Il22 (interleukin 22) - Rat Genome Database

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Pathways
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Gene: Il22 (interleukin 22) Rattus norvegicus
Analyze
Symbol: Il22
Name: interleukin 22
RGD ID: 1561292
Description: Predicted to enable cytokine activity. Involved in response to glucocorticoid. Located in extracellular space. Used to study asthma and myocarditis. Orthologous to human IL22 (interleukin 22); PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; copper atom.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: If2b1; interferon 2b1; interleukin-22; LOC500836; RGD1561292; similar to TIF alpha protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8755,687,061 - 55,691,526 (+)NCBIGRCr8
mRatBN7.2753,801,206 - 53,805,673 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl753,801,206 - 53,806,186 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx755,707,913 - 55,712,384 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0757,911,013 - 57,915,480 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0757,688,861 - 57,693,326 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0761,236,037 - 61,240,502 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl761,236,037 - 61,240,502 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0761,232,296 - 61,236,761 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4757,517,321 - 57,521,786 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera750,569,426 - 50,573,904 (+)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Dual Role of IL-22 in allergic airway inflammation and its cross-talk with IL-17A. Besnard AG, etal., Am J Respir Crit Care Med. 2011 May 1;183(9):1153-63. Epub 2011 Feb 4.
2. Hydrodynamic-based delivery of an interleukin-22-Ig fusion gene ameliorates experimental autoimmune myocarditis in rats. Chang H, etal., J Immunol. 2006 Sep 15;177(6):3635-43.
3. Role of group 3 innate lymphoid cells during experimental otitis media in a rat model. Cho CG, etal., Int J Pediatr Otorhinolaryngol. 2016 Sep;88:146-52. doi: 10.1016/j.ijporl.2016.07.001. Epub 2016 Jul 6.
4. IL-22 produced by human NK cells inhibits growth of Mycobacterium tuberculosis by enhancing phagolysosomal fusion. Dhiman R, etal., J Immunol. 2009 Nov 15;183(10):6639-45. Epub 2009 Oct 28.
5. IL-22 mRNA in peripheral blood mononuclear cells from allergic rhinitic and asthmatic pediatric patients. Farfariello V, etal., Pediatr Allergy Immunol. 2011 Jun;22(4):419-23. doi: 10.1111/j.1399-3038.2010.01116.x.
6. Interleukin-22 (IL-22) production by pulmonary Natural Killer cells and the potential role of IL-22 during primary influenza virus infection. Guo H and Topham DJ, J Virol. 2010 Aug;84(15):7750-9. Epub 2010 May 26.
7. Protective properties of inhaled IL-22 in a model of ventilator-induced lung injury. Hoegl S, etal., Am J Respir Cell Mol Biol. 2011 Mar;44(3):369-76. Epub 2010 May 12.
8. Influenza A inhibits Th17-mediated host defense against bacterial pneumonia in mice. Kudva A, etal., J Immunol. 2011 Feb 1;186(3):1666-74. Epub 2010 Dec 22.
9. Predominance of interleukin-22 over interleukin-17 at the site of disease in human tuberculosis. Matthews K, etal., Tuberculosis (Edinb). 2011 Jul 16.
10. High expression of IL-22 suppresses antigen-induced immune responses and eosinophilic airway inflammation via an IL-10-associated mechanism. Nakagome K, etal., J Immunol. 2011 Nov 15;187(10):5077-89. doi: 10.4049/jimmunol.1001560. Epub 2011 Oct 12.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A. Sonnenberg GF, etal., J Exp Med. 2010 Jun 7;207(6):1293-305. Epub 2010 May 24.
16. IL-22 Is Produced by Innate Lymphoid Cells and Limits Inflammation in Allergic Airway Disease. Taube C, etal., PLoS One. 2011;6(7):e21799. Epub 2011 Jul 18.
17. Characterization of Multiple Sclerosis candidate gene expression kinetics in rat experimental autoimmune encephalomyelitis. Thessen Hedreul M, etal., J Neuroimmunol. 2009 May 29;210(1-2):30-9. Epub 2009 Mar 9.
18. Dexamethasone suppresses interleukin-22 associated with bacterial infection in vitro and in vivo. Ziesche E, etal., Clin Exp Immunol. 2009 Sep;157(3):370-6.
Additional References at PubMed
PMID:12700595   PMID:16982811   PMID:22110656   PMID:22983826   PMID:23075849   PMID:25939251   PMID:26329427   PMID:26960328   PMID:28069865   PMID:28627588   PMID:29182672   PMID:31828174  


Genomics

Comparative Map Data
Il22
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8755,687,061 - 55,691,526 (+)NCBIGRCr8
mRatBN7.2753,801,206 - 53,805,673 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl753,801,206 - 53,806,186 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx755,707,913 - 55,712,384 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0757,911,013 - 57,915,480 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0757,688,861 - 57,693,326 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0761,236,037 - 61,240,502 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl761,236,037 - 61,240,502 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0761,232,296 - 61,236,761 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4757,517,321 - 57,521,786 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera750,569,426 - 50,573,904 (+)NCBICelera
Cytogenetic Map7q22NCBI
IL22
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381268,248,242 - 68,253,604 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1268,248,242 - 68,253,604 (-)EnsemblGRCh38hg38GRCh38
GRCh371268,642,022 - 68,647,384 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361266,928,292 - 66,933,548 (-)NCBINCBI36Build 36hg18NCBI36
Build 341266,928,291 - 66,933,548NCBI
Celera1268,306,041 - 68,311,297 (-)NCBICelera
Cytogenetic Map12q15NCBI
HuRef1265,693,180 - 65,698,437 (-)NCBIHuRef
CHM1_11268,610,008 - 68,615,263 (-)NCBICHM1_1
T2T-CHM13v2.01268,227,763 - 68,233,125 (-)NCBIT2T-CHM13v2.0
Il22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910118,040,456 - 118,045,952 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10118,040,847 - 118,045,952 (+)EnsemblGRCm39 Ensembl
GRCm3810118,204,584 - 118,210,047 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10118,204,942 - 118,210,047 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710117,642,020 - 117,647,103 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera10120,158,587 - 120,163,674 (+)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1066.67NCBI
Il22
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545814,747,084 - 14,752,553 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545814,747,339 - 14,755,602 (-)NCBIChiLan1.0ChiLan1.0
IL22
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21076,263,868 - 76,269,488 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11276,260,265 - 76,265,847 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01265,757,069 - 65,762,418 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11268,542,076 - 68,547,421 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1268,542,076 - 68,547,421 (-)Ensemblpanpan1.1panPan2
IL22
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11010,487,367 - 10,492,238 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1010,487,262 - 10,492,371 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1010,421,073 - 10,425,517 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01010,611,869 - 10,616,320 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1010,611,869 - 10,616,478 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11010,480,058 - 10,484,490 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01010,726,498 - 10,730,947 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01010,849,045 - 10,853,495 (-)NCBIUU_Cfam_GSD_1.0
Il22
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494547,878,379 - 47,883,251 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365456,227,118 - 6,231,745 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365456,227,118 - 6,231,745 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL22
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl532,599,471 - 32,604,513 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1532,599,522 - 32,604,507 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2535,412,598 - 35,417,067 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL22
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11163,881,743 - 63,887,695 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1163,882,093 - 63,886,761 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037181,819,049 - 181,824,422 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il22
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480246,585 - 51,095 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480246,585 - 51,095 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il22
30 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:84
Count of miRNA genes:68
Interacting mature miRNAs:68
Transcripts:ENSRNOT00000009776
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
2303629Vencon3Ventilatory control QTL 37.25respiration trait (VT:0001943)respiration rate (CMO:0000289)74110969256793354Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system respiratory system
High
Medium 2 2
Low 2 6 6 18 2 8
Below cutoff 1 2 2 5 2 8 6 7 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000009776   ⟹   ENSRNOP00000009776
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl753,801,206 - 53,806,186 (+)Ensembl
Rnor_6.0 Ensembl761,236,037 - 61,240,502 (+)Ensembl
RefSeq Acc Id: NM_001191988   ⟹   NP_001178917
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8755,687,061 - 55,691,526 (+)NCBI
mRatBN7.2753,801,206 - 53,805,673 (+)NCBI
Rnor_6.0761,236,037 - 61,240,502 (+)NCBI
Rnor_5.0761,232,296 - 61,236,761 (+)NCBI
Celera750,569,426 - 50,573,904 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001178917 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABF82262 (Get FASTA)   NCBI Sequence Viewer  
  CAB0000202 (Get FASTA)   NCBI Sequence Viewer  
  EDM16599 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009776
  ENSRNOP00000009776.3
Reference Protein Sequences
RefSeq Acc Id: NP_001178917   ⟸   NM_001191988
- Peptide Label: precursor
- UniProtKB: G3V6X6 (UniProtKB/TrEMBL),   A6IGU9 (UniProtKB/TrEMBL),   Q198B4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009776   ⟸   ENSRNOT00000009776

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V6X6-F1-model_v2 AlphaFold G3V6X6 1-179 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561292 AgrOrtholog
BioCyc Gene G2FUF-33944 BioCyc
Ensembl Genes ENSRNOG00000007365 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009776 ENTREZGENE
  ENSRNOT00000009776.5 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/TrEMBL
  Interleukin-10_CS UniProtKB/TrEMBL
  Interleukin-22 UniProtKB/TrEMBL
KEGG Report rno:500836 UniProtKB/TrEMBL
NCBI Gene 500836 ENTREZGENE
PANTHER INTERLEUKIN-22 UniProtKB/TrEMBL
  INTERLEUKIN-22 UniProtKB/TrEMBL
Pfam IL22 UniProtKB/TrEMBL
PhenoGen Il22 PhenoGen
PRINTS INTRLEUKIN22 UniProtKB/TrEMBL
PROSITE INTERLEUKIN_10 UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007365 RatGTEx
Superfamily-SCOP 4_helix_cytokine UniProtKB/TrEMBL
UniProt A6IGU9 ENTREZGENE, UniProtKB/TrEMBL
  G3V6X6 ENTREZGENE, UniProtKB/TrEMBL
  Q198B4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-23 Il22  interleukin 22  RGD1561292  similar to TIF alpha protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1561292  similar to TIF alpha protein   RGD1561292_predicted  similar to TIF alpha protein (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1561292_predicted  similar to TIF alpha protein (predicted)  LOC500836  similar to TIF alpha protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC500836  similar to TIF alpha protein      Symbol and Name status set to provisional 70820 PROVISIONAL