TBK1 (TANK binding kinase 1) - Rat Genome Database

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Gene: TBK1 (TANK binding kinase 1) Canis lupus familiaris
Analyze
Symbol: TBK1
Name: TANK binding kinase 1
RGD ID: 12170633
Description: ENCODES a protein that exhibits identical protein binding (ortholog); nucleic acid binding (ortholog); phosphoprotein binding (ortholog); INVOLVED IN activation of innate immune response (ortholog); defense response to Gram-positive bacterium (ortholog); dendritic cell proliferation (ortholog); PARTICIPATES IN Toll-like receptor signaling pathway; ASSOCIATED WITH ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), 8 (ortholog); frontotemporal dementia and/or amyotrophic lateral sclerosis-4 (ortholog); Glaucoma 1, Open Angle, P (ortholog); FOUND IN cytoplasm (ortholog); intracellular membrane-bounded organelle (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: serine/threonine-protein kinase TBK1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1107,169,664 - 7,208,890 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl107,168,007 - 7,208,899 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha107,102,668 - 7,144,367 (+)NCBI
ROS_Cfam_1.0107,276,927 - 7,318,803 (+)NCBI
UMICH_Zoey_3.1107,142,851 - 7,184,688 (+)NCBI
UNSW_CanFamBas_1.0107,395,493 - 7,437,313 (+)NCBI
UU_Cfam_GSD_1.0107,526,057 - 7,567,705 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
TBK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1107,169,664 - 7,208,890 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl107,168,007 - 7,208,899 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha107,102,668 - 7,144,367 (+)NCBI
ROS_Cfam_1.0107,276,927 - 7,318,803 (+)NCBI
UMICH_Zoey_3.1107,142,851 - 7,184,688 (+)NCBI
UNSW_CanFamBas_1.0107,395,493 - 7,437,313 (+)NCBI
UU_Cfam_GSD_1.0107,526,057 - 7,567,705 (+)NCBI
TBK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1264,452,090 - 64,502,114 (+)EnsemblGRCh38hg38GRCh38
GRCh381264,452,105 - 64,502,114 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371264,845,900 - 64,895,894 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361263,132,204 - 63,182,158 (+)NCBINCBI36hg18NCBI36
Build 341263,132,203 - 63,182,158NCBI
Celera1264,510,375 - 64,560,181 (+)NCBI
Cytogenetic Map12q14.2NCBI
HuRef1261,898,186 - 61,948,226 (+)NCBIHuRef
CHM1_11264,812,935 - 64,863,007 (+)NCBICHM1_1
Tbk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910121,382,360 - 121,422,699 (-)NCBIGRCm39mm39
GRCm39 Ensembl10121,382,360 - 121,422,692 (-)Ensembl
GRCm3810121,546,455 - 121,586,794 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10121,546,455 - 121,586,787 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710120,983,511 - 121,023,850 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610120,949,520 - 120,989,807 (-)NCBImm8
Celera10123,931,313 - 123,970,044 (-)NCBICelera
Cytogenetic Map10D2NCBI
Tbk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2757,077,830 - 57,110,868 (-)NCBI
Rnor_6.0 Ensembl763,655,247 - 63,687,978 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0763,655,247 - 63,687,978 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0763,877,567 - 63,910,298 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4760,863,099 - 60,896,131 (-)NCBIRGSC3.4rn4RGSC3.4
Celera753,819,361 - 53,852,262 (-)NCBICelera
Cytogenetic Map7q22NCBI
Tbk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545811,211,398 - 11,263,867 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545811,210,120 - 11,263,632 (+)NCBIChiLan1.0ChiLan1.0
TBK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11224,919,412 - 24,968,587 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1224,917,246 - 24,968,587 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01224,419,271 - 24,469,164 (-)NCBIMhudiblu_PPA_v0panPan3
Tbk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494551,300,898 - 51,346,375 (-)NCBI
SpeTri2.0NW_0049365452,763,755 - 2,809,229 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TBK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl528,828,568 - 28,929,964 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1528,880,210 - 28,929,964 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TBK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11160,136,162 - 60,182,354 (+)NCBI
ChlSab1.1 Ensembl1160,136,232 - 60,182,344 (+)Ensembl
Vero_WHO_p1.0NW_023666037185,623,292 - 185,669,524 (-)NCBI
Tbk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248023,861,821 - 3,914,061 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 3 19 3 6 3 6 4 12 10 6
Low 2 3 3 3 2 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022424156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022424157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022424158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038488016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038488017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038488018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038549910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038549911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038549912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038613887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038613888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038613889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038639796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038679237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038679238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038679239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000000555   ⟹   ENSCAFP00000000505
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl107,169,664 - 7,208,899 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000064997   ⟹   ENSCAFP00000049327
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl107,168,007 - 7,208,899 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000071096   ⟹   ENSCAFP00000044621
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl107,169,664 - 7,208,147 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000087225   ⟹   ENSCAFP00000053036
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl107,168,007 - 7,208,899 (+)Ensembl
RefSeq Acc Id: XM_022424156   ⟹   XP_022279864
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1107,169,665 - 7,208,890 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022424157   ⟹   XP_022279865
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1107,169,664 - 7,208,890 (+)NCBI
Dog10K_Boxer_Tasha107,109,324 - 7,143,643 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022424158   ⟹   XP_022279866
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1107,179,503 - 7,208,890 (+)NCBI
Dog10K_Boxer_Tasha107,115,015 - 7,143,643 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038488016   ⟹   XP_038343944
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1107,142,851 - 7,184,688 (+)NCBI
RefSeq Acc Id: XM_038488017   ⟹   XP_038343945
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1107,149,501 - 7,183,964 (+)NCBI
RefSeq Acc Id: XM_038488018   ⟹   XP_038343946
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1107,155,190 - 7,183,964 (+)NCBI
RefSeq Acc Id: XM_038549910   ⟹   XP_038405838
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0107,526,057 - 7,567,705 (+)NCBI
RefSeq Acc Id: XM_038549911   ⟹   XP_038405839
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0107,532,722 - 7,566,981 (+)NCBI
RefSeq Acc Id: XM_038549912   ⟹   XP_038405840
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0107,538,410 - 7,566,981 (+)NCBI
RefSeq Acc Id: XM_038613887   ⟹   XP_038469815
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0107,395,493 - 7,437,313 (+)NCBI
RefSeq Acc Id: XM_038613888   ⟹   XP_038469816
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0107,402,140 - 7,436,589 (+)NCBI
RefSeq Acc Id: XM_038613889   ⟹   XP_038469817
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0107,407,827 - 7,436,589 (+)NCBI
RefSeq Acc Id: XM_038639796   ⟹   XP_038495724
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha107,102,668 - 7,144,367 (+)NCBI
RefSeq Acc Id: XM_038679237   ⟹   XP_038535165
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0107,276,927 - 7,318,803 (+)NCBI
RefSeq Acc Id: XM_038679238   ⟹   XP_038535166
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0107,283,582 - 7,318,079 (+)NCBI
RefSeq Acc Id: XM_038679239   ⟹   XP_038535167
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0107,289,276 - 7,318,079 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_022279865   ⟸   XM_022424157
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_022279864   ⟸   XM_022424156
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_022279866   ⟸   XM_022424158
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSCAFP00000049327   ⟸   ENSCAFT00000064997
RefSeq Acc Id: ENSCAFP00000053036   ⟸   ENSCAFT00000087225
RefSeq Acc Id: ENSCAFP00000000505   ⟸   ENSCAFT00000000555
RefSeq Acc Id: ENSCAFP00000044621   ⟸   ENSCAFT00000071096
RefSeq Acc Id: XP_038343944   ⟸   XM_038488016
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038343945   ⟸   XM_038488017
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038343946   ⟸   XM_038488018
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038469815   ⟸   XM_038613887
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038469816   ⟸   XM_038613888
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038469817   ⟸   XM_038613889
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038535165   ⟸   XM_038679237
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038535166   ⟸   XM_038679238
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038535167   ⟸   XM_038679239
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038495724   ⟸   XM_038639796
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038405838   ⟸   XM_038549910
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038405839   ⟸   XM_038549911
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038405840   ⟸   XM_038549912
- Peptide Label: isoform X3
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000356 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000000505 ENTREZGENE
NCBI Gene TBK1 ENTREZGENE
VGNC ID VGNC:47160 ENTREZGENE