Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | ISO | Trhde (Rattus norvegicus) | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of TRHDE mRNA] | CTD | PMID:31150632 | (1->4)-beta-D-glucan | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of TRHDE mRNA | CTD | PMID:36331819 | 1-naphthyl isothiocyanate | decreases expression | ISO | Trhde (Rattus norvegicus) | 6480464 | 1-Naphthylisothiocyanate results in decreased expression of TRHDE mRNA | CTD | PMID:30723492 | 17beta-estradiol | decreases expression | ISO | TRHDE (Homo sapiens) | 6480464 | Estradiol results in decreased expression of TRHDE mRNA | CTD | PMID:20106945 | 2,2',5,5'-tetrachlorobiphenyl | decreases expression | ISO | TRHDE (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:36804509 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | TRHDE (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of TRHDE mRNA | CTD | PMID:20106945 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Trhde (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of TRHDE mRNA | CTD | PMID:32109520 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Trhde (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of TRHDE mRNA | CTD | PMID:22298810 | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | ISO | Trhde (Rattus norvegicus) | 6480464 | 2 more ... | CTD | PMID:32109520 | 2-palmitoylglycerol | increases expression | ISO | TRHDE (Homo sapiens) | 6480464 | 2-palmitoylglycerol results in increased expression of TRHDE mRNA | CTD | PMID:37199045 | 4,4'-sulfonyldiphenol | increases expression | ISO | TRHDE (Homo sapiens) | 6480464 | bisphenol S results in increased expression of TRHDE mRNA | CTD | PMID:30616060 | 4,4'-sulfonyldiphenol | affects methylation | EXP | | 6480464 | bisphenol S affects the methylation of TRHDE gene | CTD | PMID:31683443 | 6-propyl-2-thiouracil | decreases expression | ISO | Trhde (Rattus norvegicus) | 6480464 | Propylthiouracil results in decreased expression of TRHDE mRNA | CTD | PMID:24780913 and PMID:25825206 | acetamide | decreases expression | ISO | Trhde (Rattus norvegicus) | 6480464 | acetamide results in decreased expression of TRHDE mRNA | CTD | PMID:31881176 | aflatoxin B1 | affects expression | ISO | TRHDE (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of TRHDE protein | CTD | PMID:20106945 | aflatoxin B1 | increases methylation | ISO | TRHDE (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of TRHDE intron | CTD | PMID:30157460 | aflatoxin B1 | decreases methylation | ISO | TRHDE (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of TRHDE gene | CTD | PMID:27153756 | aristolochic acid A | decreases expression | ISO | TRHDE (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of TRHDE mRNA | CTD | PMID:33212167 | arsane | affects methylation | ISO | TRHDE (Homo sapiens) | 6480464 | Arsenic affects the methylation of TRHDE gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | TRHDE (Homo sapiens) | 6480464 | Arsenic affects the methylation of TRHDE gene | CTD | PMID:25304211 | arsenite(3-) | multiple interactions | ISO | TRHDE (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to TRHDE mRNA] | CTD | PMID:32406909 | atrazine | affects methylation | ISO | Trhde (Rattus norvegicus) | 6480464 | Atrazine affects the methylation of TRHDE gene | CTD | PMID:35440735 | benzo[a]pyrene | decreases expression | ISO | TRHDE (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of TRHDE mRNA | CTD | PMID:20106945 and PMID:32234424 | benzo[a]pyrene | affects methylation | ISO | TRHDE (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of TRHDE intron | CTD | PMID:30157460 | benzo[a]pyrene | increases expression | ISO | Trhde (Rattus norvegicus) | 6480464 | Benzo(a)pyrene results in increased expression of TRHDE mRNA | CTD | PMID:21839799 | benzo[e]pyrene | decreases methylation | ISO | TRHDE (Homo sapiens) | 6480464 | benzo(e)pyrene results in decreased methylation of TRHDE intron | CTD | PMID:30157460 | bisphenol A | decreases expression | ISO | Trhde (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of TRHDE mRNA | CTD | PMID:25181051 more ... | bisphenol A | increases expression | ISO | Trhde (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of TRHDE mRNA | CTD | PMID:33296240 | carbamazepine | affects expression | ISO | TRHDE (Homo sapiens) | 6480464 | Carbamazepine affects the expression of TRHDE mRNA | CTD | PMID:25979313 | chlorpyrifos | decreases expression | EXP | | 6480464 | Chlorpyrifos results in decreased expression of TRHDE mRNA | CTD | PMID:37019170 | choline | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TRHDE gene | CTD | PMID:20938992 | cisplatin | multiple interactions | ISO | TRHDE (Homo sapiens) | 6480464 | Cisplatin inhibits the reaction [Piroxicam results in decreased expression of TRHDE mRNA] | CTD | PMID:21858171 | Cuprizon | decreases expression | ISO | Trhde (Rattus norvegicus) | 6480464 | Cuprizone results in decreased expression of TRHDE mRNA | CTD | PMID:26577399 | cyclosporin A | decreases expression | ISO | TRHDE (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of TRHDE mRNA | CTD | PMID:20106945 and PMID:27989131 | dorsomorphin | multiple interactions | ISO | TRHDE (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | endosulfan | decreases expression | ISO | Trhde (Rattus norvegicus) | 6480464 | Endosulfan results in decreased expression of TRHDE mRNA | CTD | PMID:29391264 | ethanol | affects splicing | EXP | | 6480464 | Ethanol affects the splicing of TRHDE mRNA | CTD | PMID:30319688 | folic acid | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TRHDE gene | CTD | PMID:20938992 | folic acid | decreases expression | EXP | | 6480464 | Folic Acid results in decreased expression of TRHDE mRNA | CTD | PMID:25629700 | fonofos | increases methylation | ISO | TRHDE (Homo sapiens) | 6480464 | Fonofos results in increased methylation of TRHDE promoter | CTD | PMID:22847954 | furan | decreases expression | ISO | Trhde (Rattus norvegicus) | 6480464 | furan results in decreased expression of TRHDE mRNA | CTD | PMID:25539665 | glycidol | decreases expression | ISO | Trhde (Rattus norvegicus) | 6480464 | glycidol results in decreased expression of TRHDE mRNA | CTD | PMID:24915197 | L-methionine | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TRHDE gene | CTD | PMID:20938992 | lead diacetate | affects methylation | ISO | Trhde (Rattus norvegicus) | 6480464 | lead acetate affects the methylation of TRHDE gene | CTD | PMID:29571894 | lead diacetate | increases expression | ISO | Trhde (Rattus norvegicus) | 6480464 | lead acetate results in increased expression of TRHDE mRNA | CTD | PMID:29571894 | methapyrilene | decreases methylation | ISO | TRHDE (Homo sapiens) | 6480464 | Methapyrilene results in decreased methylation of TRHDE intron | CTD | PMID:30157460 | N-Nitrosopyrrolidine | decreases expression | ISO | TRHDE (Homo sapiens) | 6480464 | N-Nitrosopyrrolidine results in decreased expression of TRHDE mRNA | CTD | PMID:32234424 | O-methyleugenol | decreases expression | ISO | TRHDE (Homo sapiens) | 6480464 | methyleugenol results in decreased expression of TRHDE mRNA | CTD | PMID:32234424 | parathion | increases methylation | ISO | TRHDE (Homo sapiens) | 6480464 | Parathion results in increased methylation of TRHDE promoter | CTD | PMID:22847954 | perfluorooctane-1-sulfonic acid | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of TRHDE mRNA and [perfluorooctane sulfonic acid co-treated with Pectins] results in decreased expression of TRHDE mRNA | CTD | PMID:36331819 | phenylmercury acetate | increases expression | ISO | TRHDE (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of TRHDE mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | TRHDE (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRHDE mRNA | CTD | PMID:27188386 | phorbol 13-acetate 12-myristate | multiple interactions | ISO | TRHDE (Homo sapiens) | 6480464 | [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of TRHDE mRNA | CTD | PMID:16979875 | piroxicam | decreases expression | ISO | TRHDE (Homo sapiens) | 6480464 | Piroxicam results in decreased expression of TRHDE mRNA | CTD | PMID:21858171 | piroxicam | multiple interactions | ISO | TRHDE (Homo sapiens) | 6480464 | Cisplatin inhibits the reaction [Piroxicam results in decreased expression of TRHDE mRNA] | CTD | PMID:21858171 | SB 431542 | multiple interactions | ISO | TRHDE (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | sodium arsenite | decreases expression | EXP | | 6480464 | sodium arsenite results in decreased expression of TRHDE mRNA | CTD | PMID:36209798 | sodium dichromate | decreases expression | ISO | Trhde (Rattus norvegicus) | 6480464 | sodium bichromate results in decreased expression of TRHDE mRNA | CTD | PMID:25993096 | terbufos | increases methylation | ISO | TRHDE (Homo sapiens) | 6480464 | terbufos results in increased methylation of TRHDE promoter | CTD | PMID:22847954 | tetrachloromethane | decreases expression | ISO | Trhde (Rattus norvegicus) | 6480464 | Carbon Tetrachloride results in decreased expression of TRHDE mRNA | CTD | PMID:31150632 | tetrachloromethane | multiple interactions | ISO | Trhde (Rattus norvegicus) | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of TRHDE mRNA] | CTD | PMID:31150632 | thioacetamide | decreases activity | ISO | Trhde (Rattus norvegicus) | 6480464 | Thioacetamide results in decreased activity of TRHDE protein | CTD | PMID:11856362 | thioacetamide | decreases expression | ISO | Trhde (Rattus norvegicus) | 6480464 | Thioacetamide results in decreased expression of TRHDE mRNA | CTD | PMID:23411599 and PMID:34492290 | trichloroethene | increases expression | ISO | Trhde (Rattus norvegicus) | 6480464 | Trichloroethylene results in increased expression of TRHDE mRNA | CTD | PMID:33387578 | valproic acid | affects expression | ISO | TRHDE (Homo sapiens) | 6480464 | Valproic Acid affects the expression of TRHDE mRNA | CTD | PMID:25979313 | valproic acid | multiple interactions | ISO | TRHDE (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRHDE mRNA | CTD | PMID:27188386 | valproic acid | increases expression | ISO | TRHDE (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of TRHDE mRNA | CTD | PMID:23179753 more ... | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of TRHDE mRNA | CTD | PMID:24896083 | valproic acid | decreases methylation | ISO | TRHDE (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of TRHDE gene | CTD | PMID:29154799 | vorinostat | increases expression | ISO | TRHDE (Homo sapiens) | 6480464 | vorinostat results in increased expression of TRHDE mRNA | CTD | PMID:27188386 | zinc atom | multiple interactions | ISO | TRHDE (Homo sapiens) | 6480464 | [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of TRHDE mRNA | CTD | PMID:16979875 | zinc(0) | multiple interactions | ISO | TRHDE (Homo sapiens) | 6480464 | [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of TRHDE mRNA | CTD | PMID:16979875 | |