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Gene: Trhde (TRH-degrading enzyme) Mus musculus
Symbol: Trhde
Name: TRH-degrading enzyme
RGD ID: 730937
Description: Predicted to have metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including peptide catabolic process; proteolysis; and regulation of blood pressure. Predicted to localize to cytoplasm and plasma membrane. Is expressed in cerebral cortex and hippocampus region. Orthologous to human TRHDE (thyrotropin releasing hormone degrading enzyme); INTERACTS WITH choline; ethanol; folic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 9330155P21Rik; MGC40831; PAP-II; pyroglutamyl-peptidase II; thyroliberinase; thyrotropin-releasing hormone degrading ectoenzyme; thyrotropin-releasing hormone-degrading ectoenzyme; TRH-DE; TRH-degrading ectoenzyme; TRH-specific aminopeptidase
Homo sapiens (human) : TRHDE (thyrotropin releasing hormone degrading enzyme)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Trhde (thyrotropin-releasing hormone degrading enzyme)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Trhde (thyrotropin releasing hormone degrading enzyme)
Pan paniscus (bonobo/pygmy chimpanzee) : TRHDE (thyrotropin releasing hormone degrading enzyme)
Canis lupus familiaris (dog) : TRHDE (thyrotropin releasing hormone degrading enzyme)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Trhde (thyrotropin releasing hormone degrading enzyme)
Sus scrofa (pig) : TRHDE (thyrotropin releasing hormone degrading enzyme)
Chlorocebus sabaeus (African green monkey) : TRHDE (thyrotropin releasing hormone degrading enzyme)
Heterocephalus glaber (naked mole-rat) : Trhde (thyrotropin releasing hormone degrading enzyme)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3910114,234,725 - 114,638,207 (-)NCBI
GRCm3810114,398,820 - 114,802,302 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10114,398,823 - 114,802,307 (-)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl10114,398,821 - 114,802,307 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710113,835,877 - 114,238,426 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610113,803,133 - 114,205,474 (-)NCBImm8
Celera10116,334,960 - 116,737,119 (-)NCBICelera
Cytogenetic Map10D2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Trhde
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730937
Created: 2003-12-10
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.