Trhde (thyrotropin-releasing hormone degrading enzyme) - Rat Genome Database

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Gene: Trhde (thyrotropin-releasing hormone degrading enzyme) Rattus norvegicus
Analyze
Symbol: Trhde
Name: thyrotropin-releasing hormone degrading enzyme
RGD ID: 728895
Description: Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be active in cytoplasm; extracellular space; and membrane. Orthologous to human TRHDE (thyrotropin releasing hormone degrading enzyme); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: PAP-II; pyroglutamyl-peptidase II; thyroliberinase; thyrotropin-releasing hormone degrading ectoenzyme; thyrotropin-releasing hormone-degrading ectoenzyme; TRH-DE; TRH-degrading ectoenzyme; TRH-specific aminopeptidase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8751,829,473 - 52,236,843 (-)NCBIGRCr8
mRatBN7.2749,943,271 - 50,350,613 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl749,945,766 - 50,367,371 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx751,852,771 - 52,257,524 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0754,055,893 - 54,460,654 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0753,833,748 - 54,238,531 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0757,253,023 - 57,679,795 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl757,253,023 - 57,679,795 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0757,265,684 - 57,693,174 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4753,591,770 - 54,021,219 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1753,612,156 - 54,024,183 (-)NCBI
Celera746,740,631 - 47,161,218 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
extracellular space  (IBA)
membrane  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Purification and characterization of the thyrotropin-releasing hormone (TRH)-degrading serum enzyme and its identification as a product of liver origin. Schmitmeier S, etal., Eur J Biochem 2002 Feb;269(4):1278-86.
Additional References at PubMed
PMID:7937801   PMID:10785382   PMID:16611635   PMID:19179432   PMID:21329657   PMID:22532627   PMID:22719053   PMID:23376485   PMID:23533145   PMID:25942072  


Genomics

Comparative Map Data
Trhde
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8751,829,473 - 52,236,843 (-)NCBIGRCr8
mRatBN7.2749,943,271 - 50,350,613 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl749,945,766 - 50,367,371 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx751,852,771 - 52,257,524 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0754,055,893 - 54,460,654 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0753,833,748 - 54,238,531 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0757,253,023 - 57,679,795 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl757,253,023 - 57,679,795 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0757,265,684 - 57,693,174 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4753,591,770 - 54,021,219 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1753,612,156 - 54,024,183 (-)NCBI
Celera746,740,631 - 47,161,218 (-)NCBICelera
Cytogenetic Map7q22NCBI
TRHDE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381272,087,266 - 72,670,758 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1272,087,266 - 72,670,758 (+)EnsemblGRCh38hg38GRCh38
GRCh371272,666,150 - 73,064,538 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361270,952,730 - 71,345,689 (+)NCBINCBI36Build 36hg18NCBI36
Build 341270,952,729 - 71,345,688NCBI
Celera1272,329,850 - 72,723,987 (+)NCBICelera
Cytogenetic Map12q21.1NCBI
HuRef1269,714,852 - 70,107,634 (+)NCBIHuRef
CHM1_11272,632,089 - 73,024,946 (+)NCBICHM1_1
T2T-CHM13v2.01272,063,195 - 72,646,521 (+)NCBIT2T-CHM13v2.0
Trhde
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910114,234,725 - 114,638,207 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10114,234,726 - 114,638,212 (-)EnsemblGRCm39 Ensembl
GRCm3810114,398,820 - 114,802,302 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10114,398,821 - 114,802,307 (-)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl10114,398,823 - 114,802,307 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710113,835,877 - 114,238,426 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610113,803,133 - 114,205,474 (-)NCBIMGSCv36mm8
Celera10116,334,960 - 116,737,119 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1061.59NCBI
Trhde
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540512,229,448 - 12,623,675 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540512,229,448 - 12,624,753 (+)NCBIChiLan1.0ChiLan1.0
TRHDE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21080,300,714 - 80,696,949 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11280,297,114 - 80,693,349 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01269,795,208 - 70,191,298 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11272,652,776 - 73,047,182 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1272,652,958 - 73,073,418 (+)Ensemblpanpan1.1panPan2
TRHDE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11013,744,907 - 14,118,023 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1013,744,591 - 14,115,437 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1013,685,019 - 14,055,891 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01013,883,046 - 14,254,797 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1013,883,046 - 14,249,827 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11013,743,941 - 14,115,272 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01013,995,000 - 14,365,815 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01014,116,319 - 14,488,005 (+)NCBIUU_Cfam_GSD_1.0
Trhde
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494544,067,297 - 44,437,562 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365681,290,774 - 1,662,542 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365681,290,758 - 1,660,520 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRHDE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl536,274,165 - 36,658,701 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1536,266,883 - 36,663,208 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2539,289,649 - 39,520,695 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TRHDE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11167,912,122 - 68,313,509 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1167,912,138 - 68,315,962 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037177,295,134 - 177,727,707 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Trhde
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475025,007,540 - 25,419,433 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475025,000,907 - 25,419,628 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Trhde
2184 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:508
Count of miRNA genes:267
Interacting mature miRNAs:321
Transcripts:ENSRNOT00000007461
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)71965431752888450Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
2303629Vencon3Ventilatory control QTL 37.25respiration trait (VT:0001943)respiration rate (CMO:0000289)74110969256793354Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)72940968353612950Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat

Markers in Region
D7Got80  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2750,032,914 - 50,033,085 (+)MAPPERmRatBN7.2
Rnor_6.0757,340,069 - 57,340,239NCBIRnor6.0
Rnor_5.0757,352,464 - 57,352,634UniSTSRnor5.0
RGSC_v3.4753,679,915 - 53,680,086RGDRGSC3.4
RGSC_v3.4753,679,916 - 53,680,086UniSTSRGSC3.4
RGSC_v3.1753,700,549 - 53,700,719RGD
Celera746,827,288 - 46,827,458UniSTS
RH 3.4 Map7440.1UniSTS
RH 3.4 Map7440.1RGD
RH 2.0 Map7403.5RGD
Cytogenetic Map7q22UniSTS
D7Wox33  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2749,947,519 - 49,947,647 (+)MAPPERmRatBN7.2
Rnor_6.0757,254,777 - 57,254,902NCBIRnor6.0
Rnor_5.0757,267,438 - 57,267,563UniSTSRnor5.0
RGSC_v3.4753,593,524 - 53,593,651UniSTSRGSC3.4
Celera746,742,385 - 46,742,510UniSTS
Cytogenetic Map7q22UniSTS
RH131058  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2750,368,172 - 50,368,392 (+)MAPPERmRatBN7.2
Rnor_6.0757,680,597 - 57,680,816NCBIRnor6.0
Rnor_5.0757,693,976 - 57,694,195UniSTSRnor5.0
RGSC_v3.4754,022,021 - 54,022,240UniSTSRGSC3.4
Celera747,162,017 - 47,162,236UniSTS
RH 3.4 Map7442.8UniSTS
Cytogenetic Map7q22UniSTS
RH144062  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2750,352,592 - 50,352,699 (+)MAPPERmRatBN7.2
Rnor_6.0757,665,019 - 57,665,125NCBIRnor6.0
Rnor_5.0757,678,398 - 57,678,504UniSTSRnor5.0
RGSC_v3.4754,006,445 - 54,006,551UniSTSRGSC3.4
Celera747,146,450 - 47,146,556UniSTS
RH 3.4 Map7442.21UniSTS
Cytogenetic Map7q22UniSTS
BI302213  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2750,068,604 - 50,068,813 (+)MAPPERmRatBN7.2
Rnor_6.0757,375,691 - 57,375,899NCBIRnor6.0
Rnor_5.0757,388,086 - 57,388,294UniSTSRnor5.0
RGSC_v3.4753,715,604 - 53,715,812UniSTSRGSC3.4
Celera746,862,952 - 46,863,160UniSTS
RH 3.4 Map7442.6UniSTS
Cytogenetic Map7q22UniSTS
RH141425  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2749,946,078 - 49,946,258 (+)MAPPERmRatBN7.2
Rnor_6.0757,253,336 - 57,253,515NCBIRnor6.0
Rnor_5.0757,265,997 - 57,266,176UniSTSRnor5.0
RGSC_v3.4753,592,083 - 53,592,262UniSTSRGSC3.4
Celera746,740,944 - 46,741,123UniSTS
RH 3.4 Map7440.8UniSTS
Cytogenetic Map7q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 47 113 79 78 47 25 47 6 203 94 93 45 58 31

Sequence


Ensembl Acc Id: ENSRNOT00000007461   ⟹   ENSRNOP00000007461
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl749,945,766 - 50,367,371 (-)Ensembl
Rnor_6.0 Ensembl757,253,023 - 57,679,795 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109488   ⟹   ENSRNOP00000079029
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl749,948,355 - 50,367,371 (-)Ensembl
RefSeq Acc Id: NM_001108991   ⟹   NP_001102461
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8751,832,111 - 52,236,843 (-)NCBI
mRatBN7.2749,945,907 - 50,350,613 (-)NCBI
Rnor_6.0757,253,023 - 57,679,795 (-)NCBI
Rnor_5.0757,265,684 - 57,693,174 (-)NCBI
RGSC_v3.4753,591,770 - 54,021,219 (-)RGD
Celera746,740,631 - 47,161,218 (-)RGD
Sequence:
RefSeq Acc Id: XM_039079684   ⟹   XP_038935612
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8751,829,473 - 52,236,096 (-)NCBI
mRatBN7.2749,943,271 - 50,349,819 (-)NCBI
RefSeq Acc Id: XM_039079685   ⟹   XP_038935613
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8751,970,855 - 52,236,096 (-)NCBI
mRatBN7.2750,098,062 - 50,349,819 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001102461 (Get FASTA)   NCBI Sequence Viewer  
  XP_038935612 (Get FASTA)   NCBI Sequence Viewer  
  XP_038935613 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM16698 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007461.4
  ENSRNOP00000079029.1
  ENSRNOP00055016927
  ENSRNOP00060013645
  ENSRNOP00065017403
GenBank Protein Q10836 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001102461   ⟸   NM_001108991
- UniProtKB: Q10836 (UniProtKB/Swiss-Prot),   G3V6Q2 (UniProtKB/Swiss-Prot),   A0A8I5ZM45 (UniProtKB/TrEMBL),   A6IGK0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007461   ⟸   ENSRNOT00000007461
RefSeq Acc Id: XP_038935612   ⟸   XM_039079684
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZM45 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935613   ⟸   XM_039079685
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000079029   ⟸   ENSRNOT00000109488
Protein Domains
Aminopeptidase N-like N-terminal   ERAP1-like C-terminal   Peptidase M1 membrane alanine aminopeptidase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q10836-F1-model_v2 AlphaFold Q10836 1-1025 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:728895 AgrOrtholog
BioCyc Gene G2FUF-34083 BioCyc
Ensembl Genes ENSRNOG00000005278 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055012309 UniProtKB/Swiss-Prot
  ENSRNOG00060010381 UniProtKB/Swiss-Prot
  ENSRNOG00065013639 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007461.6 UniProtKB/Swiss-Prot
  ENSRNOT00000109488.1 UniProtKB/TrEMBL
  ENSRNOT00055020955 UniProtKB/Swiss-Prot
  ENSRNOT00060017558 UniProtKB/Swiss-Prot
  ENSRNOT00065022445 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.50.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.1730 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.1910 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Aminopeptidase_N-like_N UniProtKB/Swiss-Prot
  Aminopeptidase_N-like_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aminopeptidase_N-like_N UniProtKB/TrEMBL
  ERAP1-like_C_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  M1_APN-typ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1_aminopeptidases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M4/M1_CTD_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:366894 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene Trhde ENTREZGENE
PANTHER PROTEASE M1 ZINC METALLOPROTEASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11533:SF40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ERAP1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Trhde PhenoGen
PRINTS ALADIPTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ZINC_PROTEASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005278 RatGTEx
  ENSRNOG00055012309 RatGTEx
  ENSRNOG00060010381 RatGTEx
  ENSRNOG00065013639 RatGTEx
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF63737 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZM45 ENTREZGENE, UniProtKB/TrEMBL
  A6IGK0 ENTREZGENE, UniProtKB/TrEMBL
  G3V6Q2 ENTREZGENE
  Q10836 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary G3V6Q2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Trhde  thyrotropin-releasing hormone degrading enzyme      Symbol and Name status set to approved 1299863 APPROVED
2005-09-30 Trhde        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the brain, liver and serum 625628
gene_function catalyzes the hydrolysis of hyrotropin-releasing hormone (TRH) at the pyroGlu-His bond 625628
gene_protein 97 kDa 625628