Tbk1 (TANK binding kinase 1) - Rat Genome Database

Name: Tbk1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Advanced Search (OLGA)

Gene: Tbk1 (TANK binding kinase 1) Ictidomys tridecemlineatus

Analyze

Symbol:

Tbk1

Name:

TANK binding kinase 1

RGD ID:

12621496

Description:

ENCODES a protein that exhibits ATP binding (inferred); identical protein binding (inferred); nucleic acid binding (inferred); INVOLVED IN activation of innate immune response (ortholog); defense response to Gram-positive bacterium (ortholog); dendritic cell proliferation (ortholog); PARTICIPATES IN Toll-like receptor signaling pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); AUTOINFLAMMATION WITH ARTHRITIS AND VASCULITIS (ortholog); ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), 8 (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

serine/threonine-protein kinase TBK1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TBK1 (TANK binding kinase 1)	NCBI	Ortholog
Mus musculus (house mouse):	Tbk1 (TANK-binding kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Tbk1 (TANK-binding kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tbk1 (TANK binding kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TBK1 (TANK binding kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TBK1 (TANK binding kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TBK1 (TANK binding kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TBK1 (TANK binding kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tbk1 (TANK binding kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	51,300,898 - 51,346,375 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936545	2,763,596 - 2,809,709 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936545	2,763,755 - 2,809,229 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amyotrophic lateral sclerosis (ISO)

AUTOINFLAMMATION WITH ARTHRITIS AND VASCULITIS (ISO)

ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), 8 (ISO)

frontotemporal dementia and/or amyotrophic lateral sclerosis 4 (ISO)

genetic disease (ISO)

Glaucoma 1, Open Angle, P (ISO)

hereditary spastic paraplegia 8 (ISO)

Herpes Simplex Encephalitis 1 (ISO)

motor neuron disease (ISO)

mucopolysaccharidosis type IIID (ISO)

primary open angle glaucoma (ISO)

progressive non-fluent aphasia (ISO)

severe acute respiratory syndrome (ISO)

severe COVID-19 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of innate immune response (IEA,ISO)

antiviral innate immune response (IEA)

cytoplasmic pattern recognition receptor signaling pathway (IEA)

defense response to Gram-positive bacterium (IEA,ISO)

dendritic cell proliferation (IEA,ISO)

innate immune response (IEA)

negative regulation of gene expression (IEA)

negative regulation of TORC1 signaling (IEA)

peptidyl-serine phosphorylation (ISO)

peptidyl-threonine phosphorylation (ISO)

positive regulation of autophagy (IEA)

positive regulation of canonical NF-kappaB signal transduction (IEA)

positive regulation of gene expression (IEA)

positive regulation of interferon-alpha production (IEA)

positive regulation of interferon-beta production (IEA,ISO)

positive regulation of macroautophagy (IEA)

positive regulation of TORC1 signaling (IEA)

positive regulation of TORC2 signaling (ISO)

positive regulation of transcription by RNA polymerase II (IEA)

positive regulation of type I interferon production (IEA)

positive regulation of type I interferon-mediated signaling pathway (IEA)

positive regulation of xenophagy (IEA)

protein phosphorylation (ISO)

regulation of gene expression (IEA,ISO)

regulation of metabolic process (ISO)

regulation of type I interferon production (IEA)

T follicular helper cell differentiation (ISO)

toll-like receptor 4 signaling pathway (IEA)

Cellular Component

cytoplasm (IEA,ISO)

cytosol (IEA,ISO)

intracellular membrane-bounded organelle (IEA)

nucleoplasm (IEA)

Molecular Function

ATP binding (IEA)

identical protein binding (IEA)

nucleic acid binding (IEA)

phosphoprotein binding (IEA)

protein binding (ISO)

protein kinase activity (IEA)

protein phosphatase binding (IEA)

protein serine/threonine kinase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

Toll-like receptor signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Tbk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	51,300,898 - 51,346,375 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936545	2,763,596 - 2,809,709 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936545	2,763,755 - 2,809,229 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TBK1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	64,452,120 - 64,502,114 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	64,452,090 - 64,502,114 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	64,845,900 - 64,895,894 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	63,132,204 - 63,182,158 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	63,132,203 - 63,182,158	NCBI
Celera	12	64,510,375 - 64,560,181 (+)	NCBI		Celera
Cytogenetic Map	12	q14.2	NCBI
HuRef	12	61,898,186 - 61,948,226 (+)	NCBI		HuRef
CHM1_1	12	64,812,935 - 64,863,007 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	64,430,747 - 64,480,735 (+)	NCBI		T2T-CHM13v2.0

Tbk1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	121,382,360 - 121,422,699 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	121,382,360 - 121,422,692 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	121,546,455 - 121,586,794 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	121,546,455 - 121,586,787 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	120,983,511 - 121,023,850 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	120,949,520 - 120,989,807 (-)	NCBI		MGSCv36	mm8
Celera	10	123,931,313 - 123,970,044 (-)	NCBI		Celera
Cytogenetic Map	10	D2	NCBI
cM Map	10	69.84	NCBI

Tbk1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	58,963,319 - 58,996,357 (-)	NCBI		GRCr8
mRatBN7.2	7	57,077,830 - 57,110,868 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	57,077,830 - 57,110,892 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	58,989,079 - 59,022,620 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	61,191,956 - 61,225,497 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	60,969,664 - 61,003,205 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	63,655,247 - 63,687,978 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	63,655,247 - 63,687,978 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	63,877,567 - 63,910,298 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	60,863,099 - 60,896,131 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	7	53,819,361 - 53,852,262 (-)	NCBI		Celera
Cytogenetic Map	7	q22	NCBI

Tbk1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955458	11,211,398 - 11,263,867 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955458	11,210,120 - 11,263,632 (+)	NCBI	ChiLan1.0	ChiLan1.0

TBK1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	29,864,914 - 29,915,549 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	29,861,685 - 29,912,320 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	24,419,271 - 24,469,164 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	24,919,412 - 24,968,587 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	24,917,246 - 24,968,587 (-)	Ensembl	panpan1.1		panPan2

TBK1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	7,169,664 - 7,208,890 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	7,168,007 - 7,208,899 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	7,102,668 - 7,144,367 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	7,276,927 - 7,318,803 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	7,276,875 - 7,318,755 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	7,142,851 - 7,184,688 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	7,395,493 - 7,437,313 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	7,526,057 - 7,567,705 (+)	NCBI		UU_Cfam_GSD_1.0

TBK1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	28,880,205 - 28,929,963 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	28,880,210 - 28,929,964 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

TBK1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	60,136,162 - 60,182,354 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	60,136,232 - 60,182,344 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	185,623,292 - 185,669,524 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tbk1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624802	3,862,709 - 3,914,028 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624802	3,861,821 - 3,914,061 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005328694	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040280378	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000008314 ⟹ ENSSTOP00000007452

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936545	2,763,596 - 2,809,709 (+)	Ensembl

RefSeq Acc Id:

XM_005328694 ⟹ XP_005328751

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404945	51,300,906 - 51,346,375 (-)	NCBI
SpeTri2.0	NW_004936545	2,763,755 - 2,809,229 (+)	NCBI

Sequence:

show sequence

CGCATCCGCGCGCGCCGGCCGTCGGTCACGTGACCCCCGGCCAGGGCTCGCGAAGCCGGAAGTA
GCCCCGGGCTCCTGAAGGCCGCGGGAACCCGCTGGCGGTGGCGCGGCGGAGACCCGGCTGGTAT
AACAAAAGAAACATCTGACCAAGCCGAGATGCAGAGCACTTCTAATCATCTGTGGCTTTTATCT
GATATCTTAGGCCAAGGAGCTACAGCAAATGTCTTTCGTGGAAGACATAAGAAAACTGGTGATT
TATTTGCTATCAAAGTATTTAATAACATAAGTTTCCTTCGTCCAGTGGATGTTCAAATGAGAGA
ATTTGAAGTGTTAAAAAAACTTAATCACAAAAATATTGTCAAATTATTTGCTATTGAAGAGGAG
ACAACAACAAGACATAAAGTACTCATTATGGAATTCTGTCCATGTGGGAGTCTATACACTGTTT
TAGAAGAGCCATCTAATGCCTATGGACTACCAGAATCAGAATTTTTAATTGTCTTACGAGATGT
GGTGGGAGGAATGAATCACCTTCGAGAAAATGGAATAGTACACCGTGATATCAAGCCAGGAAAT
ATCATGCGTGTCATAGGGGAAGATGGACAGTCTGTGTACAAACTCACAGATTTTGGTGCAGCTA
GAGAATTAGAAGATGATGAACAGTTTGTTTCTCTGTATGGTACAGAAGAATATTTGCATCCTGA
TATGTATGAGAGAGCAGTGCTAAGAAAAGATCATCAAAAAAAATATGGAGCAACAGTTGATCTT
TGGAGCATTGGAGTAACATTTTACCATGCAGCTACTGGATCCCTACCATTTAGACCATTTGAAG
GACCTCGCAGGAATAAAGAAGTGATGTATAAAATAATCACTGGAAAGCCTTCTGGTGCAATATC
TGGAGTACAGAAAGCAGAAAATGGACCAATTGATTGGAGTGGAGACATGCCTGTTTCTTGTAGT
CTTTCTCGGGGTCTTCAGGTTCTACTTACCCCTGTTCTTGCAAACATCCTTGAAGCAGATCAGG
AAAAGTGTTGGGGTTTTGACCAGTTTTTTGCAGAAACTAGTGATATACTTCATCGAATGATAAT
TCATGTTTTTTCACTACAACAAATGACAGCTCATAAGATTTATATTCATAGCTATAATACTGCT
ACAGTATTTCATGAACTGGTATATAAACAAACCAAAATTATTTCTTCAAATCAAGAACTTATCT
ATGAAGGACGACGCTTAGTCCTAGAACCTGGAAGACTGGCACAGCATTTCCCTAGAACCACAGA
GGAGAATCCTATCTTTGTTGTAAGCCGGGAACCCCTGAGTACCATAGGATTAATATATGAAAAA
ATTTCCCTCCCTAAAGTACATCCACGTTATGATTTAGATGGGGATGCTAGCATGGCTAAGGCAA
TAACAGGGGTTGTATGTTATGCCTGTAGAATTACCAGTACCTTGCTGCTTTATCAGGAATTAAT
GCGAAAAGGGATACGATGGTTAATTGAATTAGTTAAAGATGATTACAATGAAACTGTACACAAA
AAGACAGAAGTTGTGATCACATTGGATTTCTGTATCAGAAACATTGAAAAAACTGTGAAAGTAT
ATGAAAAGTTAATGAAGATCAACCTAGAAGCAACAGAGTTAGGTGAAATTTCAGACATACACAC
CAAATTGTTGAGACTTTCCAGTTCCCAGGGAACAATAGAAACAAGTCTTCAGGATATCGACAGC
AGGTTATCTCCAGGTGGACTGCTGACAGATGCATGGGCACATCAGGAAGGCACCCATCCGAAAG
ACAGAAATGTAGAAAAACTACAGGTCTTATTAAACTGCATCACGGAAATTTACTATCAGTTCAA
AAAAGACAAAGCAGAACGTAGACTAGCTTACAATGAAGAACAGATCCACAAATTTGATAAGCAA
AAACTGTATTACCATGCAACAAAAGCTATGACCCACTTTGCAGATGAATGCGTTAAAAAGTATG
AAGCATTTTTGGATAAGTCAGAAGAATGGATGAGAAAGATGCTTCATCTTAGGAAACAGTTATT
ATCTCTAACTAATCAGTGTTTTGATATTGAAGAAGAAGTATCAAAGTATCAAGACTATACTAAT
GAGTTACAAGAAACTCTGCCTCAGAAAATGTTTGCAGCCTCCAGTGGAATCAAACATACCATAA
CCCCAATTTATCCAAGTTCTAACACGTTAGTGGAAATGACTCTTGGTATGAAGAAATTGAAGGA
AGAGATGGAAGGGGTGGTTAAAGAACTTGCTGAAAATAATCATATTTTAGAAAGGTTTGGTTCC
TTAACCATGGATGGTGGCCTACGCAACGTCGACTGTCTTTAGCTTTCTAAGAAGTTTCAGAAAA
ATTTCAGTTTGCACAAGATAATGTTGGGATATTAAATGAAAGCCTTTATAGGTGGTCTCTCATT
TCTACAATTCAGTATTTGATGTGGTCTTGTAAATATGTATAATATTGTAAATACATAAAATATA
TAAATTTTTGGCTGCTGTTAAGATGTAATTTTGCCTTTTAACATTTATAACTACACGAGGCAGT
TTGACCTCAGCAAGCACTAGAAGAAAGCCATGACTGGCTGACAAATTGAGATGCTAGTCCTTCA
CTCTGACGAAAGCTGGAGAAGTCATATTTCTCCAGCTGCCTATTGGAATATTTTTAAGTGGAAC
CAAATTGGCATCCTTACAAATCAAAGACTAATAGTTGGCAGGTTTGTAAATGGTTAGAATAGAA
AGGTGACTTTTGTGAGTGGGGAGCAGAAGTGAACCACTGTTTTATTGGAGTCACTTTTTTTTGA
GAGGGGTAAATGTACATTATTTCATTTTATAAGGTGCCCAGAGCCCAGTTTTTCTCCTGTTTGT
TTAATTTCAGATGAATTATTGAACAAAATTTTTAAAGTGAATTAATTACTTTATTCATTTTTGG
CCATAAGAGTATAATTGTCATTAAAGTTTTAAGGTCATTTCAATTATTTAAAGCTGTATATTTC
TTTAATTCTGCTTACTATTTCATGAAAAAAATAAATTTCTCAATTTTAACATAAAAAGTT

hide sequence

RefSeq Acc Id:

XM_040280378 ⟹ XP_040136312

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404945	51,300,898 - 51,346,375 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_005328751	(Get FASTA)	NCBI Sequence Viewer
	XP_040136312	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000007452.3
GenBank Protein	KAG3291451	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005328751 ⟸ XM_005328694
- Peptide Label:	isoform X1
- UniProtKB:	I3MBE7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNH KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRK DHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGP IDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAETSDILHRMIIHVFSLQQMT AHKIYIHSYNTATVFHELVYKQTKIISSNQELIYEGRRLVLEPGRLAQHFPRTTEENPIFVVSR EPLSTIGLIYEKISLPKVHPRYDLDGDASMAKAITGVVCYACRITSTLLLYQELMRKGIRWLIE LVKDDYNETVHKKTEVVITLDFCIRNIEKTVKVYEKLMKINLEATELGEISDIHTKLLRLSSSQ GTIETSLQDIDSRLSPGGLLTDAWAHQEGTHPKDRNVEKLQVLLNCITEIYYQFKKDKAERRLA YNEEQIHKFDKQKLYYHATKAMTHFADECVKKYEAFLDKSEEWMRKMLHLRKQLLSLTNQCFDI EEEVSKYQDYTNELQETLPQKMFAASSGIKHTITPIYPSSNTLVEMTLGMKKLKEEMEGVVKEL AENNHILERFGSLTMDGGLRNVDCL hide sequence

RefSeq Acc Id:	XP_040136312 ⟸ XM_040280378
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSSTOP00000007452 ⟸ ENSSTOT00000008314

Protein Domains

Protein kinase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000008299	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000008314.3	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1270.420	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	IKK	UniProtKB/TrEMBL
	Kinase-like_dom_sf	UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	TBK1_CCD1	UniProtKB/TrEMBL
	TBK1_ULD	UniProtKB/TrEMBL
NCBI Gene	Tbk1	ENTREZGENE
PANTHER	IKB KINASE	UniProtKB/TrEMBL
	SERINE/THREONINE-PROTEIN KINASE TBK1	UniProtKB/TrEMBL
Pfam	Pkinase	UniProtKB/TrEMBL
	TBK1_CCD1	UniProtKB/TrEMBL
	TBK1_ULD	UniProtKB/TrEMBL
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
SMART	S_TKc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56112	UniProtKB/TrEMBL
UniProt	I3MBE7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations