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Gene: TRHDE (thyrotropin releasing hormone degrading enzyme) Homo sapiens
Symbol: TRHDE
Name: thyrotropin releasing hormone degrading enzyme
Description: This gene encodes a member of the peptidase M1 family. The encoded protein is an extracellular peptidase that specifically cleaves and inactivates the neuropeptide thyrotropin-releasing hormone.[provided by RefSeq, Dec 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ22381; PAP-II; PGPEP2; pyroglutamyl aminopeptidase II; pyroglutamyl-peptidase II; thyroliberinase; thyrotropin-releasing hormone degrading ectoenzyme; thyrotropin-releasing hormone degrading enzyme; thyrotropin-releasing hormone-degrading ectoenzyme; TRH-DE; TRH-degrading ectoenzyme; TRH-specific aminopeptidase
Mus musculus (house mouse) : Trhde (TRH-degrading enzyme)  MGI  Alliance
Rattus norvegicus (Norway rat) : Trhde (thyrotropin-releasing hormone degrading enzyme)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Trhde (thyrotropin releasing hormone degrading enzyme)
Pan paniscus (bonobo/pygmy chimpanzee) : TRHDE (thyrotropin releasing hormone degrading enzyme)
Canis lupus familiaris (dog) : TRHDE (thyrotropin releasing hormone degrading enzyme)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Trhde (thyrotropin releasing hormone degrading enzyme)
Sus scrofa (pig) : TRHDE (thyrotropin releasing hormone degrading enzyme)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381272,087,288 - 72,666,662 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371272,666,314 - 73,059,422 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361270,952,730 - 71,345,689 (+)NCBINCBI36hg18NCBI36
Build 341270,952,729 - 71,345,688NCBI
Celera1272,329,850 - 72,723,987 (+)NCBI
Cytogenetic Map12q21.1NCBI
HuRef1269,714,852 - 70,107,634 (+)NCBIHuRef
CHM1_11272,632,089 - 73,024,946 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TRHDE
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730936
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2019-05-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.