Tbk1 (TANK-binding kinase 1) - Rat Genome Database

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Gene: Tbk1 (TANK-binding kinase 1) Mus musculus
Analyze
Symbol: Tbk1
Name: TANK-binding kinase 1
RGD ID: 1313753
MGI Page MGI
Description: Enables several functions, including identical protein binding activity; protein phosphatase binding activity; and protein serine/threonine kinase activity. Involved in negative regulation of gene expression; peptidyl-serine phosphorylation; and positive regulation of defense response. Acts upstream of or within several processes, including defense response to Gram-positive bacterium; dendritic cell proliferation; and positive regulation of interferon-beta production. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in brain disease and frontotemporal dementia and/or amyotrophic lateral sclerosis 4. Orthologous to human TBK1 (TANK binding kinase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1200008B05Rik; AI462036; AW048562; MGC150301; MGC150302; serine/threonine protein kinase TBK1; serine/threonine-protein kinase TBK1; T2K
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910121,382,360 - 121,422,699 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10121,382,360 - 121,422,692 (-)EnsemblGRCm39 Ensembl
GRCm3810121,546,455 - 121,586,794 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10121,546,455 - 121,586,787 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710120,983,511 - 121,023,850 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610120,949,520 - 120,989,807 (-)NCBIMGSCv36mm8
Celera10123,931,313 - 123,970,044 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1069.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
6-propyl-2-thiouracil  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amlexanox  (EXP,ISO)
aristolochic acid A  (ISO)
auranofin  (EXP)
bafilomycin A1  (EXP)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
chromium(6+)  (EXP)
chrysin  (ISO)
cisplatin  (EXP)
clofibrate  (EXP)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
dioxygen  (ISO)
disodium selenite  (EXP)
eriodictyol  (ISO)
ethyl methanesulfonate  (ISO)
fenthion  (EXP)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glyphosate  (ISO)
graphene oxide  (EXP)
hexadecanoic acid  (EXP)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
lipopolysaccharide  (EXP,ISO)
luteolin  (ISO)
lycopene  (EXP)
mangiferin  (EXP)
methyl methanesulfonate  (ISO)
nefazodone  (ISO)
o-anisidine  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentachlorophenol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
Phytolaccoside E  (ISO)
poly(I:C)  (EXP)
propiconazole  (EXP)
quercetin  (ISO)
resveratrol  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sulindac  (ISO)
tamoxifen  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
Triptolide  (EXP)
tunicamycin  (EXP,ISO)
vadimezan  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell differentiation  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal class switch recombination  (IAGP)
abnormal cytokine level  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal cytotoxic T cell physiology  (IAGP)
abnormal hair cycle anagen phase  (IAGP)
abnormal immunoglobulin level  (IAGP)
abnormal inflammatory response  (IAGP)
abnormal interferon secretion  (IEA)
abnormal kidney physiology  (IAGP)
abnormal macrophage physiology  (IEA)
abnormal skin morphology  (IAGP)
decreased basophil cell number  (IAGP)
decreased cytotoxic T cell cytolysis  (IAGP)
decreased eosinophil cell number  (IAGP)
decreased IgG level  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG2a level  (IAGP)
decreased interferon-beta secretion  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased NK T cell number  (IAGP)
dermal hyperplasia  (IAGP)
disheveled coat  (IAGP)
hyperkeratosis  (IAGP)
increased anti-double stranded DNA antibody level  (IAGP)
increased anti-nuclear antigen antibody level  (IAGP)
increased blood urea nitrogen level  (IAGP)
increased circulating creatinine level  (IAGP)
increased circulating interleukin-1 beta level  (IAGP)
increased circulating interleukin-10 level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased IgA level  (IAGP)
increased IgM level  (IAGP)
increased interleukin-6 secretion  (IAGP)
increased mature B cell number  (IAGP)
increased monocyte cell number  (IAGP)
increased NK T cell number  (IAGP)
increased spleen weight  (IAGP)
increased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
increased susceptibility to endotoxin shock  (IAGP)
increased tumor necrosis factor secretion  (IAGP)
increased urine protein level  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
liver degeneration  (IAGP)
liver hemorrhage  (IAGP)
lymphoid hyperplasia  (IAGP)
pallor  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
prenatal lethality, complete penetrance  (IEA)
prenatal lethality, incomplete penetrance  (IAGP)
skin edema  (IAGP)
skin hyperplasia  (IAGP)
skin inflammation  (IAGP)
sparse hair  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Pathogen recognition by the innate immune system. Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10581243   PMID:10990461   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273   PMID:14679297   PMID:14681479  
PMID:15210742   PMID:15210743   PMID:15361868   PMID:15661922   PMID:16039576   PMID:16141072   PMID:16141073   PMID:16286919   PMID:16380379   PMID:16586493   PMID:16783635   PMID:17015689  
PMID:17018283   PMID:17056502   PMID:17312162   PMID:17327220   PMID:17335348   PMID:17468758   PMID:17562815   PMID:17599067   PMID:17925397   PMID:17954568   PMID:18256672   PMID:18287559  
PMID:18467330   PMID:18554416   PMID:18583960   PMID:18665841   PMID:18799693   PMID:18977754   PMID:19010780   PMID:19017982   PMID:19158679   PMID:19201879   PMID:19251743   PMID:19483718  
PMID:20100929   PMID:20304918   PMID:20389019   PMID:20651301   PMID:20890285   PMID:21074459   PMID:21106850   PMID:21204785   PMID:21267068   PMID:21270402   PMID:21329883   PMID:21441935  
PMID:21464307   PMID:21617041   PMID:21677750   PMID:21765404   PMID:21820332   PMID:21862579   PMID:21873635   PMID:21903422   PMID:21931631   PMID:22000020   PMID:22007846   PMID:22171259  
PMID:22203995   PMID:22252317   PMID:22454496   PMID:22634618   PMID:22728658   PMID:22842346   PMID:22851696   PMID:22921120   PMID:22945920   PMID:23023393   PMID:23028052   PMID:23028469  
PMID:23142775   PMID:23160154   PMID:23349877   PMID:23396947   PMID:23610142   PMID:23746807   PMID:23794264   PMID:23950712   PMID:23962979   PMID:24043892   PMID:24198409   PMID:24244017  
PMID:24335288   PMID:24349538   PMID:24368730   PMID:24457600   PMID:24560620   PMID:24562310   PMID:24600004   PMID:24696485   PMID:24722368   PMID:24929003   PMID:25606824   PMID:25681338  
PMID:25780039   PMID:25810395   PMID:25815785   PMID:25997745   PMID:26320659   PMID:26358190   PMID:26376340   PMID:26474655   PMID:26489883   PMID:27043414   PMID:27103069   PMID:27129230  
PMID:27135603   PMID:27183626   PMID:27249321   PMID:27374884   PMID:27692986   PMID:27753621   PMID:27776110   PMID:27917412   PMID:28049150   PMID:28049762   PMID:28069950   PMID:28159912  
PMID:28237848   PMID:28325821   PMID:28356390   PMID:28425986   PMID:28671696   PMID:28747347   PMID:28874664   PMID:28954889   PMID:29138248   PMID:29150432   PMID:29425491   PMID:29563620  
PMID:29870684   PMID:29935921   PMID:30042930   PMID:30108181   PMID:30146158   PMID:30196744   PMID:30290124   PMID:30420664   PMID:30515151   PMID:30635357   PMID:30683688   PMID:30804548  
PMID:30912981   PMID:30938713   PMID:31039129   PMID:31087643   PMID:31390091   PMID:31400857   PMID:31616416   PMID:31690171   PMID:31792381   PMID:32220666   PMID:32268090   PMID:32324863  
PMID:32325033   PMID:32505355   PMID:32554809   PMID:32636381   PMID:32678307   PMID:32723479   PMID:32732870   PMID:32745468   PMID:32772249   PMID:32814047   PMID:32900826   PMID:32968282  
PMID:33038415   PMID:33086059   PMID:33152322   PMID:33164878   PMID:33171123   PMID:33304758   PMID:33326766   PMID:33378226   PMID:33439438   PMID:33608556   PMID:33741962   PMID:33785602  
PMID:33822771   PMID:34023381   PMID:34245780   PMID:34255829   PMID:34382418   PMID:34473814   PMID:34518217   PMID:34646390   PMID:34678655   PMID:34901991   PMID:34903812   PMID:34910106  
PMID:34990937   PMID:35074921   PMID:35129065   PMID:35172162   PMID:35358404   PMID:35983955   PMID:36114006   PMID:36201573   PMID:36342281   PMID:36384137   PMID:36603304   PMID:36719141  
PMID:36795563   PMID:36958140   PMID:37099423   PMID:37255478   PMID:37352355   PMID:37395713   PMID:37434364   PMID:37531828   PMID:37854611   PMID:37967220   PMID:38043800   PMID:38167258  
PMID:38481817   PMID:38517332   PMID:38697117   PMID:39019135   PMID:39031880   PMID:39305055   PMID:39328932   PMID:39423796  


Genomics

Comparative Map Data
Tbk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910121,382,360 - 121,422,699 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10121,382,360 - 121,422,692 (-)EnsemblGRCm39 Ensembl
GRCm3810121,546,455 - 121,586,794 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10121,546,455 - 121,586,787 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710120,983,511 - 121,023,850 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610120,949,520 - 120,989,807 (-)NCBIMGSCv36mm8
Celera10123,931,313 - 123,970,044 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1069.84NCBI
TBK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381264,452,120 - 64,502,114 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1264,452,090 - 64,502,114 (+)EnsemblGRCh38hg38GRCh38
GRCh371264,845,900 - 64,895,894 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361263,132,204 - 63,182,158 (+)NCBINCBI36Build 36hg18NCBI36
Build 341263,132,203 - 63,182,158NCBI
Celera1264,510,375 - 64,560,181 (+)NCBICelera
Cytogenetic Map12q14.2NCBI
HuRef1261,898,186 - 61,948,226 (+)NCBIHuRef
CHM1_11264,812,935 - 64,863,007 (+)NCBICHM1_1
T2T-CHM13v2.01264,430,747 - 64,480,735 (+)NCBIT2T-CHM13v2.0
Tbk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8758,963,319 - 58,996,357 (-)NCBIGRCr8
mRatBN7.2757,077,830 - 57,110,868 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl757,077,830 - 57,110,892 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx758,989,079 - 59,022,620 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0761,191,956 - 61,225,497 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0760,969,664 - 61,003,205 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0763,655,247 - 63,687,978 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl763,655,247 - 63,687,978 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0763,877,567 - 63,910,298 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4760,863,099 - 60,896,131 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera753,819,361 - 53,852,262 (-)NCBICelera
Cytogenetic Map7q22NCBI
Tbk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545811,211,398 - 11,263,867 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545811,210,120 - 11,263,632 (+)NCBIChiLan1.0ChiLan1.0
TBK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21029,864,914 - 29,915,549 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11229,861,685 - 29,912,320 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01224,419,271 - 24,469,164 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11224,919,412 - 24,968,587 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1224,917,246 - 24,968,587 (-)Ensemblpanpan1.1panPan2
TBK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1107,169,664 - 7,208,890 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl107,168,007 - 7,208,899 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha107,102,668 - 7,144,367 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0107,276,927 - 7,318,803 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl107,276,875 - 7,318,755 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1107,142,851 - 7,184,688 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0107,395,493 - 7,437,313 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0107,526,057 - 7,567,705 (+)NCBIUU_Cfam_GSD_1.0
Tbk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494551,300,898 - 51,346,375 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365452,763,596 - 2,809,709 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365452,763,755 - 2,809,229 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TBK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl528,880,205 - 28,929,963 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1528,880,210 - 28,929,964 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TBK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11160,136,162 - 60,182,354 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1160,136,232 - 60,182,344 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037185,623,292 - 185,669,524 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tbk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248023,862,709 - 3,914,028 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248023,861,821 - 3,914,061 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tbk1
1798 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:189
Count of miRNA genes:161
Interacting mature miRNAs:180
Transcripts:ENSMUST00000020316
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884377Skwq3_mskull length QTL 3, 5 week (mouse)10114635905122735905Mouse
26884383Bzwq3_mbi-zygomatic width QTL 3, 5 week (mouse)10114235905122735905Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
4142386Tgq20_mtriglyceride QTL 20 (mouse)Not determined88836456122836456Mouse
1357594Estoq3_membryo survival total QTL 3 (mouse)Not determined1084079650122041528Mouse
4141361Cfmq3_mcystic fibrosis modifier QTL 3 (mouse)Not determined10101497164130530862Mouse
4141487Tgq21_mtriglyceride QTL 21 (mouse)Not determined104110021130530862Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
1301895Exq1_mexploratory and excitability QTL 1 (mouse)Not determined10102847852130530862Mouse
14746996Manh69_mmandible shape 69 (mouse)10104763638130530862Mouse
4141479W10q8_mweight 10 weeks QTL 8 (mouse)Not determined84079650122041528Mouse
13801032Hwtf2_mheart weight by femur 2 (mouse)10119835905121835905Mouse
1301901Im5_mimmunoregulatory 5 (mouse)Not determined10101497164130530862Mouse
4142496W6q8_mweight 6 weeks QTL 8 (mouse)Not determined84079650122041528Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
11039496Ltpr5b_mLeishmania tropica response 5b (mouse)10108575094130530862Mouse
1357622Espq3_membryo survival preimplantation QTL 3 (mouse)Not determined1084079650122041528Mouse
4142365Egq9_mearly growth QTL 9 (mouse)Not determined84079650122041528Mouse
1357744Cfbw4_mcystic fibrosis body weight 4 (mouse)Not determined10100986516130530862Mouse
11041664Lmr25_mleishmaniasis resistance 25 (mouse)10108575094130530862Mouse
1300921Skl4_mskeletal size (tail length) 4 (mouse)Not determined1088088254122088391Mouse
1302200Sle12_msystematic lupus erythematosus susceptibility 12 (mouse)Not determined10105041304130530862Mouse
1300796Lmr5_mleishmaniasis resistance 5 (mouse)Not determined10116220635122179828Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
11039516Ltpr5_mLeishmania tropica response 5 (mouse)1090506901125575232Mouse
27226795Scvln17_msacral vertebrae length 2, 16 week (mouse)10118435905124835905Mouse
4142089Obrq9_mobesity resistance QTL 9 (mouse)Not determined108515907130530862Mouse
27226791Feml8_mfemur length 8, 5 week (mouse)10119035905125735869Mouse
26884391Skwq11_mskull length QTL 11, 16 week (mouse)10113535905121635905Mouse
13506931Recrq11_mrecombination rate in male meiosis QTL 11 (mouse)10114335905123635905Mouse
1357482Nhdlq4_mnon-HDL QTL 4 (mouse)Not determined10105041304130530862Mouse
27226784Tibl4_mtibia length 4, 5 week (mouse)10119035905125435869Mouse
26884443Sklq5_mskull length QTL 5, 5 week (mouse)10119035905124835905Mouse
27226718Tibw3_mtibia width 3, proximal, 10 week (mouse)10118835905125435869Mouse
4142461Bmd25_mbone mineral density 25 (mouse)Not determined1097217101130530862Mouse
1301968Estq4_mestradiol regulated response QTL 4 (mouse)Not determined10100986516130530862Mouse
11353838Gluq3_mblood glucose QTL 3 (mouse)10120243727125515907Mouse
27095902Scvln11_msacral vertebrae length 2, 10 week (mouse)10110035861125435869Mouse
11353832Pcholq4_mplasma cholesterol QTL 4 (mouse)1073987216125515907Mouse
1357779Tesq3_mtestis weight QTL 3 (mouse)Not determined1084079650122041528Mouse
11353834Pcholq2_mplasma cholesterol QTL 2 (mouse)10120243727125515907Mouse
11049570Lmr25b_mleishmaniasis resistance 25b (mouse)10108575094130530862Mouse
26884433Zlq2_mzygomatic length QTL 2, 5 week (mouse)10113535905125735869Mouse
11533921Mvb2_mmodifier of vibrator 2 (mouse)1097217101130530862Mouse
1300679Nociq2_mnociceptive sensitivity inflammatory QTL 2 (mouse)Not determined10105041304130530862Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1067835830124835905Mouse
1300678Leg2_mlongevity extending gene 2 (mouse)Not determined10102506908130530862Mouse
1301701Aggr1_maggression 1 (mouse)Not determined10119506908125575232Mouse
12880413V125Dq9_mvitamin D active form serum level QTL 9 (mouse)1097535905130530862Mouse
4141153Ltgq2_mliver triglyceride QTL 2 (mouse)Not determined108515907130530862Mouse
11353843Gluq1_mblood glucose QTL 1 (mouse)1073987216125515907Mouse
27226747Metcl10_mmetatarsal-calcaneal length 10, 10 week (mouse)10119035905124835905Mouse
4141402T2dm1sa_mtype 2 diabetes mellitus 1 in SMXA RI mice (mouse)Not determined97758644130530862Mouse
27226742Metcl4_mmetatarsal-calcaneal length 4, 5 week (mouse)10118135905125435869Mouse
27095926Pglq4_mpelvic girdle length QTL 4, 5 week (mouse)10119035905124835905Mouse
1301758Fcsa3_mfemoral cross-sectional area 3 (mouse)Not determined1089927651123927754Mouse
27226736Metcl15_mmetatarsal-calcaneal length 15, 16 week (mouse)10119035905124835905Mouse
4141007Obrq10_mobesity resistance QTL 10 (mouse)Not determined103243727130530862Mouse
11533919Mvb4_mmodifier of vibrator 4 (mouse)397217101130530862Mouse
11353823Homaq2_mhomeostatic model assessment QTL 2 (mouse)10110453347125515907Mouse
11353822Insq12_minsulin QTL 12 (mouse)10110453347125515907Mouse
11049563Lmr25a_mleishmaniasis resistance 25a (mouse)10108575094130530862Mouse
4141387Lgaq5_mlate growth adjusted QTL 5 (mouse)Not determined84079650122041528Mouse
14696727Kidrq2_mkidney weight, right QTL 2 (mouse)10102902508130530862Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059335822122335905Mouse
11040593Lmr5e_mleishmaniasis resistance 5e (mouse)1099220635130530862Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
27226725Tibw1_mtibia width 1, proximal, 5 week (mouse)10102735861123235905Mouse
25394553Skmw68_mskeletal muscle weight 68, TA (mouse)10121376111121855130Mouse
11040594Lmr5f_mleishmaniasis resistance 5f (mouse)10105179713130530862Mouse
11040595Lmr5c_mleishmaniasis resistance 5c (mouse)1099220635130530862Mouse
1357544Vtbt10_mvertebral trabecular bone trait 10 (mouse)Not determined1097217101130530862Mouse
11040596Lmr5d_mleishmaniasis resistance 5d (mouse)10105179713130530862Mouse
11040597Lmr5a_mleishmaniasis resistance 5a (mouse)1099220635130530862Mouse
27226722Tibw7_mtibia width 7, proximal, 16 week (mouse)10108635861125435869Mouse
11040598Lmr5b_mleishmaniasis resistance 5b (mouse)10105179713130530862Mouse
27095906Scvln5_msacral vertebrae length 2, 5 week (mouse)10119035905124835905Mouse

Markers in Region
AU014973  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810121,584,690 - 121,584,895UniSTSGRCm38
MGSCv3710121,021,746 - 121,021,951UniSTSGRCm37
Celera10123,967,940 - 123,968,145UniSTS
Cytogenetic Map10D2UniSTS
Whitehead/MRC_RH101274.11UniSTS
RH126705  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810121,587,400 - 121,587,608UniSTSGRCm38
MGSCv3710121,024,456 - 121,024,664UniSTSGRCm37
Celera10123,970,650 - 123,970,858UniSTS
Cytogenetic Map10D3UniSTS
Cytogenetic Map10D2UniSTS
Whitehead/MRC_RH101274.11UniSTS
AW048562  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810121,546,752 - 121,546,897UniSTSGRCm38
MGSCv3710120,983,808 - 120,983,953UniSTSGRCm37
Celera10123,931,610 - 123,931,755UniSTS
Cytogenetic Map10D2UniSTS
Whitehead/MRC_RH101275.61UniSTS
AI452076  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810121,587,430 - 121,587,710UniSTSGRCm38
MGSCv3710121,024,486 - 121,024,766UniSTSGRCm37
Celera10123,970,680 - 123,970,960UniSTS
Cytogenetic Map10D2UniSTS
Cytogenetic Map10D3UniSTS
Whitehead/MRC_RH101275.61UniSTS
AI462036  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810121,546,658 - 121,546,896UniSTSGRCm38
MGSCv3710120,983,714 - 120,983,952UniSTSGRCm37
Celera10123,931,516 - 123,931,754UniSTS
Cytogenetic Map10D2UniSTS
Whitehead/MRC_RH101275.61UniSTS
Tbk1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10D2UniSTS
cM Map10 UniSTS
PMC314216P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810121,575,860 - 121,576,297UniSTSGRCm38
MGSCv3710121,012,916 - 121,013,353UniSTSGRCm37
Celera10123,960,315 - 123,960,752UniSTS
Cytogenetic Map10D2UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000020316   ⟹   ENSMUSP00000020316
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10121,382,360 - 121,422,692 (-)Ensembl
GRCm38.p6 Ensembl10121,546,455 - 121,586,787 (-)Ensembl
Ensembl Acc Id: ENSMUST00000218460
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10121,398,077 - 121,400,003 (-)Ensembl
GRCm38.p6 Ensembl10121,562,172 - 121,564,098 (-)Ensembl
Ensembl Acc Id: ENSMUST00000219244
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10121,399,830 - 121,404,386 (-)Ensembl
GRCm38.p6 Ensembl10121,563,925 - 121,568,481 (-)Ensembl
Ensembl Acc Id: ENSMUST00000219400   ⟹   ENSMUSP00000151440
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10121,382,365 - 121,422,682 (-)Ensembl
GRCm38.p6 Ensembl10121,546,460 - 121,586,777 (-)Ensembl
Ensembl Acc Id: ENSMUST00000219439
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10121,386,985 - 121,388,354 (-)Ensembl
GRCm38.p6 Ensembl10121,551,080 - 121,552,449 (-)Ensembl
Ensembl Acc Id: ENSMUST00000219493   ⟹   ENSMUSP00000151935
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10121,407,806 - 121,422,646 (-)Ensembl
GRCm38.p6 Ensembl10121,571,901 - 121,586,741 (-)Ensembl
Ensembl Acc Id: ENSMUST00000220386
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10121,387,165 - 121,390,068 (-)Ensembl
GRCm38.p6 Ensembl10121,551,260 - 121,554,163 (-)Ensembl
RefSeq Acc Id: NM_019786   ⟹   NP_062760
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910121,382,360 - 121,422,699 (-)NCBI
GRCm3810121,546,455 - 121,586,794 (-)NCBI
MGSCv3710120,983,511 - 121,023,850 (-)RGD
Celera10123,931,313 - 123,970,044 (-)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_062760   ⟸   NM_019786
- UniProtKB: Q9CT90 (UniProtKB/Swiss-Prot),   Q9DC03 (UniProtKB/Swiss-Prot),   Q9WUN2 (UniProtKB/Swiss-Prot),   A1L361 (UniProtKB/TrEMBL),   Q3THP3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000020316   ⟸   ENSMUST00000020316
Ensembl Acc Id: ENSMUSP00000151440   ⟸   ENSMUST00000219400
Ensembl Acc Id: ENSMUSP00000151935   ⟸   ENSMUST00000219493
Protein Domains
Protein kinase   Ubiquitin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WUN2-F1-model_v2 AlphaFold Q9WUN2 1-729 view protein structure

Promoters
RGD ID:6819994
Promoter ID:MM_KWN:5796
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_019786,   UC007HFU.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610121,023,721 - 121,024,772 (-)MPROMDB
RGD ID:8673402
Promoter ID:EPDNEW_M14732
Type:initiation region
Name:Tbk1_1
Description:Mus musculus TANK-binding kinase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3810121,586,758 - 121,586,818EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1929658 AgrOrtholog
Ensembl Genes ENSMUSG00000020115 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000020316 ENTREZGENE
  ENSMUST00000020316.4 UniProtKB/Swiss-Prot
  ENSMUST00000219400.2 UniProtKB/TrEMBL
  ENSMUST00000219493.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.420 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro IKK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TBK1_CCD1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TBK1_ULD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:56480 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1929658 ENTREZGENE
NCBI Gene 56480 ENTREZGENE
PANTHER IKB KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE TBK1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TBK1_CCD1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TBK1_ULD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tbk1 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1W2P6W7_MOUSE UniProtKB/TrEMBL
  A0A1W2P835_MOUSE UniProtKB/TrEMBL
  A1L361 ENTREZGENE, UniProtKB/TrEMBL
  Q3THP3 ENTREZGENE, UniProtKB/TrEMBL
  Q9CT90 ENTREZGENE
  Q9DC03 ENTREZGENE
  Q9WUN2 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q9CT90 UniProtKB/Swiss-Prot
  Q9DC03 UniProtKB/Swiss-Prot