Rap1b (RAP1B, member of RAS oncogene family) - Rat Genome Database

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Gene: Rap1b (RAP1B, member of RAS oncogene family) Rattus norvegicus
Analyze
Symbol: Rap1b
Name: RAP1B, member of RAS oncogene family
RGD ID: 620577
Description: Predicted to enable G protein activity; GDP binding activity; and GTP binding activity. Involved in several processes, including cellular response to gonadotropin-releasing hormone; cellular response to xenobiotic stimulus; and response to carbohydrate. Predicted to be located in several cellular components, including cell-cell junction; exocytic vesicle; and lipid droplet. Predicted to be active in glutamatergic synapse and plasma membrane. Orthologous to several human genes including RAP1B (RAP1B, member of RAS oncogene family); PARTICIPATES IN E-cadherin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; platelet-derived growth factor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid; 3',5'-cyclic AMP.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GTP-binding protein smg p21B; MGC93206; RAS related protein 1b; ras-related protein Rap-1b
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2753,423,039 - 53,456,388 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl753,423,130 - 53,456,370 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx755,333,280 - 55,340,337 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0757,536,389 - 57,543,446 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0757,314,247 - 57,321,304 (-)NCBIRnor_WKY
Rnor_6.0760,850,406 - 60,878,226 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl760,853,930 - 60,860,990 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0760,850,369 - 60,879,083 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4757,132,750 - 57,139,811 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1757,150,631 - 57,182,957 (-)NCBI
Celera750,197,811 - 50,204,871 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function
G protein activity  (ISO)
GDP binding  (IBA,ISO,ISS)
GTP binding  (IBA,IEA,ISO,ISS,TAS)
GTPase activity  (IBA,IEA,ISO,ISS,TAS)
protein binding  (ISO)
protein-containing complex binding  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. High glucose stimulates synthesis of fibronectin via a novel protein kinase C, Rap1b, and B-Raf signaling pathway. Lin S, etal., J Biol Chem. 2002 Nov 1;277(44):41725-35. Epub 2002 Aug 23.
3. cAMP inhibition of Akt is mediated by activated and phosphorylated Rap1b. Lou L, etal., J Biol Chem 2002 Sep 6;277(36):32799-806.
4. Use of an activation-specific probe to show that Rap1A and Rap1B display different sensitivities to activation by forskolin in rat1 cells. McPhee I, etal., FEBS Lett. 2000 Jul 21;477(3):213-8.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. On the mitogenic properties of Rap1b: cAMP-induced G(1)/S entry requires activated and phosphorylated Rap1b. Ribeiro-Neto F, etal., Proc Natl Acad Sci U S A 2002 Apr 16;99(8):5418-23.
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. Coincident induction of K rev-1/rap 1A, rap 1B and H-ras mRNAs in the rat spinal cord by noxious stimulation. Urayama O, etal., Brain Res Mol Brain Res 1997 May;45(2):331-4.
14. Optimized amplification and single-cell analysis identify GnRH-mediated activation of Rap1b in primary rat gonadotropes. Yuen T, etal., Mol Cell Endocrinol. 2012 Mar 5;350(1):10-9. doi: 10.1016/j.mce.2011.11.017. Epub 2011 Nov 25.
Additional References at PubMed
PMID:14712229   PMID:14741744   PMID:15489334   PMID:18309292   PMID:18504258   PMID:18550542   PMID:18582561   PMID:18842593   PMID:19199708   PMID:19461049   PMID:20332120   PMID:20458337  
PMID:21700703   PMID:21840392   PMID:22797597   PMID:23209302   PMID:23376485   PMID:23616533   PMID:24165023   PMID:25935485  


Genomics

Comparative Map Data
Rap1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2753,423,039 - 53,456,388 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl753,423,130 - 53,456,370 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx755,333,280 - 55,340,337 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0757,536,389 - 57,543,446 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0757,314,247 - 57,321,304 (-)NCBIRnor_WKY
Rnor_6.0760,850,406 - 60,878,226 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl760,853,930 - 60,860,990 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0760,850,369 - 60,879,083 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4757,132,750 - 57,139,811 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1757,150,631 - 57,182,957 (-)NCBI
Celera750,197,811 - 50,204,871 (-)NCBICelera
Cytogenetic Map7q22NCBI
RAP1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381268,610,899 - 68,671,901 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1268,610,855 - 68,671,901 (+)EnsemblGRCh38hg38GRCh38
GRCh371269,004,679 - 69,065,681 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361267,290,919 - 67,340,641 (+)NCBINCBI36Build 36hg18NCBI36
Build 341267,290,918 - 67,340,644NCBI
Celera1268,668,392 - 68,717,826 (+)NCBICelera
Cytogenetic Map12q15NCBI
HuRef1266,093,121 - 66,105,030 (+)NCBIHuRef
CHM1_11268,972,799 - 69,022,538 (+)NCBICHM1_1
T2T-CHM13v2.01268,590,436 - 68,651,443 (+)NCBIT2T-CHM13v2.0
Rap1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910117,650,502 - 117,681,879 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10117,649,776 - 117,681,940 (-)EnsemblGRCm39 Ensembl
GRCm3810117,814,597 - 117,845,974 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10117,813,871 - 117,846,035 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710117,251,653 - 117,283,030 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610117,217,590 - 117,248,967 (-)NCBIMGSCv36mm8
Celera10119,752,445 - 119,762,526 (-)NCBICelera
Cytogenetic Map10D2NCBI
Rap1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545815,080,778 - 15,123,203 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545815,110,709 - 15,121,868 (+)NCBIChiLan1.0ChiLan1.0
RAP1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11268,919,369 - 68,955,650 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1268,942,053 - 68,955,649 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01266,122,212 - 66,172,450 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
RAP1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11010,805,359 - 10,816,839 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1010,805,357 - 10,815,575 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1010,700,667 - 10,750,121 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01010,891,820 - 10,941,270 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1010,891,815 - 10,941,253 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11010,759,466 - 10,808,891 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01011,005,977 - 11,055,507 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01011,128,484 - 11,177,911 (+)NCBIUU_Cfam_GSD_1.0
Rap1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494547,531,710 - 47,542,147 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365456,568,577 - 6,574,595 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365456,567,873 - 6,578,404 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAP1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl532,910,259 - 32,964,870 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1532,910,181 - 32,961,972 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2535,681,835 - 35,733,656 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RAP1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11164,240,501 - 64,290,515 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1164,240,651 - 64,286,727 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037181,414,337 - 181,465,079 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rap1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624948623,527 - 664,000 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624948623,527 - 664,044 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rap1b
127 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:581
Count of miRNA genes:259
Interacting mature miRNAs:308
Transcripts:ENSRNOT00000009511
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)72940968353612950Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
2303629Vencon3Ventilatory control QTL 37.25respiration trait (VT:0001943)respiration rate (CMO:0000289)74110969256793354Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat

Markers in Region
BF386582  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2753,425,770 - 53,425,957 (+)MAPPERmRatBN7.2
Rnor_6.0760,853,138 - 60,853,324NCBIRnor6.0
Rnor_5.0760,853,101 - 60,853,287UniSTSRnor5.0
RGSC_v3.4757,131,958 - 57,132,144UniSTSRGSC3.4
Celera750,197,019 - 50,197,205UniSTS
RH 3.4 Map7489.1UniSTS
Cytogenetic Map7q22UniSTS
BF401892  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2753,456,892 - 53,456,983 (+)MAPPERmRatBN7.2
Rnor_6.0760,891,298 - 60,891,388NCBIRnor6.0
Rnor_5.0760,891,554 - 60,891,644UniSTSRnor5.0
RGSC_v3.4757,162,810 - 57,162,900UniSTSRGSC3.4
Celera750,227,774 - 50,227,864UniSTS
RH 3.4 Map7486.2UniSTS
Cytogenetic Map7q22UniSTS
MARC_2660-2661:991933047:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21217,733,490 - 17,733,786 (+)MAPPERmRatBN7.2
mRatBN7.21217,756,893 - 17,757,189 (+)MAPPERmRatBN7.2
mRatBN7.21218,838,325 - 18,838,621 (+)MAPPERmRatBN7.2
mRatBN7.21218,821,229 - 18,821,524 (+)MAPPERmRatBN7.2
Rnor_6.01221,894,096 - 21,894,391NCBIRnor6.0
Rnor_5.01223,911,144 - 23,911,439UniSTSRnor5.0
RGSC_v3.41220,568,395 - 20,568,690UniSTSRGSC3.4
Celera1220,639,611 - 20,639,906UniSTS
Cytogenetic Map12q12UniSTS
Cytogenetic Map7q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001412600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_134346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY607847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D88313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U07795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000009511   ⟹   ENSRNOP00000009511
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl753,427,389 - 53,456,370 (-)Ensembl
Rnor_6.0 Ensembl760,853,930 - 60,860,990 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113270   ⟹   ENSRNOP00000078778
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl753,423,130 - 53,456,295 (-)Ensembl
RefSeq Acc Id: NM_134346   ⟹   NP_599173
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2753,426,563 - 53,433,623 (-)NCBI
Rnor_6.0760,853,930 - 60,860,990 (-)NCBI
Rnor_5.0760,850,369 - 60,879,083 (-)NCBI
RGSC_v3.4757,132,750 - 57,139,811 (-)RGD
Celera750,197,811 - 50,204,871 (-)RGD
Sequence:
RefSeq Acc Id: XM_039078354   ⟹   XP_038934282
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2753,423,039 - 53,456,388 (-)NCBI
RefSeq Acc Id: XM_039078356   ⟹   XP_038934284
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2753,423,039 - 53,456,333 (-)NCBI
RefSeq Acc Id: XM_039078357   ⟹   XP_038934285
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2753,423,039 - 53,456,329 (-)NCBI
RefSeq Acc Id: XM_039078358   ⟹   XP_038934286
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2753,426,278 - 53,456,349 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_599173   ⟸   NM_134346
- UniProtKB: Q6J167 (UniProtKB/Swiss-Prot),   Q62636 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009511   ⟸   ENSRNOT00000009511
RefSeq Acc Id: XP_038934282   ⟸   XM_039078354
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038934284   ⟸   XM_039078356
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038934285   ⟸   XM_039078357
- Peptide Label: isoform X1
- UniProtKB: Q6J167 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038934286   ⟸   XM_039078358
- Peptide Label: isoform X1
- UniProtKB: Q6J167 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSRNOP00000078778   ⟸   ENSRNOT00000113270

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62636-F1-model_v2 AlphaFold Q62636 1-184 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620577 AgrOrtholog
BioCyc Gene G2FUF-33976 BioCyc
Ensembl Genes ENSRNOG00000007048 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000009511 ENTREZGENE
  ENSRNOP00000009511.4 UniProtKB/TrEMBL
  ENSRNOP00000078778 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009511 ENTREZGENE
  ENSRNOT00000009511.6 UniProtKB/TrEMBL
  ENSRNOT00000113270 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7192310 IMAGE-MGC_LOAD
InterPro P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rap1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase_Ras-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171337 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93206 IMAGE-MGC_LOAD
NCBI Gene 171337 ENTREZGENE
PANTHER PTHR24070 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ras UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rap1b PhenoGen
PROSITE RAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RHO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs small_GTP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2UI57_RAT UniProtKB/TrEMBL
  Q62636 ENTREZGENE
  Q6J167 ENTREZGENE
  RAP1B_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q6J167 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-24 Rap1b  RAP1B, member of RAS oncogene family  Rap1b  RAS related protein 1b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Rap1b  RAS related protein 1b    RAP1B, member of RAS oncogene family  Name updated 1299863 APPROVED
2002-08-07 Rap1b  RAP1B, member of RAS oncogene family      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation phosphorylated and activated by cAMP 633761