Gene: Trhde (thyrotropin-releasing hormone degrading enzyme) Rattus norvegicus
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Symbol: Trhde
Name: thyrotropin-releasing hormone degrading enzyme
Description: ENCODES a protein that exhibits aminopeptidase activity (inferred); metallopeptidase activity (inferred); zinc ion binding (inferred); INVOLVED IN proteolysis (inferred); ASSOCIATED WITH long QT syndrome (ortholog); FOUND IN integral component of membrane (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; benzo[a]pyrene
AGR Description: Predicted to have metalloaminopeptidase activity, peptide binding activity, and zinc ion binding activity; predicted to be involved in peptide catabolic process and proteolysis; predicted to localize to the cytoplasm and plasma membrane; orthologous to human TRHDE (thyrotropin releasing hormone degrading enzyme).
Merged Description: Predicted to have metalloaminopeptidase activity, peptide binding activity, and zinc ion binding activity; predicted to be involved in peptide catabolic process and proteolysis; predicted to localize to the cytoplasm and plasma membrane; orthologous to human TRHDE (thyrotropin releasing hormone degrading enzyme); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: PAP-II; pyroglutamyl-peptidase II; thyroliberinase; thyrotropin-releasing hormone degrading ectoenzyme; thyrotropin-releasing hormone-degrading ectoenzyme; TRH-DE; TRH-degrading ectoenzyme; TRH-specific aminopeptidase
Orthologs:
Homo sapiens (human) : TRHDE (thyrotropin releasing hormone degrading enzyme)  HGNC  Alliance
Mus musculus (house mouse) : Trhde (TRH-degrading enzyme)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Trhde (thyrotropin releasing hormone degrading enzyme)
Pan paniscus (bonobo/pygmy chimpanzee) : TRHDE (thyrotropin releasing hormone degrading enzyme)
Canis lupus familiaris (dog) : TRHDE (thyrotropin releasing hormone degrading enzyme)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Trhde (thyrotropin releasing hormone degrading enzyme)
Sus scrofa (pig) : TRHDE (thyrotropin releasing hormone degrading enzyme)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0757,253,023 - 57,679,795 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0757,265,684 - 57,693,174 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4753,591,770 - 54,021,219 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1753,612,156 - 54,024,183 (-)NCBI
Celera746,740,631 - 47,161,218 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Trhde
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 728895
Created: 2003-11-21
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.