TBK1 (TANK binding kinase 1) - Rat Genome Database

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Gene: TBK1 (TANK binding kinase 1) Homo sapiens
Analyze
Symbol: TBK1
Name: TANK binding kinase 1
RGD ID: 1313752
HGNC Page HGNC
Description: Exhibits phosphoprotein binding activity and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of cellular metabolic process; positive regulation of type I interferon production; and protein phosphorylation. Localizes to cytoplasm and nucleoplasm. Implicated in brain disease and frontotemporal dementia and/or amyotrophic lateral sclerosis-4.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ11330; FTDALS4; IIAE8; NAK; NF-kappa-B-activating kinase; NF-kB-activating kinase; serine/threonine-protein kinase TBK1; T2K; TANK-binding kinase 1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1264,452,090 - 64,502,114 (+)EnsemblGRCh38hg38GRCh38
GRCh381264,452,105 - 64,502,114 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371264,845,900 - 64,895,894 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361263,132,204 - 63,182,158 (+)NCBINCBI36hg18NCBI36
Build 341263,132,203 - 63,182,158NCBI
Celera1264,510,375 - 64,560,181 (+)NCBI
Cytogenetic Map12q14.2NCBI
HuRef1261,898,186 - 61,948,226 (+)NCBIHuRef
CHM1_11264,812,935 - 64,863,007 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Abnormal lower motor neuron morphology  (IAGP)
Abnormal mitochondrial morphology  (IAGP)
Abnormal upper motor neuron morphology  (IAGP)
Adult onset  (IAGP)
Agitation  (IAGP)
Alcoholism  (IAGP)
Amyotrophic lateral sclerosis  (IAGP)
Anxiety  (IAGP)
Apathy  (IAGP)
Apraxia  (IAGP)
Autosomal dominant inheritance  (IAGP)
Babinski sign  (IAGP)
Bilateral sensorineural hearing impairment  (IAGP)
Bulbar palsy  (IAGP)
Cerebral cortical atrophy  (IAGP)
Cerebral edema  (IAGP)
Chills  (IAGP)
Coma  (IAGP)
Confusion  (IAGP)
CSF lymphocytic pleiocytosis  (IAGP)
Degeneration of the lateral corticospinal tracts  (IAGP)
Depressivity  (IAGP)
Disinhibition  (IAGP)
Distal muscle weakness  (IAGP)
Dysarthria  (IAGP)
Dyscalculia  (IAGP)
Dysphagia  (IAGP)
Dyspnea  (IAGP)
EEG abnormality  (IAGP)
Elevated C-reactive protein level  (IAGP)
Emotional lability  (IAGP)
Excessive daytime somnolence  (IAGP)
Fasciculations  (IAGP)
Fatigable weakness of respiratory muscles  (IAGP)
Fatigable weakness of swallowing muscles  (IAGP)
Fatigue  (IAGP)
Fever  (IAGP)
Focal aware seizure  (IAGP)
Focal impaired awareness seizure  (IAGP)
Frontotemporal dementia  (IAGP)
Functional motor deficit  (IAGP)
Generalized amyotrophy  (IAGP)
Generalized muscle weakness  (IAGP)
Gliosis  (IAGP)
Global brain atrophy  (IAGP)
Hallucinations  (IAGP)
Headache  (IAGP)
Hemiparesis  (IAGP)
Herpes simplex encephalitis  (IAGP)
Hyperreflexia  (IAGP)
Hypoglycorrhachia  (IAGP)
Hyponatremia  (IAGP)
Hyporeflexia  (IAGP)
Immunodeficiency  (IAGP)
Incomplete penetrance  (IAGP)
Increased CSF protein  (IAGP)
Language impairment  (IAGP)
Laryngospasm  (IAGP)
Lethargy  (IAGP)
Leukocytosis  (IAGP)
Loss of consciousness  (IAGP)
Meningitis  (IAGP)
Mental deterioration  (IAGP)
Muscle spasm  (IAGP)
Mutism  (IAGP)
Nausea and vomiting  (IAGP)
Neurodegeneration  (IAGP)
Neurological speech impairment  (IAGP)
Neuronal loss in the cerebral cortex  (IAGP)
Neutrophilia  (IAGP)
Nuchal rigidity  (IAGP)
Pain  (IAGP)
Paralysis  (IAGP)
Paraparesis  (IAGP)
Parkinsonism  (IAGP)
Perseveration  (IAGP)
Personality changes  (IAGP)
Progressive  (IAGP)
Progressive cerebellar ataxia  (IAGP)
Proximal muscle weakness  (IAGP)
Ptosis  (IAGP)
Respiratory failure  (IAGP)
Respiratory failure requiring assisted ventilation  (IAGP)
Seizure  (IAGP)
Skeletal muscle atrophy  (IAGP)
Spasticity  (IAGP)
Status epilepticus  (IAGP)
Supranuclear gaze palsy  (IAGP)
Tetraparesis  (IAGP)
Xerostomia  (IAGP)
References

Additional References at PubMed
PMID:7706279   PMID:8601309   PMID:9721103   PMID:10581243   PMID:10783893   PMID:10990461   PMID:11839743   PMID:12133833   PMID:12477932   PMID:12568715   PMID:12692549   PMID:12702806  
PMID:12761501   PMID:14530355   PMID:14560022   PMID:14702039   PMID:14743216   PMID:15276183   PMID:15367631   PMID:15485837   PMID:15489227   PMID:15489334   PMID:15556946   PMID:15619605  
PMID:15661910   PMID:15695821   PMID:15841462   PMID:16051665   PMID:16127453   PMID:16153868   PMID:16155125   PMID:16223731   PMID:16281057   PMID:16306936   PMID:16344560   PMID:16380379  
PMID:16393995   PMID:16394098   PMID:16537515   PMID:16887178   PMID:16888014   PMID:16914100   PMID:16973572   PMID:17018283   PMID:17327220   PMID:17526488   PMID:17568778   PMID:17599067  
PMID:17823124   PMID:17991829   PMID:18307994   PMID:18353649   PMID:18508731   PMID:18583960   PMID:18614628   PMID:18636086   PMID:18724357   PMID:18977754   PMID:19017982   PMID:19153231  
PMID:19160540   PMID:19307177   PMID:19380580   PMID:19380831   PMID:19416887   PMID:19419966   PMID:19433799   PMID:19615732   PMID:19656901   PMID:19820708   PMID:19847166   PMID:19953087  
PMID:19955181   PMID:19958770   PMID:20098747   PMID:20174559   PMID:20301623   PMID:20304918   PMID:20331378   PMID:20449947   PMID:20462248   PMID:20562859   PMID:20588308   PMID:20628368  
PMID:20804422   PMID:21042276   PMID:21048031   PMID:21074459   PMID:21106850   PMID:21204785   PMID:21270402   PMID:21332394   PMID:21364999   PMID:21447600   PMID:21464307   PMID:21492457  
PMID:21617041   PMID:21813773   PMID:21832049   PMID:21868362   PMID:21873635   PMID:21885437   PMID:21903422   PMID:21911421   PMID:21931555   PMID:21931631   PMID:21939555   PMID:21988832  
PMID:22000020   PMID:22072751   PMID:22079989   PMID:22127978   PMID:22261722   PMID:22305495   PMID:22306015   PMID:22330071   PMID:22388039   PMID:22394562   PMID:22412986   PMID:22610919  
PMID:22619329   PMID:22745133   PMID:22787218   PMID:22792062   PMID:22851595   PMID:22851696   PMID:22908223   PMID:22939624   PMID:22945920   PMID:23007157   PMID:23028469   PMID:23096996  
PMID:23157677   PMID:23209807   PMID:23286385   PMID:23308279   PMID:23395611   PMID:23395801   PMID:23414517   PMID:23421332   PMID:23453972   PMID:23542348   PMID:23649622   PMID:23675467  
PMID:23717208   PMID:23836654   PMID:23950712   PMID:23962979   PMID:23979707   PMID:23986588   PMID:24027431   PMID:24056301   PMID:24062311   PMID:24255178   PMID:24335286   PMID:24349538  
PMID:24379373   PMID:24449872   PMID:24468793   PMID:24488098   PMID:24509444   PMID:24549848   PMID:24560620   PMID:24622840   PMID:24643253   PMID:24696485   PMID:24699864   PMID:24706939  
PMID:24711643   PMID:24722368   PMID:24763515   PMID:24797263   PMID:24807708   PMID:24872591   PMID:24962318   PMID:25070846   PMID:25142606   PMID:25281560   PMID:25284765   PMID:25297994  
PMID:25409927   PMID:25531185   PMID:25606824   PMID:25636800   PMID:25659891   PMID:25700176   PMID:25736436   PMID:25780039   PMID:25803835   PMID:25815785   PMID:25855743   PMID:25921289  
PMID:25923723   PMID:25939384   PMID:25943890   PMID:25963833   PMID:25972374   PMID:25996949   PMID:26082489   PMID:26186194   PMID:26186972   PMID:26350399   PMID:26365381   PMID:26407194  
PMID:26476236   PMID:26581300   PMID:26611359   PMID:26638075   PMID:26656453   PMID:26673895   PMID:26674655   PMID:26804609   PMID:26915459   PMID:26928339   PMID:26972000   PMID:26976762  
PMID:27035970   PMID:27086836   PMID:27094905   PMID:27103069   PMID:27123832   PMID:27135603   PMID:27145266   PMID:27156075   PMID:27173435   PMID:27211305   PMID:27234299   PMID:27247382  
PMID:27260353   PMID:27307491   PMID:27350692   PMID:27355837   PMID:27370208   PMID:27538435   PMID:27545878   PMID:27568284   PMID:27570907   PMID:27609421   PMID:27620379   PMID:27684187  
PMID:27705791   PMID:27776110   PMID:27810922   PMID:27881886   PMID:27892983   PMID:27939697   PMID:28008748   PMID:28011935   PMID:28025332   PMID:28049150   PMID:28119118   PMID:28159912  
PMID:28188292   PMID:28282485   PMID:28346439   PMID:28365590   PMID:28487378   PMID:28514442   PMID:28611215   PMID:28716898   PMID:28718761   PMID:28747347   PMID:28763789   PMID:28822984  
PMID:28848048   PMID:28871090   PMID:28877469   PMID:28954889   PMID:28984711   PMID:29103041   PMID:29125880   PMID:29137817   PMID:29138248   PMID:29146049   PMID:29251827   PMID:29349657  
PMID:29394115   PMID:29395067   PMID:29398122   PMID:29509190   PMID:29559975   PMID:29653159   PMID:29667579   PMID:29673738   PMID:29676528   PMID:29688809   PMID:29743353   PMID:29743370  
PMID:29755980   PMID:29797567   PMID:29886477   PMID:29899553   PMID:29903906   PMID:29920243   PMID:30021902   PMID:30033073   PMID:30082428   PMID:30183071   PMID:30196251   PMID:30196744  
PMID:30267576   PMID:30296527   PMID:30309841   PMID:30327196   PMID:30349097   PMID:30354798   PMID:30397336   PMID:30404831   PMID:30420664   PMID:30504235   PMID:30530224   PMID:30561431  
PMID:30627666   PMID:30672142   PMID:30737378   PMID:30769920   PMID:30827897   PMID:30842653   PMID:30853401   PMID:30912981   PMID:30943264   PMID:30948266   PMID:30995277   PMID:31073040  
PMID:31091453   PMID:31113902   PMID:31114588   PMID:31118511   PMID:31189704   PMID:31235549   PMID:31256920   PMID:31362587   PMID:31404116   PMID:31462741   PMID:31498468   PMID:31509299  
PMID:31511519   PMID:31534043   PMID:31577952   PMID:31617661   PMID:31662325   PMID:31709703   PMID:31723608   PMID:31732153   PMID:31748271   PMID:31753913   PMID:31792381   PMID:31818880  
PMID:31987900   PMID:32034138   PMID:32041822   PMID:32079994   PMID:32129710   PMID:32159970   PMID:32238587   PMID:32241891   PMID:32268090   PMID:32298923   PMID:32324863   PMID:32353859  
PMID:32366851   PMID:32413959   PMID:32757223   PMID:32814047   PMID:32838362   PMID:32858764   PMID:32979938   PMID:33060197   PMID:33168920   PMID:33171123   PMID:33372174   PMID:33411856  
PMID:33692778   PMID:33767151  


Genomics

Comparative Map Data
TBK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1264,452,090 - 64,502,114 (+)EnsemblGRCh38hg38GRCh38
GRCh381264,452,105 - 64,502,114 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371264,845,900 - 64,895,894 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361263,132,204 - 63,182,158 (+)NCBINCBI36hg18NCBI36
Build 341263,132,203 - 63,182,158NCBI
Celera1264,510,375 - 64,560,181 (+)NCBI
Cytogenetic Map12q14.2NCBI
HuRef1261,898,186 - 61,948,226 (+)NCBIHuRef
CHM1_11264,812,935 - 64,863,007 (+)NCBICHM1_1
Tbk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910121,382,360 - 121,422,699 (-)NCBIGRCm39mm39
GRCm39 Ensembl10121,382,360 - 121,422,692 (-)Ensembl
GRCm3810121,546,455 - 121,586,794 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10121,546,455 - 121,586,787 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710120,983,511 - 121,023,850 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610120,949,520 - 120,989,807 (-)NCBImm8
Celera10123,931,313 - 123,970,044 (-)NCBICelera
Cytogenetic Map10D2NCBI
Tbk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2757,077,830 - 57,110,868 (-)NCBI
Rnor_6.0 Ensembl763,655,247 - 63,687,978 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0763,655,247 - 63,687,978 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0763,877,567 - 63,910,298 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4760,863,099 - 60,896,131 (-)NCBIRGSC3.4rn4RGSC3.4
Celera753,819,361 - 53,852,262 (-)NCBICelera
Cytogenetic Map7q22NCBI
Tbk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545811,211,398 - 11,263,867 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545811,210,120 - 11,263,632 (+)NCBIChiLan1.0ChiLan1.0
TBK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11224,919,412 - 24,968,587 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1224,917,246 - 24,968,587 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01224,419,271 - 24,469,164 (-)NCBIMhudiblu_PPA_v0panPan3
TBK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1107,169,664 - 7,208,890 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl107,168,007 - 7,208,899 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha107,102,668 - 7,144,367 (+)NCBI
ROS_Cfam_1.0107,276,927 - 7,318,803 (+)NCBI
UMICH_Zoey_3.1107,142,851 - 7,184,688 (+)NCBI
UNSW_CanFamBas_1.0107,395,493 - 7,437,313 (+)NCBI
UU_Cfam_GSD_1.0107,526,057 - 7,567,705 (+)NCBI
Tbk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494551,300,898 - 51,346,375 (-)NCBI
SpeTri2.0NW_0049365452,763,755 - 2,809,229 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TBK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl528,828,568 - 28,929,964 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1528,880,210 - 28,929,964 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TBK1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11160,136,162 - 60,182,354 (+)NCBI
ChlSab1.1 Ensembl1160,136,232 - 60,182,344 (+)Ensembl
Vero_WHO_p1.0NW_023666037185,623,292 - 185,669,524 (-)NCBI
Tbk1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248023,861,821 - 3,914,061 (-)NCBI

Position Markers
RH77769  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371264,895,605 - 64,895,704UniSTSGRCh37
Build 361263,181,872 - 63,181,971RGDNCBI36
Celera1264,559,896 - 64,559,995RGD
Cytogenetic Map12q14.1UniSTS
HuRef1261,947,934 - 61,948,033UniSTS
GeneMap99-GB4 RH Map12277.77UniSTS
RH15751  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371264,895,590 - 64,895,777UniSTSGRCh37
Build 361263,181,857 - 63,182,044RGDNCBI36
Celera1264,559,881 - 64,560,068RGD
Cytogenetic Map12q14.1UniSTS
HuRef1261,947,919 - 61,948,106UniSTS
GeneMap99-GB4 RH Map12288.19UniSTS
TBK1_1450  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371264,895,110 - 64,895,818UniSTSGRCh37
Build 361263,181,377 - 63,182,085RGDNCBI36
Celera1264,559,401 - 64,560,109RGD
HuRef1261,947,439 - 61,948,147UniSTS
WI-20972  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371264,844,631 - 64,844,836UniSTSGRCh37
Build 361263,130,898 - 63,131,103RGDNCBI36
Celera1264,509,069 - 64,509,274RGD
Cytogenetic Map12q14.1UniSTS
HuRef1261,896,977 - 61,897,182UniSTS
GeneMap99-GB4 RH Map12292.52UniSTS
Whitehead-RH Map12378.2UniSTS
D5S2649  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371349,837,939 - 49,838,075UniSTSGRCh37
GRCh371264,844,722 - 64,844,858UniSTSGRCh37
Build 361263,130,989 - 63,131,125RGDNCBI36
Celera1330,893,824 - 30,893,960UniSTS
Celera1264,509,160 - 64,509,296RGD
Cytogenetic Map12q14.1UniSTS
Cytogenetic Map13q14.2UniSTS
HuRef1330,631,747 - 30,631,883UniSTS
HuRef1261,897,068 - 61,897,204UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR200Chsa-miR-200c-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22991189
MIR221hsa-miR-221-3pMirtarbaseexternal_infoReporter assay;Western blot;MicroarrayFunctional MTI20018759

Predicted Target Of
Summary Value
Count of predictions:636
Count of miRNA genes:436
Interacting mature miRNAs:473
Transcripts:ENST00000331710, ENST00000536906, ENST00000538890, ENST00000539810, ENST00000540417, ENST00000541805, ENST00000545025, ENST00000545392
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2320 1798 1517 423 1462 276 4087 1597 2520 305 1420 1600 161 1197 2566 4
Low 113 1186 206 199 486 188 268 596 1188 113 29 8 10 7 222
Below cutoff 1 3 1 1 2 1 1 12 1 1 2 4 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_046906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_013254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005268809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005268810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001748674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA970899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC135279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC136977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF174536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF191838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW275367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC034950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA788357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT585079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000331710   ⟹   ENSP00000329967
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,452,120 - 64,502,114 (+)Ensembl
RefSeq Acc Id: ENST00000536906
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,484,407 - 64,488,586 (+)Ensembl
RefSeq Acc Id: ENST00000538890   ⟹   ENSP00000445834
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,452,190 - 64,464,415 (+)Ensembl
RefSeq Acc Id: ENST00000539810   ⟹   ENSP00000444428
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,452,475 - 64,464,406 (+)Ensembl
RefSeq Acc Id: ENST00000540417   ⟹   ENSP00000445628
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,452,451 - 64,464,399 (+)Ensembl
RefSeq Acc Id: ENST00000541805
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,495,368 - 64,495,931 (+)Ensembl
RefSeq Acc Id: ENST00000545025
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,484,041 - 64,485,486 (+)Ensembl
RefSeq Acc Id: ENST00000545392
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,497,014 - 64,497,921 (+)Ensembl
RefSeq Acc Id: ENST00000650708   ⟹   ENSP00000498667
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,460,226 - 64,501,905 (+)Ensembl
RefSeq Acc Id: ENST00000650762   ⟹   ENSP00000498758
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,452,131 - 64,501,741 (+)Ensembl
RefSeq Acc Id: ENST00000650786   ⟹   ENSP00000498280
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,452,138 - 64,502,086 (+)Ensembl
RefSeq Acc Id: ENST00000650790   ⟹   ENSP00000498995
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,452,101 - 64,502,055 (+)Ensembl
RefSeq Acc Id: ENST00000650997   ⟹   ENSP00000498341
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,452,120 - 64,502,056 (+)Ensembl
RefSeq Acc Id: ENST00000651014   ⟹   ENSP00000498885
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,452,142 - 64,502,049 (+)Ensembl
RefSeq Acc Id: ENST00000651262   ⟹   ENSP00000498461
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,452,120 - 64,502,071 (+)Ensembl
RefSeq Acc Id: ENST00000651878   ⟹   ENSP00000499077
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,452,340 - 64,502,048 (+)Ensembl
RefSeq Acc Id: ENST00000651889
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,464,355 - 64,490,452 (+)Ensembl
RefSeq Acc Id: ENST00000651947
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,452,131 - 64,490,376 (+)Ensembl
RefSeq Acc Id: ENST00000652389   ⟹   ENSP00000498414
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,452,117 - 64,494,037 (+)Ensembl
RefSeq Acc Id: ENST00000652537   ⟹   ENSP00000499102
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,452,092 - 64,502,048 (+)Ensembl
RefSeq Acc Id: ENST00000652657   ⟹   ENSP00000498887
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,452,112 - 64,502,100 (+)Ensembl
RefSeq Acc Id: ENST00000676469   ⟹   ENSP00000503155
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,455,840 - 64,464,463 (+)Ensembl
RefSeq Acc Id: ENST00000676490   ⟹   ENSP00000503569
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,484,303 - 64,490,119 (+)Ensembl
RefSeq Acc Id: ENST00000676521   ⟹   ENSP00000503000
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,495,483 - 64,497,259 (+)Ensembl
RefSeq Acc Id: ENST00000676539   ⟹   ENSP00000504315
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,485,455 - 64,490,119 (+)Ensembl
RefSeq Acc Id: ENST00000676551
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,452,120 - 64,490,830 (+)Ensembl
RefSeq Acc Id: ENST00000676587   ⟹   ENSP00000504858
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,490,041 - 64,502,114 (+)Ensembl
RefSeq Acc Id: ENST00000676593   ⟹   ENSP00000503458
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,497,968 - 64,502,056 (+)Ensembl
RefSeq Acc Id: ENST00000676654
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,452,090 - 64,502,053 (+)Ensembl
RefSeq Acc Id: ENST00000676684
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,452,090 - 64,502,100 (+)Ensembl
RefSeq Acc Id: ENST00000676774
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,485,823 - 64,490,903 (+)Ensembl
RefSeq Acc Id: ENST00000676809   ⟹   ENSP00000504298
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,452,094 - 64,502,114 (+)Ensembl
RefSeq Acc Id: ENST00000676901
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,463,066 - 64,464,463 (+)Ensembl
RefSeq Acc Id: ENST00000676912   ⟹   ENSP00000503567
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,452,114 - 64,502,100 (+)Ensembl
RefSeq Acc Id: ENST00000676930   ⟹   ENSP00000502899
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,452,131 - 64,502,100 (+)Ensembl
RefSeq Acc Id: ENST00000676983   ⟹   ENSP00000503561
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,480,012 - 64,484,499 (+)Ensembl
RefSeq Acc Id: ENST00000677016   ⟹   ENSP00000504578
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,466,901 - 64,474,390 (+)Ensembl
RefSeq Acc Id: ENST00000677112   ⟹   ENSP00000504208
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,466,901 - 64,474,390 (+)Ensembl
RefSeq Acc Id: ENST00000677242
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,473,925 - 64,474,390 (+)Ensembl
RefSeq Acc Id: ENST00000677313   ⟹   ENSP00000503363
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,497,968 - 64,502,056 (+)Ensembl
RefSeq Acc Id: ENST00000677435   ⟹   ENSP00000504836
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,488,487 - 64,495,775 (+)Ensembl
RefSeq Acc Id: ENST00000677499   ⟹   ENSP00000502875
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,452,090 - 64,502,066 (+)Ensembl
RefSeq Acc Id: ENST00000677545   ⟹   ENSP00000504729
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,452,120 - 64,460,329 (+)Ensembl
RefSeq Acc Id: ENST00000677549
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,452,157 - 64,485,235 (+)Ensembl
RefSeq Acc Id: ENST00000677632   ⟹   ENSP00000504586
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,452,120 - 64,502,066 (+)Ensembl
RefSeq Acc Id: ENST00000677641   ⟹   ENSP00000504637
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,452,090 - 64,502,066 (+)Ensembl
RefSeq Acc Id: ENST00000677670
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,481,842 - 64,483,010 (+)Ensembl
RefSeq Acc Id: ENST00000677686
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,452,116 - 64,502,066 (+)Ensembl
RefSeq Acc Id: ENST00000677714
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,490,627 - 64,492,613 (+)Ensembl
RefSeq Acc Id: ENST00000677759   ⟹   ENSP00000503847
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,464,334 - 64,474,390 (+)Ensembl
RefSeq Acc Id: ENST00000677831   ⟹   ENSP00000503760
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,452,140 - 64,502,066 (+)Ensembl
RefSeq Acc Id: ENST00000677858   ⟹   ENSP00000502994
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,481,842 - 64,485,513 (+)Ensembl
RefSeq Acc Id: ENST00000677973   ⟹   ENSP00000503248
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,466,901 - 64,482,021 (+)Ensembl
RefSeq Acc Id: ENST00000678079   ⟹   ENSP00000503613
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,464,334 - 64,467,082 (+)Ensembl
RefSeq Acc Id: ENST00000678125   ⟹   ENSP00000504253
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,495,699 - 64,496,406 (+)Ensembl
RefSeq Acc Id: ENST00000678180   ⟹   ENSP00000504132
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,452,123 - 64,502,066 (+)Ensembl
RefSeq Acc Id: ENST00000678197
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,460,118 - 64,502,114 (+)Ensembl
RefSeq Acc Id: ENST00000678235
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,481,842 - 64,483,010 (+)Ensembl
RefSeq Acc Id: ENST00000678368   ⟹   ENSP00000504296
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,452,475 - 64,455,957 (+)Ensembl
RefSeq Acc Id: ENST00000678430
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,452,120 - 64,465,267 (+)Ensembl
RefSeq Acc Id: ENST00000678567   ⟹   ENSP00000504755
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,490,041 - 64,497,259 (+)Ensembl
RefSeq Acc Id: ENST00000678582   ⟹   ENSP00000504002
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,485,926 - 64,488,588 (+)Ensembl
RefSeq Acc Id: ENST00000678718   ⟹   ENSP00000504038
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,474,230 - 64,480,122 (+)Ensembl
RefSeq Acc Id: ENST00000678738   ⟹   ENSP00000503263
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,466,901 - 64,474,390 (+)Ensembl
RefSeq Acc Id: ENST00000678808   ⟹   ENSP00000503260
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,466,901 - 64,474,390 (+)Ensembl
RefSeq Acc Id: ENST00000678992
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,500,830 - 64,502,055 (+)Ensembl
RefSeq Acc Id: ENST00000678996   ⟹   ENSP00000503169
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,495,483 - 64,496,406 (+)Ensembl
RefSeq Acc Id: ENST00000679010
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,487,965 - 64,490,373 (+)Ensembl
RefSeq Acc Id: ENST00000679050   ⟹   ENSP00000503595
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,460,189 - 64,467,082 (+)Ensembl
RefSeq Acc Id: ENST00000679065
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,452,129 - 64,456,855 (+)Ensembl
RefSeq Acc Id: ENST00000679302   ⟹   ENSP00000503553
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1264,464,334 - 64,474,390 (+)Ensembl
RefSeq Acc Id: NM_013254   ⟹   NP_037386
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381264,452,120 - 64,502,114 (+)NCBI
GRCh371264,845,840 - 64,895,899 (+)ENTREZGENE
Build 361263,132,204 - 63,182,158 (+)NCBI Archive
HuRef1261,898,186 - 61,948,226 (+)ENTREZGENE
CHM1_11264,812,935 - 64,863,007 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005268809   ⟹   XP_005268866
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381264,452,190 - 64,502,114 (+)NCBI
GRCh371264,845,840 - 64,895,899 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005268810   ⟹   XP_005268867
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381264,452,451 - 64,502,114 (+)NCBI
GRCh371264,845,840 - 64,895,899 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001748674
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381264,452,105 - 64,502,114 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_037386   ⟸   NM_013254
- UniProtKB: Q9UHD2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005268866   ⟸   XM_005268809
- Peptide Label: isoform X1
- UniProtKB: Q9UHD2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005268867   ⟸   XM_005268810
- Peptide Label: isoform X1
- UniProtKB: Q9UHD2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000329967   ⟸   ENST00000331710
RefSeq Acc Id: ENSP00000498341   ⟸   ENST00000650997
RefSeq Acc Id: ENSP00000498667   ⟸   ENST00000650708
RefSeq Acc Id: ENSP00000498280   ⟸   ENST00000650786
RefSeq Acc Id: ENSP00000498995   ⟸   ENST00000650790
RefSeq Acc Id: ENSP00000498758   ⟸   ENST00000650762
RefSeq Acc Id: ENSP00000499077   ⟸   ENST00000651878
RefSeq Acc Id: ENSP00000498461   ⟸   ENST00000651262
RefSeq Acc Id: ENSP00000498885   ⟸   ENST00000651014
RefSeq Acc Id: ENSP00000498887   ⟸   ENST00000652657
RefSeq Acc Id: ENSP00000499102   ⟸   ENST00000652537
RefSeq Acc Id: ENSP00000498414   ⟸   ENST00000652389
RefSeq Acc Id: ENSP00000445834   ⟸   ENST00000538890
RefSeq Acc Id: ENSP00000444428   ⟸   ENST00000539810
RefSeq Acc Id: ENSP00000445628   ⟸   ENST00000540417
RefSeq Acc Id: ENSP00000503561   ⟸   ENST00000676983
RefSeq Acc Id: ENSP00000503567   ⟸   ENST00000676912
RefSeq Acc Id: ENSP00000502899   ⟸   ENST00000676930
RefSeq Acc Id: ENSP00000504298   ⟸   ENST00000676809
RefSeq Acc Id: ENSP00000503000   ⟸   ENST00000676521
RefSeq Acc Id: ENSP00000504315   ⟸   ENST00000676539
RefSeq Acc Id: ENSP00000503458   ⟸   ENST00000676593
RefSeq Acc Id: ENSP00000504858   ⟸   ENST00000676587
RefSeq Acc Id: ENSP00000503569   ⟸   ENST00000676490
RefSeq Acc Id: ENSP00000503155   ⟸   ENST00000676469
RefSeq Acc Id: ENSP00000504208   ⟸   ENST00000677112
RefSeq Acc Id: ENSP00000504578   ⟸   ENST00000677016
RefSeq Acc Id: ENSP00000504729   ⟸   ENST00000677545
RefSeq Acc Id: ENSP00000502875   ⟸   ENST00000677499
RefSeq Acc Id: ENSP00000504836   ⟸   ENST00000677435
RefSeq Acc Id: ENSP00000503363   ⟸   ENST00000677313
RefSeq Acc Id: ENSP00000503248   ⟸   ENST00000677973
RefSeq Acc Id: ENSP00000502994   ⟸   ENST00000677858
RefSeq Acc Id: ENSP00000503760   ⟸   ENST00000677831
RefSeq Acc Id: ENSP00000503847   ⟸   ENST00000677759
RefSeq Acc Id: ENSP00000504586   ⟸   ENST00000677632
RefSeq Acc Id: ENSP00000504637   ⟸   ENST00000677641
RefSeq Acc Id: ENSP00000503613   ⟸   ENST00000678079
RefSeq Acc Id: ENSP00000504296   ⟸   ENST00000678368
RefSeq Acc Id: ENSP00000504253   ⟸   ENST00000678125
RefSeq Acc Id: ENSP00000504132   ⟸   ENST00000678180
RefSeq Acc Id: ENSP00000503260   ⟸   ENST00000678808
RefSeq Acc Id: ENSP00000504038   ⟸   ENST00000678718
RefSeq Acc Id: ENSP00000503263   ⟸   ENST00000678738
RefSeq Acc Id: ENSP00000504002   ⟸   ENST00000678582
RefSeq Acc Id: ENSP00000504755   ⟸   ENST00000678567
RefSeq Acc Id: ENSP00000503169   ⟸   ENST00000678996
RefSeq Acc Id: ENSP00000503553   ⟸   ENST00000679302
RefSeq Acc Id: ENSP00000503595   ⟸   ENST00000679050
Protein Domains
Protein kinase   Ubiquitin-like

Promoters
RGD ID:6790534
Promoter ID:HG_KWN:16060
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_013254
Position:
Human AssemblyChrPosition (strand)Source
Build 361263,131,346 - 63,132,457 (+)MPROMDB
RGD ID:7224675
Promoter ID:EPDNEW_H18083
Type:initiation region
Name:TBK1_2
Description:TANK binding kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H18084  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381264,451,916 - 64,451,976EPDNEW
RGD ID:7224677
Promoter ID:EPDNEW_H18084
Type:initiation region
Name:TBK1_1
Description:TANK binding kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H18083  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381264,452,138 - 64,452,198EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_013254.4(TBK1):c.1341-3del deletion Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000554302] Chr12:64488478 [GRCh38]
Chr12:64882258 [GRCh37]
Chr12:12q14.2
benign
NM_013254.4(TBK1):c.40A>G (p.Ile14Val) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000546706] Chr12:64455910 [GRCh38]
Chr12:64849690 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.66T>C (p.Asn22=) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000530892]|Glaucoma 1, open angle, p [RCV000625497] Chr12:64455936 [GRCh38]
Chr12:64849716 [GRCh37]
Chr12:12q14.2
benign|likely benign
GRCh38/hg38 12q14.2-15(chr12:64368308-69123358)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052815]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052815]|See cases [RCV000052815] Chr12:64368308..69123358 [GRCh38]
Chr12:64762088..69517138 [GRCh37]
Chr12:63048355..67803405 [NCBI36]
Chr12:12q14.2-15
pathogenic
NM_013254.3(TBK1):c.1486G>A (p.Gly496Ser) single nucleotide variant Malignant melanoma [RCV000070158] Chr12:64490084 [GRCh38]
Chr12:64883864 [GRCh37]
Chr12:63170131 [NCBI36]
Chr12:12q14.2
not provided
NM_013254.3(TBK1):c.1521+1923G>C single nucleotide variant Lung cancer [RCV000111201] Chr12:64492042 [GRCh38]
Chr12:64885822 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.1340+1G>A single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000185599] Chr12:64486018 [GRCh38]
Chr12:64879798 [GRCh37]
Chr12:12q14.2
pathogenic
NM_013254.4(TBK1):c.958del (p.Thr320fs) deletion Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000185598] Chr12:64481987 [GRCh38]
Chr12:64875767 [GRCh37]
Chr12:12q14.2
pathogenic
NM_013254.4(TBK1):c.2138+2T>C single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000185597] Chr12:64498041 [GRCh38]
Chr12:64891821 [GRCh37]
Chr12:12q14.2
pathogenic
NM_013254.4(TBK1):c.1436_1437del (p.Val479fs) microsatellite Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000185596] Chr12:64488580..64488581 [GRCh38]
Chr12:64882360..64882361 [GRCh37]
Chr12:12q14.2
pathogenic|likely pathogenic
NM_013254.4(TBK1):c.1349_1352del (p.Ile450fs) microsatellite Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000185595] Chr12:64488489..64488492 [GRCh38]
Chr12:64882269..64882272 [GRCh37]
Chr12:12q14.2
pathogenic
GRCh38/hg38 12q14.1-14.3(chr12:60907151-66568077)x1 copy number loss See cases [RCV000138985] Chr12:60907151..66568077 [GRCh38]
Chr12:61300932..66961857 [GRCh37]
Chr12:59587199..65248124 [NCBI36]
Chr12:12q14.1-14.3
pathogenic
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33
pathogenic
NM_013254.4(TBK1):c.2086G>A (p.Glu696Lys) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000185600] Chr12:64497987 [GRCh38]
Chr12:64891767 [GRCh37]
Chr12:12q14.2
pathogenic
NM_013254.4(TBK1):c.1201A>G (p.Lys401Glu) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000185601] Chr12:64485466 [GRCh38]
Chr12:64879246 [GRCh37]
Chr12:12q14.2
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic|likely pathogenic
NM_013254.4(TBK1):c.1110C>T (p.Phe370=) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000524582] Chr12:64484420 [GRCh38]
Chr12:64878200 [GRCh37]
Chr12:12q14.2
benign
NM_013254.4(TBK1):c.2107G>T (p.Glu703Ter) single nucleotide variant Primary progressive non fluent aphasia [RCV000768401] Chr12:64498008 [GRCh38]
Chr12:64891788 [GRCh37]
Chr12:12q14.2
likely pathogenic
NM_013254.4(TBK1):c.964C>T (p.His322Tyr) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000545768]|not specified [RCV000238938] Chr12:64481993 [GRCh38]
Chr12:64875773 [GRCh37]
Chr12:12q14.2
likely benign|uncertain significance
NM_013254.4(TBK1):c.519G>A (p.Leu173=) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000552474] Chr12:64467061 [GRCh38]
Chr12:64860841 [GRCh37]
Chr12:12q14.2
benign
NM_013254.4(TBK1):c.476G>C (p.Gly159Ala) single nucleotide variant Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 8 [RCV000589574] Chr12:64467018 [GRCh38]
Chr12:64860798 [GRCh37]
Chr12:12q14.2
risk factor
NM_013254.4(TBK1):c.871A>G (p.Lys291Glu) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV001043489]|not provided [RCV000487810] Chr12:64481900 [GRCh38]
Chr12:64875680 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.813-12A>G single nucleotide variant not provided [RCV000578578] Chr12:64481830 [GRCh38]
Chr12:64875610 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.379C>T (p.Arg127Ter) single nucleotide variant not provided [RCV000488316] Chr12:64466921 [GRCh38]
Chr12:64860701 [GRCh37]
Chr12:12q14.2
likely pathogenic
NM_013254.4(TBK1):c.1960-10G>T single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000553403]|Glaucoma 1, open angle, p [RCV000625326] Chr12:64497638 [GRCh38]
Chr12:64891418 [GRCh37]
Chr12:12q14.2
benign|likely benign
NM_013254.4(TBK1):c.149A>C (p.Asp50Ala) single nucleotide variant Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 8 [RCV000586295] Chr12:64460250 [GRCh38]
Chr12:64854030 [GRCh37]
Chr12:12q14.2
risk factor
NM_013254.4(TBK1):c.1391T>C (p.Val464Ala) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000528199]|Glaucoma 1, open angle, p [RCV000625059] Chr12:64488537 [GRCh38]
Chr12:64882317 [GRCh37]
Chr12:12q14.2
benign|conflicting interpretations of pathogenicity
NM_013254.4(TBK1):c.358+9_358+12del microsatellite Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000531831] Chr12:64464467..64464470 [GRCh38]
Chr12:64858247..64858250 [GRCh37]
Chr12:12q14.2
likely benign
NM_013254.4(TBK1):c.1718G>A (p.Arg573His) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000538483] Chr12:64495773 [GRCh38]
Chr12:64889553 [GRCh37]
Chr12:12q14.2
uncertain significance
GRCh37/hg19 12q14.1-15(chr12:59495114-70574966)x1 copy number loss See cases [RCV000447164] Chr12:59495114..70574966 [GRCh37]
Chr12:12q14.1-15
pathogenic
NM_013254.4(TBK1):c.2139-11G>A single nucleotide variant not specified [RCV000454770] Chr12:64501319 [GRCh38]
Chr12:64895099 [GRCh37]
Chr12:12q14.2
benign
NM_013254.4(TBK1):c.229-4dup duplication Glaucoma 1, open angle, p [RCV000625058]|not specified [RCV000455230] Chr12:64464320..64464321 [GRCh38]
Chr12:64858100..64858101 [GRCh37]
Chr12:12q14.2
benign
NM_013254.4(TBK1):c.978T>A (p.Ile326=) single nucleotide variant Glaucoma 1, open angle, p [RCV000625499]|not provided [RCV000834431]|not specified [RCV000455777] Chr12:64482007 [GRCh38]
Chr12:64875787 [GRCh37]
Chr12:12q14.2
benign
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
NM_013254.4(TBK1):c.452C>T (p.Ser151Phe) single nucleotide variant Motor neuron disease [RCV000492091] Chr12:64466994 [GRCh38]
Chr12:64860774 [GRCh37]
Chr12:12q14.2
likely pathogenic
NM_013254.4(TBK1):c.1508C>T (p.Thr503Ile) single nucleotide variant Motor neuron disease [RCV000492111] Chr12:64490106 [GRCh38]
Chr12:64883886 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.1432del (p.Thr478fs) deletion Motor neuron disease [RCV000492262] Chr12:64488573 [GRCh38]
Chr12:64882353 [GRCh37]
Chr12:12q14.2
other
NM_013254.4(TBK1):c.829C>G (p.Leu277Val) single nucleotide variant Motor neuron disease [RCV000492371]|not provided [RCV000520272] Chr12:64481858 [GRCh38]
Chr12:64875638 [GRCh37]
Chr12:12q14.2
likely pathogenic|uncertain significance
NM_013254.4(TBK1):c.1330C>T (p.Arg444Ter) single nucleotide variant Motor neuron disease [RCV000492391]|not provided [RCV000760460] Chr12:64486007 [GRCh38]
Chr12:64879787 [GRCh37]
Chr12:12q14.2
pathogenic|other
NM_013254.4(TBK1):c.2115_2127del (p.Glu706fs) deletion Motor neuron disease [RCV000492536] Chr12:64498015..64498027 [GRCh38]
Chr12:64891795..64891807 [GRCh37]
Chr12:12q14.2
other
NM_013254.4(TBK1):c.1135A>G (p.Ile379Val) single nucleotide variant Motor neuron disease [RCV000492553] Chr12:64484445 [GRCh38]
Chr12:64878225 [GRCh37]
Chr12:12q14.2
uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
NM_013254.4(TBK1):c.992C>T (p.Thr331Ile) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000560570] Chr12:64482021 [GRCh38]
Chr12:64875801 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.619A>G (p.Ile207Val) single nucleotide variant Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 8 [RCV000587986] Chr12:64474308 [GRCh38]
Chr12:64868088 [GRCh37]
Chr12:12q14.2
risk factor
NM_013254.4(TBK1):c.541-9del deletion Glaucoma 1, open angle, p [RCV000625498] Chr12:64474212 [GRCh38]
Chr12:64867992 [GRCh37]
Chr12:12q14.2
likely benign
NM_013254.4(TBK1):c.1412G>C (p.Cys471Ser) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000652981] Chr12:64488558 [GRCh38]
Chr12:64882338 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.1387_1388del (p.Glu463fs) deletion Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000652982] Chr12:64488532..64488533 [GRCh38]
Chr12:64882312..64882313 [GRCh37]
Chr12:12q14.2
pathogenic
NM_013254.4(TBK1):c.812G>A (p.Arg271Gln) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000652983] Chr12:64480122 [GRCh38]
Chr12:64873902 [GRCh37]
Chr12:12q14.2
likely benign
NM_013254.4(TBK1):c.1522C>A (p.Leu508Ile) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000652984] Chr12:64495483 [GRCh38]
Chr12:64889263 [GRCh37]
Chr12:12q14.2
benign
NM_013254.4(TBK1):c.1190-9A>G single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000652985] Chr12:64485446 [GRCh38]
Chr12:64879226 [GRCh37]
Chr12:12q14.2
likely benign
NM_013254.4(TBK1):c.1960-7G>T single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000652986]|not provided [RCV000836832] Chr12:64497641 [GRCh38]
Chr12:64891421 [GRCh37]
Chr12:12q14.2
likely benign
NM_013254.4(TBK1):c.9C>T (p.Ser3=) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000652987] Chr12:64455879 [GRCh38]
Chr12:64849659 [GRCh37]
Chr12:12q14.2
benign
NM_013254.3(TBK1):c.229-14_229-13insT insertion Glaucoma 1, open angle, p [RCV000625058] Chr12:64464320..64464321 [GRCh38]
Chr12:64858100..64858101 [GRCh37]
Chr12:12q14.2
benign
NM_013254.4(TBK1):c.1176A>G (p.Leu392=) single nucleotide variant not provided [RCV000539427] Chr12:64484486 [GRCh38]
Chr12:64878266 [GRCh37]
Chr12:12q14.2
likely benign
NM_013254.4(TBK1):c.1792A>G (p.Met598Val) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000687975]|not specified [RCV000614658] Chr12:64496980 [GRCh38]
Chr12:64890760 [GRCh37]
Chr12:12q14.2
likely benign|uncertain significance
NM_013254.3(TBK1):c.1644-5_1644-2del deletion Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000685263]|not provided [RCV000513177] Chr12:64495692..64495695 [GRCh38]
Chr12:64889472..64889475 [GRCh37]
Chr12:12q14.2
likely benign|uncertain significance
NM_013254.4(TBK1):c.1957G>C (p.Glu653Gln) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000704095] Chr12:64497257 [GRCh38]
Chr12:64891037 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.1116A>G (p.Lys372=) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000692692] Chr12:64484426 [GRCh38]
Chr12:64878206 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.1359T>G (p.Asp453Glu) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000688383] Chr12:64488505 [GRCh38]
Chr12:64882285 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.230CAA[2] (p.Thr79del) microsatellite Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000684999] Chr12:64464334..64464336 [GRCh38]
Chr12:64858114..64858116 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.421dup (p.Ile141fs) duplication Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000703742] Chr12:64466962..64466963 [GRCh38]
Chr12:64860742..64860743 [GRCh37]
Chr12:12q14.2
pathogenic
NM_013254.4(TBK1):c.1603G>A (p.Ala535Thr) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000698157] Chr12:64495564 [GRCh38]
Chr12:64889344 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.2177T>C (p.Val726Ala) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000695573] Chr12:64501368 [GRCh38]
Chr12:64895148 [GRCh37]
Chr12:12q14.2
uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12q14.2-14.3(chr12:64745313-65184236)x3 copy number gain not provided [RCV000750439] Chr12:64745313..65184236 [GRCh37]
Chr12:12q14.2-14.3
benign
NM_013254.4(TBK1):c.87+8C>T single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000874784] Chr12:64455965 [GRCh38]
Chr12:64849745 [GRCh37]
Chr12:12q14.2
likely benign
NM_013254.4(TBK1):c.381A>C (p.Arg127=) single nucleotide variant not provided [RCV000960749] Chr12:64466923 [GRCh38]
Chr12:64860703 [GRCh37]
Chr12:12q14.2
likely benign
NM_013254.4(TBK1):c.1069C>T (p.Arg357Ter) single nucleotide variant not provided [RCV000760459] Chr12:64484379 [GRCh38]
Chr12:64878159 [GRCh37]
Chr12:12q14.2
pathogenic
NM_013254.4(TBK1):c.1189+10G>A single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000876874] Chr12:64484509 [GRCh38]
Chr12:64878289 [GRCh37]
Chr12:12q14.2
benign
NM_013254.4(TBK1):c.2175C>T (p.Asn725=) single nucleotide variant not provided [RCV000899409] Chr12:64501366 [GRCh38]
Chr12:64895146 [GRCh37]
Chr12:12q14.2
likely benign
NM_013254.4(TBK1):c.135C>T (p.Phe45=) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000877984] Chr12:64460236 [GRCh38]
Chr12:64854016 [GRCh37]
Chr12:12q14.2
benign
NM_013254.4(TBK1):c.1709A>G (p.Lys570Arg) single nucleotide variant not provided [RCV000904708] Chr12:64495764 [GRCh38]
Chr12:64889544 [GRCh37]
Chr12:12q14.2
likely benign
NM_013254.4(TBK1):c.807T>G (p.Leu269=) single nucleotide variant not provided [RCV000944601] Chr12:64480117 [GRCh38]
Chr12:64873897 [GRCh37]
Chr12:12q14.2
likely benign
NM_013254.4(TBK1):c.1770G>A (p.Leu590=) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000969908] Chr12:64496958 [GRCh38]
Chr12:64890738 [GRCh37]
Chr12:12q14.2
likely benign
NM_013254.4(TBK1):c.2047T>C (p.Leu683=) single nucleotide variant not provided [RCV000878390] Chr12:64497735 [GRCh38]
Chr12:64891515 [GRCh37]
Chr12:12q14.2
likely benign
NM_013254.4(TBK1):c.1659A>C (p.Gln553His) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV001061061] Chr12:64495714 [GRCh38]
Chr12:64889494 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.1073G>A (p.Arg358His) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV001058696] Chr12:64484383 [GRCh38]
Chr12:64878163 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.87G>A (p.Lys29=) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000995895] Chr12:64455957 [GRCh38]
Chr12:64849737 [GRCh37]
Chr12:12q14.2
pathogenic
NM_013254.4(TBK1):c.427C>T (p.Arg143Cys) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000995896] Chr12:64466969 [GRCh38]
Chr12:64860749 [GRCh37]
Chr12:12q14.2
pathogenic
NM_013254.4(TBK1):c.992+1G>A single nucleotide variant Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 8 [RCV001196463]|Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000995897] Chr12:64482022 [GRCh38]
Chr12:64875802 [GRCh37]
Chr12:12q14.2
pathogenic
NM_013254.4(TBK1):c.630A>T (p.Thr210=) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000873781] Chr12:64474319 [GRCh38]
Chr12:64868099 [GRCh37]
Chr12:12q14.2
benign
NM_013254.4(TBK1):c.1551C>T (p.Thr517=) single nucleotide variant not provided [RCV000941518] Chr12:64495512 [GRCh38]
Chr12:64889292 [GRCh37]
Chr12:12q14.2
likely benign
NM_013254.4(TBK1):c.330T>C (p.Ser110=) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV001439088]|not provided [RCV000941917] Chr12:64464435 [GRCh38]
Chr12:64858215 [GRCh37]
Chr12:12q14.2
likely benign
NM_013254.4(TBK1):c.1479A>G (p.Ala493=) single nucleotide variant not provided [RCV000900386] Chr12:64490077 [GRCh38]
Chr12:64883857 [GRCh37]
Chr12:12q14.2
likely benign
NM_013254.4(TBK1):c.916C>A (p.Leu306Ile) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000876885] Chr12:64481945 [GRCh38]
Chr12:64875725 [GRCh37]
Chr12:12q14.2
benign
NM_013254.4(TBK1):c.1584A>G (p.Pro528=) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV001422879]|not provided [RCV000959465] Chr12:64495545 [GRCh38]
Chr12:64889325 [GRCh37]
Chr12:12q14.2
likely benign
NM_013254.4(TBK1):c.378A>G (p.Leu126=) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV001406370]|not provided [RCV000875645] Chr12:64466920 [GRCh38]
Chr12:64860700 [GRCh37]
Chr12:12q14.2
likely benign
NM_013254.4(TBK1):c.108T>C (p.Ala36=) single nucleotide variant not provided [RCV000876873] Chr12:64460209 [GRCh38]
Chr12:64853989 [GRCh37]
Chr12:12q14.2
benign
NM_013254.4(TBK1):c.701+1G>A single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000797764] Chr12:64474391 [GRCh38]
Chr12:64868171 [GRCh37]
Chr12:12q14.2
likely pathogenic
NM_013254.4(TBK1):c.1072C>T (p.Arg358Cys) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000810739] Chr12:64484382 [GRCh38]
Chr12:64878162 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.1505A>G (p.His502Arg) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000811612] Chr12:64490103 [GRCh38]
Chr12:64883883 [GRCh37]
Chr12:12q14.2
uncertain significance
NC_000012.12:g.64497641G>T single nucleotide variant not provided [RCV000836832] Chr12:64891421 [GRCh37]
Chr12:12q14.2
likely benign
NM_013254.4(TBK1):c.1960-3C>T single nucleotide variant not provided [RCV000836833] Chr12:64497645 [GRCh38]
Chr12:64891425 [GRCh37]
Chr12:12q14.2
likely benign
NM_013254.4(TBK1):c.1954_1956del (p.Asn652del) deletion not provided [RCV000871138] Chr12:64497253..64497255 [GRCh38]
Chr12:64891033..64891035 [GRCh37]
Chr12:12q14.2
benign
NM_013254.4(TBK1):c.802A>G (p.Ser268Gly) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000822732] Chr12:64480112 [GRCh38]
Chr12:64873892 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.1148G>T (p.Ser383Ile) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000800054] Chr12:64484458 [GRCh38]
Chr12:64878238 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.290T>A (p.Val97Asp) single nucleotide variant Hereditary spastic paraplegia 8 [RCV000785125] Chr12:64464395 [GRCh38]
Chr12:64858175 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.1952C>A (p.Thr651Asn) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000801728] Chr12:64497252 [GRCh38]
Chr12:64891032 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.400C>T (p.Arg134Cys) single nucleotide variant Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 8 [RCV001028037] Chr12:64466942 [GRCh38]
Chr12:64860722 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.548A>G (p.Asp183Gly) single nucleotide variant not provided [RCV000994946] Chr12:64474237 [GRCh38]
Chr12:64868017 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.314A>G (p.Tyr105Cys) single nucleotide variant not provided [RCV001171890] Chr12:64464419 [GRCh38]
Chr12:64858199 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.1179A>G (p.Ile393Met) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV001239173] Chr12:64484489 [GRCh38]
Chr12:64878269 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.813-3T>C single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV001234770] Chr12:64481839 [GRCh38]
Chr12:64875619 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.1922AAG[2] (p.Glu643del) microsatellite Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000995659]|not provided [RCV001093319] Chr12:64497221..64497223 [GRCh38]
Chr12:64891001..64891003 [GRCh37]
Chr12:12q14.2
pathogenic
NM_013254.4(TBK1):c.86dup (p.Lys30fs) duplication Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000995894] Chr12:64455954..64455955 [GRCh38]
Chr12:64849734..64849735 [GRCh37]
Chr12:12q14.2
pathogenic
NM_013254.4(TBK1):c.922C>T (p.Arg308Ter) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV001095423] Chr12:64481951 [GRCh38]
Chr12:64875731 [GRCh37]
Chr12:12q14.2
pathogenic
NM_013254.4(TBK1):c.2139-9G>T single nucleotide variant not provided [RCV000907765] Chr12:64501321 [GRCh38]
Chr12:64895101 [GRCh37]
Chr12:12q14.2
likely benign
NM_013254.4(TBK1):c.1227C>T (p.Asp409=) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV000874258] Chr12:64485492 [GRCh38]
Chr12:64879272 [GRCh37]
Chr12:12q14.2
benign
NM_013254.4(TBK1):c.1839G>T (p.Leu613Phe) single nucleotide variant not provided [RCV000952445] Chr12:64497027 [GRCh38]
Chr12:64890807 [GRCh37]
Chr12:12q14.2
benign
NM_013254.4(TBK1):c.540+8_540+9del deletion Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV001427458]|not provided [RCV000941328] Chr12:64467090..64467091 [GRCh38]
Chr12:64860870..64860871 [GRCh37]
Chr12:12q14.2
likely benign
NM_013254.4(TBK1):c.1485A>G (p.Leu495=) single nucleotide variant not provided [RCV000910835] Chr12:64490083 [GRCh38]
Chr12:64883863 [GRCh37]
Chr12:12q14.2
likely benign
NM_013254.4(TBK1):c.231A>G (p.Thr77=) single nucleotide variant not provided [RCV000902353] Chr12:64464336 [GRCh38]
Chr12:64858116 [GRCh37]
Chr12:12q14.2
likely benign
NM_013254.4(TBK1):c.1887G>C (p.Gln629His) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV001243865] Chr12:64497187 [GRCh38]
Chr12:64890967 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.965A>T (p.His322Leu) single nucleotide variant Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 8 [RCV001196635] Chr12:64481994 [GRCh38]
Chr12:64875774 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.1619A>T (p.Glu540Val) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV001206693] Chr12:64495580 [GRCh38]
Chr12:64889360 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.1734T>C (p.Asn578=) single nucleotide variant not provided [RCV000933979] Chr12:64496380 [GRCh38]
Chr12:64890160 [GRCh37]
Chr12:12q14.2
likely benign
GRCh37/hg19 12q14.2(chr12:64868010-64895161) copy number loss Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV001004099] Chr12:64868010..64895161 [GRCh37]
Chr12:12q14.2
pathogenic
NM_013254.4(TBK1):c.1622G>A (p.Gly541Asp) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV001056684] Chr12:64495583 [GRCh38]
Chr12:64889363 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.2080_2082del (p.Lys694del) deletion Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV001204131] Chr12:64497981..64497983 [GRCh38]
Chr12:64891761..64891763 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.683G>A (p.Arg228His) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV001051776] Chr12:64474372 [GRCh38]
Chr12:64868152 [GRCh37]
Chr12:12q14.2
uncertain significance
NC_000012.12:g.(?_63779951)_(64501391_?)dup duplication not provided [RCV001033402] Chr12:64173731..64895171 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.1739A>G (p.Glu580Gly) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV001253470] Chr12:64496385 [GRCh38]
Chr12:64890165 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.1588G>A (p.Gly530Arg) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV001328680] Chr12:64495549 [GRCh38]
Chr12:64889329 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.1318C>T (p.Arg440Ter) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV001291944] Chr12:64485995 [GRCh38]
Chr12:64879775 [GRCh37]
Chr12:12q14.2
pathogenic
NM_013254.4(TBK1):c.996T>A (p.Ala332=) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV001392164] Chr12:64484306 [GRCh38]
Chr12:64878086 [GRCh37]
Chr12:12q14.2
likely benign
NM_013254.4(TBK1):c.1760+4_1760+7del microsatellite Severe SARS-CoV-2 infection, susceptibility to [RCV001358670] Chr12:64496404..64496407 [GRCh38]
Chr12:64890184..64890187 [GRCh37]
Chr12:12q14.2
risk factor
NM_013254.4(TBK1):c.1691A>G (p.Tyr564Cys) single nucleotide variant not provided [RCV001356161] Chr12:64495746 [GRCh38]
Chr12:64889526 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.1865A>G (p.Lys622Arg) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV001395805] Chr12:64497165 [GRCh38]
Chr12:64890945 [GRCh37]
Chr12:12q14.2
likely benign
NM_013254.4(TBK1):c.358+5G>A single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV001360981] Chr12:64464468 [GRCh38]
Chr12:64858248 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.1180T>G (p.Tyr394Asp) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV001347468] Chr12:64484490 [GRCh38]
Chr12:64878270 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.1261G>A (p.Val421Ile) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV001301000] Chr12:64485938 [GRCh38]
Chr12:64879718 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.146T>G (p.Val49Gly) single nucleotide variant not provided [RCV001310999] Chr12:64460247 [GRCh38]
Chr12:64854027 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.1153G>T (p.Glu385Ter) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV001328679] Chr12:64484463 [GRCh38]
Chr12:64878243 [GRCh37]
Chr12:12q14.2
likely pathogenic
NC_000012.11:g.(?_64173731)_(64895171_?)dup duplication not provided [RCV001314630] Chr12:64173731..64895171 [GRCh37]
Chr12:12q14.2
uncertain significance
NM_013254.4(TBK1):c.945G>A (p.Ser315=) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV001408287] Chr12:64481974 [GRCh38]
Chr12:64875754 [GRCh37]
Chr12:12q14.2
likely benign
NM_013254.4(TBK1):c.1934C>G (p.Ser645Ter) single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV001388492] Chr12:64497234 [GRCh38]
Chr12:64891014 [GRCh37]
Chr12:12q14.2
pathogenic
NM_013254.4(TBK1):c.1740del (p.Glu580fs) deletion Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV001386793] Chr12:64496385 [GRCh38]
Chr12:64890165 [GRCh37]
Chr12:12q14.2
pathogenic
NM_013254.4(TBK1):c.1862+7A>C single nucleotide variant Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 [RCV001401739] Chr12:64497057 [GRCh38]
Chr12:64890837 [GRCh37]
Chr12:12q14.2
likely benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:11584 AgrOrtholog
COSMIC TBK1 COSMIC
Ensembl Genes ENSG00000183735 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000329967 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000444428 UniProtKB/TrEMBL
  ENSP00000445628 UniProtKB/TrEMBL
  ENSP00000445834 UniProtKB/TrEMBL
  ENSP00000498280 UniProtKB/TrEMBL
  ENSP00000498341 UniProtKB/TrEMBL
  ENSP00000498414 UniProtKB/TrEMBL
  ENSP00000498461 UniProtKB/TrEMBL
  ENSP00000498667 UniProtKB/TrEMBL
  ENSP00000498758 UniProtKB/TrEMBL
  ENSP00000498885 UniProtKB/TrEMBL
  ENSP00000498887 UniProtKB/TrEMBL
  ENSP00000498995 UniProtKB/Swiss-Prot
  ENSP00000499077 UniProtKB/TrEMBL
  ENSP00000499102 UniProtKB/TrEMBL
  ENSP00000502875 UniProtKB/TrEMBL
  ENSP00000502899 UniProtKB/TrEMBL
  ENSP00000502994 UniProtKB/TrEMBL
  ENSP00000503000 UniProtKB/TrEMBL
  ENSP00000503155 UniProtKB/TrEMBL
  ENSP00000503169 UniProtKB/TrEMBL
  ENSP00000503248 UniProtKB/TrEMBL
  ENSP00000503260 UniProtKB/TrEMBL
  ENSP00000503263 UniProtKB/TrEMBL
  ENSP00000503363 UniProtKB/TrEMBL
  ENSP00000503458 UniProtKB/TrEMBL
  ENSP00000503553 UniProtKB/TrEMBL
  ENSP00000503561 UniProtKB/TrEMBL
  ENSP00000503567 UniProtKB/TrEMBL
  ENSP00000503569 UniProtKB/TrEMBL
  ENSP00000503595 UniProtKB/TrEMBL
  ENSP00000503613 UniProtKB/TrEMBL
  ENSP00000503760 UniProtKB/TrEMBL
  ENSP00000503847 UniProtKB/TrEMBL
  ENSP00000504002 UniProtKB/TrEMBL
  ENSP00000504038 UniProtKB/TrEMBL
  ENSP00000504046 UniProtKB/TrEMBL
  ENSP00000504132 UniProtKB/TrEMBL
  ENSP00000504208 UniProtKB/TrEMBL
  ENSP00000504253 UniProtKB/TrEMBL
  ENSP00000504296 UniProtKB/TrEMBL
  ENSP00000504298 UniProtKB/TrEMBL
  ENSP00000504315 UniProtKB/TrEMBL
  ENSP00000504578 UniProtKB/TrEMBL
  ENSP00000504586 UniProtKB/TrEMBL
  ENSP00000504637 UniProtKB/TrEMBL
  ENSP00000504729 UniProtKB/TrEMBL
  ENSP00000504755 UniProtKB/TrEMBL
  ENSP00000504836 UniProtKB/TrEMBL
  ENSP00000504858 UniProtKB/TrEMBL
Ensembl Transcript ENST00000331710 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000538890 UniProtKB/TrEMBL
  ENST00000539810 UniProtKB/TrEMBL
  ENST00000540417 UniProtKB/TrEMBL
  ENST00000545025 UniProtKB/TrEMBL
  ENST00000650708 UniProtKB/TrEMBL
  ENST00000650762 UniProtKB/TrEMBL
  ENST00000650786 UniProtKB/TrEMBL
  ENST00000650790 UniProtKB/Swiss-Prot
  ENST00000650997 UniProtKB/TrEMBL
  ENST00000651014 UniProtKB/TrEMBL
  ENST00000651262 UniProtKB/TrEMBL
  ENST00000651878 UniProtKB/TrEMBL
  ENST00000652389 UniProtKB/TrEMBL
  ENST00000652537 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000652657 UniProtKB/TrEMBL
  ENST00000676469 UniProtKB/TrEMBL
  ENST00000676490 UniProtKB/TrEMBL
  ENST00000676521 UniProtKB/TrEMBL
  ENST00000676539 UniProtKB/TrEMBL
  ENST00000676587 UniProtKB/TrEMBL
  ENST00000676593 UniProtKB/TrEMBL
  ENST00000676809 UniProtKB/TrEMBL
  ENST00000676912 UniProtKB/TrEMBL
  ENST00000676930 UniProtKB/TrEMBL
  ENST00000676983 UniProtKB/TrEMBL
  ENST00000677016 UniProtKB/TrEMBL
  ENST00000677112 UniProtKB/TrEMBL
  ENST00000677313 UniProtKB/TrEMBL
  ENST00000677435 UniProtKB/TrEMBL
  ENST00000677499 UniProtKB/TrEMBL
  ENST00000677545 UniProtKB/TrEMBL
  ENST00000677632 UniProtKB/TrEMBL
  ENST00000677641 UniProtKB/TrEMBL
  ENST00000677759 UniProtKB/TrEMBL
  ENST00000677831 UniProtKB/TrEMBL
  ENST00000677858 UniProtKB/TrEMBL
  ENST00000677973 UniProtKB/TrEMBL
  ENST00000678079 UniProtKB/TrEMBL
  ENST00000678125 UniProtKB/TrEMBL
  ENST00000678180 UniProtKB/TrEMBL
  ENST00000678368 UniProtKB/TrEMBL
  ENST00000678567 UniProtKB/TrEMBL
  ENST00000678582 UniProtKB/TrEMBL
  ENST00000678718 UniProtKB/TrEMBL
  ENST00000678738 UniProtKB/TrEMBL
  ENST00000678808 UniProtKB/TrEMBL
  ENST00000678996 UniProtKB/TrEMBL
  ENST00000679050 UniProtKB/TrEMBL
  ENST00000679302 UniProtKB/TrEMBL
GTEx ENSG00000183735 GTEx
HGNC ID HGNC:11584 ENTREZGENE
Human Proteome Map TBK1 Human Proteome Map
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TBK1_CCD1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TBK1_ULD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:29110 UniProtKB/Swiss-Prot
NCBI Gene 29110 ENTREZGENE
OMIM 604834 OMIM
  616439 OMIM
  617900 OMIM
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TBK1_CCD1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TBK1_ULD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA36348 PharmGKB
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A494BZY3_HUMAN UniProtKB/TrEMBL
  A0A494C045_HUMAN UniProtKB/TrEMBL
  A0A494C079_HUMAN UniProtKB/TrEMBL
  A0A494C0A8_HUMAN UniProtKB/TrEMBL
  A0A494C0R4_HUMAN UniProtKB/TrEMBL
  A0A494C0X2_HUMAN UniProtKB/TrEMBL
  A0A494C148_HUMAN UniProtKB/TrEMBL
  A0A494C167_HUMAN UniProtKB/TrEMBL
  A0A494C1I2_HUMAN UniProtKB/TrEMBL
  A0A494C1M6_HUMAN UniProtKB/TrEMBL
  A0A7I2V2F4_HUMAN UniProtKB/TrEMBL
  A0A7I2V2N0_HUMAN UniProtKB/TrEMBL
  A0A7I2V2N9_HUMAN UniProtKB/TrEMBL
  A0A7I2V2V9_HUMAN UniProtKB/TrEMBL
  A0A7I2V322_HUMAN UniProtKB/TrEMBL
  A0A7I2V387_HUMAN UniProtKB/TrEMBL
  A0A7I2V3B7_HUMAN UniProtKB/TrEMBL
  A0A7I2V3E0_HUMAN UniProtKB/TrEMBL
  A0A7I2V3P0_HUMAN UniProtKB/TrEMBL
  A0A7I2V3S9_HUMAN UniProtKB/TrEMBL
  A0A7I2V3Y6_HUMAN UniProtKB/TrEMBL
  A0A7I2V463_HUMAN UniProtKB/TrEMBL
  A0A7I2V476_HUMAN UniProtKB/TrEMBL
  A0A7I2V4C0_HUMAN UniProtKB/TrEMBL
  A0A7I2V4M2_HUMAN UniProtKB/TrEMBL
  A0A7I2V4M8_HUMAN UniProtKB/TrEMBL
  A0A7I2V4S0_HUMAN UniProtKB/TrEMBL
  A0A7I2V4W4_HUMAN UniProtKB/TrEMBL
  A0A7I2V4Y1_HUMAN UniProtKB/TrEMBL
  A0A7I2V4Z2_HUMAN UniProtKB/TrEMBL
  A0A7I2V502_HUMAN UniProtKB/TrEMBL
  A0A7I2V573_HUMAN UniProtKB/TrEMBL
  A0A7I2V5W0_HUMAN UniProtKB/TrEMBL
  A0A7I2V5Y4_HUMAN UniProtKB/TrEMBL
  A0A7I2V5Z0_HUMAN UniProtKB/TrEMBL
  A0A7I2V615_HUMAN UniProtKB/TrEMBL
  A0A7I2V636_HUMAN UniProtKB/TrEMBL
  A0A7I2V643_HUMAN UniProtKB/TrEMBL
  A0A7I2V646_HUMAN UniProtKB/TrEMBL
  A0A7I2YQG1_HUMAN UniProtKB/TrEMBL
  A0A7I2YQG4_HUMAN UniProtKB/TrEMBL
  A0A7I2YQM3_HUMAN UniProtKB/TrEMBL
  F5GZI4_HUMAN UniProtKB/TrEMBL
  F5H1A3_HUMAN UniProtKB/TrEMBL
  F5H206_HUMAN UniProtKB/TrEMBL
  Q9UHD2 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A8K4S4 UniProtKB/Swiss-Prot
  Q8IYV3 UniProtKB/Swiss-Prot
  Q9NUJ5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-21 TBK1  TANK binding kinase 1    TANK-binding kinase 1  Symbol and/or name change 5135510 APPROVED