Tbk1 (TANK-binding kinase 1) - Rat Genome Database

Name: Tbk1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Advanced Search (OLGA)

Gene: Tbk1 (TANK-binding kinase 1) Rattus norvegicus

Analyze

Symbol:

Tbk1

Name:

TANK-binding kinase 1

RGD ID:

1588588

Description:

Predicted to enable several functions, including identical protein binding activity; phosphoprotein binding activity; and protein phosphatase binding activity. Predicted to be involved in several processes, including positive regulation of defense response; protein phosphorylation; and regulation of intracellular signal transduction. Predicted to act upstream of or within defense response to Gram-positive bacterium; dendritic cell proliferation; and positive regulation of interferon-beta production. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in brain disease and frontotemporal dementia and/or amyotrophic lateral sclerosis 4. Orthologous to human TBK1 (TANK binding kinase 1); PARTICIPATES IN Toll-like receptor signaling pathway; hepatitis C pathway; influenza A pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC299827; serine/threonine-protein kinase TBK1; similar to TANK-binding kinase 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TBK1 (TANK binding kinase 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Tbk1 (TANK-binding kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tbk1 (TANK binding kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TBK1 (TANK binding kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TBK1 (TANK binding kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tbk1 (TANK binding kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TBK1 (TANK binding kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TBK1 (TANK binding kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tbk1 (TANK binding kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	TBK1 (TANK binding kinase 1)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Tbk1 (TANK-binding kinase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tbk1 (TANK-binding kinase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	IKKepsilon	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	tbk1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	58,963,319 - 58,996,357 (-)	NCBI		GRCr8
mRatBN7.2	7	57,077,830 - 57,110,868 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	57,077,830 - 57,110,892 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	58,989,079 - 59,022,620 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	61,191,956 - 61,225,497 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	60,969,664 - 61,003,205 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	63,655,247 - 63,687,978 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	63,655,247 - 63,687,978 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	63,877,567 - 63,910,298 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	60,863,099 - 60,896,131 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	7	53,819,361 - 53,852,262 (-)	NCBI		Celera
Cytogenetic Map	7	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amyotrophic lateral sclerosis (ISO)

AUTOINFLAMMATION WITH ARTHRITIS AND VASCULITIS (ISO)

ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), 8 (ISO)

frontotemporal dementia and/or amyotrophic lateral sclerosis 4 (ISO)

genetic disease (ISO)

Glaucoma 1, Open Angle, P (ISO)

hereditary spastic paraplegia 8 (ISO)

Herpes Simplex Encephalitis 1 (ISO)

motor neuron disease (ISO)

mucopolysaccharidosis type IIID (ISO)

primary open angle glaucoma (ISO)

progressive non-fluent aphasia (ISO)

severe acute respiratory syndrome (ISO)

severe COVID-19 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,4-methylenedioxymethamphetamine (ISO)

3H-1,2-dithiole-3-thione (EXP)

6-propyl-2-thiouracil (EXP)

acrolein (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

amlexanox (ISO)

aristolochic acid A (ISO)

auranofin (ISO)

bafilomycin A1 (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (ISO)

caffeine (ISO)

chromium(6+) (ISO)

chrysin (ISO)

cisplatin (ISO)

clofibrate (ISO)

copper(II) sulfate (ISO)

curcumin (ISO)

cyclosporin A (ISO)

dicrotophos (ISO)

dieldrin (ISO)

dioxygen (ISO)

disodium selenite (ISO)

eriodictyol (ISO)

ethyl methanesulfonate (ISO)

fenthion (ISO)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

genistein (EXP,ISO)

gentamycin (EXP)

glyphosate (ISO)

graphene oxide (ISO)

hexadecanoic acid (ISO)

isoprenaline (EXP,ISO)

ivermectin (ISO)

lipopolysaccharide (ISO)

luteolin (ISO)

lycopene (ISO)

mangiferin (ISO)

methyl methanesulfonate (ISO)

nefazodone (EXP)

o-anisidine (ISO)

oxybenzone (ISO)

ozone (ISO)

paracetamol (ISO)

paraquat (ISO)

pentachlorophenol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

Phytolaccoside E (ISO)

poly(I:C) (ISO)

propiconazole (ISO)

quercetin (ISO)

resveratrol (ISO)

sodium arsenite (ISO)

sulindac (ISO)

tamoxifen (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

Triptolide (ISO)

tunicamycin (ISO)

vadimezan (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of innate immune response (IBA,ISO)

antiviral innate immune response (ISO)

cytoplasmic pattern recognition receptor signaling pathway (ISO)

defense response to Gram-positive bacterium (ISO)

dendritic cell proliferation (ISO)

innate immune response (ISO)

negative regulation of gene expression (ISO)

negative regulation of TORC1 signaling (ISO)

peptidyl-serine phosphorylation (ISO)

peptidyl-threonine phosphorylation (ISO)

positive regulation of autophagy (ISO)

positive regulation of canonical NF-kappaB signal transduction (ISO)

positive regulation of interferon-alpha production (ISO)

positive regulation of interferon-beta production (ISO)

positive regulation of macroautophagy (ISO)

positive regulation of TORC1 signaling (ISO)

positive regulation of TORC2 signaling (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

positive regulation of type I interferon production (IBA,ISO)

positive regulation of type I interferon-mediated signaling pathway (ISO)

positive regulation of xenophagy (ISO)

protein phosphorylation (ISO)

regulation of gene expression (ISO)

regulation of metabolic process (ISO)

regulation of type I interferon production (ISO)

T follicular helper cell differentiation (ISO)

toll-like receptor 4 signaling pathway (ISO)

Cellular Component

cytoplasm (IBA,ISO)

cytosol (ISO)

intracellular membrane-bounded organelle (ISO)

nucleoplasm (IEA,ISO)

Molecular Function

ATP binding (IEA)

identical protein binding (ISO)

nucleic acid binding (ISO)

phosphoprotein binding (ISO)

protein binding (ISO)

protein phosphatase binding (ISO)

protein serine/threonine kinase activity (IBA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

hepatitis C pathway (IEA)

influenza A pathway (IEA)

measles pathway (IEA)

Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway (IEA)

Toll-like receptor signaling pathway (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Pathogen recognition by the innate immune system.	Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12761501	PMID:14530355	PMID:14743216	PMID:15661922	PMID:16127453	PMID:17599067	PMID:17954568	PMID:18665841	PMID:19158679	PMID:19375882	PMID:21617041	PMID:21813773
PMID:22728658	PMID:23160154	PMID:23610142	PMID:23746807	PMID:24380861	PMID:25636800	PMID:25803835	PMID:27103069	PMID:27129230	PMID:27797401	PMID:28069950	PMID:29251827
PMID:32757223	PMID:33168920	PMID:36805078	PMID:37935918

Genomics

Comparative Map Data

Tbk1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	58,963,319 - 58,996,357 (-)	NCBI		GRCr8
mRatBN7.2	7	57,077,830 - 57,110,868 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	57,077,830 - 57,110,892 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	58,989,079 - 59,022,620 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	61,191,956 - 61,225,497 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	60,969,664 - 61,003,205 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	63,655,247 - 63,687,978 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	63,655,247 - 63,687,978 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	63,877,567 - 63,910,298 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	60,863,099 - 60,896,131 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	7	53,819,361 - 53,852,262 (-)	NCBI		Celera
Cytogenetic Map	7	q22	NCBI

TBK1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	64,452,120 - 64,502,114 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	64,452,090 - 64,502,114 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	64,845,900 - 64,895,894 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	63,132,204 - 63,182,158 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	63,132,203 - 63,182,158	NCBI
Celera	12	64,510,375 - 64,560,181 (+)	NCBI		Celera
Cytogenetic Map	12	q14.2	NCBI
HuRef	12	61,898,186 - 61,948,226 (+)	NCBI		HuRef
CHM1_1	12	64,812,935 - 64,863,007 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	64,430,747 - 64,480,735 (+)	NCBI		T2T-CHM13v2.0

Tbk1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	121,382,360 - 121,422,699 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	121,382,360 - 121,422,692 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	121,546,455 - 121,586,794 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	121,546,455 - 121,586,787 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	120,983,511 - 121,023,850 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	120,949,520 - 120,989,807 (-)	NCBI		MGSCv36	mm8
Celera	10	123,931,313 - 123,970,044 (-)	NCBI		Celera
Cytogenetic Map	10	D2	NCBI
cM Map	10	69.84	NCBI

Tbk1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955458	11,211,398 - 11,263,867 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955458	11,210,120 - 11,263,632 (+)	NCBI	ChiLan1.0	ChiLan1.0

TBK1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	29,864,914 - 29,915,549 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	29,861,685 - 29,912,320 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	24,419,271 - 24,469,164 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	24,919,412 - 24,968,587 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	24,917,246 - 24,968,587 (-)	Ensembl	panpan1.1		panPan2

TBK1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	7,169,664 - 7,208,890 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	7,168,007 - 7,208,899 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	7,102,668 - 7,144,367 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	7,276,927 - 7,318,803 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	7,276,875 - 7,318,755 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	7,142,851 - 7,184,688 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	7,395,493 - 7,437,313 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	7,526,057 - 7,567,705 (+)	NCBI		UU_Cfam_GSD_1.0

Tbk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	51,300,898 - 51,346,375 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936545	2,763,596 - 2,809,709 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936545	2,763,755 - 2,809,229 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TBK1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	28,880,205 - 28,929,963 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	28,880,210 - 28,929,964 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

TBK1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	60,136,162 - 60,182,354 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	60,136,232 - 60,182,344 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	185,623,292 - 185,669,524 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tbk1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624802	3,862,709 - 3,914,028 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624802	3,861,821 - 3,914,061 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Tbk1
145 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	330
Count of miRNA genes:	212
Interacting mature miRNAs:	250
Transcripts:	ENSRNOT00000009260
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7411569	Bw137	Body weight QTL 137		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	21921195	66921195	Rat
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	43747012	135012528	Rat
2293667	Bss42	Bone structure and strength QTL 42	7.25	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	7	47651439	92651439	Rat
10053722	Scort27	Serum corticosterone level QTL 27	2.41	0.0083	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	43228750	88228750	Rat
1578652	Bmd15	Bone mineral density QTL 15	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	7	9866467	60460686	Rat
1641885	Alcrsp9	Alcohol response QTL 9			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	7	24099606	69099606	Rat
1549840	Bss5	Bone structure and strength QTL 5	9.8		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	7	24751841	69751841	Rat
1300127	Srn1	Serum renin concentration QTL 1	3.87		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	7	29409683	84928080	Rat
10059605	Kidm47	Kidney mass QTL 47	2.91	0.05	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	7	47251783	65728867	Rat
2293678	Bss24	Bone structure and strength QTL 24	6.71	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	7	47651439	92651439	Rat
1358361	Sradr5	Stress Responsive Adrenal Weight QTL 5	5.55		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	7	43747012	108555253	Rat
2298547	Neuinf5	Neuroinflammation QTL 5	3.7		nervous system integrity trait (VT:0010566)	spinal cord Cd74 protein level (CMO:0002131)	7	9462246	58265113	Rat
631513	Scl7	Serum cholesterol level QTL 7	4.1		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	37960569	82960569	Rat
2293685	Bmd21	Bone mineral density QTL 21	4.2	0.0003	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	7	47651439	92651439	Rat
10755453	Coatc12	Coat color QTL 12		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	31112832	76112832	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	44421311	118198041	Rat
10755451	Coatc11	Coat color QTL 11		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	17944357	62944357	Rat
634326	Hc3	Hypercalciuria QTL 3	2.1		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	7	42787314	87787314	Rat
2317059	Aia15	Adjuvant induced arthritis QTL 15	2.46		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	7	17004598	62004598	Rat
2293696	Bmd32	Bone mineral density QTL 32	5.1	0.0001	femur strength trait (VT:0010010)	femoral neck polar moment of inertia (CMO:0001670)	7	47651439	92651439	Rat
7411605	Foco14	Food consumption QTL 14	24.1	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	34293282	79293282	Rat
1300151	Bp181	Blood pressure QTL 181	3.36		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	7	53612714	103945643	Rat
1643004	Pain2	Pain QTL 2	1		mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	7	9462246	98011544	Rat
738030	Anxrr8	Anxiety related response QTL 8	4.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	46590070	91590070	Rat
1300149	Cm6	Cardiac mass QTL 6	4.09		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	7	43747099	102228765	Rat
631534	Lnnr1	Liver neoplastic nodule remodeling QTL 1	3.85	0.001	liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)	7	34293282	79293282	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	924703	115097879	Rat
2293707	Bss32	Bone structure and strength QTL 32	7.64	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	7	47651439	92651439	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	41333674	119109060	Rat
2293644	Bmd29	Bone mineral density QTL 29	5.4	0.0001	femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	7	47651439	92651439	Rat
70190	Mcs6	Mammary carcinoma susceptibility QTL 6	2.29		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	7	26737401	63902784	Rat
2300178	Bmd54	Bone mineral density QTL 54	5.3	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	7	47651439	92651439	Rat
61428	Scl3	Serum cholesterol level QTL 3	3.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	44867533	89867533	Rat
1300132	Bp182	Blood pressure QTL 182	3.49		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	19654317	84928080	Rat
10402855	Bp379	Blood pressure QTL 379		0.21	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	29409683	74409683	Rat
738033	Anxrr6	Anxiety related response QTL 6	4.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	7	15573889	60573889	Rat

Markers in Region

AW048562

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	57,078,149 - 57,078,295 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	63,655,561 - 63,655,706	NCBI	Rnor6.0
Rnor_5.0	7	63,877,881 - 63,878,026	UniSTS	Rnor5.0
RGSC_v3.4	7	60,863,413 - 60,863,558	UniSTS	RGSC3.4
Celera	7	53,819,675 - 53,819,820	UniSTS
Cytogenetic Map	7	q22	UniSTS

RH137867

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	57,082,289 - 57,082,531 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	63,659,701 - 63,659,942	NCBI	Rnor6.0
Rnor_5.0	7	63,882,021 - 63,882,262	UniSTS	Rnor5.0
RGSC_v3.4	7	60,867,553 - 60,867,794	UniSTS	RGSC3.4
Celera	7	53,823,815 - 53,824,056	UniSTS
RH 3.4 Map	7	500.5	UniSTS
Cytogenetic Map	7	q22	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106786	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039078743	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473960	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213563	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000009260 ⟹ ENSRNOP00000009260

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	57,077,830 - 57,110,892 (-)	Ensembl
Rnor_6.0 Ensembl	7	63,655,247 - 63,687,978 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000111412 ⟹ ENSRNOP00000081507

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	57,081,296 - 57,110,892 (-)	Ensembl

RefSeq Acc Id:

NM_001106786 ⟹ NP_001100256

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	58,963,325 - 58,996,357 (-)	NCBI
mRatBN7.2	7	57,077,836 - 57,110,868 (-)	NCBI
Rnor_6.0	7	63,655,247 - 63,687,978 (-)	NCBI
Rnor_5.0	7	63,877,567 - 63,910,298 (-)	NCBI
RGSC_v3.4	7	60,863,099 - 60,896,131 (-)	RGD
Celera	7	53,819,361 - 53,852,262 (-)	RGD

Sequence:

show sequence

GCCCGGGAGCCGCGGGCTGTACGCGGCGGACGCTCGCTGGCGTACATGCAAATCTCTTCTTCCC
CCTTATCGTGAGGAGAAGCGTCTGACCAAGCCGAGATGCAGAGCACTTCCAACCATCTGTGGCT
TTTGTCTGATATCCTAGGCCAAGGGGCTACTGCAAATGTCTTCCGAGGAAGGCATAAGAAAACT
GGTGATCTCTATGCTGTCAAAGTATTTAATAACATAAGCTTCCTTCGCCCAGTGGATGTTCAAA
TGAGAGAATTTGAAGTGTTAAAAAAGCTCAATCACAAAAACATTGTCAAATTATTTGCTATTGA
AGAAGAGACAACAACAAGACATAAAGTACTTATCATGGAGTTCTGTCCCTGTGGGAGTTTATAC
ACTGTGTTAGAGGAGCCATCCAATGCCTATGGACTGCCAGAATCAGAGTTTTTAATTGTTTTAC
GAGATGTGGTGGGCGGAATGAATCATCTCCGAGAGAACGGCATAGTGCACCGTGATATCAAGCC
AGGGAACATCATGCGCGTCATAGGAGAAGACGGACAGTCTGTGTACAAACTCACAGACTTTGGT
GCCGCTAGAGAGTTAGAGGACGATGAGCAGTTCGTGTCTCTGTATGGCACAGAAGAGTATTTGC
ACCCGGACATGTATGAGAGGGCAGTGCTAAGGAAGGACCATCAGAAGAAGTACGGAGCCACCGT
TGATCTGTGGAGTGTCGGAGTCACATTCTACCACGCAGCCACGGGGTCGCTGCCCTTTAGACCC
TTCGAGGGGCCTCGGAGGAACAAAGAAGTAATGTATAAAATAATCACTGGGAAGCCTTCTGGTG
CAATATCTGGAGTACAGAAAGCAGAAAACGGACCAATTGACTGGAGTGGAGACATGCCTCTTTC
TTGTAGTCTTTCTCAGGGTCTTCAGGCACTGCTTACCCCAGTTCTTGCAAACATACTTGAAGCT
GATCAGGAGAAGTGCTGGGGCTTTGACCAGTTCTTTGCAGAGACTAGTGATGTGCTGCACCGAA
TGGTAATCCATGTTTTCTCGCTACAGCACATGACAGCGCTTAAGATCTATATTCATAGCTATAA
CACAGCTGCTGTGTTCCATGAACTGGTCTATAAACAAACCAAGATTATTTCTTCAAATCAAGAA
CTTATCTACGAAGGACGACGCTTGGTCCTAGAACTTGGAAGACTAGCCCAGCATTTCCCTAAAA
CCACAGAAGAAAATCCTATCTTTGTCACAAGCCGGGAACAACTCAATTCCATAGGTCTGAGATA
TGAAAAAATTTCCCTACCTAAAATACATCCACGCTATGACCTGGACGGGGACGCCAGCATGGCC
AAGGCAGTGACCGGGGTTGTGTGCTACGCCTGCAGAACTGCTGGCACCCTGCTGCTCTATCAAG
AACTAATGCGGAAGGGGGTGCGGTGGCTGATTGAACTAGTTAAAGACGACTACAATGAGACTGT
CCACAAGAAGACAGAAGTTGTGATCACACTGGATTTCTGCATCAGAAACATTGAGAAGACTGTG
AAAGTATATGAGAAGTTGATGAAGGTCAGCCTGGACGCCGCAGAGCTGGGTGAGATTTCAGACA
TACACACCAAGCTGCTGAGACTTTCCAGCTCTCAGGGAACAATAGAGAGCAGTCTTCAGGACAT
CAACAGCAGGCTGTCCCCAGGGGGATCGCTGGCTGACACCTGGGCACATCAGGAAGGCACTCAT
CCAAGAGACAGGAATGTAGAAAAGCTACAAGTCTTGTTGAATTGCATCACAGAGATTTACTATC
AGTTTAAAAAGGACAAGGCAGAGCGCAGACTAGCGTATAATGAAGAACAGATCCACAAGTTTGA
TAAACAAAAATTGTATTACCATGCAACAAAAGCAATGACCCACTTTACCGATGAATGTGTCAGG
AAGTATGAAGCATTTAAAGACACGTCTGAAGAATGGATGCGAAAGATGCTTCATCTTCGGAAAC
AGCTGCTATCACTGACTAATCAGTGTTTTGACATCGAAGAGGAGGTGTCCAAGTATCAAGACTA
CACTAACGAGTTACAAGAAACTCTGCCTCAGAAAATGCTTGCAGCCTCCAGTGGAATCAAGCAC
ACCGTGGCCCCGATCTACCCCAGTTCTAACACCTTAGTGGAGATGACTCTCGGTATGAAGAAGC
TGAAGGAGGAGATGGAGGGCGTGGTCAAGGAGCTGGCCGAAAACAATCATATTTTAGAAAGGTT
TGGGTCTTTGACAATGGATGGTGGCCTCCGCAATGTGGACTGTCTTTAGCTTCTTCGGGAGTCT
GGGAAGTTCTAGTTTGCACAAGAAGATGACACTGGGGCACGAAGTGAATGCCTTTATGAATGGC
ATTCTTATTTCTACAATTCAGTATTTGATGAGGTCGTGTAAATATGTACAGTTTGTAAATACAT
ATACATATATATATATGAATTTTTGGCTGCTGTAAGTAAACAAGACAGATTGACCTCAGTGAGC
TGTAGAAGAAAGCCATGACCAGCCAATGCTTTGGGGTGCTCTCCCTAATTCTTCACATGAGGCT
GGAGAAATCTATGCTTGGTGCCTAAAGAAAGTATTTTTTGAATTGGCGTCCTTAAAATTTTGAA
AGGACTGATAGTTGACACAGTTGTGAATGGAGGAGACACAGGGCTTTGTGATAGGAACCGAACC
ACGGTTTTACTAGGGTCAGTTCCTCTGACAAGGATGAAGCGGCATTATTTCATTTGACGAGGTG
CCCAAATCTGTTTTCCTCGTATGTTTCATTTCAGGTGAATTATTGAGCAAAAACTTTAAAGTGA
ATTCATTGTTTAAACTATTCATTTTTCGTTTGGTCACAATGTGTAATTGTCATTCAGATCCTCG
TATCATTTCAATTGTCTTAAGATGTATATTTCTGTACTTTAATTCTGCTGTTTCATGAAAAATT
CTGCCTACTATTTCATGAAAAATAAATTTCTCAATTTTAATGT

hide sequence

RefSeq Acc Id:

XM_039078743 ⟹ XP_038934671

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	58,963,319 - 58,987,796 (-)	NCBI
mRatBN7.2	7	57,077,830 - 57,102,308 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001100256	(Get FASTA)	NCBI Sequence Viewer
	XP_038934671	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM16548	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000009260.4
	ENSRNOP00000081507.1

RefSeq Acc Id:

NP_001100256 ⟸ NM_001106786

- UniProtKB:

D4A7D3 (UniProtKB/TrEMBL), A6IH00 (UniProtKB/TrEMBL), A0A8I5ZSX1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLKKLNH
KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE
NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRK
DHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGP
IDWSGDMPLSCSLSQGLQALLTPVLANILEADQEKCWGFDQFFAETSDVLHRMVIHVFSLQHMT
ALKIYIHSYNTAAVFHELVYKQTKIISSNQELIYEGRRLVLELGRLAQHFPKTTEENPIFVTSR
EQLNSIGLRYEKISLPKIHPRYDLDGDASMAKAVTGVVCYACRTAGTLLLYQELMRKGVRWLIE
LVKDDYNETVHKKTEVVITLDFCIRNIEKTVKVYEKLMKVSLDAAELGEISDIHTKLLRLSSSQ
GTIESSLQDINSRLSPGGSLADTWAHQEGTHPRDRNVEKLQVLLNCITEIYYQFKKDKAERRLA
YNEEQIHKFDKQKLYYHATKAMTHFTDECVRKYEAFKDTSEEWMRKMLHLRKQLLSLTNQCFDI
EEEVSKYQDYTNELQETLPQKMLAASSGIKHTVAPIYPSSNTLVEMTLGMKKLKEEMEGVVKEL
AENNHILERFGSLTMDGGLRNVDCL

hide sequence

Ensembl Acc Id:

ENSRNOP00000009260 ⟸ ENSRNOT00000009260

RefSeq Acc Id:	XP_038934671 ⟸ XM_039078743
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5ZSX1 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000081507 ⟸ ENSRNOT00000111412

Protein Domains

Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A7D3-F1-model_v2	AlphaFold	D4A7D3	1-729	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695227

Promoter ID:

EPDNEW_R5751

Type:

multiple initiation site

Name:

Tbk1_1

Description:

TANK-binding kinase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	63,687,981 - 63,688,041	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1588588	AgrOrtholog
BioCyc Gene	G2FUF-33871	BioCyc
Ensembl Genes	ENSRNOG00000005528	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000009260.6	UniProtKB/TrEMBL
	ENSRNOT00000111412.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1270.420	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	IKK	UniProtKB/TrEMBL
	Kinase-like_dom	UniProtKB/TrEMBL
	Prot_kinase_cat_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	TBK1_CCD1	UniProtKB/TrEMBL
	TBK1_ULD	UniProtKB/TrEMBL
KEGG Report	rno:299827	UniProtKB/TrEMBL
NCBI Gene	299827	ENTREZGENE
PANTHER	IKB KINASE	UniProtKB/TrEMBL
	SERINE/THREONINE-PROTEIN KINASE TBK1	UniProtKB/TrEMBL
Pfam	Pkinase	UniProtKB/TrEMBL
	TBK1_CCD1	UniProtKB/TrEMBL
	TBK1_ULD	UniProtKB/TrEMBL
PhenoGen	Tbk1	PhenoGen
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000005528	RatGTEx
SMART	S_TKc	UniProtKB/TrEMBL
Superfamily-SCOP	Kinase_like	UniProtKB/TrEMBL
UniProt	A0A8I5ZSX1	ENTREZGENE, UniProtKB/TrEMBL
	A6IH00	ENTREZGENE, UniProtKB/TrEMBL
	D4A7D3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-04	Tbk1	TANK-binding kinase 1	LOC299827	similar to TANK-binding kinase 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-19	LOC299827	similar to TANK-binding kinase 1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)