Hmga2 (high mobility group AT-hook 2) - Rat Genome Database

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Gene: Hmga2 (high mobility group AT-hook 2) Rattus norvegicus
Analyze
Symbol: Hmga2
Name: high mobility group AT-hook 2
RGD ID: 620617
Description: Enables enzyme binding activity. Involved in negative regulation of intracellular steroid hormone receptor signaling pathway; negative regulation of receptor signaling pathway via JAK-STAT; and negative regulation of transcription by RNA polymerase II. Predicted to be located in male germ cell nucleus and nuclear chromosome. Predicted to be part of SMAD protein complex and senescence-associated heterochromatin focus. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Silver-Russell syndrome; leiomyoma; lipoma; and ovarian cancer. Orthologous to human HMGA2 (high mobility group AT-hook 2); PARTICIPATES IN Ras mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol; atrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: high mobility group protein HMGI-C; Hmgic; non-histone chromosomal architectural protein HMGI-C
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8757,762,710 - 57,884,555 (-)NCBIGRCr8
mRatBN7.2755,877,145 - 55,998,813 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl755,880,112 - 55,994,784 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx757,786,495 - 57,901,148 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0759,989,707 - 60,104,351 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0759,767,092 - 59,881,753 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0765,159,944 - 65,275,408 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl765,159,944 - 65,275,408 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0765,375,936 - 65,490,635 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4759,638,555 - 59,753,791 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1759,659,284 - 59,774,521 (-)NCBI
Celera752,634,133 - 52,748,501 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-deoxy-D-glucose  (ISO)
2-methoxyethanol  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitrophenol  (ISO)
4-phenylbutyric acid  (ISO)
5-azacytidine  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
dexamethasone  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
hypochlorous acid  (ISO)
indometacin  (ISO)
itraconazole  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
maneb  (ISO)
melphalan  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
permethrin  (ISO)
phenanthrene  (ISO)
phenobarbital  (EXP)
pirinixic acid  (EXP)
piroxicam  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
quercitrin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thiram  (ISO)
topotecan  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adipose tissue development  (ISO)
adrenal gland development  (ISO)
astrocyte differentiation  (ISO)
base-excision repair  (ISO,ISS)
cell population proliferation  (ISO)
cell proliferation in forebrain  (ISO)
chondrocyte differentiation  (ISO,ISS)
chondrocyte proliferation  (ISO,ISS)
endodermal cell differentiation  (ISO,ISS)
epithelial to mesenchymal transition  (ISO,ISS)
epithelial tube branching involved in lung morphogenesis  (ISO)
fat cell differentiation  (ISO,ISS)
fat pad development  (ISO)
fibroblast proliferation  (ISO)
heterochromatin formation  (ISO,ISS)
intracellular signal transduction  (ISO,ISS)
lung epithelium development  (ISO)
male gonad development  (ISO)
mesenchymal cell differentiation  (ISO,ISS)
mesodermal cell differentiation  (ISO,ISS)
mesodermal-endodermal cell signaling  (ISO,ISS)
multicellular organism growth  (ISO)
negative regulation by host of viral transcription  (ISO,ISS)
negative regulation of apoptotic process  (ISO,ISS)
negative regulation of astrocyte differentiation  (ISO)
negative regulation of cellular senescence  (ISO)
negative regulation of DNA-templated transcription  (ISO,ISS)
negative regulation of double-strand break repair via nonhomologous end joining  (ISO,ISS)
negative regulation of intracellular steroid hormone receptor signaling pathway  (IDA)
negative regulation of receptor signaling pathway via JAK-STAT  (IDA)
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate  (ISO,ISS)
negative regulation of transcription by RNA polymerase II  (IDA,ISO,ISS)
negative regulation of Wnt signaling pathway  (ISO)
oncogene-induced cell senescence  (ISO,ISS)
pituitary gland development  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell proliferation in bone marrow  (ISO)
positive regulation of DNA-binding transcription factor activity  (IMP)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial cell proliferation involved in lung morphogenesis  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of gene expression  (ISO,ISS)
positive regulation of multicellular organism growth  (ISO)
positive regulation of stem cell proliferation  (ISO,ISS)
positive regulation of transcription by RNA polymerase II  (ISO,ISS)
regulation of cell cycle process  (ISO,ISS)
regulation of DNA-templated transcription  (IBA,ISO,ISS)
regulation of growth hormone secretion  (ISO)
regulation of peptide hormone secretion  (ISO)
regulation of stem cell population maintenance  (ISO,ISS)
response to virus  (ISO)
somatic stem cell population maintenance  (ISO)
spermatogenesis  (ISO)
stem cell differentiation  (ISO)
stem cell proliferation  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. In vivo modulation of Hmgic reduces obesity. Anand A and Chada K, Nat Genet. 2000 Apr;24(4):377-80.
2. Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. Ashar HR, etal., Cell. 1995 Jul 14;82(1):57-65.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Fusion transcripts between the HMGIC gene and RTVL-H-related sequences in mesenchymal tumors without cytogenetic aberrations. Kazmierczak B, etal., Genomics. 1996 Dec 1;38(2):223-6.
5. Oncogenic raf-1 induces the expression of non-histone chromosomal architectural protein HMGI-C via a p44/p42 mitogen-activated protein kinase-dependent pathway in salivary epithelial cells. Li D, etal., J Biol Chem 1997 Oct 3;272(40):25062-70.
6. HMGA2 gene is a promising target for ovarian cancer silencing therapy. Malek A, etal., Int J Cancer. 2008 Jul 15;123(2):348-56.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Neoplastic transformation of rat thyroid cells requires the junB and fra-1 gene induction which is dependent on the HMGI-C gene product. Vallone D, etal., EMBO J. 1997 Sep 1;16(17):5310-21.
13. Requirement for high mobility group protein HMGI-C interaction with STAT3 inhibitor PIAS3 in repression of alpha-subunit of epithelial Na+ channel (alpha-ENaC) transcription by Ras activation in salivary epithelial cells. Zentner MD, etal., J Biol Chem. 2001 Aug 10;276(32):29805-14. Epub 2001 Jun 4.
Additional References at PubMed
PMID:504232   PMID:5051369   PMID:7651535   PMID:7958830   PMID:11555636   PMID:12032866   PMID:14627817   PMID:14645522   PMID:14668482   PMID:14794889   PMID:15225648   PMID:15645138  
PMID:15755872   PMID:16061642   PMID:16109425   PMID:16791210   PMID:16901784   PMID:17005673   PMID:17078040   PMID:17305714   PMID:17324944   PMID:17426251   PMID:17624332   PMID:17854662  
PMID:18640244   PMID:18832382   PMID:18957199   PMID:19465398   PMID:19549901   PMID:20108983   PMID:21484705   PMID:21533145   PMID:23072816   PMID:24661562   PMID:25557289   PMID:25623534  
PMID:26698218   PMID:27693697   PMID:30934671   PMID:32068957   PMID:32370714   PMID:33749722   PMID:35966335  


Genomics

Comparative Map Data
Hmga2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8757,762,710 - 57,884,555 (-)NCBIGRCr8
mRatBN7.2755,877,145 - 55,998,813 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl755,880,112 - 55,994,784 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx757,786,495 - 57,901,148 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0759,989,707 - 60,104,351 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0759,767,092 - 59,881,753 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0765,159,944 - 65,275,408 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl765,159,944 - 65,275,408 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0765,375,936 - 65,490,635 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4759,638,555 - 59,753,791 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1759,659,284 - 59,774,521 (-)NCBI
Celera752,634,133 - 52,748,501 (-)NCBICelera
Cytogenetic Map7q22NCBI
HMGA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381265,824,460 - 65,966,291 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1265,824,460 - 65,966,291 (+)EnsemblGRCh38hg38GRCh38
GRCh371266,218,240 - 66,360,071 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361264,504,507 - 64,646,338 (+)NCBINCBI36Build 36hg18NCBI36
Build 341264,504,457 - 64,646,266NCBI
Celera1265,883,845 - 66,025,902 (+)NCBICelera
Cytogenetic Map12q14.3NCBI
HuRef1263,271,242 - 63,413,086 (+)NCBIHuRef
CHM1_11266,185,507 - 66,327,350 (+)NCBICHM1_1
T2T-CHM13v2.01265,803,963 - 65,945,820 (+)NCBIT2T-CHM13v2.0
Hmga2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910120,197,173 - 120,312,374 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10120,197,180 - 120,312,374 (-)EnsemblGRCm39 Ensembl
GRCm3810120,361,268 - 120,476,469 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10120,361,275 - 120,476,469 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710119,798,331 - 119,913,991 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610119,764,721 - 119,880,028 (-)NCBIMGSCv36mm8
Celera10122,723,179 - 122,838,757 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1067.94NCBI
Hmga2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545812,493,790 - 12,624,805 (+)NCBIChiLan1.0ChiLan1.0
HMGA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21028,400,118 - 28,548,065 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11228,396,888 - 28,538,621 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01222,954,946 - 23,096,623 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
HMGA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1108,348,101 - 8,491,435 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha108,278,957 - 8,424,016 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0108,459,176 - 8,604,625 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl108,459,180 - 8,601,880 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1108,335,596 - 8,480,987 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0108,581,865 - 8,727,080 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0108,703,471 - 8,848,741 (+)NCBIUU_Cfam_GSD_1.0
Hmga2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494550,151,774 - 50,166,701 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365453,944,419 - 4,064,193 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365453,944,419 - 3,958,289 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HMGA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1530,188,521 - 30,329,635 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2533,375,397 - 33,516,455 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HMGA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11161,509,114 - 61,655,633 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037184,069,350 - 184,211,090 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hmga2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248022,337,464 - 2,467,990 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248022,337,344 - 2,468,757 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hmga2
443 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:51
Interacting mature miRNAs:54
Transcripts:ENSRNOT00000065137
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
2303629Vencon3Ventilatory control QTL 37.25respiration trait (VT:0001943)respiration rate (CMO:0000289)74110969256793354Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 14 10 10 10 16 16 18
Low 2 10 22 12 9 12 31 6 16
Below cutoff 1 8 8 6 3 6 1 1 12 11 7 1 1

Sequence


RefSeq Acc Id: ENSRNOT00000065137   ⟹   ENSRNOP00000061041
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl755,880,112 - 55,994,784 (-)Ensembl
Rnor_6.0 Ensembl765,159,944 - 65,275,408 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103543   ⟹   ENSRNOP00000084064
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl755,980,980 - 55,994,784 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000120053   ⟹   ENSRNOP00000085277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl755,991,273 - 55,994,784 (-)Ensembl
RefSeq Acc Id: NM_032070   ⟹   NP_114459
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8757,765,675 - 57,880,341 (-)NCBI
mRatBN7.2755,880,112 - 55,994,784 (-)NCBI
Rnor_6.0765,159,944 - 65,275,408 (-)NCBI
Rnor_5.0765,375,936 - 65,490,635 (-)NCBI
RGSC_v3.4759,638,555 - 59,753,791 (-)RGD
Celera752,634,133 - 52,748,501 (-)RGD
Sequence:
RefSeq Acc Id: XM_039079971   ⟹   XP_038935899
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8757,762,710 - 57,884,555 (-)NCBI
mRatBN7.2755,877,145 - 55,998,813 (-)NCBI
RefSeq Acc Id: NP_114459   ⟸   NM_032070
- UniProtKB: O88791 (UniProtKB/TrEMBL),   F1M940 (UniProtKB/TrEMBL),   A0A9K3Y850 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000061041   ⟸   ENSRNOT00000065137
RefSeq Acc Id: XP_038935899   ⟸   XM_039079971
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000084064   ⟸   ENSRNOT00000103543
RefSeq Acc Id: ENSRNOP00000085277   ⟸   ENSRNOT00000120053

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88791-F1-model_v2 AlphaFold O88791 1-107 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695235
Promoter ID:EPDNEW_R5760
Type:initiation region
Name:Hmga2_1
Description:high mobility group AT-hook 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0765,275,414 - 65,275,474EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620617 AgrOrtholog
BioCyc Gene G2FUF-33911 BioCyc
Ensembl Genes ENSRNOG00000042460 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065137 ENTREZGENE
  ENSRNOT00000065137.3 UniProtKB/TrEMBL
  ENSRNOT00000103543.1 UniProtKB/TrEMBL
  ENSRNOT00000120053.1 UniProtKB/TrEMBL
InterPro AT_hook_DNA-bd_motif UniProtKB/TrEMBL
  HMGI/HMGY UniProtKB/TrEMBL
  HMGI/Y_DNA-bd_CS UniProtKB/TrEMBL
KEGG Report rno:84017 UniProtKB/TrEMBL
NCBI Gene 84017 ENTREZGENE
PANTHER HIGH MOBILITY GROUP AT-HOOK 2 UniProtKB/TrEMBL
  HIGH MOBILITY GROUP PROTEIN HMGI-C UniProtKB/TrEMBL
  HIGH MOBILITY GROUP PROTEINS HMG-A AND C UniProtKB/TrEMBL
Pfam AT_hook UniProtKB/TrEMBL
PhenoGen Hmga2 PhenoGen
PRINTS ATHOOK UniProtKB/TrEMBL
  HIGHMOBLTYIY UniProtKB/TrEMBL
PROSITE HMGI_Y UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042460 RatGTEx
SMART AT_hook UniProtKB/TrEMBL
UniProt A0A8I6A172_RAT UniProtKB/TrEMBL
  A0A8I6GCP7_RAT UniProtKB/TrEMBL
  A0A9K3Y850 ENTREZGENE, UniProtKB/TrEMBL
  F1M940 ENTREZGENE
  O88791 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1M940 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Hmga2  high mobility group AT-hook 2  Hmgic  non-histone chromosomal architectural protein HMGI-C  Symbol and Name updated 1299863 APPROVED
2002-08-07 Hmgic  non-histone chromosomal architectural protein HMGI-C      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation transcription is activated by oncogenic Raf-1 kinase 632948