Tbk1 (TANK binding kinase 1) - Rat Genome Database

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Gene: Tbk1 (TANK binding kinase 1) Chinchilla lanigera
Analyze
Symbol: Tbk1
Name: TANK binding kinase 1
RGD ID: 8837653
Description: ENCODES a protein that exhibits identical protein binding (ortholog); nucleic acid binding (ortholog); phosphoprotein binding (ortholog); INVOLVED IN activation of innate immune response (ortholog); antiviral innate immune response (ortholog); cytoplasmic pattern recognition receptor signaling pathway (ortholog); PARTICIPATES IN Toll-like receptor signaling pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); AUTOINFLAMMATION WITH ARTHRITIS AND VASCULITIS (ortholog); ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), 8 (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); intracellular membrane-bounded organelle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: serine/threonine-protein kinase TBK1; TANK-binding kinase 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545811,211,398 - 11,263,867 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545811,210,120 - 11,263,632 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tbk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545811,211,398 - 11,263,867 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545811,210,120 - 11,263,632 (+)NCBIChiLan1.0ChiLan1.0
TBK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381264,452,120 - 64,502,114 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1264,452,090 - 64,502,114 (+)EnsemblGRCh38hg38GRCh38
GRCh371264,845,900 - 64,895,894 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361263,132,204 - 63,182,158 (+)NCBINCBI36Build 36hg18NCBI36
Build 341263,132,203 - 63,182,158NCBI
Celera1264,510,375 - 64,560,181 (+)NCBICelera
Cytogenetic Map12q14.2NCBI
HuRef1261,898,186 - 61,948,226 (+)NCBIHuRef
CHM1_11264,812,935 - 64,863,007 (+)NCBICHM1_1
T2T-CHM13v2.01264,430,747 - 64,480,735 (+)NCBIT2T-CHM13v2.0
Tbk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910121,382,360 - 121,422,699 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10121,382,360 - 121,422,692 (-)EnsemblGRCm39 Ensembl
GRCm3810121,546,455 - 121,586,794 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10121,546,455 - 121,586,787 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710120,983,511 - 121,023,850 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610120,949,520 - 120,989,807 (-)NCBIMGSCv36mm8
Celera10123,931,313 - 123,970,044 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1069.84NCBI
Tbk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8758,963,319 - 58,996,357 (-)NCBIGRCr8
mRatBN7.2757,077,830 - 57,110,868 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl757,077,830 - 57,110,892 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx758,989,079 - 59,022,620 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0761,191,956 - 61,225,497 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0760,969,664 - 61,003,205 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0763,655,247 - 63,687,978 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl763,655,247 - 63,687,978 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0763,877,567 - 63,910,298 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4760,863,099 - 60,896,131 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera753,819,361 - 53,852,262 (-)NCBICelera
Cytogenetic Map7q22NCBI
TBK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21029,864,914 - 29,915,549 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11229,861,685 - 29,912,320 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01224,419,271 - 24,469,164 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11224,919,412 - 24,968,587 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1224,917,246 - 24,968,587 (-)Ensemblpanpan1.1panPan2
TBK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1107,169,664 - 7,208,890 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl107,168,007 - 7,208,899 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha107,102,668 - 7,144,367 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0107,276,927 - 7,318,803 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl107,276,875 - 7,318,755 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1107,142,851 - 7,184,688 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0107,395,493 - 7,437,313 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0107,526,057 - 7,567,705 (+)NCBIUU_Cfam_GSD_1.0
Tbk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494551,300,898 - 51,346,375 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365452,763,596 - 2,809,709 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365452,763,755 - 2,809,229 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TBK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl528,880,205 - 28,929,963 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1528,880,210 - 28,929,964 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TBK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11160,136,162 - 60,182,354 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1160,136,232 - 60,182,344 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037185,623,292 - 185,669,524 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tbk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248023,862,709 - 3,914,028 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248023,861,821 - 3,914,061 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000015186   ⟹   ENSCLAP00000015027
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545811,211,398 - 11,263,867 (+)Ensembl
RefSeq Acc Id: XM_013520995   ⟹   XP_013376449
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545811,210,120 - 11,263,632 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013520996   ⟹   XP_013376450
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545811,211,499 - 11,263,632 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013376449 (Get FASTA)   NCBI Sequence Viewer  
  XP_013376450 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000015027
  ENSCLAP00000015027.1
RefSeq Acc Id: XP_013376449   ⟸   XM_013520995
- UniProtKB: A0A8C2VGA7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013376450   ⟸   XM_013520996
- UniProtKB: A0A8C2VGA7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000015027   ⟸   ENSCLAT00000015186
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000010356 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000015186 ENTREZGENE
  ENSCLAT00000015186.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.420 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro IKK UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  TBK1_CCD1 UniProtKB/TrEMBL
  TBK1_ULD UniProtKB/TrEMBL
NCBI Gene Tbk1 ENTREZGENE
PANTHER IKB KINASE UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE TBK1 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
  TBK1_CCD1 UniProtKB/TrEMBL
  TBK1_ULD UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A8C2VGA7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Tbk1  TANK binding kinase 1    TANK-binding kinase 1  Symbol and/or name change 5135510 APPROVED