Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730937
Species: Mus musculus
RGD Object: Gene
Symbol: Trhde
Name: TRH-degrading enzyme
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDValproic Acid results in decreased expression of TRHDE mRNA

PMID:24896083
affects expressionISORGD:7309366480464CTDValproic Acid affects the expression of TRHDE mRNA

PMID:25979313
decreases methylationISORGD:7309366480464CTDValproic Acid results in decreased methylation of TRHDE gene

PMID:29154799
increases expressionISORGD:7309366480464CTDValproic Acid results in increased expression of TRHDE mRNA

PMID:23179753, PMID:24383497, PMID:26272509, PMID:28001369
multiple interactionsISORGD:7309366480464CTD[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRHDE mRNA

PMID:27188386
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.