GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730937
Species: Mus musculus
RGD Object: Gene
Symbol: Trhde
Name: TRH-degrading enzyme
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7309366480464CTDCisplatin inhibits the reaction [Piroxicam results in decreased expression of TRHDE mRNA]

PMID:21858171
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.