![]()
Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of CCT2 mRNA] | CTD | PMID:31150632 | 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane | increases expression | ISO | RGD:1552962 | 6480464 | o, p'-DDT results in increased expression of CCT2 mRNA | CTD | PMID:24096037 | 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane | increases expression | EXP | | 6480464 | o, p'-DDT results in increased expression of CCT2 mRNA | CTD | PMID:24096037 | 1,2-dimethylhydrazine | increases expression | ISO | RGD:1552962 | 6480464 | 1, 2-Dimethylhydrazine results in increased expression of CCT2 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | affects expression | ISO | RGD:1552962 | 6480464 | Ethinyl Estradiol affects the expression of CCT2 mRNA | CTD | PMID:17555576 | 17alpha-ethynylestradiol | increases expression | ISO | RGD:1552962 | 6480464 | Ethinyl Estradiol results in increased expression of CCT2 mRNA | CTD | PMID:17942748, PMID:24096037 | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of CCT2 mRNA | CTD | PMID:24096037 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:1552962 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCT2 mRNA | CTD | PMID:17942748 | 1H-pyrazole | increases expression | ISO | RGD:1552962 | 6480464 | pyrazole results in increased expression of CCT2 mRNA | CTD | PMID:17945193 | 2,2',4,4'-Tetrabromodiphenyl ether | affects expression | ISO | RGD:1552962 | 6480464 | 2 more ... | CTD | PMID:30294300 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1552962 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCT2 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1552962 | 6480464 | Tetrachlorodibenzodioxin affects the expression of CCT2 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CCT2 protein | CTD | PMID:19201780 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1552962 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of CCT2 mRNA | CTD | PMID:15591033, PMID:17942748 | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | increases expression | ISO | RGD:1552962 | 6480464 | 2 more ... | CTD | PMID:16451863 | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:19954255 | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:19954255 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2, 4-dinitrotoluene affects the expression of CCT2 mRNA | CTD | PMID:21346803 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2, 6-dinitrotoluene affects the expression of CCT2 mRNA | CTD | PMID:21346803 | 3-chloropropane-1,2-diol | increases expression | EXP | | 6480464 | alpha-Chlorohydrin analog results in increased expression of CCT2 protein | CTD | PMID:26072098 | 4-amino-2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 4-amino-2, 6-dinitrotoluene affects the expression of CCT2 mRNA | CTD | PMID:21346803 | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of CCT2 mRNA | CTD | PMID:28959563 | aflatoxin B1 | increases expression | ISO | RGD:1352326 | 6480464 | Aflatoxin B1 results in increased expression of CCT2 mRNA | CTD | PMID:27153756 | amphetamine | multiple interactions | ISO | RGD:1552962 | 6480464 | [MDK gene mutant form results in decreased susceptibility to Amphetamine] which results in increased expression of CCT2 protein | CTD | PMID:23459167 | arsenous acid | increases expression | ISO | RGD:1352326 | 6480464 | Arsenic Trioxide results in increased expression of CCT2 protein | CTD | PMID:19364129 | artesunate | decreases response to substance | ISO | RGD:1352326 | 6480464 | CCT2 mRNA results in decreased susceptibility to artesunate | CTD | PMID:20144594 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | RGD:1352326 | 6480464 | 7 more ... | CTD | PMID:20018196 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of CCT2 mRNA | CTD | PMID:25181051 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of CCT2 gene | CTD | PMID:28505145 | cadmium dichloride | multiple interactions | ISO | RGD:1552962 | 6480464 | [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CCT2 mRNA | CTD | PMID:19840844 | cadmium dichloride | decreases expression | ISO | RGD:1352326 | 6480464 | Cadmium Chloride results in decreased expression of CCT2 protein | CTD | PMID:24419708 | carbon nanotube | increases expression | ISO | RGD:1552962 | 6480464 | Nanotubes, Carbon results in increased expression of CCT2 mRNA | CTD | PMID:25554681, PMID:25620056 | ceruletide | increases expression | EXP | | 6480464 | Ceruletide results in increased expression of CCT2 protein | CTD | PMID:18024178 | chloropicrin | increases expression | ISO | RGD:1352326 | 6480464 | chloropicrin results in increased expression of CCT2 mRNA | CTD | PMID:26352163 | chromium(6+) | affects expression | ISO | RGD:1552962 | 6480464 | chromium hexavalent ion affects the expression of CCT2 mRNA | CTD | PMID:28472532 | clobetasol | increases expression | ISO | RGD:1552962 | 6480464 | Clobetasol results in increased expression of CCT2 mRNA | CTD | PMID:27462272 | clofibrate | increases expression | ISO | RGD:1552962 | 6480464 | Clofibrate results in increased expression of CCT2 mRNA | CTD | PMID:17585979 | clofibric acid | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CCT2 mRNA | CTD | PMID:17602206 | cobalt dichloride | decreases expression | ISO | RGD:1352326 | 6480464 | cobaltous chloride results in decreased expression of CCT2 mRNA | CTD | PMID:19376846 | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of CCT2 mRNA | CTD | PMID:20187946 | copper atom | multiple interactions | ISO | RGD:1552962 | 6480464 | [ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of CCT2 mRNA | CTD | PMID:15467011 | copper(0) | multiple interactions | ISO | RGD:1552962 | 6480464 | [ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of CCT2 mRNA | CTD | PMID:15467011 | cyclosporin A | decreases expression | ISO | RGD:1352326 | 6480464 | Cyclosporine results in decreased expression of CCT2 mRNA | CTD | PMID:27989131 | diarsenic trioxide | increases expression | ISO | RGD:1352326 | 6480464 | Arsenic Trioxide results in increased expression of CCT2 protein | CTD | PMID:19364129 | diazinon | affects expression | EXP | | 6480464 | Diazinon affects the expression of CCT2 mRNA | CTD | PMID:22546817 | dicrotophos | decreases expression | ISO | RGD:1352326 | 6480464 | dicrotophos results in decreased expression of CCT2 mRNA | CTD | PMID:28302478 | diethylstilbestrol | increases expression | EXP | | 6480464 | Diethylstilbestrol results in increased expression of CCT2 protein | CTD | PMID:20932895 | dioxygen | multiple interactions | ISO | RGD:1552962 | 6480464 | [sulforafan affects the susceptibility to Oxygen] which affects the expression of CCT2 mRNA | CTD | PMID:30529165 | doxorubicin | decreases expression | ISO | RGD:1352326 | 6480464 | Doxorubicin results in decreased expression of CCT2 mRNA | CTD | PMID:29803840 | enzyme inhibitor | multiple interactions | ISO | RGD:1352326 | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CCT2 protein | CTD | PMID:23301498 | ethanol | increases expression | EXP | | 6480464 | Ethanol results in increased expression of CCT2 protein | CTD | PMID:23702218 | ethanol | affects splicing | ISO | RGD:1552962 | 6480464 | Ethanol affects the splicing of CCT2 mRNA | CTD | PMID:30319688 | finasteride | increases expression | EXP | | 6480464 | Finasteride results in increased expression of CCT2 mRNA | CTD | PMID:24136188 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of CCT2 mRNA | CTD | PMID:24136188 | folic acid | decreases expression | ISO | RGD:1552962 | 6480464 | Folic Acid results in decreased expression of CCT2 mRNA | CTD | PMID:25629700 | formaldehyde | decreases expression | ISO | RGD:1352326 | 6480464 | Formaldehyde results in decreased expression of CCT2 mRNA | CTD | PMID:23649840 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of CCT2 protein | CTD | PMID:22061828 | hyaluronic acid | multiple interactions | EXP | | 6480464 | Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of CCT2 protein] | CTD | PMID:23178681 | hyaluronic acid | decreases expression | EXP | | 6480464 | Hyaluronic Acid analog results in decreased expression of CCT2 protein | CTD | PMID:23178681 | hydralazine | multiple interactions | ISO | RGD:1352326 | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of CCT2 mRNA | CTD | PMID:17183730 | hydrogen peroxide | affects expression | ISO | RGD:1352326 | 6480464 | Hydrogen Peroxide affects the expression of CCT2 mRNA | CTD | PMID:20044591 | hydrogen peroxide | decreases expression | EXP | | 6480464 | Hydrogen Peroxide results in decreased expression of CCT2 protein | CTD | PMID:23178681 | hydrogen peroxide | multiple interactions | EXP | | 6480464 | Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of CCT2 protein] | CTD | PMID:23178681 | hydrogen peroxide | decreases secretion | ISO | RGD:1552962 | 6480464 | Hydrogen Peroxide results in decreased secretion of CCT2 mRNA | CTD | PMID:21179422 | lead(II) chloride | decreases expression | ISO | RGD:1352326 | 6480464 | lead chloride results in decreased expression of CCT2 protein | CTD | PMID:24419708 | menadione | affects expression | ISO | RGD:1352326 | 6480464 | Vitamin K 3 affects the expression of CCT2 mRNA | CTD | PMID:20044591 | methamphetamine | decreases expression | EXP | | 6480464 | Methamphetamine results in decreased expression of CCT2 protein | CTD | PMID:19826936 | N-methyl-N'-nitro-N-nitrosoguanidine | multiple interactions | ISO | RGD:1552962 | 6480464 | [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CCT2 mRNA | CTD | PMID:19840844 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CCT2 mRNA | CTD | PMID:17602206 | N-nitrosomorpholine | increases expression | EXP | | 6480464 | N-nitrosomorpholine results in increased expression of CCT2 protein | CTD | PMID:19716841 | naphthalene | multiple interactions | ISO | RGD:1552962 | 6480464 | [naphthalene co-treated with CFTR gene mutant form] results in decreased expression of CCT2 protein | CTD | PMID:19438287 | nefazodone | increases expression | EXP | | 6480464 | nefazodone results in increased expression of CCT2 mRNA | CTD | PMID:24136188 | nickel dichloride | affects expression | EXP | | 6480464 | nickel chloride affects the expression of CCT2 mRNA | CTD | PMID:22546817 | nimesulide | increases expression | EXP | | 6480464 | nimesulide results in increased expression of CCT2 mRNA | CTD | PMID:24136188 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of CCT2 mRNA | CTD | PMID:25729387 | p-menthan-3-ol | decreases expression | ISO | RGD:1352326 | 6480464 | Menthol results in decreased expression of CCT2 protein | CTD | PMID:26760959 | paracetamol | affects expression | ISO | RGD:1552962 | 6480464 | Acetaminophen affects the expression of CCT2 mRNA | CTD | PMID:17562736 | PhIP | increases expression | EXP | | 6480464 | 2-amino-1-methyl-6-phenylimidazo4, 5-bpyridine results in increased expression of CCT2 mRNA | CTD | PMID:15215175 | pirinixic acid | increases expression | ISO | RGD:1552962 | 6480464 | pirinixic acid results in increased expression of CCT2 mRNA | CTD | PMID:23811191 | potassium dichromate | increases expression | ISO | RGD:1352326 | 6480464 | Potassium Dichromate results in increased expression of CCT2 mRNA | CTD | PMID:18332044 | pregnenolone 16alpha-carbonitrile | increases expression | ISO | RGD:1552962 | 6480464 | Pregnenolone Carbonitrile results in increased expression of CCT2 mRNA | CTD | PMID:28903501 | propiconazole | increases expression | ISO | RGD:1552962 | 6480464 | propiconazole results in increased expression of CCT2 mRNA | CTD | PMID:21278054 | resveratrol | affects expression | ISO | RGD:1352326 | 6480464 | resveratrol affects the expression of CCT2 protein | CTD | PMID:23255428 | silicon dioxide | affects secretion | ISO | RGD:1352326 | 6480464 | Silicon Dioxide analog affects the secretion of CCT2 protein | CTD | PMID:25895662 | sodium dichromate | increases expression | EXP | | 6480464 | sodium bichromate results in increased expression of CCT2 mRNA | CTD | PMID:25993096 | sulforaphane | affects binding | ISO | RGD:1352326 | 6480464 | CCT2 protein binds to sulforafan | CTD | PMID:21838287 | sulforaphane | multiple interactions | ISO | RGD:1552962 | 6480464 | [sulforafan affects the susceptibility to Oxygen] which affects the expression of CCT2 mRNA | CTD | PMID:30529165 | sunitinib | increases expression | ISO | RGD:1352326 | 6480464 | Sunitinib results in increased expression of CCT2 mRNA | CTD | PMID:31533062 | tamoxifen | affects expression | ISO | RGD:1552962 | 6480464 | Tamoxifen affects the expression of CCT2 mRNA | CTD | PMID:17555576 | tetrachloromethane | increases expression | ISO | RGD:1552962 | 6480464 | Carbon Tetrachloride results in increased expression of CCT2 mRNA | CTD | PMID:27339419, PMID:31919559 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of CCT2 mRNA | CTD | PMID:31150632 | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of CCT2 mRNA] | CTD | PMID:31150632 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of CCT2 mRNA | CTD | PMID:23411599 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of CCT2 mRNA | CTD | PMID:25729387 | trimellitic anhydride | increases expression | ISO | RGD:1552962 | 6480464 | trimellitic anhydride results in increased expression of CCT2 mRNA | CTD | PMID:19042947 | valdecoxib | increases expression | EXP | | 6480464 | valdecoxib results in increased expression of CCT2 mRNA | CTD | PMID:24136188 | valproic acid | affects expression | ISO | RGD:1552962 | 6480464 | Valproic Acid affects the expression of CCT2 mRNA | CTD | PMID:17292431 | valproic acid | multiple interactions | ISO | RGD:1352326 | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of CCT2 mRNA | CTD | PMID:17183730 | |