Msrb3 (methionine sulfoxide reductase B3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Msrb3 (methionine sulfoxide reductase B3) Rattus norvegicus
Analyze
Symbol: Msrb3
Name: methionine sulfoxide reductase B3
RGD ID: 1596851
Description: Predicted to enable peptide-methionine (R)-S-oxide reductase activity and zinc ion binding activity. Predicted to be involved in protein repair. Predicted to be located in endoplasmic reticulum and mitochondrion. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 74. Orthologous to human MSRB3 (methionine sulfoxide reductase B3); PARTICIPATES IN glycine N-methyltransferase deficiency pathway; homocystinuria pathway; hypermethioninemia pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC680036; methionine-R-sulfoxide reductase B3; similar to methionine sulfoxide reductase B3 isoform 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8758,188,827 - 58,311,459 (-)NCBIGRCr8
mRatBN7.2756,260,985 - 56,426,004 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl756,303,308 - 56,425,496 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx758,210,057 - 58,332,036 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0760,413,274 - 60,535,252 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0760,190,641 - 60,312,634 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0762,850,506 - 62,972,487 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl762,850,515 - 62,972,084 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0762,835,857 - 62,954,890 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4760,148,413 - 60,206,141 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera753,051,311 - 53,172,931 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Msrb3Ratautosomal recessive nonsyndromic deafness  ISORGD:13515118554872ClinVar Annotator: match by term: Autosomal recessive nonsyndromic deafnessClinVarPMID:19650862|PMID:21185009|PMID:25741868|PMID:30303587
Msrb3Ratautosomal recessive nonsyndromic deafness 74  ISORGD:13515118554872ClinVar Annotator: match by term: Deafness, autosomal recessive 74 | ClinVar Annotator: match by term: more ...ClinVarPMID:19650862|PMID:21185009|PMID:24033266|PMID:25741868|PMID:26467025|PMID:28492532|PMID:30303587|PMID:30311386
Msrb3Ratgenetic disease  ISORGD:13515118554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:24033266|PMID:24949729|PMID:25741868|PMID:26467025|PMID:28492532
Msrb3RatHearing Loss  ISORGD:13515118554872ClinVar Annotator: match by term: Hearing loss | ClinVar Annotator: match by term: Nonsyndromic Hearing more ...ClinVarPMID:19650862|PMID:21185009|PMID:24033266|PMID:25741868|PMID:30303587
Msrb3Ratmucopolysaccharidosis type IIID  ISORGD:13515118554872ClinVar Annotator: match by term: Mucopolysaccharidosis, MPS-III-DClinVarPMID:20232353|PMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Msrb3RatHearing Loss  ISORGD:135151111554173CTD Direct Evidence: marker/mechanismCTDPMID:21782914
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Msrb3Ratautosomal recessive nonsyndromic deafness 74  ISSRGD:155276113592920OMIM:613718MouseDO 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Msrb3Ratautosomal recessive nonsyndromic deafness 74  ISORGD:13515117240710 OMIM 

1 to 20 of 89 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Msrb3Rat1,4-dithiothreitol increases reductionISORGD:13515116480464Dithiothreitol results in increased reduction of MSRB3 proteinCTDPMID:16735467
Msrb3Rat17beta-estradiol multiple interactionsISORGD:13515116480464[Estradiol co-treated with TGFB1 protein] results in increased expression of MSRB3 mRNACTDPMID:30165855
Msrb3Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISORGD:15527616480464[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of MSRB3 mRNA; [TIPARP gene more ...CTDPMID:16214954|PMID:25975270
Msrb3Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of MSRB3 mRNACTDPMID:34747641
Msrb3Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISORGD:15527616480464Tetrachlorodibenzodioxin results in decreased expression of MSRB3 mRNACTDPMID:27913140|PMID:33956508
Msrb3Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISORGD:15527616480464Tetrachlorodibenzodioxin results in increased expression of MSRB3 mRNACTDPMID:19465110|PMID:26290441
Msrb3Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:15527616480464Tetrachlorodibenzodioxin affects the expression of MSRB3 mRNACTDPMID:21570461|PMID:26377647
Msrb3Rat3,4-dichloroaniline decreases expressionISORGD:135151164804643,4-dichloroaniline results in decreased expression of MSRB3 mRNACTDPMID:24172598
Msrb3Rat4,4'-sulfonyldiphenol increases expressionISORGD:15527616480464bisphenol S results in increased expression of MSRB3 mRNACTDPMID:30951980
Msrb3Rat4,4'-sulfonyldiphenol affects methylationISORGD:15527616480464bisphenol S affects the methylation of MSRB3 geneCTDPMID:31683443
Msrb3Rat4,4'-sulfonyldiphenol multiple interactionsEXP 6480464[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of more ...CTDPMID:36041667
Msrb3Rat8-Br-cAMP decreases expressionISORGD:135151164804648-Bromo Cyclic Adenosine Monophosphate results in decreased expression of MSRB3 mRNACTDPMID:22079614
Msrb3Rataflatoxin B1 decreases methylationISORGD:13515116480464Aflatoxin B1 results in decreased methylation of MSRB3 geneCTDPMID:27153756
Msrb3Ratall-trans-retinoic acid multiple interactionsISORGD:15527616480464[bisphenol F co-treated with Tretinoin] results in decreased expression of MSRB3 mRNACTDPMID:30951980
Msrb3Ratantirheumatic drug increases expressionISORGD:13515116480464Antirheumatic Agents results in increased expression of MSRB3 mRNACTDPMID:24449571
Msrb3Ratarsane decreases expressionISORGD:15527616480464Arsenic results in decreased expression of MSRB3 mRNACTDPMID:19654921
Msrb3Ratarsane multiple interactionsISORGD:13515116480464[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of MSRB3 more ...CTDPMID:39836092
Msrb3Ratarsenic atom decreases expressionISORGD:15527616480464Arsenic results in decreased expression of MSRB3 mRNACTDPMID:19654921
Msrb3Ratarsenic atom multiple interactionsISORGD:13515116480464[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of MSRB3 more ...CTDPMID:39836092
Msrb3Ratbenzo[a]pyrene decreases expressionISORGD:15527616480464Benzo(a)pyrene results in decreased expression of MSRB3 mRNACTDPMID:19770486|PMID:21715664

1 to 20 of 89 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Msrb3Ratprotein repair involved_inISORGD:13515111624291 PMID:14699060RGDPMID:14699060
Msrb3Ratprotein repair involved_inIEAInterPro:IPR0284271600115GO_REF:0000002InterProGO_REF:0000002
Msrb3Ratresponse to oxidative stress involved_inIEAInterPro:IPR0284271600115GO_REF:0000002InterProGO_REF:0000002

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Msrb3Ratcytoplasm is_active_inIBAMGI:1923717|PANTHER:PTN000019160|TAIR:locus:2024817|UniProtKB:P0A746|UniProtKB:Q0DC89|UniProtKB:Q8IXL71600115GO_REF:0000033GO_CentralGO_REF:0000033
Msrb3Ratendoplasmic reticulum located_inISORGD:13515111624291 PMID:14699060RGDPMID:14699060
Msrb3Ratmitochondrion located_inISORGD:13515111624291 PMID:14699060RGDPMID:14699060
Msrb3Ratmitochondrion NOT|located_inISORGD:15527611624291 PMID:15249228RGDPMID:15249228

Molecular Function
1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Msrb3RatL-methionine-(R)-S-oxide reductase activity enablesIEAEC:1.8.4.141600115GO_REF:0000003UniProtGO_REF:0000003
Msrb3RatL-methionine-(R)-S-oxide reductase activity enablesIEARHEA:212601600115GO_REF:0000116RHEAGO_REF:0000116
Msrb3Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Msrb3Ratoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
Msrb3Ratoxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor enablesIEAInterPro:IPR0284271600115GO_REF:0000002InterProGO_REF:0000002
Msrb3Ratpeptide-methionine (R)-S-oxide reductase activity enablesISORGD:13515111624291 PMID:14699060RGDPMID:14699060
Msrb3Ratpeptide-methionine (R)-S-oxide reductase activity enablesIEAEC:1.8.4.121600115GO_REF:0000003UniProtGO_REF:0000003
Msrb3Ratpeptide-methionine (R)-S-oxide reductase activity enablesIBAFB:FBgn0267376|MGI:1923717|PANTHER:PTN000019160|TAIR:locus:2024817|UniProtKB:P0A746|UniProtKB:Q0DC89|UniProtKB:Q8IXL71600115GO_REF:0000033GO_CentralGO_REF:0000033
Msrb3Ratpeptide-methionine (R)-S-oxide reductase activity enablesIEAInterPro:IPR0025791600115GO_REF:0000002InterProGO_REF:0000002
Msrb3Ratprotein binding enablesISORGD:13515111624291UniProtKB:P15884|UniProtKB:Q08379|UniProtKB:Q15654|UniProtKB:Q9UKN5 PMID:25416956RGDPMID:25416956
Msrb3Ratprotein binding enablesISORGD:1351511,UniProtKB:Q8IXL7-21624291UniProtKB:A0A0C4DFN3|UniProtKB:A1KXE4-2|UniProtKB:A6NJ78-4|UniProtKB:O15354|UniProtKB:O60333-2|UniProtKB:O76011|UniProtKB:O76024|UniProtKB:P07196|UniProtKB:P28799|UniProtKB:P28799-2|UniProtKB:P36406|UniProtKB:P56537|UniProtKB:P56545-3|UniProtKB:P78424|UniProtKB:P80188|UniProtKB:Q04864-2|UniProtKB:Q08379|UniProtKB:Q12805|UniProtKB:Q13643|UniProtKB:Q15323|UniProtKB:Q58EX7|UniProtKB:Q6A162|UniProtKB:Q6NVU6|UniProtKB:Q7Z699|UniProtKB:Q86YW9|UniProtKB:Q8N9N5-2|UniProtKB:Q8WXB1|UniProtKB:Q8WXK3-2|UniProtKB:Q96AZ1|UniProtKB:Q9GZS3|UniProtKB:Q9H0C1|UniProtKB:Q9NRD5|UniProtKB:Q9Y3C5 PMID:32296183, PMID:32814053RGDPMID:32296183|PMID:32814053
Msrb3Ratzinc ion binding enablesISORGD:13515111624291 PMID:14699060RGDPMID:14699060
1 to 12 of 12 rows

Imported Annotations - SMPDB

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Msrb3Ratglycine N-methyltransferase deficiency pathway  ISORGD:135151110402751 SMPDBSMP:00222
Msrb3Rathomocystinuria pathway  ISORGD:135151110402751 SMPDBSMP:00177
Msrb3Rathypermethioninemia pathway  ISORGD:135151110402751 SMPDBSMP:00221
Msrb3Rathypermethioninemia pathway  ISORGD:135151110402751 SMPDBSMP:00341
Msrb3Ratmethionine cycle/metabolic pathway   ISORGD:135151110402751 SMPDBSMP:00033
Msrb3Ratmethylenetetrahydrofolate reductase deficiency pathway  ISORGD:135151110402751 SMPDBSMP:00340

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:14699060   PMID:15249228  



Msrb3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8758,188,827 - 58,311,459 (-)NCBIGRCr8
mRatBN7.2756,260,985 - 56,426,004 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl756,303,308 - 56,425,496 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx758,210,057 - 58,332,036 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0760,413,274 - 60,535,252 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0760,190,641 - 60,312,634 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0762,850,506 - 62,972,487 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl762,850,515 - 62,972,084 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0762,835,857 - 62,954,890 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4760,148,413 - 60,206,141 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera753,051,311 - 53,172,931 (-)NCBICelera
Cytogenetic Map7q22NCBI
MSRB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381265,278,683 - 65,466,907 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1265,278,643 - 65,491,430 (+)EnsemblGRCh38hg38GRCh38
GRCh371265,672,463 - 65,860,687 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361263,958,755 - 64,146,954 (+)NCBINCBI36Build 36hg18NCBI36
Build 341263,958,754 - 64,144,495NCBI
Celera1265,337,946 - 65,526,205 (+)NCBICelera
Cytogenetic Map12q14.3NCBI
HuRef1262,724,179 - 62,912,947 (+)NCBIHuRef
CHM1_11265,639,431 - 65,827,664 (+)NCBICHM1_1
T2T-CHM13v2.01265,257,707 - 65,446,355 (+)NCBIT2T-CHM13v2.0
Msrb3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910120,617,005 - 120,735,132 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10120,617,001 - 120,735,006 (-)EnsemblGRCm39 Ensembl
GRCm3810120,781,100 - 120,899,011 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10120,781,096 - 120,899,101 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710120,218,156 - 120,336,027 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610120,184,160 - 120,274,211 (-)NCBIMGSCv36mm8
Celera10123,146,728 - 123,236,798 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1068.75NCBI
Msrb3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545812,004,806 - 12,159,954 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545812,004,928 - 12,159,625 (+)NCBIChiLan1.0ChiLan1.0
MSRB3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21028,894,443 - 29,083,544 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11228,890,817 - 29,080,312 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01223,449,225 - 23,638,287 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11223,932,605 - 24,142,666 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1223,953,759 - 24,142,578 (-)Ensemblpanpan1.1panPan2
MSRB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1107,892,745 - 8,040,196 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl107,892,640 - 8,038,043 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha107,795,959 - 7,973,184 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0107,971,606 - 8,151,219 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl107,971,175 - 8,150,414 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1107,848,391 - 8,027,768 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0108,089,388 - 8,267,938 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0108,220,048 - 8,397,853 (+)NCBIUU_Cfam_GSD_1.0
Msrb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494550,469,459 - 50,629,140 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365453,480,853 - 3,640,924 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365453,480,995 - 3,637,913 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MSRB3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl529,695,640 - 29,863,599 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1529,695,824 - 29,863,601 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2532,920,043 - 33,088,181 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MSRB3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11160,970,103 - 61,157,950 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1160,969,985 - 61,154,356 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037184,566,475 - 184,731,720 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Msrb3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248022,860,319 - 2,997,908 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248022,863,930 - 3,025,345 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Msrb3
816 total Variants

Predicted Target Of
Summary Value
Count of predictions:164
Count of miRNA genes:124
Interacting mature miRNAs:137
Transcripts:ENSRNOT00000064251
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 37 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat

1 to 10 of 37 rows
BI276618  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2756,421,369 - 56,421,544 (+)MAPPERmRatBN7.2
Rnor_6.0762,968,038 - 62,968,212NCBIRnor6.0
Rnor_5.0762,950,805 - 62,950,979UniSTSRnor5.0
RGSC_v3.4760,202,206 - 60,202,380UniSTSRGSC3.4
Celera753,168,482 - 53,168,656UniSTS
RH 3.4 Map7492.4UniSTS
Cytogenetic Map7q22UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000064251   ⟹   ENSRNOP00000061871
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl756,303,315 - 56,425,496 (-)Ensembl
Rnor_6.0 Ensembl762,850,515 - 62,972,084 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113440   ⟹   ENSRNOP00000084360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl756,303,315 - 56,425,496 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116858   ⟹   ENSRNOP00000087206
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl756,303,308 - 56,425,329 (-)Ensembl
RefSeq Acc Id: NM_001398959   ⟹   NP_001385888
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8758,188,831 - 58,310,851 (-)NCBI
mRatBN7.2756,303,307 - 56,425,354 (-)NCBI
RefSeq Acc Id: XM_063264243   ⟹   XP_063120313
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8758,188,827 - 58,311,459 (-)NCBI
RefSeq Acc Id: XM_063264244   ⟹   XP_063120314
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8758,188,827 - 58,304,675 (-)NCBI
RefSeq Acc Id: XM_063264245   ⟹   XP_063120315
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8758,188,827 - 58,302,512 (-)NCBI
1 to 9 of 9 rows
Protein RefSeqs NP_001385888 (Get FASTA)   NCBI Sequence Viewer  
  XP_063120313 (Get FASTA)   NCBI Sequence Viewer  
  XP_063120314 (Get FASTA)   NCBI Sequence Viewer  
  XP_063120315 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM16562 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000061871.4
  ENSRNOP00000084360
  ENSRNOP00000084360.1
  ENSRNOP00000087206.1
1 to 9 of 9 rows
Ensembl Acc Id: ENSRNOP00000061871   ⟸   ENSRNOT00000064251
Ensembl Acc Id: ENSRNOP00000084360   ⟸   ENSRNOT00000113440
Ensembl Acc Id: ENSRNOP00000087206   ⟸   ENSRNOT00000116858
RefSeq Acc Id: NP_001385888   ⟸   NM_001398959
- UniProtKB: A0A8I6A7J1 (UniProtKB/TrEMBL),   A6IGY5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120313   ⟸   XM_063264243
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZZ33 (UniProtKB/TrEMBL)
MsrB

Name Modeler Protein Id AA Range Protein Structure
AF-D4A650-F1-model_v2 AlphaFold D4A650 1-271 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13695232
Promoter ID:EPDNEW_R5747
Type:initiation region
Name:Msrb3_1
Description:methionine sulfoxide reductase B3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0762,972,019 - 62,972,079EPDNEW


1 to 22 of 22 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-33886 BioCyc
Ensembl Genes ENSRNOG00000042668 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064251.4 UniProtKB/TrEMBL
  ENSRNOT00000113440 ENTREZGENE
  ENSRNOT00000113440.1 UniProtKB/TrEMBL
  ENSRNOT00000116858.1 UniProtKB/TrEMBL
Gene3D-CATH Peptide methionine sulfoxide reductase UniProtKB/TrEMBL
InterPro Met_Sox_Rdtase UniProtKB/TrEMBL
  Methionine_sulphoxide_MsrB UniProtKB/TrEMBL
  Mss4-like UniProtKB/TrEMBL
NCBI Gene 680036 ENTREZGENE
PANTHER METHIONINE-R-SULFOXIDE REDUCTASE B3 UniProtKB/TrEMBL
  PTHR10173 UniProtKB/TrEMBL
Pfam SelR UniProtKB/TrEMBL
PhenoGen Msrb3 PhenoGen
PROSITE MSRB UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042668 RatGTEx
Superfamily-SCOP Mss4_like UniProtKB/TrEMBL
UniProt A0A8I5ZZ33 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A7J1 ENTREZGENE, UniProtKB/TrEMBL
  A6IGY5 ENTREZGENE, UniProtKB/TrEMBL
  D4A650_RAT UniProtKB/TrEMBL
1 to 22 of 22 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-09 Msrb3  methionine sulfoxide reductase B3  LOC680036  similar to methionine sulfoxide reductase B3 isoform 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC680036  similar to methionine sulfoxide reductase B3 isoform 2      Symbol and Name status set to provisional 70820 PROVISIONAL