Wif1 (Wnt inhibitory factor 1) - Rat Genome Database

Name: Wif1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Wif1 (Wnt inhibitory factor 1) Rattus norvegicus

Analyze

Symbol:

Wif1

Name:

Wnt inhibitory factor 1

RGD ID:

619774

Description:

Predicted to be involved in positive regulation of fat cell differentiation. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and urinary bladder cancer. Orthologous to human WIF1 (WNT inhibitory factor 1); PARTICIPATES IN Wnt signaling, canonical pathway; Wnt signaling pathway; INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 17alpha-ethynylestradiol; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

WIF-1

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	WIF1 (WNT inhibitory factor 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, PhylomeDB
Mus musculus (house mouse):	Wif1 (Wnt inhibitory factor 1)	HGNC	EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Wif1 (WNT inhibitory factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	WIF1 (WNT inhibitory factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	WIF1 (WNT inhibitory factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Wif1 (WNT inhibitory factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	WIF1 (WNT inhibitory factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	WIF1 (WNT inhibitory factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Wif1 (WNT inhibitory factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	WIF1 (WNT inhibitory factor 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	Wif1 (Wnt inhibitory factor 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	wif1 (wnt inhibitory factor 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	R05G6.9	Alliance	DIOPT (Ensembl Compara\|OrthoFinder)
Drosophila melanogaster (fruit fly):	shf	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PhylomeDB)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	56,548,058 - 56,618,364 (+)	NCBI
Rnor_6.0 Ensembl	7	63,094,911 - 63,165,159 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	7	63,094,955 - 63,165,158 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	7	63,077,688 - 63,147,646 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	60,330,517 - 60,400,697 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	7	60,417,062 - 60,421,426 (+)	NCBI
Celera	7	53,295,112 - 53,365,064 (+)	NCBI		Celera
Cytogenetic Map	7	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

breast cancer (ISO)

Colorectal Neoplasms (ISO)

Endometrioid Carcinomas (ISO)

Esophageal Neoplasms (ISO)

granulosa cell tumor (ISO)

invasive ductal carcinoma (ISO)

Nasopharyngeal Neoplasms (ISO)

nephroblastoma (ISO)

prostate cancer (ISO)

renal cell carcinoma (ISO)

small cell carcinoma (ISO)

Stomach Neoplasms (ISO)

urinary bladder cancer (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine (EXP)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-butoxyethanol (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

8-Br-cAMP (ISO)

acetylsalicylic acid (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

arsenous acid (ISO)

belinostat (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

carbon nanotube (ISO)

cobalt dichloride (EXP)

copper atom (EXP)

copper(0) (EXP)

curcumin (EXP)

Deguelin (ISO)

dexamethasone (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

dichloroacetic acid (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

entinostat (ISO)

ethosuximide (EXP)

etoposide (ISO)

flavonoids (EXP)

folic acid (ISO)

formaldehyde (ISO)

graphite (EXP)

isotretinoin (ISO)

manganese(II) chloride (EXP)

nitrofen (EXP)

oxaliplatin (EXP)

p-chloromercuribenzoic acid (ISO)

paclitaxel (ISO)

phenobarbital (ISO)

phenylephrine (EXP)

Pristimerin (ISO)

progesterone (ISO)

SB 431542 (ISO)

silicon dioxide (EXP)

Sporidesmin (ISO)

titanium dioxide (ISO)

topotecan (EXP)

trichostatin A (ISO)

trimellitic anhydride (ISO)

ursodeoxycholic acid (EXP)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anatomical structure development (IBA)

biological_process (ND)

multicellular organism development (IEA)

positive regulation of fat cell differentiation (ISO)

Wnt signaling pathway (IEA)

Cellular Component

cell surface (IBA)

cellular_component (ND)

extracellular region (IBA)

Molecular Function

molecular_function (ND)

protein binding (ISO)

signaling receptor binding (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

Wnt signaling pathway (IEA)

Wnt signaling, canonical pathway (ISO)

References

References - curated


1.	Ai L, etal., Carcinogenesis. 2006 Jul;27(7):1341-8. Epub 2006 Feb 25.
2.	Boerboom D, etal., Cancer Res. 2006 Feb 15;66(4):1964-73.
3.	De Smet C, etal., J Neurochem 2002 May;81(3):575-88.
4.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	GOA data from the GO Consortium
6.	Jimenez AL, etal., Neurochem Int 2003 Mar;42(4):345-51.
7.	Klaus A and Birchmeier W, Nat Rev Cancer. 2008 May;8(5):387-98.
8.	MGD data from the GO Consortium
9.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
10.	Pipeline to import KEGG annotations from KEGG into RGD
11.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	RGD automated import pipeline for gene-chemical interactions
13.	RGD comprehensive gene curation
14.	Roupret M, etal., BJU Int. 2008 Mar 4;.
15.	Steg A, etal., J Mol Diagn. 2006 Feb;8(1):76-83.
16.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
17.	Urakami S, etal., Clin Cancer Res. 2006 Dec 1;12(23):6989-97.
18.	Wissmann C, etal., J Pathol 2003 Oct;201(2):204-12.
19.	Zirn B, etal., Genes Chromosomes Cancer. 2006 Jun;45(6):565-74.

Additional References at PubMed

PMID:12055200	PMID:15489334	PMID:19621428	PMID:21986617	PMID:26637809

Genomics

Comparative Map Data

Wif1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	56,548,058 - 56,618,364 (+)	NCBI
Rnor_6.0 Ensembl	7	63,094,911 - 63,165,159 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	7	63,094,955 - 63,165,158 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	7	63,077,688 - 63,147,646 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	60,330,517 - 60,400,697 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	7	60,417,062 - 60,421,426 (+)	NCBI
Celera	7	53,295,112 - 53,365,064 (+)	NCBI		Celera
Cytogenetic Map	7	q22	NCBI

WIF1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	12	65,050,626 - 65,121,305 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	12	65,050,626 - 65,121,305 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	12	65,444,406 - 65,515,085 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	63,730,673 - 63,801,383 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	12	63,730,675 - 63,801,356	NCBI
Celera	12	65,109,871 - 65,180,833 (-)	NCBI
Cytogenetic Map	12	q14.3	NCBI
HuRef	12	62,496,029 - 62,566,998 (-)	NCBI		HuRef
CHM1_1	12	65,411,498 - 65,482,433 (-)	NCBI		CHM1_1

Wif1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	120,869,909 - 120,936,547 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	10	120,869,865 - 120,936,555 (+)	Ensembl
GRCm38	10	121,034,004 - 121,100,642 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	121,033,960 - 121,100,650 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	120,471,060 - 120,537,698 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	10	120,437,290 - 120,503,702 (+)	NCBI			mm8
Celera	10	123,398,945 - 123,465,434 (+)	NCBI		Celera
Cytogenetic Map	10	D2	NCBI

Wif1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955458	11,754,120 - 11,834,047 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955458	11,755,147 - 11,834,047 (-)	NCBI	ChiLan1.0	ChiLan1.0

WIF1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	12	24,299,354 - 24,370,591 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	24,299,351 - 24,370,807 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	12	23,795,280 - 23,866,666 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

WIF1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	10	7,659,491 - 7,726,859 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	10	7,659,277 - 7,726,175 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Wif1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936545	3,263,646 - 3,334,163 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

WIF1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	29,450,442 - 29,548,116 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	29,450,442 - 29,543,913 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	32,490,649 - 32,517,056 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

WIF1
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	60,728,316 - 60,800,181 (-)	NCBI
ChlSab1.1 Ensembl	11	60,727,948 - 60,799,960 (-)	Ensembl

Wif1
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624802	3,248,934 - 3,333,263 (+)	NCBI

Position Markers

D7Got45

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	7	63,158,966 - 63,159,113	NCBI	Rnor6.0
Rnor_5.0	7	63,141,454 - 63,141,601	UniSTS	Rnor5.0
RGSC_v3.4	7	60,394,506 - 60,394,777	RGD	RGSC3.4
RGSC_v3.4	7	60,394,505 - 60,394,652	UniSTS	RGSC3.4
RGSC_v3.1	7	60,415,236 - 60,415,382	RGD
Celera	7	53,358,878 - 53,359,025	UniSTS
RH 3.4 Map	7	499.9	UniSTS
RH 3.4 Map	7	499.9	RGD
Cytogenetic Map	7	q22	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	2920071	124838025	Rat
2298547	Neuinf5	Neuroinflammation QTL 5	3.7		nervous system integrity trait (VT:0010566)	spinal cord Cd74 protein level (CMO:0002131)	7	12328467	67193263	Rat
1643004	Pain2	Pain QTL 2	1		mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	7	12328467	106995532	Rat
1578652	Bmd15	Bone mineral density QTL 15	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	7	12687850	67801690	Rat
738033	Anxrr6	Anxiety related response QTL 6	4.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	7	22168412	67168412	Rat
10755451	Coatc11	Coat color QTL 11		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	24731465	69731465	Rat
1300132	Bp182	Blood pressure QTL 182	3.49		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	25365633	93155402	Rat
7411569	Bw137	Body weight QTL 137		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	28204653	73204653	Rat
1641885	Alcrsp9	Alcohol response QTL 9			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	7	31381529	76381529	Rat
1549840	Bss5	Bone structure and strength QTL 5	9.8		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	7	32035053	77035053	Rat
61439	Cia8	Collagen induced arthritis QTL 8	5.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	7	32572942	77572942	Rat
70190	Mcs6	Mammary carcinoma susceptibility QTL 6	2.29		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	7	33044449	71352127	Rat
10402855	Bp379	Blood pressure QTL 379		0.21	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	35867729	80867729	Rat
1300127	Srn1	Serum renin concentration QTL 1	3.87		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	7	35867729	93155402	Rat
10755453	Coatc12	Coat color QTL 12		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	38547706	83547706	Rat
631534	Lnnr1	Liver neoplastic nodule remodeling QTL 1	3.85	0.001	liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)	7	40872682	85872682	Rat
7411605	Foco14	Food consumption QTL 14	24.1	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	40872682	85872682	Rat
631513	Scl7	Serum cholesterol level QTL 7	4.1		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	45301573	90301573	Rat
2303629	Vencon3	Ventilatory control QTL 3	7.25		respiration trait (VT:0001943)	respiration rate (CMO:0000289)	7	47895099	63372754	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	48118835	128611831	Rat
634326	Hc3	Hypercalciuria QTL 3	2.1		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	7	50252103	95252103	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	50704769	128085642	Rat
10053722	Scort27	Serum corticosterone level QTL 27	2.41	0.0083	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	50793818	95793818	Rat
1358361	Sradr5	Stress Responsive Adrenal Weight QTL 5	5.55		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	7	51251919	118477612	Rat
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	51251919	145729302	Rat
1300149	Cm6	Cardiac mass QTL 6	4.09		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	7	51252005	111589099	Rat
61428	Scl3	Serum cholesterol level QTL 3	3.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	53200344	98200344	Rat
738030	Anxrr8	Anxiety related response QTL 8	4.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	54259512	99259512	Rat
10059605	Kidm47	Kidney mass QTL 47	2.91	0.05	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	7	54534996	73293934	Rat
2317059	Aia15	Adjuvant induced arthritis QTL 15	2.46		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	7	55072862	69399731	Rat
2316947	Rf58	Renal function QTL 58	7.8		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	7	55072862	123602998	Rat
2316952	Pur22	Proteinuria QTL 22	5.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	7	55072862	123602998	Rat
2316955	Stl24	Serum triglyceride level QTL 24	7.1		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	7	55072862	123602998	Rat
2300178	Bmd54	Bone mineral density QTL 54	5.3	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	7	55495689	100495689	Rat
2293644	Bmd29	Bone mineral density QTL 29	5.4	0.0001	femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	7	55495689	100495689	Rat
2293667	Bss42	Bone structure and strength QTL 42	7.25	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	7	55495689	100495689	Rat
2293678	Bss24	Bone structure and strength QTL 24	6.71	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	7	55495689	100495689	Rat
2293685	Bmd21	Bone mineral density QTL 21	4.2	0.0003	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	7	55495689	100495689	Rat
2293696	Bmd32	Bone mineral density QTL 32	5.1	0.0001	femur strength trait (VT:0010010)	femoral neck polar moment of inertia (CMO:0001670)	7	55495689	100495689	Rat
2293707	Bss32	Bone structure and strength QTL 32	7.64	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	7	55495689	100495689	Rat
1300151	Bp181	Blood pressure QTL 181	3.36		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	7	61047589	113228378	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	344
Count of miRNA genes:	212
Interacting mature miRNAs:	239
Transcripts:	ENSRNOT00000006426
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		8			2				26		13	11
Low	2	35	44	28	17	28	7	10	48	34	28		7
Below cutoff	1		13	13		13	1	1		1			1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053738	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006241395	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005486537	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY030278	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC072473	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473960	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000185	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000006426 ⟹ ENSRNOP00000006426

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	7	63,094,911 - 63,165,159 (+)	Ensembl

RefSeq Acc Id:

NM_053738 ⟹ NP_446190

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	56,548,110 - 56,618,364 (+)	NCBI
Rnor_6.0	7	63,094,955 - 63,165,158 (+)	NCBI
Rnor_5.0	7	63,077,688 - 63,147,646 (+)	NCBI
RGSC_v3.4	7	60,330,517 - 60,400,697 (+)	RGD
Celera	7	53,295,112 - 53,365,064 (+)	RGD

Sequence:

show sequence

GGCACGAGCTCGAGTGTGATCCTCGAACTGCTGGCGCTGCGGGACGTGCTGGCATCGCCAGCTT
TGCCAGCATCGTGTCTCTGCGGTCCCCTCTCCCTCCAGGCCCCCTCCTTCTGCGCGGCCGCGCA
TCCACTCCCTCCTCTCCAGCTCTCCCAGGCTCACTCGCACCGGAGACTGGAGACTTGCACGCCC
AGTCGTTTAAGTGGGAACAGCTCCAGCCCCGCCAGCTGCAGCCCAGGCGAGAACTTCACAAGCA
GCGCAGGTTGGGTCGCTGAGGCAGGAGTTGCACCACCAGCGAGAAGGTCCTGAGCAGCATGGCC
CGGAGAAGAGCCTTCCCTGCTTTCGTGCTCCGGCTCTGGAGCATCCTACCTTGCCTGCTCCTGC
TACGAGCGGATGCAGGGCAGCCGCCAGAGGAGAGCTTGTACCTGTGGATCGACGCCCATCAGGC
CAGAGTACTCATAGGATTTGAAGAAGATATTCTGATTGTCTCGGAGGGGAAAATGGCCCCCTTT
ACACATGATTTCAGGAAAGCCCAACAAAGAATGCCAGCCATTCCCGTCAATATCCACTCCATGA
ATTTTACCTGGCAAGCTTCAGGGCAGGCAGAGTACTTCTATGAGTTCCTGTCGCTGCGCTCGCT
GGATAAAGGCATCATGGCAGACCCAACTGTCAATGTCCCTCGGCTGGGAACAGTGCCTCACAAG
GCATCAGTTGTTCAAGTTGGTTTCCCGTGTCTCGGCAAACAGGATGGGGTGGCAGCATTTGAAG
TGAATGTGATTGTCATGAATTCTGAAGGCAACCCCATCCTTCGGACCCCTCAAAATGCTATCTT
CTTTAAAACATGTCAACAAGCTGAGTGCCCAGGAGGGTGTCGAAATGGAGGCTTTTGTAACGAA
AGGCGGGTCTGCGAGTGTCCCGATGGGTTCTATGGACCTCACTGTGAGAAAGCCCTCTGCATAC
CTCGATGTATGAACGGTGGTCTGTGTGTCACTCCTGGCTTCTGCATCTGCCCGCCTGGATTCTA
CGGTGTCAACTGTGACAAAGCAAACTGCTCGGCCACCTGCTTTAATGGAGGGACCTGTTTTTAC
CCAGGAAAATGTATTTGCCCTCCAGGACTTGAGGGAGAGCAGTGTGAACTCAGCAAGTGCCCCC
AACCCTGCCGAAACGGAGGTAAATGCATTGGTAAAAGCAAGTCTGTCTGCGAGCCTGGCTGCGG
TGCCCATGGAACCTGCCACGAACCCAACAAATGCCAGTGTCGAGAGGGCTGGCATGGGAGACAC
TGCAATAAAAGGTACGGAGCCAGCCTCATGCATGCCCCGAGGCCAGCAGGCGCCGGGCTGGAGC
GGCACACGCCTTCACTTAAAAAGGCTGAGGGGCGGAGGGATCCACCTGAATCCAATTACATCTG
GTGAACTCCACCATCTGAAACGGTTCGAGTTACGCCGAGTTCACAGCCTTTGTTAACCTTTCGT
GTGTTGGATGTTCAAATGATGTTCATTACACTTTAGAGTACTGGCCTGAATTTTATTAGCTTCA
TTATGAATCACTGGGCTGATATTTACTCTCCCTTTTAGGTTTCCTAAGCATGTCTAGCATGATG
GTATAGATTTTCTTCCTTCAGTCCTTTGGGACAGATCTTTCATGTCAGTTGATCAGGTTAAAAA
ATAAAAAATCTGTCTCTTCAGTATGTAGTTGACAGATACTTGCAAAATCACGACACATTTGTGG
TATTGGGATGGGGAGCCCTAGAGAGGCGAAACTGGGCAAAGATACATAAATCACAAGGTTTTGG
ATAAAGCAGATAACAGTGTTTAAGCTACAGTATTTCACATTCTGTTGTCAAATATTTGGACACT
TGTCTAATTAATATTTCAATTGCCCCCCCCCCATCTTGAATACGTACAATCTATTTCGCCCTTA
CTGTTACTCTAGACAGTTCAGTTTTGAGGGGGGAACAGAGTTAAAGGGAAAACATCACACTTGT
GTTAGTGGCATTTAAACAATATAATATATTGTAAACACGACAAAGTAAGGAATATAATGTATGG
AGTCTTTGCCTTGGATGGAAGCAATATAATATATTGTAAACAAAACACAGCTCTTACATAGTAA
ACATTTTATACTGTTTGTATGTATCAAATAAAGGTGCTGCTTTCTCTCTCTGAAAAAAAAAAAA
AAAAAA

hide sequence

RefSeq Acc Id:

XM_006241395 ⟹ XP_006241457

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	56,548,058 - 56,618,364 (+)	NCBI
Rnor_6.0	7	63,094,955 - 63,165,158 (+)	NCBI
Rnor_5.0	7	63,077,688 - 63,147,646 (+)	NCBI

Sequence:

show sequence

CTCGAGTGTGATCCTCGAACTGCTGGCGCTGCGGGACGTGCTGGCATCGCCAGCTTTGCCAGCA
TCGTGTCTCTGCGGTCCCCTCTCCCTCCAGGCCCCCTCCTTCTGCGCGGCCGCGCATCCACTCC
CTCCTCTCCAGCTCTCCCAGGCTCACTCGCACCGGAGACTGGAGACTTGCACGCCCAGTCGTTT
AAGTGGGAACAGCTCCAGCCCCGCCAGCTGCAGCCCAGGCGAGAACTTCACAAGCAGCGCAGGT
TGGGTCGCTGAGGCAGGAGTTGCACCACCAGCGAGAAGGTCCTGAGCAGCATGGCCCGGAGAAG
AGCCTTCCCTGCTTTCGTGCTCCGGCTCTGGAGCATCCTACCTTGCCTGCTCCTGCTACGAGCG
GATGCAGGGCAGCCGCCAGAGGAGAGCTTGTACCTGTGGATCGACGCCCATCAGGCCAGAGTAC
TCATAGGATTTGAAGAAGATATTCTGATTGTCTCGGAGGGGAAAATGGCCCCCTTTACACATGA
TTTCAGGAAAGCCCAACAAAGAATGCCAGCCATTCCCGTCAATATCCACTCCATGAATTTTACC
TGGCAAGCTTCAGGGCAGGCAGAGTACTTCTATGAGTTCCTGTCGCTGCGCTCGCTGGATAAAG
GCATCATGGCAGACCCAACTGTCAATGTCCCTCGGCTGGGAACAGTGCCTCACAAGGCATCAGT
TGTTCAAGTTGGTTTCCCGTGTCTCGGCAAACAGGATGGGGTGGCAGCATTTGAAGTGAATGTG
ATTGTCATGAATTCTGAAGGCAACCCCATCCTTCGGACCCCTCAAAATGCTATCTTCTTTAAAA
CATGTCAACAAGCTGAGTGCCCAGGAGGGTGTCGAAATGGAGGCTTTTGTAACGAAAGGCGGGT
CTGCGAGTGTCCCGATGGGTTCTATGGACCTCACTGTGAGAAAGCCCTCTGCATACCTCGATGT
ATGAACGGTGGTCTGTGTGTCACTCCTGGCTTCTGCATCTGCCCGCCTGGATTCTACGGTGTCA
ACTGTGACAAAGCAAACTGCTCGGCCACCTGCTTTAATGGAGGGACCTGTTTTTACCCAGGAAA
ATGTATTTGCCCTCCAGGACTTGAGGGAGAGCAGTGTGAACTCAGCAAGTGCCCCCAACCCTGC
CGAAACGGAGGTAAATGCATTGGTAAAAGCAAGTGTAAGTGTCCGAAAGGTTACCAAGGAGACC
TGTGCTCTAAGCCTGTCTGCGAGCCTGGCTGCGGTGCCCATGGAACCTGCCACGAACCCAACAA
ATGCCAGTGTCGAGAGGGCTGGCATGGGAGACACTGCAATAAAAGGTACGGAGCCAGCCTCATG
CATGCCCCGAGGCCAGCAGGCGCCGGGCTGGAGCGGCACACGCCTTCACTTAAAAAGGCTGAGG
GGCGGAGGGATCCACCTGAATCCAATTACATCTGGTGAACTCCACCATCTGAAACGGTTCGAGT
TACGCCGAGTTCACAGCCTTTGTTAACCTTTCGTGTGTTGGATGTTCAAATGATGTTCATTACA
CTTTAGAGTACTGGCCTGAATTTTATTAGCTTCATTATGAATCACTGGGCTGATATTTACTCTC
CCTTTTAGGTTTCCTAAGCATGTCTAGCATGATGGTATAGATTTTCTTCCTTCAGTCCTTTGGG
ACAGATCTTTCATGTCAGTTGATCAGGTTAAAAAATAAAAAATCTGTCTCTTCAGTATGTAGTT
GACAGATACTTGCAAAATCACGACACATTTGTGGTATTGGGATGGGGAGCCCTAGAGAGGCGAA
ACTGGGCAAAGATACATAAATCACAAGGTTTTGGATAAAGCAGATAACAGTGTTTAAGCTACAG
TATTTCACATTCTGTTGTCAAATATTTGGACACTTGTCTAATTAATATTTCAATTGCCCCCCCC
ATCTTGAATACGTACAATCTATTTCGCCCTTACTGTTACTCTAGACAGTTCAGTTTTGAGGGGG
GAACAGAGTTAAAGGGAAAACATCACACTTGTGTTAGTGGCATTTAAACAATATAATATATTGT
AAACACGACAAAGTAAGGAATATAATGTATGGAGTCTTTGCCTTGGATGGAAGCAATATAATAT
ATTGTAAACAAAACACAGCTCTTACATAGTAAACATTTTATACTGTTTGTATGTATCAAATAAA
GGTGCTGCTTTCTCTCTCTGA

hide sequence

RefSeq Acc Id:

XR_005486537

RefSeq Status:

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	56,548,060 - 56,618,364 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_446190	(Get FASTA)	NCBI Sequence Viewer
	XP_006241457	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH72473	(Get FASTA)	NCBI Sequence Viewer
	AAK51134	(Get FASTA)	NCBI Sequence Viewer
	EDM16555	(Get FASTA)	NCBI Sequence Viewer
	EDM16556	(Get FASTA)	NCBI Sequence Viewer
	Q6IN38	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_446190 ⟸ NM_053738
- Peptide Label:	precursor
- UniProtKB:	Q6IN38 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MARRRAFPAFVLRLWSILPCLLLLRADAGQPPEESLYLWIDAHQARVLIGFEEDILIVSEGKMA PFTHDFRKAQQRMPAIPVNIHSMNFTWQASGQAEYFYEFLSLRSLDKGIMADPTVNVPRLGTVP HKASVVQVGFPCLGKQDGVAAFEVNVIVMNSEGNPILRTPQNAIFFKTCQQAECPGGCRNGGFC NERRVCECPDGFYGPHCEKALCIPRCMNGGLCVTPGFCICPPGFYGVNCDKANCSATCFNGGTC FYPGKCICPPGLEGEQCELSKCPQPCRNGGKCIGKSKSVCEPGCGAHGTCHEPNKCQCREGWHG RHCNKRYGASLMHAPRPAGAGLERHTPSLKKAEGRRDPPESNYIW hide sequence

RefSeq Acc Id:	XP_006241457 ⟸ XM_006241395
- Peptide Label:	isoform X1
- UniProtKB:	Q6IN38 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MARRRAFPAFVLRLWSILPCLLLLRADAGQPPEESLYLWIDAHQARVLIGFEEDILIVSEGKMA PFTHDFRKAQQRMPAIPVNIHSMNFTWQASGQAEYFYEFLSLRSLDKGIMADPTVNVPRLGTVP HKASVVQVGFPCLGKQDGVAAFEVNVIVMNSEGNPILRTPQNAIFFKTCQQAECPGGCRNGGFC NERRVCECPDGFYGPHCEKALCIPRCMNGGLCVTPGFCICPPGFYGVNCDKANCSATCFNGGTC FYPGKCICPPGLEGEQCELSKCPQPCRNGGKCIGKSKCKCPKGYQGDLCSKPVCEPGCGAHGTC HEPNKCQCREGWHGRHCNKRYGASLMHAPRPAGAGLERHTPSLKKAEGRRDPPESNYIW hide sequence

RefSeq Acc Id:

ENSRNOP00000006426 ⟸ ENSRNOT00000006426

Protein Domains

EGF-like WIF

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695224

Promoter ID:

EPDNEW_R5749

Type:

single initiation site

Name:

Wif1_1

Description:

Wnt inhibitory factor 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	63,094,903 - 63,094,963	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:619774	AgrOrtholog
Ensembl Genes	ENSRNOG00000004476	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000006426	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000006426	UniProtKB/Swiss-Prot
Gene3D-CATH	2.60.40.2170	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7100360	IMAGE-MGC_LOAD
InterPro	EGF-like_CS	UniProtKB/Swiss-Prot
	EGF-like_dom	UniProtKB/Swiss-Prot
	WIF	UniProtKB/Swiss-Prot
	WIF_sf	UniProtKB/Swiss-Prot
	Wnt-inh	UniProtKB/Swiss-Prot
KEGG Report	rno:114557	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:91560	IMAGE-MGC_LOAD
NCBI Gene	114557	ENTREZGENE
Pfam	hEGF	UniProtKB/Swiss-Prot
	WIF	UniProtKB/Swiss-Prot
PharmGKB	WIF1	RGD
PhenoGen	Wif1	PhenoGen
PRINTS	WIFPROTEIN	UniProtKB/Swiss-Prot
PROSITE	EGF_1	UniProtKB/Swiss-Prot
	EGF_2	UniProtKB/Swiss-Prot
	EGF_3	UniProtKB/Swiss-Prot
	WIF	UniProtKB/Swiss-Prot
SMART	EGF	UniProtKB/Swiss-Prot
	WIF	UniProtKB/Swiss-Prot
UniProt	Q6IN38	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	Q924Y6	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Wif1	Wnt inhibitory factor 1			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Wif1	Wnt inhibitory factor 1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)