Il22 (interleukin 22) - Rat Genome Database

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Gene: Il22 (interleukin 22) Mus musculus
Analyze
Symbol: Il22
Name: interleukin 22
RGD ID: 1556865
MGI Page MGI
Description: Enables cytokine activity. Involved in negative regulation of inflammatory response. Acts upstream of or within positive regulation of transcription by RNA polymerase II; reactive oxygen species metabolic process; and regulation of tyrosine phosphorylation of STAT protein. Is active in extracellular space. Is expressed in ileum; retina; and skin. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IL22 (interleukin 22).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: If2b1; Il; IL-; IL-10-related T-cell-derived-inducible factor; IL-22; IL-22a; IL-TIF alpha; Iltif; ILTIF alpha; ILTIFa; interferon 2b1; interleukin 10-related T cell-derived inducible factor; interleukin-22; interleukin-22a; MGC129416; MGC129417
RGD Orthologs
Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910118,040,456 - 118,045,952 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10118,040,847 - 118,045,952 (+)EnsemblGRCm39 Ensembl
GRCm3810118,204,584 - 118,210,047 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10118,204,942 - 118,210,047 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710117,642,020 - 117,647,103 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera10120,158,587 - 120,163,674 (+)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1066.67NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal circulating cytokine level  (IAGP)
abnormal colon morphology  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal large intestine crypts of Lieberkuhn morphology  (IAGP)
abnormal skin morphology  (IAGP)
abnormal susceptibility to bacterial infection  (IAGP)
abnormal wound healing  (IAGP)
acanthosis  (IAGP)
colitis  (IAGP)
decreased alimentary system tumor incidence  (IAGP)
decreased body weight  (IAGP)
decreased circulating interleukin-1 alpha level  (IAGP)
decreased circulating interleukin-12 level  (IAGP)
decreased circulating interleukin-12b level  (IAGP)
decreased circulating tumor necrosis factor level  (IAGP)
decreased neutrophil cell number  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
delayed wound healing  (IAGP)
ear inflammation  (IAGP)
increased circulating alanine transaminase level  (IAGP)
increased circulating aspartate transaminase level  (IAGP)
increased circulating interleukin-17 level  (IAGP)
increased erythrocyte cell number  (IAGP)
increased erythroid progenitor cell number  (IAGP)
increased incidence of tumors by chemical induction  (IAGP)
increased interleukin-17 secretion  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
increased susceptibility to endotoxin shock  (IAGP)
increased susceptibility to fungal infection  (IAGP)
increased susceptibility to induced colitis  (IAGP)
increased susceptibility to weight loss  (IAGP)
liver inflammation  (IAGP)
lung inflammation  (IAGP)
mixed cellular infiltration to dermis  (IAGP)
multifocal hepatic necrosis  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
skin inflammation  (IAGP)
skin lesions  (IAGP)
thick dermal layer  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Dual Role of IL-22 in allergic airway inflammation and its cross-talk with IL-17A. Besnard AG, etal., Am J Respir Crit Care Med. 2011 May 1;183(9):1153-63. Epub 2011 Feb 4.
2. Hydrodynamic-based delivery of an interleukin-22-Ig fusion gene ameliorates experimental autoimmune myocarditis in rats. Chang H, etal., J Immunol. 2006 Sep 15;177(6):3635-43.
3. Role of group 3 innate lymphoid cells during experimental otitis media in a rat model. Cho CG, etal., Int J Pediatr Otorhinolaryngol. 2016 Sep;88:146-52. doi: 10.1016/j.ijporl.2016.07.001. Epub 2016 Jul 6.
4. IL-22 produced by human NK cells inhibits growth of Mycobacterium tuberculosis by enhancing phagolysosomal fusion. Dhiman R, etal., J Immunol. 2009 Nov 15;183(10):6639-45. Epub 2009 Oct 28.
5. IL-22 mRNA in peripheral blood mononuclear cells from allergic rhinitic and asthmatic pediatric patients. Farfariello V, etal., Pediatr Allergy Immunol. 2011 Jun;22(4):419-23. doi: 10.1111/j.1399-3038.2010.01116.x.
6. Interleukin-22 (IL-22) production by pulmonary Natural Killer cells and the potential role of IL-22 during primary influenza virus infection. Guo H and Topham DJ, J Virol. 2010 Aug;84(15):7750-9. Epub 2010 May 26.
7. Protective properties of inhaled IL-22 in a model of ventilator-induced lung injury. Hoegl S, etal., Am J Respir Cell Mol Biol. 2011 Mar;44(3):369-76. Epub 2010 May 12.
8. Influenza A inhibits Th17-mediated host defense against bacterial pneumonia in mice. Kudva A, etal., J Immunol. 2011 Feb 1;186(3):1666-74. Epub 2010 Dec 22.
9. Predominance of interleukin-22 over interleukin-17 at the site of disease in human tuberculosis. Matthews K, etal., Tuberculosis (Edinb). 2011 Jul 16.
10. MGDs mouse GO annotations MGD data from the GO Consortium
11. High expression of IL-22 suppresses antigen-induced immune responses and eosinophilic airway inflammation via an IL-10-associated mechanism. Nakagome K, etal., J Immunol. 2011 Nov 15;187(10):5077-89. doi: 10.4049/jimmunol.1001560. Epub 2011 Oct 12.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. Mouse MP Annotation Import Pipeline RGD automated import pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A. Sonnenberg GF, etal., J Exp Med. 2010 Jun 7;207(6):1293-305. Epub 2010 May 24.
16. IL-22 Is Produced by Innate Lymphoid Cells and Limits Inflammation in Allergic Airway Disease. Taube C, etal., PLoS One. 2011;6(7):e21799. Epub 2011 Jul 18.
17. Characterization of Multiple Sclerosis candidate gene expression kinetics in rat experimental autoimmune encephalomyelitis. Thessen Hedreul M, etal., J Neuroimmunol. 2009 May 29;210(1-2):30-9. Epub 2009 Mar 9.
18. Dexamethasone suppresses interleukin-22 associated with bacterial infection in vitro and in vivo. Ziesche E, etal., Clin Exp Immunol. 2009 Sep;157(3):370-6.
Additional References at PubMed
PMID:10349636   PMID:10657629   PMID:11042159   PMID:11076861   PMID:11197690   PMID:11217851   PMID:12040188   PMID:12477932   PMID:12700595   PMID:15383460   PMID:15921521   PMID:16212920  
PMID:16982811   PMID:17114505   PMID:17187052   PMID:17261606   PMID:17442982   PMID:17483407   PMID:17919941   PMID:18056351   PMID:18172556   PMID:18202747   PMID:18264109   PMID:18264110  
PMID:18506885   PMID:18589157   PMID:18992745   PMID:19010461   PMID:19084435   PMID:19100701   PMID:19114665   PMID:19180498   PMID:19204111   PMID:19297659   PMID:19342625   PMID:19564350  
PMID:19846871   PMID:19853481   PMID:19875704   PMID:19995958   PMID:20131264   PMID:20194033   PMID:20220096   PMID:20231432   PMID:20421647   PMID:20445503   PMID:20566828   PMID:20855496  
PMID:20870942   PMID:20921529   PMID:20935648   PMID:20971950   PMID:21172868   PMID:21194981   PMID:21341264   PMID:21347242   PMID:21391996   PMID:21400499   PMID:21465510   PMID:21518800  
PMID:21518851   PMID:21573786   PMID:21600206   PMID:21708106   PMID:21767811   PMID:21794904   PMID:21795593   PMID:21874025   PMID:21897855   PMID:21953641   PMID:22003199   PMID:22038916  
PMID:22101730   PMID:22131335   PMID:22207130   PMID:22253568   PMID:22266282   PMID:22294696   PMID:22306017   PMID:22383805   PMID:22546855   PMID:22624013   PMID:22691704   PMID:22711885  
PMID:22739232   PMID:22808266   PMID:22921121   PMID:22933634   PMID:22952908   PMID:22961652   PMID:23006848   PMID:23027540   PMID:23050010   PMID:23050732   PMID:23064362   PMID:23075849  
PMID:23200827   PMID:23223145   PMID:23334981   PMID:23341629   PMID:23375450   PMID:23399894   PMID:23426605   PMID:23460846   PMID:23474919   PMID:23490254   PMID:23505056   PMID:23569233  
PMID:23585682   PMID:23589566   PMID:23596287   PMID:23626860   PMID:23674871   PMID:23690441   PMID:23698371   PMID:23715173   PMID:23781104   PMID:23793061   PMID:23798999   PMID:23836059  
PMID:23853597   PMID:24040208   PMID:24045577   PMID:24130494   PMID:24211183   PMID:24238108   PMID:24333537   PMID:24367046   PMID:24412612   PMID:24442439   PMID:24459233   PMID:24459235  
PMID:24508234   PMID:24523322   PMID:24531835   PMID:24577508   PMID:24676270   PMID:24677193   PMID:24720737   PMID:24797894   PMID:24808372   PMID:24999596   PMID:25024136   PMID:25051830  
PMID:25063867   PMID:25092334   PMID:25119041   PMID:25156366   PMID:25187663   PMID:25194055   PMID:25201978   PMID:25234944   PMID:25242258   PMID:25254361   PMID:25261485   PMID:25274297  
PMID:25327211   PMID:25344377   PMID:25367575   PMID:25483133   PMID:25547181   PMID:25568302   PMID:25663772   PMID:25680273   PMID:25734538   PMID:25777289   PMID:25902484   PMID:26006013  
PMID:26034212   PMID:26153763   PMID:26261005   PMID:26285207   PMID:26286991   PMID:26298743   PMID:26330334   PMID:26341825   PMID:26351278   PMID:26400286   PMID:26431948   PMID:26432894  
PMID:26455347   PMID:26496462   PMID:26595889   PMID:26647405   PMID:26649819   PMID:26692072   PMID:26729763   PMID:26834739   PMID:26853442   PMID:26867135   PMID:26870795   PMID:26882474  
PMID:26912904   PMID:27000947   PMID:27007677   PMID:27055194   PMID:27067635   PMID:27141930   PMID:27143303   PMID:27143304   PMID:27148790   PMID:27166675   PMID:27234655   PMID:27275094  
PMID:27322540   PMID:27450811   PMID:27456484   PMID:27524110   PMID:27524624   PMID:27534553   PMID:27551155   PMID:27551984   PMID:27650379   PMID:27792459   PMID:27796296   PMID:27930971  
PMID:28051088   PMID:28100680   PMID:28125663   PMID:28198364   PMID:28247861   PMID:28286877   PMID:28356382   PMID:28363907   PMID:28373766   PMID:28498296   PMID:28583370   PMID:28586167  
PMID:28607133   PMID:28634408   PMID:28637673   PMID:28647345   PMID:28655472   PMID:28726774   PMID:28747343   PMID:28811323   PMID:28887540   PMID:28939759   PMID:28942919   PMID:28974499  
PMID:29054964   PMID:29109123   PMID:29120744   PMID:29150554   PMID:29150834   PMID:29248460   PMID:29315356   PMID:29361119   PMID:29364878   PMID:29398651   PMID:29596938   PMID:29621481  
PMID:29728643   PMID:29750958   PMID:29760082   PMID:29764837   PMID:29920352   PMID:30114627   PMID:30183325   PMID:30355616   PMID:30389414   PMID:30449315   PMID:30515423   PMID:30566883  
PMID:30617224   PMID:30700914   PMID:30724106   PMID:30726742   PMID:30816423   PMID:30842312   PMID:30937919   PMID:30949574   PMID:30962403   PMID:31032952   PMID:31057534   PMID:31080013  
PMID:31132747   PMID:31148320   PMID:31196943   PMID:31278779   PMID:31292217   PMID:31451621   PMID:31586069   PMID:31681274   PMID:31695782   PMID:31725949   PMID:31770366   PMID:31792136  
PMID:31817755   PMID:31843590   PMID:31882461   PMID:31914395   PMID:31932715   PMID:32022386   PMID:32066975   PMID:32075728   PMID:32154791   PMID:32161582   PMID:32330729   PMID:32451418  
PMID:32503875   PMID:32517114   PMID:32569771   PMID:32649314   PMID:32817517   PMID:32901017   PMID:33060802   PMID:33275986   PMID:33443222   PMID:33451114   PMID:33488580   PMID:33513946  
PMID:33531483   PMID:33547295   PMID:33589625   PMID:33717066   PMID:33737460   PMID:33753942   PMID:33784296   PMID:33876425   PMID:34015450   PMID:34195684   PMID:34253059   PMID:34383769  
PMID:34504008   PMID:34638962   PMID:34685526   PMID:34713687   PMID:34795263   PMID:34853467   PMID:34879240   PMID:35054942   PMID:35090380   PMID:35133054   PMID:35137988   PMID:35169117  
PMID:35176228   PMID:35304419   PMID:35340206   PMID:35603884   PMID:35732121   PMID:35955566   PMID:36028760   PMID:36070798   PMID:36108991   PMID:36161939   PMID:36275755   PMID:36458743  
PMID:36544775   PMID:36630911   PMID:36630913   PMID:36631003   PMID:36634807   PMID:36635952   PMID:36787741   PMID:37102758   PMID:37114045   PMID:37310646   PMID:37319277   PMID:37445595  
PMID:37680073   PMID:37726288   PMID:37876835   PMID:37908362   PMID:37952849   PMID:38036287   PMID:38047677   PMID:38054920   PMID:38101567   PMID:38492359  


Genomics

Comparative Map Data
Il22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910118,040,456 - 118,045,952 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10118,040,847 - 118,045,952 (+)EnsemblGRCm39 Ensembl
GRCm3810118,204,584 - 118,210,047 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10118,204,942 - 118,210,047 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710117,642,020 - 117,647,103 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera10120,158,587 - 120,163,674 (+)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1066.67NCBI
Il22
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8755,687,061 - 55,691,526 (+)NCBIGRCr8
mRatBN7.2753,801,206 - 53,805,673 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl753,801,206 - 53,806,186 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx755,707,913 - 55,712,384 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0757,911,013 - 57,915,480 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0757,688,861 - 57,693,326 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0761,236,037 - 61,240,502 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl761,236,037 - 61,240,502 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0761,232,296 - 61,236,761 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4757,517,321 - 57,521,786 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera750,569,426 - 50,573,904 (+)NCBICelera
Cytogenetic Map7q22NCBI

Variants

.
Variants in Il22
251 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:90
Count of miRNA genes:80
Interacting mature miRNAs:81
Transcripts:ENSMUST00000096691
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045476096120635905Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059335822122335905Mouse
13208560Wght9_mweight 9 (mouse)1059835822120835905Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1067835830124835905Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
11353832Pcholq4_mplasma cholesterol QTL 4 (mouse)1073987216125515907Mouse
11353843Gluq1_mblood glucose QTL 1 (mouse)1073987216125515907Mouse
1357594Estoq3_membryo survival total QTL 3 (mouse)Not determined1084079650122041528Mouse
1357622Espq3_membryo survival preimplantation QTL 3 (mouse)Not determined1084079650122041528Mouse
4141479W10q8_mweight 10 weeks QTL 8 (mouse)Not determined84079650122041528Mouse
4142496W6q8_mweight 6 weeks QTL 8 (mouse)Not determined84079650122041528Mouse
4141387Lgaq5_mlate growth adjusted QTL 5 (mouse)Not determined84079650122041528Mouse
4142365Egq9_mearly growth QTL 9 (mouse)Not determined84079650122041528Mouse
1357779Tesq3_mtestis weight QTL 3 (mouse)Not determined1084079650122041528Mouse
1357638Cia29_mcollagen induced arthritis 29 (mouse)Not determined1085454982118497353Mouse
1300797Sluc22_msusceptibility to lung cancer 22 (mouse)Not determined1086713608120713756Mouse
1300908Insq4_minsulin QTL 4 (mouse)Not determined1086909085120909229Mouse
1301520Uvbi1_mUVB induced immunosuppression 1 (mouse)Not determined1086909085120909229Mouse
1300921Skl4_mskeletal size (tail length) 4 (mouse)Not determined1088088254122088391Mouse
4142386Tgq20_mtriglyceride QTL 20 (mouse)Not determined88836456122836456Mouse
1301758Fcsa3_mfemoral cross-sectional area 3 (mouse)Not determined1089927651123927754Mouse
11039516Ltpr5_mLeishmania tropica response 5 (mouse)1090506901125575232Mouse
13208554Lgth11_mbody length 11 (mouse)1090835862120835905Mouse
1357544Vtbt10_mvertebral trabecular bone trait 10 (mouse)Not determined1097217101130530862Mouse
4142461Bmd25_mbone mineral density 25 (mouse)Not determined1097217101130530862Mouse
11533919Mvb4_mmodifier of vibrator 4 (mouse)397217101130530862Mouse
11533921Mvb2_mmodifier of vibrator 2 (mouse)1097217101130530862Mouse
12880413V125Dq9_mvitamin D active form serum level QTL 9 (mouse)1097535905130530862Mouse
4141402T2dm1sa_mtype 2 diabetes mellitus 1 in SMXA RI mice (mouse)Not determined97758644130530862Mouse
11040593Lmr5e_mleishmaniasis resistance 5e (mouse)1099220635130530862Mouse
11040595Lmr5c_mleishmaniasis resistance 5c (mouse)1099220635130530862Mouse
11040597Lmr5a_mleishmaniasis resistance 5a (mouse)1099220635130530862Mouse
1357744Cfbw4_mcystic fibrosis body weight 4 (mouse)Not determined10100986516130530862Mouse
1301968Estq4_mestradiol regulated response QTL 4 (mouse)Not determined10100986516130530862Mouse
1301901Im5_mimmunoregulatory 5 (mouse)Not determined10101497164130530862Mouse
4141361Cfmq3_mcystic fibrosis modifier QTL 3 (mouse)Not determined10101497164130530862Mouse
1300678Leg2_mlongevity extending gene 2 (mouse)Not determined10102506908130530862Mouse
27226725Tibw1_mtibia width 1, proximal, 5 week (mouse)10102735861123235905Mouse
1301895Exq1_mexploratory and excitability QTL 1 (mouse)Not determined10102847852130530862Mouse
14696727Kidrq2_mkidney weight, right QTL 2 (mouse)10102902508130530862Mouse
4141007Obrq10_mobesity resistance QTL 10 (mouse)Not determined103243727130530862Mouse
4141487Tgq21_mtriglyceride QTL 21 (mouse)Not determined104110021130530862Mouse
14746996Manh69_mmandible shape 69 (mouse)10104763638130530862Mouse
1302200Sle12_msystematic lupus erythematosus susceptibility 12 (mouse)Not determined10105041304130530862Mouse
1357482Nhdlq4_mnon-HDL QTL 4 (mouse)Not determined10105041304130530862Mouse
1300679Nociq2_mnociceptive sensitivity inflammatory QTL 2 (mouse)Not determined10105041304130530862Mouse
4141269Ipng2_mimprinted postnatal growth 2 (mouse)Not determined105088254118497353Mouse
11040594Lmr5f_mleishmaniasis resistance 5f (mouse)10105179713130530862Mouse
11040596Lmr5d_mleishmaniasis resistance 5d (mouse)10105179713130530862Mouse
11040598Lmr5b_mleishmaniasis resistance 5b (mouse)10105179713130530862Mouse
4142089Obrq9_mobesity resistance QTL 9 (mouse)Not determined108515907130530862Mouse
4141153Ltgq2_mliver triglyceride QTL 2 (mouse)Not determined108515907130530862Mouse
11041664Lmr25_mleishmaniasis resistance 25 (mouse)10108575094130530862Mouse
11039496Ltpr5b_mLeishmania tropica response 5b (mouse)10108575094130530862Mouse
11049570Lmr25b_mleishmaniasis resistance 25b (mouse)10108575094130530862Mouse
11049563Lmr25a_mleishmaniasis resistance 25a (mouse)10108575094130530862Mouse
27226722Tibw7_mtibia width 7, proximal, 16 week (mouse)10108635861125435869Mouse
27095902Scvln11_msacral vertebrae length 2, 10 week (mouse)10110035861125435869Mouse
11353822Insq12_minsulin QTL 12 (mouse)10110453347125515907Mouse
11353823Homaq2_mhomeostatic model assessment QTL 2 (mouse)10110453347125515907Mouse
26884391Skwq11_mskull length QTL 11, 16 week (mouse)10113535905121635905Mouse
26884433Zlq2_mzygomatic length QTL 2, 5 week (mouse)10113535905125735869Mouse
26884383Bzwq3_mbi-zygomatic width QTL 3, 5 week (mouse)10114235905122735905Mouse
13506931Recrq11_mrecombination rate in male meiosis QTL 11 (mouse)10114335905123635905Mouse
26884377Skwq3_mskull length QTL 3, 5 week (mouse)10114635905122735905Mouse
1300796Lmr5_mleishmaniasis resistance 5 (mouse)Not determined10116220635122179828Mouse

Markers in Region
Iltif  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810118,294,391 - 118,294,933UniSTSGRCm38
GRCm3810118,205,047 - 118,205,589UniSTSGRCm38
MGSCv3710117,642,103 - 117,642,645UniSTSGRCm37
MGSCv3710117,731,447 - 117,731,989UniSTSGRCm37
Celera10120,158,670 - 120,159,212UniSTS
Cytogenetic Map10D2UniSTS
cM Map1067.0UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000096691   ⟹   ENSMUSP00000094449
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10118,040,847 - 118,045,952 (+)Ensembl
GRCm38.p6 Ensembl10118,204,942 - 118,210,047 (+)Ensembl
RefSeq Acc Id: NM_016971   ⟹   NP_058667
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910118,040,869 - 118,045,952 (+)NCBI
GRCm3810118,204,964 - 118,210,047 (+)NCBI
MGSCv3710117,642,020 - 117,647,103 (+)RGD
Celera10120,158,587 - 120,163,674 (+)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006513865   ⟹   XP_006513928
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910118,040,456 - 118,045,481 (+)NCBI
GRCm3810118,204,584 - 118,209,576 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_058667   ⟸   NM_016971
- Peptide Label: precursor
- UniProtKB: Q14BB3 (UniProtKB/Swiss-Prot),   Q9JJY9 (UniProtKB/Swiss-Prot),   Q3SXE1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006513928   ⟸   XM_006513865
- Peptide Label: isoform X1
- UniProtKB: Q14BB3 (UniProtKB/Swiss-Prot),   Q9JJY9 (UniProtKB/Swiss-Prot),   Q3SXE1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000094449   ⟸   ENSMUST00000096691

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JJY9-F1-model_v2 AlphaFold Q9JJY9 1-179 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1355307 AgrOrtholog
Ensembl Genes ENSMUSG00000074695 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000096691 ENTREZGENE
  ENSMUST00000096691.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-10_CS UniProtKB/Swiss-Prot
  IL-22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:50929 UniProtKB/Swiss-Prot
MGD MGI:1355307 ENTREZGENE
NCBI Gene 50929 ENTREZGENE
PANTHER INTERLEUKIN-22 UniProtKB/Swiss-Prot
  INTERLEUKIN-22 UniProtKB/Swiss-Prot
  INTERLEUKIN-22 UniProtKB/TrEMBL
  INTERLEUKIN-22 UniProtKB/TrEMBL
Pfam IL22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Il22 PhenoGen
PIRSF Interleukin-22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS INTRLEUKIN22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE INTERLEUKIN_10 UniProtKB/Swiss-Prot
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt IL22_MOUSE UniProtKB/Swiss-Prot
  Q14BB3 ENTREZGENE
  Q3SXE1 ENTREZGENE, UniProtKB/TrEMBL
  Q9JJY9 ENTREZGENE
UniProt Secondary Q14BB3 UniProtKB/Swiss-Prot