Tbk1 (TANK-binding kinase 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Tbk1 (TANK-binding kinase 1) Mus musculus
Analyze
Symbol: Tbk1
Name: TANK-binding kinase 1
RGD ID: 1313753
MGI Page MGI
Description: Enables several functions, including identical protein binding activity; protein phosphatase binding activity; and protein serine/threonine kinase activity. Involved in negative regulation of gene expression; peptidyl-serine phosphorylation; and positive regulation of defense response. Acts upstream of or within several processes, including defense response to Gram-positive bacterium; dendritic cell proliferation; and positive regulation of interferon-beta production. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in brain disease and frontotemporal dementia and/or amyotrophic lateral sclerosis-4. Orthologous to human TBK1 (TANK binding kinase 1); PARTICIPATES IN Toll-like receptor signaling pathway; hepatitis C pathway; influenza A pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3',4,4',5-Pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1200008B05Rik; AI462036; AW048562; MGC150301; MGC150302; serine/threonine protein kinase TBK1; serine/threonine-protein kinase TBK1; T2K
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910121,382,360 - 121,422,699 (-)NCBIGRCm39mm39
GRCm39 Ensembl10121,382,360 - 121,422,692 (-)Ensembl
GRCm3810121,546,455 - 121,586,794 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10121,546,455 - 121,586,787 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710120,983,511 - 121,023,850 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610120,949,520 - 120,989,807 (-)NCBImm8
Celera10123,931,313 - 123,970,044 (-)NCBICelera
Cytogenetic Map10D2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell differentiation  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal class switch recombination  (IAGP)
abnormal cytokine level  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal cytotoxic T cell physiology  (IAGP)
abnormal hair cycle anagen phase  (IAGP)
abnormal immunoglobulin level  (IAGP)
abnormal inflammatory response  (IAGP)
abnormal interferon secretion  (IEA)
abnormal kidney physiology  (IAGP)
abnormal macrophage physiology  (IEA)
abnormal skin morphology  (IAGP)
decreased basophil cell number  (IAGP)
decreased cytotoxic T cell cytolysis  (IAGP)
decreased eosinophil cell number  (IAGP)
decreased IgG level  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG2a level  (IAGP)
decreased interferon-beta secretion  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased NK T cell number  (IAGP)
dermal hyperplasia  (IAGP)
disheveled coat  (IAGP)
hyperkeratosis  (IAGP)
increased anti-double stranded DNA antibody level  (IAGP)
increased anti-nuclear antigen antibody level  (IAGP)
increased blood urea nitrogen level  (IAGP)
increased circulating creatinine level  (IAGP)
increased circulating interleukin-1 beta level  (IAGP)
increased circulating interleukin-10 level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased IgA level  (IAGP)
increased IgM level  (IAGP)
increased interleukin-6 secretion  (IAGP)
increased mature B cell number  (IAGP)
increased monocyte cell number  (IAGP)
increased NK T cell number  (IAGP)
increased spleen weight  (IAGP)
increased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
increased susceptibility to endotoxin shock  (IAGP)
increased tumor necrosis factor secretion  (IAGP)
increased urine protein level  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
liver degeneration  (IAGP)
liver hemorrhage  (IAGP)
lymphoid hyperplasia  (IAGP)
pallor  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
prenatal lethality, complete penetrance  (IEA)
prenatal lethality, incomplete penetrance  (IAGP)
skin edema  (IAGP)
skin hyperplasia  (IAGP)
skin inflammation  (IAGP)
sparse hair  (IAGP)
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10581243   PMID:10990461   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273   PMID:14679297   PMID:14681479  
PMID:15210742   PMID:15210743   PMID:15661922   PMID:16039576   PMID:16141072   PMID:16141073   PMID:16286919   PMID:16380379   PMID:16586493   PMID:16783635   PMID:17015689   PMID:17018283  
PMID:17056502   PMID:17312162   PMID:17327220   PMID:17335348   PMID:17468758   PMID:17562815   PMID:17599067   PMID:17925397   PMID:17954568   PMID:18256672   PMID:18287559   PMID:18467330  
PMID:18554416   PMID:18583960   PMID:18665841   PMID:18799693   PMID:18977754   PMID:19010780   PMID:19017982   PMID:19158679   PMID:19201879   PMID:19251743   PMID:19483718   PMID:20100929  
PMID:20304918   PMID:20389019   PMID:20651301   PMID:20890285   PMID:21074459   PMID:21106850   PMID:21204785   PMID:21267068   PMID:21270402   PMID:21329883   PMID:21441935   PMID:21464307  
PMID:21617041   PMID:21677750   PMID:21765404   PMID:21820332   PMID:21862579   PMID:21873635   PMID:21903422   PMID:21931631   PMID:22000020   PMID:22007846   PMID:22171259   PMID:22203995  
PMID:22252317   PMID:22454496   PMID:22634618   PMID:22728658   PMID:22842346   PMID:22851696   PMID:22921120   PMID:22945920   PMID:23023393   PMID:23028052   PMID:23028469   PMID:23142775  
PMID:23160154   PMID:23349877   PMID:23396947   PMID:23610142   PMID:23746807   PMID:23794264   PMID:23950712   PMID:23962979   PMID:24043892   PMID:24198409   PMID:24244017   PMID:24335288  
PMID:24349538   PMID:24368730   PMID:24457600   PMID:24560620   PMID:24562310   PMID:24600004   PMID:24696485   PMID:24722368   PMID:24929003   PMID:25606824   PMID:25681338   PMID:25780039  
PMID:25810395   PMID:25815785   PMID:25997745   PMID:26320659   PMID:26358190   PMID:26376340   PMID:26474655   PMID:26489883   PMID:27043414   PMID:27103069   PMID:27129230   PMID:27135603  
PMID:27183626   PMID:27249321   PMID:27374884   PMID:27692986   PMID:27753621   PMID:27776110   PMID:27917412   PMID:28049150   PMID:28049762   PMID:28069950   PMID:28159912   PMID:28237848  
PMID:28325821   PMID:28356390   PMID:28425986   PMID:28671696   PMID:28747347   PMID:28874664   PMID:28954889   PMID:29138248   PMID:29425491   PMID:29563620   PMID:29870684   PMID:29935921  
PMID:30042930   PMID:30108181   PMID:30146158   PMID:30196744   PMID:30290124   PMID:30420664   PMID:30515151   PMID:30635357   PMID:30683688   PMID:30804548   PMID:30912981   PMID:31039129  
PMID:31087643   PMID:31400857   PMID:31616416   PMID:31690171   PMID:31792381   PMID:32220666   PMID:32324863   PMID:32325033   PMID:32505355   PMID:32636381   PMID:32732870   PMID:32745468  
PMID:32814047   PMID:32900826   PMID:32968282   PMID:33038415   PMID:33086059   PMID:33152322   PMID:33164878   PMID:33171123   PMID:33326766   PMID:33378226   PMID:33741962   PMID:34023381  


Genomics

Comparative Map Data
Tbk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910121,382,360 - 121,422,699 (-)NCBIGRCm39mm39
GRCm39 Ensembl10121,382,360 - 121,422,692 (-)Ensembl
GRCm3810121,546,455 - 121,586,794 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10121,546,455 - 121,586,787 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710120,983,511 - 121,023,850 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610120,949,520 - 120,989,807 (-)NCBImm8
Celera10123,931,313 - 123,970,044 (-)NCBICelera
Cytogenetic Map10D2NCBI
TBK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1264,452,090 - 64,502,114 (+)EnsemblGRCh38hg38GRCh38
GRCh381264,452,105 - 64,502,114 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371264,845,900 - 64,895,894 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361263,132,204 - 63,182,158 (+)NCBINCBI36hg18NCBI36
Build 341263,132,203 - 63,182,158NCBI
Celera1264,510,375 - 64,560,181 (+)NCBI
Cytogenetic Map12q14.2NCBI
HuRef1261,898,186 - 61,948,226 (+)NCBIHuRef
CHM1_11264,812,935 - 64,863,007 (+)NCBICHM1_1
Tbk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2757,077,830 - 57,110,868 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl757,077,830 - 57,110,892 (-)Ensembl
Rnor_6.0763,655,247 - 63,687,978 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl763,655,247 - 63,687,978 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0763,877,567 - 63,910,298 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4760,863,099 - 60,896,131 (-)NCBIRGSC3.4rn4RGSC3.4
Celera753,819,361 - 53,852,262 (-)NCBICelera
Cytogenetic Map7q22NCBI
Tbk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545811,211,398 - 11,263,867 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545811,210,120 - 11,263,632 (+)NCBIChiLan1.0ChiLan1.0
TBK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11224,919,412 - 24,968,587 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1224,917,246 - 24,968,587 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01224,419,271 - 24,469,164 (-)NCBIMhudiblu_PPA_v0panPan3
TBK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1107,169,664 - 7,208,890 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl107,168,007 - 7,208,899 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha107,102,668 - 7,144,367 (+)NCBI
ROS_Cfam_1.0107,276,927 - 7,318,803 (+)NCBI
UMICH_Zoey_3.1107,142,851 - 7,184,688 (+)NCBI
UNSW_CanFamBas_1.0107,395,493 - 7,437,313 (+)NCBI
UU_Cfam_GSD_1.0107,526,057 - 7,567,705 (+)NCBI
Tbk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494551,300,898 - 51,346,375 (-)NCBI
SpeTri2.0NW_0049365452,763,755 - 2,809,229 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TBK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl528,828,568 - 28,929,964 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1528,880,210 - 28,929,964 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TBK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11160,136,162 - 60,182,354 (+)NCBI
ChlSab1.1 Ensembl1160,136,232 - 60,182,344 (+)Ensembl
Vero_WHO_p1.0NW_023666037185,623,292 - 185,669,524 (-)NCBI
Tbk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248023,861,821 - 3,914,061 (-)NCBI

Position Markers
AU014973  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810121,584,690 - 121,584,895UniSTSGRCm38
MGSCv3710121,021,746 - 121,021,951UniSTSGRCm37
Celera10123,967,940 - 123,968,145UniSTS
Cytogenetic Map10D2UniSTS
Whitehead/MRC_RH101274.11UniSTS
RH126705  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810121,587,400 - 121,587,608UniSTSGRCm38
MGSCv3710121,024,456 - 121,024,664UniSTSGRCm37
Celera10123,970,650 - 123,970,858UniSTS
Cytogenetic Map10D3UniSTS
Cytogenetic Map10D2UniSTS
Whitehead/MRC_RH101274.11UniSTS
AW048562  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810121,546,752 - 121,546,897UniSTSGRCm38
MGSCv3710120,983,808 - 120,983,953UniSTSGRCm37
Celera10123,931,610 - 123,931,755UniSTS
Cytogenetic Map10D2UniSTS
Whitehead/MRC_RH101275.61UniSTS
AI452076  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810121,587,430 - 121,587,710UniSTSGRCm38
MGSCv3710121,024,486 - 121,024,766UniSTSGRCm37
Celera10123,970,680 - 123,970,960UniSTS
Cytogenetic Map10D2UniSTS
Cytogenetic Map10D3UniSTS
Whitehead/MRC_RH101275.61UniSTS
AI462036  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810121,546,658 - 121,546,896UniSTSGRCm38
MGSCv3710120,983,714 - 120,983,952UniSTSGRCm37
Celera10123,931,516 - 123,931,754UniSTS
Cytogenetic Map10D2UniSTS
Whitehead/MRC_RH101275.61UniSTS
Tbk1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10D2UniSTS
cM Map10 UniSTS
PMC314216P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810121,575,860 - 121,576,297UniSTSGRCm38
MGSCv3710121,012,916 - 121,013,353UniSTSGRCm37
Celera10123,960,315 - 123,960,752UniSTS
Cytogenetic Map10D2UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018383585125739363Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1019000000129800000Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039300000129800000Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039300000129800000Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059500000122500000Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1068000000125000000Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069900000132500000Mouse
11353832Pcholq4_mplasma cholesterol QTL 4 (mouse)1074151384125680038Mouse
11353843Gluq1_mblood glucose QTL 1 (mouse)1074151384125680038Mouse
1357779Tesq3_mtestis weight QTL 3 (mouse)Not determined1084243786122205623Mouse
4141479W10q8_mweight 10 weeks QTL 8 (mouse)Not determined84243786122205623Mouse
4141387Lgaq5_mlate growth adjusted QTL 5 (mouse)Not determined84243786122205623Mouse
4142496W6q8_mweight 6 weeks QTL 8 (mouse)Not determined84243786122205623Mouse
4142365Egq9_mearly growth QTL 9 (mouse)Not determined84243786122205623Mouse
1357594Estoq3_membryo survival total QTL 3 (mouse)Not determined1084243786122205623Mouse
1357622Espq3_membryo survival preimplantation QTL 3 (mouse)Not determined1084243786122205623Mouse
1300921Skl4_mskeletal size (tail length) 4 (mouse)Not determined1088252393122252530Mouse
4142386Tgq20_mtriglyceride QTL 20 (mouse)Not determined89000595123000595Mouse
1301758Fcsa3_mfemoral cross-sectional area 3 (mouse)Not determined1090091790124091893Mouse
11039516Ltpr5_mLeishmania tropica response 5 (mouse)1090671039125739363Mouse
4142461Bmd25_mbone mineral density 25 (mouse)Not determined1097381196130694993Mouse
1357544Vtbt10_mvertebral trabecular bone trait 10 (mouse)Not determined1097381196130694993Mouse
11533919Mvb4_mmodifier of vibrator 4 (mouse)397381196130694993Mouse
11533921Mvb2_mmodifier of vibrator 2 (mouse)1097381196130694993Mouse
12880413V125Dq9_mvitamin D active form serum level QTL 9 (mouse)1097700000130694993Mouse
4141402T2dm1sa_mtype 2 diabetes mellitus 1 in SMXA RI mice (mouse)Not determined97922739130694993Mouse
11040593Lmr5e_mleishmaniasis resistance 5e (mouse)1099384730130694993Mouse
11040595Lmr5c_mleishmaniasis resistance 5c (mouse)1099384730130694993Mouse
11040597Lmr5a_mleishmaniasis resistance 5a (mouse)1099384730130694993Mouse
1301968Estq4_mestradiol regulated response QTL 4 (mouse)Not determined10101150611130694993Mouse
1357744Cfbw4_mcystic fibrosis body weight 4 (mouse)Not determined10101150611130694993Mouse
1301901Im5_mimmunoregulatory 5 (mouse)Not determined10101661259130694993Mouse
4141361Cfmq3_mcystic fibrosis modifier QTL 3 (mouse)Not determined10101661259130694993Mouse
1300678Leg2_mlongevity extending gene 2 (mouse)Not determined10102671003130694993Mouse
27226725Tibw1_mtibia width 1, proximal, 5 week (mouse)10102900000123400000Mouse
1301895Exq1_mexploratory and excitability QTL 1 (mouse)Not determined10103011947130694993Mouse
14696727Kidrq2_mkidney weight, right QTL 2 (mouse)10103066603130694993Mouse
4141007Obrq10_mobesity resistance QTL 10 (mouse)Not determined103407822130694993Mouse
4141487Tgq21_mtriglyceride QTL 21 (mouse)Not determined104274116130694993Mouse
14746996Manh69_mmandible shape 69 (mouse)10104927733130694993Mouse
1357482Nhdlq4_mnon-HDL QTL 4 (mouse)Not determined10105205399130694993Mouse
1300679Nociq2_mnociceptive sensitivity inflammatory QTL 2 (mouse)Not determined10105205399130694993Mouse
1302200Sle12_msystematic lupus erythematosus susceptibility 12 (mouse)Not determined10105205399130694993Mouse
11040594Lmr5f_mleishmaniasis resistance 5f (mouse)10105343808130694993Mouse
11040596Lmr5d_mleishmaniasis resistance 5d (mouse)10105343808130694993Mouse
11040598Lmr5b_mleishmaniasis resistance 5b (mouse)10105343808130694993Mouse
4142089Obrq9_mobesity resistance QTL 9 (mouse)Not determined108680038130694993Mouse
4141153Ltgq2_mliver triglyceride QTL 2 (mouse)Not determined108680038130694993Mouse
11039496Ltpr5b_mLeishmania tropica response 5b (mouse)10108739225130694993Mouse
11041664Lmr25_mleishmaniasis resistance 25 (mouse)10108739225130694993Mouse
11049563Lmr25a_mleishmaniasis resistance 25a (mouse)10108739225130694993Mouse
11049570Lmr25b_mleishmaniasis resistance 25b (mouse)10108739225130694993Mouse
27226722Tibw7_mtibia width 7, proximal, 16 week (mouse)10108800000125600000Mouse
27095902Scvln11_msacral vertebrae length 2, 10 week (mouse)10110200000125600000Mouse
11353822Insq12_minsulin QTL 12 (mouse)10110617486125680038Mouse
11353823Homaq2_mhomeostatic model assessment QTL 2 (mouse)10110617486125680038Mouse
26884391Skwq11_mskull length QTL 11, 16 week (mouse)10113700000121800000Mouse
26884433Zlq2_mzygomatic length QTL 2, 5 week (mouse)10113700000125900000Mouse
26884383Bzwq3_mbi-zygomatic width QTL 3, 5 week (mouse)10114400000122900000Mouse
13506931Recrq11_mrecombination rate in male meiosis QTL 11 (mouse)10114500000123800000Mouse
26884377Skwq3_mskull length QTL 3, 5 week (mouse)10114800000122900000Mouse
1300796Lmr5_mleishmaniasis resistance 5 (mouse)Not determined10116384730122343923Mouse
27226742Metcl4_mmetatarsal-calcaneal length 4, 5 week (mouse)10118300000125600000Mouse
27226795Scvln17_msacral vertebrae length 2, 16 week (mouse)10118600000125000000Mouse
27226718Tibw3_mtibia width 3, proximal, 10 week (mouse)10119000000125600000Mouse
27095906Scvln5_msacral vertebrae length 2, 5 week (mouse)10119200000125000000Mouse
27226736Metcl15_mmetatarsal-calcaneal length 15, 16 week (mouse)10119200000125000000Mouse
27226747Metcl10_mmetatarsal-calcaneal length 10, 10 week (mouse)10119200000125000000Mouse
27095926Pglq4_mpelvic girdle length QTL 4, 5 week (mouse)10119200000125000000Mouse
26884443Sklq5_mskull length QTL 5, 5 week (mouse)10119200000125000000Mouse
27226784Tibl4_mtibia length 4, 5 week (mouse)10119200000125600000Mouse
27226791Feml8_mfemur length 8, 5 week (mouse)10119200000125900000Mouse
1301701Aggr1_maggression 1 (mouse)Not determined10119671003125739363Mouse
13801032Hwtf2_mheart weight by femur 2 (mouse)10120000000122000000Mouse
11353834Pcholq2_mplasma cholesterol QTL 2 (mouse)10120407822125680038Mouse
11353838Gluq3_mblood glucose QTL 3 (mouse)10120407822125680038Mouse
25394553Skmw68_mskeletal muscle weight 68, TA (mouse)10121540206122019225Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:189
Count of miRNA genes:161
Interacting mature miRNAs:180
Transcripts:ENSMUST00000020316
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000020316   ⟹   ENSMUSP00000020316
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10121,382,360 - 121,422,692 (-)Ensembl
GRCm38.p6 Ensembl10121,546,455 - 121,586,787 (-)Ensembl
RefSeq Acc Id: ENSMUST00000218460
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10121,398,077 - 121,400,003 (-)Ensembl
GRCm38.p6 Ensembl10121,562,172 - 121,564,098 (-)Ensembl
RefSeq Acc Id: ENSMUST00000219244
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10121,399,830 - 121,404,386 (-)Ensembl
GRCm38.p6 Ensembl10121,563,925 - 121,568,481 (-)Ensembl
RefSeq Acc Id: ENSMUST00000219400   ⟹   ENSMUSP00000151440
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10121,382,365 - 121,422,682 (-)Ensembl
GRCm38.p6 Ensembl10121,546,460 - 121,586,777 (-)Ensembl
RefSeq Acc Id: ENSMUST00000219439
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10121,386,985 - 121,388,354 (-)Ensembl
GRCm38.p6 Ensembl10121,551,080 - 121,552,449 (-)Ensembl
RefSeq Acc Id: ENSMUST00000219493   ⟹   ENSMUSP00000151935
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10121,407,806 - 121,422,646 (-)Ensembl
GRCm38.p6 Ensembl10121,571,901 - 121,586,741 (-)Ensembl
RefSeq Acc Id: ENSMUST00000220386
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10121,387,165 - 121,390,068 (-)Ensembl
GRCm38.p6 Ensembl10121,551,260 - 121,554,163 (-)Ensembl
RefSeq Acc Id: NM_019786   ⟹   NP_062760
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910121,382,360 - 121,422,699 (-)NCBI
GRCm3810121,546,455 - 121,586,794 (-)NCBI
MGSCv3710120,983,511 - 121,023,850 (-)RGD
Celera10123,931,313 - 123,970,044 (-)RGD
cM Map10 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_062760   ⟸   NM_019786
- UniProtKB: Q9WUN2 (UniProtKB/Swiss-Prot),   A1L361 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000020316   ⟸   ENSMUST00000020316
RefSeq Acc Id: ENSMUSP00000151440   ⟸   ENSMUST00000219400
RefSeq Acc Id: ENSMUSP00000151935   ⟸   ENSMUST00000219493
Protein Domains
Protein kinase   Ubiquitin-like

Promoters
RGD ID:6819994
Promoter ID:MM_KWN:5796
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_019786,   UC007HFU.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610121,023,721 - 121,024,772 (-)MPROMDB
RGD ID:8673402
Promoter ID:EPDNEW_M14732
Type:initiation region
Name:Tbk1_1
Description:Mus musculus TANK-binding kinase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3810121,586,758 - 121,586,818EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1929658 AgrOrtholog
Ensembl Genes ENSMUSG00000020115 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000020316 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000151440 UniProtKB/TrEMBL
  ENSMUSP00000151935 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000020316 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000219400 UniProtKB/TrEMBL
  ENSMUST00000219493 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TBK1_CCD1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TBK1_ULD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:56480 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1929658 ENTREZGENE
NCBI Gene 56480 ENTREZGENE
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TBK1_CCD1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TBK1_ULD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tbk1 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1W2P6W7_MOUSE UniProtKB/TrEMBL
  A0A1W2P835_MOUSE UniProtKB/TrEMBL
  A1L361 ENTREZGENE, UniProtKB/TrEMBL
  Q3THP3_MOUSE UniProtKB/TrEMBL
  Q9WUN2 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q9CT90 UniProtKB/Swiss-Prot
  Q9DC03 UniProtKB/Swiss-Prot