Irak3 (interleukin-1 receptor-associated kinase 3) - Rat Genome Database

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Gene: Irak3 (interleukin-1 receptor-associated kinase 3) Rattus norvegicus
Analyze
Symbol: Irak3
Name: interleukin-1 receptor-associated kinase 3
RGD ID: 1308846
Description: Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and protein dimerization activity. Predicted to be involved in several processes, including regulation of gene expression; regulation of innate immune response; and response to bacterium. Predicted to act upstream of or within protein autophosphorylation. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IRAK3 (interleukin 1 receptor associated kinase 3); PARTICIPATES IN interleukin-1 signaling pathway; Toll-like receptor signaling pathway; apoptotic cell death pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC314870
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2755,653,949 - 55,714,371 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl755,653,962 - 55,713,121 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx757,560,397 - 57,619,471 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0759,763,565 - 59,822,652 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0759,540,938 - 59,599,993 (-)NCBIRnor_WKY
Rnor_6.0764,922,830 - 64,982,224 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl764,923,615 - 64,982,281 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0765,142,540 - 65,201,013 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4759,408,198 - 59,467,821 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1759,429,927 - 59,488,412 (-)NCBI
Celera752,409,359 - 52,468,444 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
all-trans-retinoic acid  (EXP)
amphetamine  (EXP)
aristolochic acid  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
crocidolite asbestos  (ISO)
dexamethasone  (ISO)
dieldrin  (EXP)
dioxygen  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
ferulic acid  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
hyaluronic acid  (ISO)
imiquimod  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
L-methionine  (ISO)
lipoarabinomannan  (ISO)
lipopolysaccharide  (ISO)
methoxyacetic acid  (EXP)
methyl methanesulfonate  (ISO)
mifepristone  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-palmitoyl-S-[2,3-bis(palmitoyloxy)propyl]-Cys-Ser-Lys-Lys-Lys-Lys  (ISO)
paracetamol  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
prostaglandin E2  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium sulfate  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
valproic acid  (ISO)
wortmannin  (ISO)
zinc atom  (ISO)
zinc protoporphyrin  (EXP)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cellular_component  (ND)
cytoplasm  (IBA,ISO)
nucleus  (IBA,ISO)
plasma membrane  (IBA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Tuberculosis is associated with a down-modulatory lung immune response that impairs Th1-type immunity. Almeida AS, etal., J Immunol. 2009 Jul 1;183(1):718-31. doi: 10.4049/jimmunol.0801212. Epub 2009 Jun 17.
2. Peripheral blood leucocytes show differential expression of tumour progression-related genes in colorectal cancer patients who have a postoperative intra-abdominal infection: a prospective matched cohort study. Alonso S, etal., Colorectal Dis. 2017 May;19(5):O115-O125. doi: 10.1111/codi.13635.
3. Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M. Deng JC, etal., J Clin Invest. 2006 Sep;116(9):2532-42. doi: 10.1172/JCI28054. Epub 2006 Aug 17.
4. Calcineurin inhibitor Tacrolimus impairs host immune response against urinary tract infection. Emal D, etal., Sci Rep. 2019 Jan 14;9(1):106. doi: 10.1038/s41598-018-37482-x.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Interleukin-1 receptor-associated kinase M-deficient mice demonstrate an improved host defense during Gram-negative pneumonia. Hoogerwerf JJ, etal., Mol Med. 2012 Sep 25;18:1067-75. doi: 10.2119/molmed.2011.00450.
8. Plasminogen activator inhibitor type-1 deficiency exaggerates LPS-induced acute lung injury through enhancing Toll-like receptor 4 signaling pathway. Hua F, etal., Blood Coagul Fibrinolysis. 2011 Sep;22(6):480-6. doi: 10.1097/MBC.0b013e328346ef56.
9. Pretreatment of Pam3CSK4 attenuates inflammatory responses caused by systemic infection of methicillin-resistant Staphylococcus aureus in mice. Huang Z, etal., Biomed Pharmacother. 2017 Nov;95:1684-1692. doi: 10.1016/j.biopha.2017.09.058. Epub 2017 Oct 6.
10. A role for IL-1 receptor-associated kinase-M in prostaglandin E2-induced immunosuppression post-bone marrow transplantation. Hubbard LL, etal., J Immunol. 2010 Jun 1;184(11):6299-308. doi: 10.4049/jimmunol.0902828. Epub 2010 May 3.
11. A novel mouse model of conditional IRAK-M deficiency in myeloid cells: application in lung Pseudomonas aeruginosa infection. Jiang D, etal., Innate Immun. 2017 Feb;23(2):206-215. doi: 10.1177/1753425916684202. Epub 2016 Dec 18.
12. Tolerance and Cross-Tolerance following Toll-Like Receptor (TLR)-4 and -9 Activation Are Mediated by IRAK-M and Modulated by IL-7 in Murine Splenocytes. Julian MW, etal., PLoS One. 2015 Jul 28;10(7):e0132921. doi: 10.1371/journal.pone.0132921. eCollection 2015.
13. Inhibition of autoimmune diabetes by TLR2 tolerance. Kim DH, etal., J Immunol. 2011 Nov 15;187(10):5211-20. doi: 10.4049/jimmunol.1001388. Epub 2011 Oct 12.
14. Endogenous HMGB1 is required in endotoxin tolerance. Li S, etal., J Surg Res. 2013 Nov;185(1):319-28. doi: 10.1016/j.jss.2013.05.062. Epub 2013 Jun 10.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Glucocorticoids suppress inflammation via the upregulation of negative regulator IRAK-M. Miyata M, etal., Nat Commun. 2015 Jan 14;6:6062. doi: 10.1038/ncomms7062.
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. Rg6, a rare ginsenoside, inhibits systemic inflammation through the induction of interleukin-10 and microRNA-146a. Paik S, etal., Sci Rep. 2019 Mar 13;9(1):4342. doi: 10.1038/s41598-019-40690-8.
19. Mycobacterium tuberculosis lipoarabinomannan-mediated IRAK-M induction negatively regulates Toll-like receptor-dependent interleukin-12 p40 production in macrophages. Pathak SK, etal., J Biol Chem. 2005 Dec 30;280(52):42794-800. doi: 10.1074/jbc.M506471200. Epub 2005 Nov 1.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Comprehensive gene review and curation RGD comprehensive gene curation
25. TGF-β-induced IRAK-M expression in tumor-associated macrophages regulates lung tumor growth. Standiford TJ, etal., Oncogene. 2011 May 26;30(21):2475-84. doi: 10.1038/onc.2010.619. Epub 2011 Jan 31.
26. mRNA-based approach to monitor recombinant gamma-interferon restoration of LPS-induced endotoxin tolerance. Turrel-Davin F, etal., Crit Care. 2011;15(5):R252. doi: 10.1186/cc10513. Epub 2011 Oct 25.
27. Induction of IRAK-M is associated with lipopolysaccharide tolerance in a human endotoxemia model. van 't Veer C, etal., J Immunol. 2007 Nov 15;179(10):7110-20. doi: 10.4049/jimmunol.179.10.7110.
28. CD44 deficiency is associated with increased bacterial clearance but enhanced lung inflammation during Gram-negative pneumonia. van der Windt GJ, etal., Am J Pathol. 2010 Nov;177(5):2483-94. doi: 10.2353/ajpath.2010.100562. Epub 2010 Sep 23.
29. Interleukin 1 receptor-associated kinase m impairs host defense during pneumococcal pneumonia. van der Windt GJ, etal., J Infect Dis. 2012 Jun 15;205(12):1849-57. doi: 10.1093/infdis/jis290. Epub 2012 Apr 5.
30. Immunosuppression associated with interleukin-1R-associated-kinase-M upregulation predicts mortality in Gram-negative sepsis (melioidosis). Wiersinga WJ, etal., Crit Care Med. 2009 Feb;37(2):569-76. doi: 10.1097/CCM.0b013e318194b1bf.
31. Induction of endotoxin tolerance in vivo inhibits activation of IRAK4 and increases negative regulators IRAK-M, SHIP-1, and A20. Xiong Y and Medvedev AE, J Leukoc Biol. 2011 Dec;90(6):1141-8. doi: 10.1189/jlb.0611273. Epub 2011 Sep 20.
32. Expression of IRAK‑3 is associated with colitis‑associated tumorigenesis in mice. Xu D, etal., Mol Med Rep. 2017 Sep;16(3):3415-3420. doi: 10.3892/mmr.2017.6958. Epub 2017 Jul 12.
Additional References at PubMed
PMID:10383454   PMID:12054681   PMID:12150927   PMID:12477932   PMID:15728517   PMID:17379480   PMID:18156187   PMID:18497707   PMID:34757596  


Genomics

Comparative Map Data
Irak3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2755,653,949 - 55,714,371 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl755,653,962 - 55,713,121 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx757,560,397 - 57,619,471 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0759,763,565 - 59,822,652 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0759,540,938 - 59,599,993 (-)NCBIRnor_WKY
Rnor_6.0764,922,830 - 64,982,224 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl764,923,615 - 64,982,281 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0765,142,540 - 65,201,013 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4759,408,198 - 59,467,821 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1759,429,927 - 59,488,412 (-)NCBI
Celera752,409,359 - 52,468,444 (-)NCBICelera
Cytogenetic Map7q22NCBI
IRAK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381266,189,214 - 66,254,622 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1266,189,195 - 66,254,622 (+)EnsemblGRCh38hg38GRCh38
GRCh371266,582,994 - 66,648,402 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361264,869,284 - 64,928,652 (+)NCBINCBI36Build 36hg18NCBI36
Build 341264,869,283 - 64,928,652NCBI
Celera1266,247,192 - 66,312,632 (+)NCBICelera
Cytogenetic Map12q14.3NCBI
HuRef1263,633,632 - 63,699,237 (+)NCBIHuRef
CHM1_11266,549,846 - 66,615,516 (+)NCBICHM1_1
T2T-CHM13v2.01266,168,706 - 66,234,159 (+)NCBIT2T-CHM13v2.0
Irak3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910119,977,553 - 120,038,035 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10119,977,553 - 120,038,035 (-)EnsemblGRCm39 Ensembl
GRCm3810120,141,648 - 120,202,130 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10120,141,648 - 120,202,130 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710119,578,710 - 119,638,593 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610119,544,714 - 119,604,597 (-)NCBIMGSCv36mm8
Celera10122,502,683 - 122,562,840 (-)NCBICelera
Cytogenetic Map10D2NCBI
Irak3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545812,846,237 - 12,879,316 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545812,839,995 - 12,880,285 (+)NCBIChiLan1.0ChiLan1.0
IRAK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11223,168,346 - 23,282,903 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1223,168,346 - 23,227,148 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01222,661,613 - 22,721,203 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
IRAK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1108,683,541 - 8,730,757 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl108,684,242 - 8,729,268 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha108,615,238 - 8,661,295 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0108,796,309 - 8,841,957 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl108,796,309 - 8,842,463 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1108,672,755 - 8,718,373 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0108,918,266 - 8,964,392 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0109,039,804 - 9,085,368 (+)NCBIUU_Cfam_GSD_1.0
Irak3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494549,820,793 - 49,925,781 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365454,233,353 - 4,284,324 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRAK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl530,526,793 - 30,609,921 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1530,524,704 - 30,601,067 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2533,798,256 - 33,873,173 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IRAK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11161,868,817 - 61,920,896 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1161,869,173 - 61,920,406 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037183,796,994 - 183,855,987 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Irak3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248022,047,409 - 2,098,545 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248022,042,486 - 2,098,921 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
RH141464  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2755,654,036 - 55,654,220 (+)MAPPERmRatBN7.2
Rnor_6.0764,923,839 - 64,924,022NCBIRnor6.0
Rnor_5.0765,142,628 - 65,142,811UniSTSRnor5.0
RGSC_v3.4759,408,286 - 59,408,469UniSTSRGSC3.4
Celera752,409,447 - 52,409,630UniSTS
RH 3.4 Map7477.91UniSTS
Cytogenetic Map7q22UniSTS
RH133525  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2755,657,876 - 55,658,056 (+)MAPPERmRatBN7.2
Rnor_6.0764,927,679 - 64,927,858NCBIRnor6.0
Rnor_5.0765,146,468 - 65,146,647UniSTSRnor5.0
RGSC_v3.4759,412,126 - 59,412,305UniSTSRGSC3.4
Celera752,413,287 - 52,413,466UniSTS
RH 3.4 Map7478.0UniSTS
Cytogenetic Map7q22UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
2303629Vencon3Ventilatory control QTL 37.25respiration trait (VT:0001943)respiration rate (CMO:0000289)74110969256793354Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:207
Count of miRNA genes:151
Interacting mature miRNAs:168
Transcripts:ENSRNOT00000005686
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 3 12 3 4
Low 1 43 54 41 7 41 8 11 74 35 38 7 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000005686   ⟹   ENSRNOP00000005686
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl755,653,962 - 55,713,121 (-)Ensembl
Rnor_6.0 Ensembl764,923,615 - 64,982,281 (-)Ensembl
RefSeq Acc Id: NM_001108101   ⟹   NP_001101571
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2755,653,949 - 55,713,046 (-)NCBI
Rnor_6.0764,923,751 - 64,982,224 (-)NCBI
Rnor_5.0765,142,540 - 65,201,013 (-)NCBI
RGSC_v3.4759,408,198 - 59,467,821 (-)RGD
Celera752,409,359 - 52,468,444 (-)RGD
Sequence:
RefSeq Acc Id: XM_017594854   ⟹   XP_017450343
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2755,653,953 - 55,707,364 (-)NCBI
Rnor_6.0764,922,830 - 64,974,863 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039079131   ⟹   XP_038935059
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2755,653,953 - 55,714,357 (-)NCBI
RefSeq Acc Id: XM_039079132   ⟹   XP_038935060
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2755,653,953 - 55,691,910 (-)NCBI
RefSeq Acc Id: XM_039079133   ⟹   XP_038935061
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2755,653,953 - 55,707,368 (-)NCBI
RefSeq Acc Id: XM_039079134   ⟹   XP_038935062
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2755,653,953 - 55,691,910 (-)NCBI
RefSeq Acc Id: XM_039079135   ⟹   XP_038935063
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2755,653,953 - 55,689,913 (-)NCBI
RefSeq Acc Id: XM_039079136   ⟹   XP_038935064
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2755,664,748 - 55,714,371 (-)NCBI
RefSeq Acc Id: XR_005486627
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2755,657,734 - 55,714,369 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001101571   ⟸   NM_001108101
- UniProtKB: B2RYC8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450343   ⟸   XM_017594854
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000005686   ⟸   ENSRNOT00000005686
RefSeq Acc Id: XP_038935059   ⟸   XM_039079131
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038935061   ⟸   XM_039079133
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038935060   ⟸   XM_039079132
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038935062   ⟸   XM_039079134
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038935063   ⟸   XM_039079135
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038935064   ⟸   XM_039079136
- Peptide Label: isoform X7
Protein Domains
Death   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RYC8-F1-model_v2 AlphaFold B2RYC8 1-610 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695233
Promoter ID:EPDNEW_R5758
Type:initiation region
Name:Irak3_1
Description:interleukin-1 receptor-associated kinase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0764,982,167 - 64,982,227EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308846 AgrOrtholog
BioCyc Gene G2FUF-33914 BioCyc
Ensembl Genes ENSRNOG00000004226 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000005686 ENTREZGENE
  ENSRNOP00000005686.3 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005686 ENTREZGENE
  ENSRNOT00000005686.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7934689 IMAGE-MGC_LOAD
InterPro Death UniProtKB/TrEMBL
  DEATH-like UniProtKB/TrEMBL
  IRAK3 UniProtKB/TrEMBL
  IRAK3_death UniProtKB/TrEMBL
  IRAK3_PK UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
KEGG Report rno:314870 UniProtKB/TrEMBL
MGC_CLONE MGC:188449 IMAGE-MGC_LOAD
NCBI Gene 314870 ENTREZGENE
PANTHER PTHR24419:SF7 UniProtKB/TrEMBL
Pfam Death UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Irak3 PhenoGen
PROSITE DEATH_DOMAIN UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
SMART DEATH UniProtKB/TrEMBL
Superfamily-SCOP DEATH_like UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
UniProt B2RYC8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Irak3  interleukin-1 receptor-associated kinase 3   Irak3_predicted  interleukin-1 receptor-associated kinase 3 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Irak3_predicted  interleukin-1 receptor-associated kinase 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED