Wif1 (Wnt inhibitory factor 1) - Rat Genome Database

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Gene: Wif1 (Wnt inhibitory factor 1) Rattus norvegicus
Analyze
Symbol: Wif1
Name: Wnt inhibitory factor 1
RGD ID: 619774
Description: Predicted to enable activin receptor binding activity and nodal binding activity. Predicted to be involved in circulatory system development; nodal signaling pathway; and regionalization. Predicted to act upstream of or within positive regulation of fat cell differentiation. Predicted to be active in cell surface and extracellular region. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and urinary bladder cancer. Orthologous to human WIF1 (WNT inhibitory factor 1); PARTICIPATES IN Wnt signaling, canonical pathway; Wnt signaling pathway; INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: WIF-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8758,433,326 - 58,503,853 (+)NCBIGRCr8
mRatBN7.2756,548,060 - 56,618,364 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl756,548,053 - 56,618,360 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx758,454,386 - 58,524,705 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0760,657,318 - 60,727,638 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0760,434,982 - 60,505,315 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0763,094,955 - 63,165,158 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl763,094,911 - 63,165,159 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0763,077,688 - 63,147,646 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4760,330,517 - 60,400,697 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1760,417,062 - 60,421,426 (+)NCBI
Celera753,295,112 - 53,365,064 (+)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
arsenous acid  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
celastrol  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
curcumin  (EXP)
deguelin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dichloroacetic acid  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethosuximide  (EXP)
etoposide  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
graphite  (EXP)
isotretinoin  (ISO)
manganese(II) chloride  (EXP)
methimazole  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
nitrofen  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
phenylephrine  (EXP)
progesterone  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (EXP)
sporidesmin A  (ISO)
sulfadimethoxine  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer. Ai L, etal., Carcinogenesis. 2006 Jul;27(7):1341-8. Epub 2006 Feb 25.
2. Dominant-stable beta-catenin expression causes cell fate alterations and Wnt signaling antagonist expression in a murine granulosa cell tumor model. Boerboom D, etal., Cancer Res. 2006 Feb 15;66(4):1964-73.
3. A novel seven transmembrane receptor induced during the early steps of astrocyte differentiation identified by differential expression. De Smet C, etal., J Neurochem 2002 May;81(3):575-88.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Wnt-1 has multiple effects on the expression of glutamate transporters. Jimenez AL, etal., Neurochem Int 2003 Mar;42(4):345-51.
7. Wnt signalling and its impact on development and cancer. Klaus A and Birchmeier W, Nat Rev Cancer. 2008 May;8(5):387-98.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. A comparison of the performance of microsatellite and methylation urine analysis for predicting the recurrence of urothelial cell carcinoma, and definition of a set of markers by Bayesian network analysis. Roupret M, etal., BJU Int. 2008 Mar 4;.
15. Multiple gene expression analyses in paraffin-embedded tissues by TaqMan low-density array: Application to hedgehog and Wnt pathway analysis in ovarian endometrioid adenocarcinoma. Steg A, etal., J Mol Diagn. 2006 Feb;8(1):76-83.
16. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
17. Wnt antagonist family genes as biomarkers for diagnosis, staging, and prognosis of renal cell carcinoma using tumor and serum DNA. Urakami S, etal., Clin Cancer Res. 2006 Dec 1;12(23):6989-97.
18. WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer. Wissmann C, etal., J Pathol 2003 Oct;201(2):204-12.
19. Target genes of the WNT/beta-catenin pathway in Wilms tumors. Zirn B, etal., Genes Chromosomes Cancer. 2006 Jun;45(6):565-74.
Additional References at PubMed
PMID:12055200   PMID:15489334   PMID:19621428   PMID:21986617   PMID:26637809  


Genomics

Comparative Map Data
Wif1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8758,433,326 - 58,503,853 (+)NCBIGRCr8
mRatBN7.2756,548,060 - 56,618,364 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl756,548,053 - 56,618,360 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx758,454,386 - 58,524,705 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0760,657,318 - 60,727,638 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0760,434,982 - 60,505,315 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0763,094,955 - 63,165,158 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl763,094,911 - 63,165,159 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0763,077,688 - 63,147,646 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4760,330,517 - 60,400,697 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1760,417,062 - 60,421,426 (+)NCBI
Celera753,295,112 - 53,365,064 (+)NCBICelera
Cytogenetic Map7q22NCBI
WIF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381265,050,626 - 65,121,305 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1265,050,626 - 65,121,305 (-)EnsemblGRCh38hg38GRCh38
GRCh371265,444,406 - 65,515,085 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361263,730,673 - 63,801,383 (-)NCBINCBI36Build 36hg18NCBI36
Build 341263,730,675 - 63,801,356NCBI
Celera1265,109,871 - 65,180,833 (-)NCBICelera
Cytogenetic Map12q14.3NCBI
HuRef1262,496,029 - 62,566,998 (-)NCBIHuRef
CHM1_11265,411,498 - 65,482,433 (-)NCBICHM1_1
T2T-CHM13v2.01265,029,618 - 65,100,339 (-)NCBIT2T-CHM13v2.0
Wif1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910120,869,909 - 120,936,547 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10120,869,865 - 120,936,555 (+)EnsemblGRCm39 Ensembl
GRCm3810121,034,004 - 121,100,642 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10121,033,960 - 121,100,650 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710120,471,060 - 120,537,698 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610120,437,290 - 120,503,702 (+)NCBIMGSCv36mm8
Celera10123,398,945 - 123,465,434 (+)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1068.98NCBI
Wif1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545811,754,120 - 11,834,047 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545811,755,147 - 11,834,047 (-)NCBIChiLan1.0ChiLan1.0
WIF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21029,240,767 - 29,312,147 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11229,237,538 - 29,308,918 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01223,795,280 - 23,866,666 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11224,299,354 - 24,370,591 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1224,299,351 - 24,370,807 (+)Ensemblpanpan1.1panPan2
WIF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1107,659,277 - 7,726,175 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl107,659,491 - 7,726,859 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha107,593,387 - 7,659,761 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0107,769,159 - 7,835,321 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl107,769,166 - 7,835,635 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1107,633,347 - 7,712,128 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0107,887,278 - 7,953,914 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0108,017,421 - 8,084,263 (-)NCBIUU_Cfam_GSD_1.0
Wif1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494550,775,944 - 50,846,476 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365453,263,623 - 3,333,937 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365453,263,646 - 3,334,163 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WIF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl529,450,442 - 29,543,913 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1529,450,442 - 29,543,913 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2532,490,649 - 32,517,056 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WIF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11160,728,316 - 60,800,181 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1160,727,948 - 60,799,960 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037184,954,130 - 185,026,129 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wif1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248023,248,964 - 3,333,338 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248023,248,934 - 3,333,263 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Wif1
260 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:344
Count of miRNA genes:212
Interacting mature miRNAs:239
Transcripts:ENSRNOT00000006426
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
2303629Vencon3Ventilatory control QTL 37.25respiration trait (VT:0001943)respiration rate (CMO:0000289)74110969256793354Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat

Markers in Region
D7Got45  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2756,612,171 - 56,612,319 (+)MAPPERmRatBN7.2
Rnor_6.0763,158,966 - 63,159,113NCBIRnor6.0
Rnor_5.0763,141,454 - 63,141,601UniSTSRnor5.0
RGSC_v3.4760,394,506 - 60,394,777RGDRGSC3.4
RGSC_v3.4760,394,505 - 60,394,652UniSTSRGSC3.4
RGSC_v3.1760,415,236 - 60,415,382RGD
Celera753,358,878 - 53,359,025UniSTS
RH 3.4 Map7499.9RGD
RH 3.4 Map7499.9UniSTS
Cytogenetic Map7q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 24 6 78 57 45
Low 14 115 164 90 63 90 31 32 168 112 88 21
Below cutoff 7 63 57 57 3 13 3 3

Sequence


Ensembl Acc Id: ENSRNOT00000006426   ⟹   ENSRNOP00000006426
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl756,548,053 - 56,618,360 (+)Ensembl
Rnor_6.0 Ensembl763,094,911 - 63,165,159 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094641   ⟹   ENSRNOP00000093991
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl756,548,117 - 56,618,335 (+)Ensembl
RefSeq Acc Id: NM_001399510   ⟹   NP_001386439
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8758,433,579 - 58,503,853 (+)NCBI
mRatBN7.2756,548,090 - 56,618,364 (+)NCBI
RefSeq Acc Id: XM_063262863   ⟹   XP_063118933
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8758,433,326 - 58,501,471 (+)NCBI
Ensembl Acc Id: ENSRNOP00000006426   ⟸   ENSRNOT00000006426
Ensembl Acc Id: ENSRNOP00000093991   ⟸   ENSRNOT00000094641
RefSeq Acc Id: NP_001386439   ⟸   NM_001399510
- Peptide Label: precursor
- UniProtKB: Q6IN38 (UniProtKB/Swiss-Prot),   Q924Y6 (UniProtKB/Swiss-Prot),   A6IGZ3 (UniProtKB/TrEMBL),   A6IGZ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118933   ⟸   XM_063262863
- Peptide Label: isoform X1
Protein Domains
EGF-like   WIF

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IN38-F1-model_v2 AlphaFold Q6IN38 1-379 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695224
Promoter ID:EPDNEW_R5749
Type:single initiation site
Name:Wif1_1
Description:Wnt inhibitory factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0763,094,903 - 63,094,963EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619774 AgrOrtholog
BioCyc Gene G2FUF-33881 BioCyc
Ensembl Genes ENSRNOG00000004476 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055012916 UniProtKB/Swiss-Prot
  ENSRNOG00060010361 UniProtKB/Swiss-Prot
  ENSRNOG00065013498 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006426.6 UniProtKB/Swiss-Prot
  ENSRNOT00000094641.1 UniProtKB/TrEMBL
  ENSRNOT00055022134 UniProtKB/Swiss-Prot
  ENSRNOT00060017515 UniProtKB/Swiss-Prot
  ENSRNOT00065022207 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.2170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7100360 IMAGE-MGC_LOAD
InterPro Dev_Signal_Modulators UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_extracell UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WIF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WIF_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Wnt-inh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91560 IMAGE-MGC_LOAD
NCBI Gene 114557 ENTREZGENE
PANTHER 3-PHYTASE UniProtKB/TrEMBL
  EGF-LIKE-DOMAIN, MULTIPLE 7, 8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WNT INHIBITORY FACTOR 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DL-JAG_EGF-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  hEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WIF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB WIF1 RGD
PhenoGen Wif1 PhenoGen
PRINTS WIFPROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WIF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004476 RatGTEx
  ENSRNOG00055012916 RatGTEx
  ENSRNOG00060010361 RatGTEx
  ENSRNOG00065013498 RatGTEx
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WIF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
UniProt A0A8I6AXV8_RAT UniProtKB/TrEMBL
  A6IGZ2 ENTREZGENE, UniProtKB/TrEMBL
  A6IGZ3 ENTREZGENE, UniProtKB/TrEMBL
  Q6IN38 ENTREZGENE
  Q924Y6 ENTREZGENE
  WIF1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q924Y6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Wif1  Wnt inhibitory factor 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Wif1  Wnt inhibitory factor 1      Symbol and Name status set to provisional 70820 PROVISIONAL