Lemd3 (LEM domain containing 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Lemd3 (LEM domain containing 3) Rattus norvegicus
Analyze
Symbol: Lemd3
Name: LEM domain containing 3
RGD ID: 1596822
Description: Predicted to enable chromatin DNA binding activity. Predicted to be involved in negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway and nuclear envelope organization. Predicted to act upstream of or within several processes, including blood vessel endothelial cell migration involved in intussusceptive angiogenesis; regulation of extracellular matrix organization; and skeletal muscle cell differentiation. Predicted to be located in nuclear inner membrane. Human ortholog(s) of this gene implicated in Buschke-Ollendorff syndrome. Orthologous to human LEMD3 (LEM domain containing 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: inner nuclear membrane protein Man1; LOC680066; RGD1561001; similar to Inner nuclear membrane protein Man1 (LEM domain containing protein 3)
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8758,300,556 - 58,389,485 (-)NCBIGRCr8
mRatBN7.2756,415,053 - 56,499,047 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl756,305,448 - 56,502,474 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx758,356,363 - 58,404,803 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0760,559,575 - 60,608,007 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0760,336,954 - 60,385,385 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0762,976,671 - 63,045,860 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl762,996,336 - 63,045,728 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0762,960,779 - 63,032,159 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4760,232,118 - 60,281,459 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera753,196,837 - 53,246,156 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Familial cutaneous collagenomas resulting from a novel mutation in LEMD3. Hershkovitz D, etal., Br J Dermatol. 2007 Feb;156(2):375-7.
3. Buschke-Ollendorff syndrome associated with hypertrophic scar formation: a possible role for LEMD3 mutation. Korekawa A, etal., Br J Dermatol. 2012 Apr;166(4):900-3. doi: 10.1111/j.1365-2133.2011.10691.x. Epub 2012 Jan 9.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Buschke-Ollendorff syndrome: absence of LEMD3 mutation in an affected family. Yadegari M, etal., Arch Dermatol. 2010 Jan;146(1):63-8. doi: 10.1001/archdermatol.2009.320.
10. Buschke-Ollendorff syndrome with striking phenotypic variation resulting from a novel c.2203C>T nonsense mutation in LEMD3. Yuste-Chaves M, etal., Pediatr Dermatol. 2011 Jul-Aug;28(4):447-50. doi: 10.1111/j.1525-1470.2010.01206.x. Epub 2010 Jul 29.
11. Novel and recurrent germline LEMD3 mutations causing Buschke-Ollendorff syndrome and osteopoikilosis but not isolated melorheostosis. Zhang Y, etal., Clin Genet. 2009 Jun;75(6):556-61. doi: 10.1111/j.1399-0004.2009.01177.x. Epub 2009 May 5.
Additional References at PubMed
PMID:10671519   PMID:15647271   PMID:16943282   PMID:19720741  


Genomics

Comparative Map Data
Lemd3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8758,300,556 - 58,389,485 (-)NCBIGRCr8
mRatBN7.2756,415,053 - 56,499,047 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl756,305,448 - 56,502,474 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx758,356,363 - 58,404,803 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0760,559,575 - 60,608,007 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0760,336,954 - 60,385,385 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0762,976,671 - 63,045,860 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl762,996,336 - 63,045,728 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0762,960,779 - 63,032,159 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4760,232,118 - 60,281,459 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera753,196,837 - 53,246,156 (-)NCBICelera
Cytogenetic Map7q22NCBI
LEMD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381265,169,583 - 65,248,355 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1265,169,583 - 65,248,355 (+)EnsemblGRCh38hg38GRCh38
GRCh371265,563,363 - 65,642,135 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361263,849,638 - 63,928,374 (+)NCBINCBI36Build 36hg18NCBI36
Build 341263,849,637 - 63,928,374NCBI
Celera1265,228,844 - 65,307,664 (+)NCBICelera
Cytogenetic Map12q14.3NCBI
HuRef1262,615,007 - 62,693,876 (+)NCBIHuRef
CHM1_11265,530,362 - 65,609,142 (+)NCBICHM1_1
T2T-CHM13v2.01265,148,505 - 65,227,374 (+)NCBIT2T-CHM13v2.0
Lemd3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910120,759,316 - 120,815,491 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10120,759,318 - 120,815,237 (-)EnsemblGRCm39 Ensembl
GRCm3810120,923,411 - 120,979,396 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10120,923,413 - 120,979,332 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710120,360,467 - 120,416,386 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610120,326,471 - 120,382,392 (-)NCBIMGSCv36mm8
Celera10123,286,658 - 123,342,549 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1068.88NCBI
LEMD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21029,113,605 - 29,192,854 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11229,110,380 - 29,189,624 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01223,668,368 - 23,747,369 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11224,172,749 - 24,251,533 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1224,172,749 - 24,252,314 (-)Ensemblpanpan1.1panPan2
LEMD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1107,775,995 - 7,833,895 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl107,777,946 - 7,834,107 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha107,711,419 - 7,784,249 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0107,887,012 - 7,959,867 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl107,887,036 - 7,945,358 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1107,763,790 - 7,836,639 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0108,003,513 - 8,063,233 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0108,135,524 - 8,208,304 (+)NCBIUU_Cfam_GSD_1.0
Lemd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494550,656,254 - 50,724,268 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365453,385,062 - 3,454,243 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365453,385,821 - 3,453,861 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LEMD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl529,596,334 - 29,673,875 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1529,596,334 - 29,672,704 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2532,770,399 - 32,896,622 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LEMD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11160,861,671 - 60,945,858 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1160,862,265 - 60,946,040 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037184,811,579 - 184,892,026 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Lemd3
308 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:195
Count of miRNA genes:147
Interacting mature miRNAs:165
Transcripts:ENSRNOT00000039532
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2303629Vencon3Ventilatory control QTL 37.25respiration trait (VT:0001943)respiration rate (CMO:0000289)74110969256793354Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat

Markers in Region
RH132044  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2756,448,198 - 56,448,389 (+)MAPPERmRatBN7.2
Rnor_6.0762,994,859 - 62,995,049NCBIRnor6.0
Rnor_5.0762,977,589 - 62,977,779UniSTSRnor5.0
RGSC_v3.4760,230,641 - 60,230,831UniSTSRGSC3.4
Celera753,195,360 - 53,195,550UniSTS
RH 3.4 Map7500.8UniSTS
Cytogenetic Map7q22UniSTS
RH133682  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2756,449,270 - 56,449,478 (+)MAPPERmRatBN7.2
Rnor_6.0762,995,931 - 62,996,138NCBIRnor6.0
Rnor_5.0762,978,661 - 62,978,868UniSTSRnor5.0
RGSC_v3.4760,231,713 - 60,231,920UniSTSRGSC3.4
Celera753,196,432 - 53,196,639UniSTS
RH 3.4 Map7493.0UniSTS
Cytogenetic Map7q22UniSTS
AW534569  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2756,497,773 - 56,497,957 (+)MAPPERmRatBN7.2
Rnor_6.0763,044,488 - 63,044,671NCBIRnor6.0
Rnor_5.0763,027,218 - 63,027,401UniSTSRnor5.0
RGSC_v3.4760,280,219 - 60,280,402UniSTSRGSC3.4
Celera753,244,916 - 53,245,099UniSTS
RH 3.4 Map7493.0UniSTS
Cytogenetic Map7q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000039532   ⟹   ENSRNOP00000032921
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl756,449,676 - 56,499,014 (-)Ensembl
Rnor_6.0 Ensembl762,996,336 - 63,045,728 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103155   ⟹   ENSRNOP00000090081
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl756,305,448 - 56,502,474 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105233   ⟹   ENSRNOP00000092420
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl756,449,676 - 56,502,474 (-)Ensembl
RefSeq Acc Id: NM_001191000   ⟹   NP_001177929
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8758,335,170 - 58,384,508 (-)NCBI
mRatBN7.2756,449,676 - 56,499,014 (-)NCBI
Rnor_6.0762,996,336 - 63,045,728 (-)NCBI
Rnor_5.0762,960,779 - 63,032,159 (-)NCBI
Celera753,196,837 - 53,246,156 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005486725
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8758,300,556 - 58,389,485 (-)NCBI
mRatBN7.2756,415,053 - 56,499,047 (-)NCBI
RefSeq Acc Id: XR_010053041
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8758,353,502 - 58,389,485 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001177929 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000032921.6
  ENSRNOP00000090081.1
  ENSRNOP00000092420.1
RefSeq Acc Id: NP_001177929   ⟸   NM_001191000
- UniProtKB: F1LWZ8 (UniProtKB/TrEMBL),   A0A8I6GK62 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000032921   ⟸   ENSRNOT00000039532
Ensembl Acc Id: ENSRNOP00000090081   ⟸   ENSRNOT00000103155
Ensembl Acc Id: ENSRNOP00000092420   ⟸   ENSRNOT00000105233
Protein Domains
LEM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LWZ8-F1-model_v2 AlphaFold F1LWZ8 1-914 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695223
Promoter ID:EPDNEW_R5748
Type:multiple initiation site
Name:Lemd3_1
Description:LEM domain containing 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0763,045,742 - 63,045,802EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1596822 AgrOrtholog
BioCyc Gene G2FUF-33884 BioCyc
Ensembl Genes ENSRNOG00000024027 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000039532.6 UniProtKB/TrEMBL
  ENSRNOT00000103155.1 UniProtKB/TrEMBL
  ENSRNOT00000105233.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.1180 UniProtKB/TrEMBL
  1.10.720.40 UniProtKB/TrEMBL
  3.30.70.330 UniProtKB/TrEMBL
InterPro INM_ESCRT-Associated UniProtKB/TrEMBL
  Inner-Nucl-membr_MAN1 UniProtKB/TrEMBL
  LEM UniProtKB/TrEMBL
  LEM-like_dom UniProtKB/TrEMBL
  Man1_RRM UniProtKB/TrEMBL
  MAN1_winged_helix_dom UniProtKB/TrEMBL
  Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
KEGG Report rno:680066 UniProtKB/TrEMBL
NCBI Gene 680066 ENTREZGENE
PANTHER INNER NUCLEAR MEMBRANE PROTEIN MAN1 LEM DOMAIN CONTAINING PROTEIN UniProtKB/TrEMBL
  PTHR13428:SF10 UniProtKB/TrEMBL
Pfam LEM UniProtKB/TrEMBL
  MSC UniProtKB/TrEMBL
PhenoGen Lemd3 PhenoGen
PROSITE LEM UniProtKB/TrEMBL
RatGTEx ENSRNOG00000024027 RatGTEx
SMART LEM UniProtKB/TrEMBL
Superfamily-SCOP LEM_like UniProtKB/TrEMBL
  SSF54928 UniProtKB/TrEMBL
UniProt A0A8I6ACY8_RAT UniProtKB/TrEMBL
  A0A8I6GK62 ENTREZGENE, UniProtKB/TrEMBL
  F1LWZ8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 Lemd3  LEM domain containing 3  LOC680066  similar to Inner nuclear membrane protein Man1 (LEM domain containing protein 3)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC680066  similar to Inner nuclear membrane protein Man1 (LEM domain containing protein 3)      Symbol and Name status set to provisional 70820 PROVISIONAL