression of Kv3.2 and Kv3.4 channels in the cortex of rats exposed to ethanol during early postnatal life. Tavian D, etal., Neurol Sci. 2011 Aug;32(4):571-7. doi: 10.1007/s10072-010-0446-7. Epub 2011 Jan 14.
25. Gating currents from a Kv3 subfamily potassium channel: charge movement and modification by BDS-II toxin. Wang Z, etal., J Physiol. 2007 Nov 1;584(Pt 3):755-67. Epub 2007 Sep 13.
26. Modulation of Kv3 subfamily potassium currents by the sea anemone toxin BDS: significance for CNS and biophysical studies. Yeung SY, etal., J Neurosci. 2005 Sep 21;25(38):8735-45.
Additional References at PubMed
PMID:12000114   PMID:15240761   PMID:17761775   PMID:19332619   PMID:22871113  


Genomics

Comparative Map Data
Kcnc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8749,586,274 - 49,770,212 (+)NCBIGRCr8
mRatBN7.2747,700,035 - 47,883,979 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl747,700,288 - 47,883,968 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx749,609,550 - 49,792,283 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0751,812,632 - 51,995,385 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0751,590,463 - 51,773,199 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0754,978,453 - 55,159,362 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl754,980,120 - 55,159,351 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0754,998,077 - 55,177,456 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4751,326,602 - 51,487,958 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1751,347,043 - 51,508,400 (+)NCBI
Celera744,495,328 - 44,675,986 (+)NCBICelera
Cytogenetic Map7q22NCBI
KCNC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381275,040,078 - 75,209,839 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1275,040,077 - 75,209,839 (-)EnsemblGRCh38hg38GRCh38
GRCh371275,433,858 - 75,603,619 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361273,720,163 - 73,889,778 (-)NCBINCBI36Build 36hg18NCBI36
Build 341273,720,162 - 73,889,778NCBI
Celera1275,101,336 - 75,270,876 (-)NCBICelera
Cytogenetic Map12q21.1NCBI
HuRef1272,483,472 - 72,653,079 (-)NCBIHuRef
CHM1_11275,399,235 - 75,568,820 (-)NCBICHM1_1
T2T-CHM13v2.01275,014,738 - 75,184,480 (-)NCBIT2T-CHM13v2.0
Kcnc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910112,105,803 - 112,302,209 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10112,107,026 - 112,302,929 (+)EnsemblGRCm39 Ensembl
GRCm3810112,269,898 - 112,466,304 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10112,271,121 - 112,467,024 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710111,708,179 - 111,903,360 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610111,675,233 - 111,870,414 (+)NCBIMGSCv36mm8
Celera10114,210,354 - 114,400,944 (+)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1060.3NCBI
Kcnc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540514,422,396 - 14,600,341 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540514,420,447 - 14,599,780 (-)NCBIChiLan1.0ChiLan1.0
KCNC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21083,082,905 - 83,251,756 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11283,079,301 - 83,248,152 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01272,566,924 - 72,736,270 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11275,419,465 - 75,588,535 (-)NCBIpanpan1.1PanPan1.1panPan2
KCNC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11015,599,428 - 15,822,579 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1015,643,962 - 15,818,097 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1015,541,357 - 15,767,201 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01015,785,996 - 16,011,988 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1015,789,212 - 16,007,557 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11015,595,746 - 15,821,564 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01015,848,484 - 16,075,795 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01015,974,622 - 16,200,463 (-)NCBIUU_Cfam_GSD_1.0
Kcnc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494542,033,763 - 42,220,108 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365683,511,244 - 3,694,781 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365683,508,212 - 3,694,459 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl538,326,414 - 38,533,110 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1538,326,408 - 38,535,826 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2541,759,389 - 41,781,754 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11170,603,034 - 70,770,625 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1170,603,003 - 70,768,859 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037174,772,549 - 174,940,514 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475022,807,370 - 22,996,753 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475022,807,234 - 22,996,614 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnc2
887 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:649
Count of miRNA genes:275
Interacting mature miRNAs:337
Transcripts:ENSRNOT00000005690, ENSRNOT00000005700, ENSRNOT00000005773, ENSRNOT00000049943
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)71965431749753746Rat
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)71965431749753746Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)71965431752888450Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)72940968353612950Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
2303629Vencon3Ventilatory control QTL 37.25respiration trait (VT:0001943)respiration rate (CMO:0000289)74110969256793354Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat

Markers in Region
D7Rat26  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0755,072,862 - 55,073,022NCBIRnor6.0
Celera744,590,656 - 44,590,819UniSTS
RH 3.4 Map7412.9RGD
RH 3.4 Map7412.9UniSTS
RH 2.0 Map7380.4RGD
SHRSP x BN Map731.05RGD
Cytogenetic Map7q12-q22UniSTS
D7Rat169  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2747,719,466 - 47,719,673 (+)MAPPERmRatBN7.2
Rnor_6.0754,998,209 - 54,998,415NCBIRnor6.0
Rnor_5.0755,017,742 - 55,017,948UniSTSRnor5.0
RGSC_v3.4751,344,691 - 51,344,898RGDRGSC3.4
RGSC_v3.4751,344,692 - 51,344,898UniSTSRGSC3.4
RGSC_v3.1751,365,111 - 51,365,507RGD
Celera744,513,417 - 44,513,623UniSTS
FHH x ACI Map726.78RGD
FHH x ACI Map726.78UniSTS
Cytogenetic Map7q12-q22UniSTS
D7Got205  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0755,072,801 - 55,073,014NCBIRnor6.0
Celera744,590,664 - 44,590,881UniSTS
Cytogenetic Map7q12-q22UniSTS
BF404636  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2747,881,223 - 47,881,330 (+)MAPPERmRatBN7.2
Rnor_6.0755,156,607 - 55,156,713NCBIRnor6.0
Rnor_5.0755,174,701 - 55,174,807UniSTSRnor5.0
RGSC_v3.4751,485,214 - 51,485,320UniSTSRGSC3.4
Celera744,673,242 - 44,673,348UniSTS
RH 3.4 Map7417.8UniSTS
Cytogenetic Map7q12-q22UniSTS
AU046555  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2747,721,167 - 47,721,291 (+)MAPPERmRatBN7.2
mRatBN7.2747,721,167 - 47,721,315 (+)MAPPERmRatBN7.2
Rnor_6.0754,999,910 - 55,000,057NCBIRnor6.0
Rnor_6.0754,999,910 - 55,000,033NCBIRnor6.0
Rnor_5.0755,019,621 - 55,019,768UniSTSRnor5.0
Rnor_5.0755,019,621 - 55,019,744UniSTSRnor5.0
RGSC_v3.4751,346,393 - 51,346,516UniSTSRGSC3.4
RGSC_v3.4751,346,393 - 51,346,540UniSTSRGSC3.4
Celera744,515,109 - 44,515,256UniSTS
Celera744,515,109 - 44,515,232UniSTS
Cytogenetic Map7q12-q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 31
Low 1 4 35 7
Below cutoff 3 20 11 5 13 5 7 7 6 12 30 9 7

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_139216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_139217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005486545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC109965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC127978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX839889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M34052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M59211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M59313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M84202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M84203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000005690   ⟹   ENSRNOP00000005690
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl747,701,378 - 47,883,968 (+)Ensembl
Rnor_6.0 Ensembl754,980,120 - 55,159,351 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000005773   ⟹   ENSRNOP00000005773
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl747,701,421 - 47,881,436 (+)Ensembl
Rnor_6.0 Ensembl754,980,163 - 55,156,819 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099049   ⟹   ENSRNOP00000084708
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl747,700,288 - 47,880,696 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000105247   ⟹   ENSRNOP00000088724
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl747,700,288 - 47,883,968 (+)Ensembl
RefSeq Acc Id: NM_139216   ⟹   NP_631962
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8749,587,614 - 49,770,202 (+)NCBI
mRatBN7.2747,701,378 - 47,883,968 (+)NCBI
Rnor_6.0754,980,120 - 55,159,351 (+)NCBI
Rnor_5.0754,998,077 - 55,177,456 (+)NCBI
RGSC_v3.4751,326,602 - 51,487,958 (+)RGD
Celera744,495,328 - 44,675,986 (+)RGD
Sequence:
RefSeq Acc Id: NM_139217   ⟹   NP_631963
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8749,587,657 - 49,767,670 (+)NCBI
mRatBN7.2747,701,421 - 47,881,436 (+)NCBI
Rnor_6.0754,980,163 - 55,156,819 (+)NCBI
Rnor_5.0754,998,077 - 55,177,456 (+)NCBI
RGSC_v3.4751,326,602 - 51,487,958 (+)RGD
Celera744,495,371 - 44,673,454 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006241327   ⟹   XP_006241389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8749,586,274 - 49,770,212 (+)NCBI
mRatBN7.2747,700,035 - 47,883,979 (+)NCBI
Rnor_6.0754,978,783 - 55,159,362 (+)NCBI
Rnor_5.0754,998,077 - 55,177,456 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594660   ⟹   XP_017450149
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8749,586,771 - 49,770,212 (+)NCBI
mRatBN7.2747,700,511 - 47,883,979 (+)NCBI
Rnor_6.0754,979,277 - 55,159,362 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594661   ⟹   XP_017450150
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8749,586,274 - 49,770,212 (+)NCBI
mRatBN7.2747,700,035 - 47,880,956 (+)NCBI
Rnor_6.0754,978,783 - 55,156,287 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594662   ⟹   XP_017450151
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8749,586,274 - 49,770,212 (+)NCBI
mRatBN7.2747,700,035 - 47,883,979 (+)NCBI
Rnor_6.0754,978,453 - 55,159,362 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039078411   ⟹   XP_038934339
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8749,586,274 - 49,770,212 (+)NCBI
mRatBN7.2747,700,035 - 47,883,979 (+)NCBI
RefSeq Acc Id: XM_039078412   ⟹   XP_038934340
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8749,586,274 - 49,767,181 (+)NCBI
mRatBN7.2747,700,035 - 47,883,979 (+)NCBI
RefSeq Acc Id: XM_039078413   ⟹   XP_038934341
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8749,586,274 - 49,770,212 (+)NCBI
mRatBN7.2747,700,035 - 47,883,979 (+)NCBI
RefSeq Acc Id: XM_039078416   ⟹   XP_038934344
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8749,586,274 - 49,770,212 (+)NCBI
mRatBN7.2747,700,035 - 47,883,979 (+)NCBI
RefSeq Acc Id: XR_005486545
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8749,586,274 - 49,769,130 (+)NCBI
mRatBN7.2747,700,035 - 47,882,895 (+)NCBI
Protein Sequences
Protein RefSeqs NP_631962 (Get FASTA)   NCBI Sequence Viewer  
  NP_631963 (Get FASTA)   NCBI Sequence Viewer  
  XP_006241389 (Get FASTA)   NCBI Sequence Viewer  
  XP_017450149 (Get FASTA)   NCBI Sequence Viewer  
  XP_017450150 (Get FASTA)   NCBI Sequence Viewer  
  XP_017450151 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934339 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934340 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934341 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934344 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41819 (Get FASTA)   NCBI Sequence Viewer  
  AAA41820 (Get FASTA)   NCBI Sequence Viewer  
  AAA42142 (Get FASTA)   NCBI Sequence Viewer  
  AAA42143 (Get FASTA)   NCBI Sequence Viewer  
  CAE85434 (Get FASTA)   NCBI Sequence Viewer  
  EDM16703 (Get FASTA)   NCBI Sequence Viewer  
  EDM16704 (Get FASTA)   NCBI Sequence Viewer  
  EDM16705 (Get FASTA)   NCBI Sequence Viewer  
  EDM16706 (Get FASTA)   NCBI Sequence Viewer  
  EDM16707 (Get FASTA)   NCBI Sequence Viewer  
  EDM16708 (Get FASTA)   NCBI Sequence Viewer  
  EDM16709 (Get FASTA)   NCBI Sequence Viewer  
  EDM16710 (Get FASTA)   NCBI Sequence Viewer  
  EDM16711 (Get FASTA)   NCBI Sequence Viewer  
  EDM16712 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005690
  ENSRNOP00000005690.2
  ENSRNOP00000005773
  ENSRNOP00000005773.4
  ENSRNOP00000084708
  ENSRNOP00000084708.1
  ENSRNOP00000088724
  ENSRNOP00000088724.1
  ENSRNOP00055016940
  ENSRNOP00060004592
  ENSRNOP00065017701
GenBank Protein P22462 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_631962   ⟸   NM_139216
- Peptide Label: isoform a
- UniProtKB: A6IGJ0 (UniProtKB/TrEMBL),   A6IGI6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_631963   ⟸   NM_139217
- Peptide Label: isoform b
- UniProtKB: P22463 (UniProtKB/Swiss-Prot),   P22461 (UniProtKB/Swiss-Prot),   Q63735 (UniProtKB/Swiss-Prot),   P22462 (UniProtKB/Swiss-Prot),   A6IGJ3 (UniProtKB/TrEMBL),   A6IGI6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241389   ⟸   XM_006241327
- Peptide Label: isoform X1
- UniProtKB: P22463 (UniProtKB/Swiss-Prot),   P22461 (UniProtKB/Swiss-Prot),   Q63735 (UniProtKB/Swiss-Prot),   P22462 (UniProtKB/Swiss-Prot),   A6IGJ3 (UniProtKB/TrEMBL),   A6IGI6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450151   ⟸   XM_017594662
- Peptide Label: isoform X3
- UniProtKB: A6IGI7 (UniProtKB/TrEMBL),   A6IGI6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450150   ⟸   XM_017594661
- Peptide Label: isoform X2
- UniProtKB: A6IGI6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450149   ⟸   XM_017594660
- Peptide Label: isoform X1
- UniProtKB: P22463 (UniProtKB/Swiss-Prot),   P22461 (UniProtKB/Swiss-Prot),   Q63735 (UniProtKB/Swiss-Prot),   P22462 (UniProtKB/Swiss-Prot),   A6IGJ3 (UniProtKB/TrEMBL),   A6IGI6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000005690   ⟸   ENSRNOT00000005690
RefSeq Acc Id: ENSRNOP00000005773   ⟸   ENSRNOT00000005773
RefSeq Acc Id: XP_038934340   ⟸   XM_039078412
- Peptide Label: isoform X5
- UniProtKB: A6IGJ4 (UniProtKB/TrEMBL),   A6IGI6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934341   ⟸   XM_039078413
- Peptide Label: isoform X5
- UniProtKB: A6IGJ4 (UniProtKB/TrEMBL),   A6IGI6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934344   ⟸   XM_039078416
- Peptide Label: isoform X5
- UniProtKB: A6IGJ4 (UniProtKB/TrEMBL),   A6IGI6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934339   ⟸   XM_039078411
- Peptide Label: isoform X4
- UniProtKB: A6IGJ0 (UniProtKB/TrEMBL),   A6IGI6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000088724   ⟸   ENSRNOT00000105247
RefSeq Acc Id: ENSRNOP00000084708   ⟸   ENSRNOT00000099049
Protein Domains
BTB   Ion transport

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22462-F1-model_v2 AlphaFold P22462 1-638 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628829 AgrOrtholog
BioCyc Gene G2FUF-34097 BioCyc
Ensembl Genes ENSRNOG00000004077 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055012317 UniProtKB/Swiss-Prot
  ENSRNOG00060003730 UniProtKB/Swiss-Prot
  ENSRNOG00065013851 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005690 ENTREZGENE
  ENSRNOT00000005690.5 UniProtKB/Swiss-Prot
  ENSRNOT00000005773 ENTREZGENE
  ENSRNOT00000005773.8 UniProtKB/Swiss-Prot
  ENSRNOT00000099049.1 UniProtKB/Swiss-Prot
  ENSRNOT00000105247.1 UniProtKB/Swiss-Prot
  ENSRNOT00055020968 UniProtKB/Swiss-Prot
  ENSRNOT00060006183 UniProtKB/Swiss-Prot
  ENSRNOT00065022805 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BTB/POZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T1-type_BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:246153 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 246153 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY C MEMBER 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11537 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BTB_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnc2 PhenoGen
PRINTS KCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KVCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SHAWCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004077 RatGTEx
  ENSRNOG00055012317 RatGTEx
  ENSRNOG00060003730 RatGTEx
  ENSRNOG00065013851 RatGTEx
SMART BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP POZ domain UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6IGI6 ENTREZGENE, UniProtKB/TrEMBL
  A6IGI7 ENTREZGENE, UniProtKB/TrEMBL
  A6IGJ0 ENTREZGENE, UniProtKB/TrEMBL
  A6IGJ3 ENTREZGENE, UniProtKB/TrEMBL
  A6IGJ4 ENTREZGENE, UniProtKB/TrEMBL
  A6IGJ5_RAT UniProtKB/TrEMBL
  KCNC2_RAT UniProtKB/Swiss-Prot
  P22461 ENTREZGENE
  P22462 ENTREZGENE
  P22463 ENTREZGENE
  Q63735 ENTREZGENE
UniProt Secondary P22461 UniProtKB/Swiss-Prot
  P22463 UniProtKB/Swiss-Prot
  Q63735 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnc2  potassium voltage-gated channel subfamily C member 2  Kcnc2  potassium channel, voltage gated Shaw-related subfamily C, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnc2  potassium channel, voltage gated Shaw-related subfamily C, member 2  Kcnc2  potassium voltage gated channel, Shaw-related subfamily, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Kcnc2  potassium voltage gated channel, Shaw-related subfamily, member 2      Symbol and Name status set to approved 625702 APPROVED
2003-02-27 Kcnc2  potassium voltage gated channel, Shaw-related subfamily, member 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression prominantly expressed in dorsal thalamus 729132