Irak3 (interleukin-1 receptor-associated kinase 3) - Rat Genome Database
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Gene: Irak3 (interleukin-1 receptor-associated kinase 3) Rattus norvegicus
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Symbol: Irak3
Name: interleukin-1 receptor-associated kinase 3
RGD ID: 1308846
Description: Predicted to have several functions, including ATP binding activity; magnesium ion binding activity; and protein dimerization activity. Predicted to be involved in several processes, including negative regulation of macromolecule metabolic process; regulation of DNA-binding transcription factor activity; and response to bacterium. Predicted to localize to cytoplasm; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IRAK3 (interleukin 1 receptor associated kinase 3); PARTICIPATES IN interleukin-1 signaling pathway; Toll-like receptor signaling pathway; apoptotic cell death pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC314870
Orthologs:
Homo sapiens (human) : IRAK3 (interleukin 1 receptor associated kinase 3)  HGNC  Alliance
Mus musculus (house mouse) : Irak3 (interleukin-1 receptor-associated kinase 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Irak3 (interleukin 1 receptor associated kinase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : IRAK3 (interleukin 1 receptor associated kinase 3)
Canis lupus familiaris (dog) : IRAK3 (interleukin 1 receptor associated kinase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Irak3 (interleukin 1 receptor associated kinase 3)
Sus scrofa (pig) : IRAK3 (interleukin 1 receptor associated kinase 3)
Chlorocebus sabaeus (African green monkey) : IRAK3 (interleukin 1 receptor associated kinase 3)
Heterocephalus glaber (naked mole-rat) : Irak3 (interleukin 1 receptor associated kinase 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0764,922,830 - 64,982,224 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl764,923,615 - 64,982,281 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0765,142,540 - 65,201,013 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4759,408,198 - 59,467,821 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1759,429,927 - 59,488,412 (-)NCBI
Celera752,409,359 - 52,468,444 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
all-trans-retinoic acid  (EXP)
amphetamine  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
choline  (ISO)
crocidolite asbestos  (ISO)
dexamethasone  (ISO)
dieldrin  (EXP)
dioxygen  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
ferulic acid  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
hyaluronic acid  (ISO)
imiquimod  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
L-methionine  (ISO)
lipoarabinomannan  (ISO)
lipopolysaccharide  (ISO)
methoxyacetic acid  (EXP)
methyl methanesulfonate  (ISO)
mifepristone  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-palmitoyl-S-[2,3-bis(palmitoyloxy)propyl]-Cys-Ser-Lys-Lys-Lys-Lys  (ISO)
paracetamol  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
prostaglandin E2  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium sulfate  (ISO)
tetrachloromethane  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
valproic acid  (ISO)
wortmannin  (ISO)
zinc atom  (ISO)
zinc protoporphyrin  (EXP)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cellular_component  (ND)
cytoplasm  (IBA,ISO)
nucleus  (IBA,ISO)
plasma membrane  (IBA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Almeida AS, etal., J Immunol. 2009 Jul 1;183(1):718-31. doi: 10.4049/jimmunol.0801212. Epub 2009 Jun 17.
2. Alonso S, etal., Colorectal Dis. 2017 May;19(5):O115-O125. doi: 10.1111/codi.13635.
3. Deng JC, etal., J Clin Invest. 2006 Sep;116(9):2532-42. doi: 10.1172/JCI28054. Epub 2006 Aug 17.
4. Emal D, etal., Sci Rep. 2019 Jan 14;9(1):106. doi: 10.1038/s41598-018-37482-x.
5. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. GOA data from the GO Consortium
7. Hoogerwerf JJ, etal., Mol Med. 2012 Sep 25;18:1067-75. doi: 10.2119/molmed.2011.00450.
8. Hua F, etal., Blood Coagul Fibrinolysis. 2011 Sep;22(6):480-6. doi: 10.1097/MBC.0b013e328346ef56.
9. Huang Z, etal., Biomed Pharmacother. 2017 Nov;95:1684-1692. doi: 10.1016/j.biopha.2017.09.058. Epub 2017 Oct 6.
10. Hubbard LL, etal., J Immunol. 2010 Jun 1;184(11):6299-308. doi: 10.4049/jimmunol.0902828. Epub 2010 May 3.
11. Jiang D, etal., Innate Immun. 2017 Feb;23(2):206-215. doi: 10.1177/1753425916684202. Epub 2016 Dec 18.
12. Julian MW, etal., PLoS One. 2015 Jul 28;10(7):e0132921. doi: 10.1371/journal.pone.0132921. eCollection 2015.
13. Kim DH, etal., J Immunol. 2011 Nov 15;187(10):5211-20. doi: 10.4049/jimmunol.1001388. Epub 2011 Oct 12.
14. Li S, etal., J Surg Res. 2013 Nov;185(1):319-28. doi: 10.1016/j.jss.2013.05.062. Epub 2013 Jun 10.
15. MGD data from the GO Consortium
16. Miyata M, etal., Nat Commun. 2015 Jan 14;6:6062. doi: 10.1038/ncomms7062.
17. OMIM Disease Annotation Pipeline
18. Paik S, etal., Sci Rep. 2019 Mar 13;9(1):4342. doi: 10.1038/s41598-019-40690-8.
19. Pathak SK, etal., J Biol Chem. 2005 Dec 30;280(52):42794-800. doi: 10.1074/jbc.M506471200. Epub 2005 Nov 1.
20. Pipeline to import KEGG annotations from KEGG into RGD
21. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. RGD automated import pipeline for gene-chemical interactions
24. RGD comprehensive gene curation
25. Standiford TJ, etal., Oncogene. 2011 May 26;30(21):2475-84. doi: 10.1038/onc.2010.619. Epub 2011 Jan 31.
26. Turrel-Davin F, etal., Crit Care. 2011;15(5):R252. doi: 10.1186/cc10513. Epub 2011 Oct 25.
27. van 't Veer C, etal., J Immunol. 2007 Nov 15;179(10):7110-20. doi: 10.4049/jimmunol.179.10.7110.
28. van der Windt GJ, etal., Am J Pathol. 2010 Nov;177(5):2483-94. doi: 10.2353/ajpath.2010.100562. Epub 2010 Sep 23.
29. van der Windt GJ, etal., J Infect Dis. 2012 Jun 15;205(12):1849-57. doi: 10.1093/infdis/jis290. Epub 2012 Apr 5.
30. Wiersinga WJ, etal., Crit Care Med. 2009 Feb;37(2):569-76. doi: 10.1097/CCM.0b013e318194b1bf.
31. Xiong Y and Medvedev AE, J Leukoc Biol. 2011 Dec;90(6):1141-8. doi: 10.1189/jlb.0611273. Epub 2011 Sep 20.
32. Xu D, etal., Mol Med Rep. 2017 Sep;16(3):3415-3420. doi: 10.3892/mmr.2017.6958. Epub 2017 Jul 12.
Additional References at PubMed
PMID:10383454   PMID:12054681   PMID:12150927   PMID:12477932   PMID:15728517   PMID:17379480   PMID:18156187   PMID:18497707  


Genomics

Comparative Map Data
Irak3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0764,922,830 - 64,982,224 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl764,923,615 - 64,982,281 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0765,142,540 - 65,201,013 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4759,408,198 - 59,467,821 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1759,429,927 - 59,488,412 (-)NCBI
Celera752,409,359 - 52,468,444 (-)NCBICelera
Cytogenetic Map7q22NCBI
IRAK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1266,189,195 - 66,254,622 (+)EnsemblGRCh38hg38GRCh38
GRCh381266,189,214 - 66,254,622 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371266,582,978 - 66,648,402 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361264,869,284 - 64,928,652 (+)NCBINCBI36hg18NCBI36
Build 341264,869,283 - 64,928,652NCBI
Celera1266,247,192 - 66,312,632 (+)NCBI
Cytogenetic Map12q14.3NCBI
HuRef1263,633,632 - 63,699,237 (+)NCBIHuRef
CHM1_11266,549,846 - 66,615,516 (+)NCBICHM1_1
Irak3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910119,977,553 - 120,038,035 (-)NCBI
GRCm3810120,141,648 - 120,202,130 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10120,141,648 - 120,202,130 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710119,578,710 - 119,638,593 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610119,544,714 - 119,604,597 (-)NCBImm8
Celera10122,502,683 - 122,562,840 (-)NCBICelera
Cytogenetic Map10D2NCBI
Irak3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545812,846,237 - 12,879,316 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545812,839,995 - 12,880,285 (+)NCBIChiLan1.0ChiLan1.0
IRAK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11223,168,346 - 23,282,903 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1223,168,346 - 23,227,148 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01222,661,613 - 22,721,203 (-)NCBIMhudiblu_PPA_v0panPan3
IRAK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl108,684,242 - 8,729,268 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1108,683,541 - 8,730,757 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Irak3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365454,233,353 - 4,284,324 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRAK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl530,525,948 - 30,609,922 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1530,524,704 - 30,601,067 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2533,798,256 - 33,873,173 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IRAK3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1161,869,173 - 61,920,406 (+)Ensembl
ChlSab1.11161,868,817 - 61,920,896 (+)NCBI
Irak3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248022,042,486 - 2,098,921 (-)NCBI

Position Markers
RH141464  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0764,923,839 - 64,924,022NCBIRnor6.0
Rnor_5.0765,142,628 - 65,142,811UniSTSRnor5.0
RGSC_v3.4759,408,286 - 59,408,469UniSTSRGSC3.4
Celera752,409,447 - 52,409,630UniSTS
Cytogenetic Map7q22UniSTS
RH 3.4 Map7477.91UniSTS
RH133525  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0764,927,679 - 64,927,858NCBIRnor6.0
Rnor_5.0765,146,468 - 65,146,647UniSTSRnor5.0
RGSC_v3.4759,412,126 - 59,412,305UniSTSRGSC3.4
Celera752,413,287 - 52,413,466UniSTS
Cytogenetic Map7q22UniSTS
RH 3.4 Map7478.0UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)72920071124838025Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71232846767193263Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)712328467106995532Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71268785067801690Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)72216841267168412Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)72473146569731465Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72536563393155402Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72820465373204653Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)73138152976381529Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)73203505377035053Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)73257294277572942Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)73304444971352127Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)73586772980867729Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)73586772993155402Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73854770683547706Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)74087268285872682Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)74087268285872682Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74530157390301573Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)748118835128611831Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)75025210395252103Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)750704769128085642Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)75079381895793818Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)751251919118477612Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)751251919145729302Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)751252005111589099Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)75320034498200344Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)75425951299259512Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)75453499673293934Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)75507286269399731Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)755072862123602998Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)755072862123602998Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)755072862123602998Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)755495689100495689Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)755495689100495689Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)755495689100495689Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)755495689100495689Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)755495689100495689Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)755495689100495689Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)755495689100495689Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)761047589113228378Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:207
Count of miRNA genes:151
Interacting mature miRNAs:168
Transcripts:ENSRNOT00000005686
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 3 12 3 4
Low 1 43 54 41 7 41 8 11 74 35 38 7 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000005686   ⟹   ENSRNOP00000005686
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl764,923,615 - 64,982,281 (-)Ensembl
RefSeq Acc Id: NM_001108101   ⟹   NP_001101571
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0764,923,751 - 64,982,224 (-)NCBI
Rnor_5.0765,142,540 - 65,201,013 (-)NCBI
RGSC_v3.4759,408,198 - 59,467,821 (-)RGD
Celera752,409,359 - 52,468,444 (-)RGD
Sequence:
RefSeq Acc Id: XM_017594854   ⟹   XP_017450343
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0764,922,830 - 64,974,863 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001101571 (Get FASTA)   NCBI Sequence Viewer  
  XP_017450343 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66731 (Get FASTA)   NCBI Sequence Viewer  
  EDM16573 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001101571   ⟸   NM_001108101
- UniProtKB: B2RYC8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450343   ⟸   XM_017594854
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000005686   ⟸   ENSRNOT00000005686
Protein Domains
Death   Protein kinase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695233
Promoter ID:EPDNEW_R5758
Type:initiation region
Name:Irak3_1
Description:interleukin-1 receptor-associated kinase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0764,982,167 - 64,982,227EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308846 AgrOrtholog
Ensembl Genes ENSRNOG00000004226 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000005686 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005686 ENTREZGENE, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7934689 IMAGE-MGC_LOAD
InterPro Death UniProtKB/TrEMBL
  DEATH-like UniProtKB/TrEMBL
  IRAK3 UniProtKB/TrEMBL
  IRAK3_death UniProtKB/TrEMBL
  IRAK3_PK UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
KEGG Report rno:314870 UniProtKB/TrEMBL
MGC_CLONE MGC:188449 IMAGE-MGC_LOAD
NCBI Gene 314870 ENTREZGENE
PANTHER PTHR24419:SF7 UniProtKB/TrEMBL
Pfam Death UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Irak3 PhenoGen
PROSITE DEATH_DOMAIN UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
SMART DEATH UniProtKB/TrEMBL
Superfamily-SCOP DEATH_like UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
UniGene Rn.126158 ENTREZGENE
  Rn.147737 ENTREZGENE
UniProt B2RYC8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Irak3  interleukin-1 receptor-associated kinase 3   Irak3_predicted  interleukin-1 receptor-associated kinase 3 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Irak3_predicted  interleukin-1 receptor-associated kinase 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED