Mirlet7i (microRNA let-7i) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Mirlet7i (microRNA let-7i) Rattus norvegicus
Analyze
Symbol: Mirlet7i
Name: microRNA let-7i
RGD ID: 2325604
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Predicted to be involved in miRNA-mediated gene silencing by inhibition of translation. Predicted to act upstream of or within several processes, including cellular response to amino acid stimulus; cellular response to leukemia inhibitory factor; and long-term synaptic potentiation. Predicted to be located in cytoplasm. Predicted to be part of RISC complex. Orthologous to human MIRLET7I (microRNA let-7i); INTERACTS WITH 2,5-hexanedione; 2-acetamidofluorene; atrazine.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: rno-let-7i
RGD Orthologs
Human
Mouse
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8760,527,877 - 60,527,961 (-)NCBIGRCr8
mRatBN7.2758,642,485 - 58,642,569 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl758,642,480 - 58,642,571 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx760,514,724 - 60,514,808 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0762,717,359 - 62,717,443 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0762,494,683 - 62,494,767 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0766,802,731 - 66,802,815 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl766,802,732 - 66,802,821 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0767,000,236 - 67,000,320 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera755,814,162 - 55,814,246 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mirlet7iRatacute kidney failure  ISOMIRLET7I (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30682439
Mirlet7iRatChemical and Drug Induced Liver Injury  ISOMIRLET7I (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28545106
Mirlet7iRatcholestasis  ISOMIRLET7I (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22363424
Mirlet7iRatcongestive heart failure  ISOMIRLET7I (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:36071497
Mirlet7iRatExperimental Liver Neoplasms  ISOMIRLET7I (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21035526
Mirlet7iRatMyocardial Reperfusion Injury  ISOMIRLET7I (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22050707

1 to 20 of 41 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mirlet7iRat(S)-nicotine decreases expressionISOMirlet7i (Mus musculus)6480464Nicotine results in decreased expression of MIRLET7I mRNACTDPMID:33082140
Mirlet7iRat1,3,5-trinitro-1,3,5-triazinane affects expressionISOMirlet7i (Mus musculus)6480464cyclonite affects the expression of MIRLET7I mRNACTDPMID:19270793
Mirlet7iRat17beta-hydroxy-5alpha-androstan-3-one decreases expressionISOMIRLET7I (Homo sapiens)6480464Dihydrotestosterone results in decreased expression of MIRLET7I mRNACTDPMID:25846647
Mirlet7iRat2,5-hexanedione increases expressionEXP 64804642 and 5-hexanedione results in increased expression of MIRLET7I mRNACTDPMID:31760062
Mirlet7iRat2-acetamidofluorene increases expressionEXP 64804642-Acetylaminofluorene results in increased expression of MIRLET7I mRNACTDPMID:19167416
Mirlet7iRatarsane increases expressionISOMirlet7i (Mus musculus)6480464Arsenic results in increased expression of MIRLET7I mRNACTDPMID:36463740
Mirlet7iRatarsenic atom increases expressionISOMirlet7i (Mus musculus)6480464Arsenic results in increased expression of MIRLET7I mRNACTDPMID:36463740
Mirlet7iRatarsenite(3-) increases expressionISOMIRLET7I (Homo sapiens)6480464arsenite results in increased expression of MIRLET7I mRNACTDPMID:22728250
Mirlet7iRatatrazine increases expressionEXP 6480464Atrazine results in increased expression of MIRLET7I mRNACTDPMID:31185338
Mirlet7iRatbis(2-ethylhexyl) phthalate increases expressionISOMirlet7i (Mus musculus)6480464Diethylhexyl Phthalate results in increased expression of MIRLET7ICTDPMID:32642447
Mirlet7iRatbleomycin A2 decreases expressionEXP 6480464Bleomycin results in decreased expression of MIRLET7I mRNACTDPMID:25933445
Mirlet7iRatbuta-1,3-diene increases expressionISOMirlet7i (Mus musculus)64804641 and 3-butadiene results in increased expression of MIRLET7I mRNACTDPMID:29038090
Mirlet7iRatcadmium atom multiple interactionsEXP 6480464[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MIRLET7I mRNACTDPMID:33652105
Mirlet7iRatcadmium dichloride decreases expressionISOMIRLET7I (Homo sapiens)6480464Cadmium Chloride results in decreased expression of MIRLET7I mRNACTDPMID:20145152
Mirlet7iRatcadmium dichloride multiple interactionsEXP 6480464[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MIRLET7I mRNACTDPMID:33652105
Mirlet7iRatcarbon atom multiple interactionsISOMIRLET7I (Homo sapiens)6480464[Air Pollutants results in increased abundance of [Carbon co-treated with Particulate Matter]] which results in increased expression of MIRLET7I mRNA and [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIRLET7I mRNACTDPMID:31268311
Mirlet7iRatcarbon monoxide multiple interactionsISOMIRLET7I (Homo sapiens)6480464[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIRLET7I mRNACTDPMID:31268311
Mirlet7iRatcisplatin increases expressionEXP 6480464Cisplatin results in increased expression of MIRLET7I mRNACTDPMID:24880025
Mirlet7iRatcisplatin increases expressionISOMirlet7i (Mus musculus)6480464Cisplatin results in increased expression of MIRLET7I mRNACTDPMID:28119452
Mirlet7iRatelemental carbon multiple interactionsISOMIRLET7I (Homo sapiens)6480464[Air Pollutants results in increased abundance of [Carbon co-treated with Particulate Matter]] which results in increased expression of MIRLET7I mRNA and [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIRLET7I mRNACTDPMID:31268311

1 to 20 of 41 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mirlet7iRatcytoplasm located_inISOMIRLET7I (Homo sapiens)1624291 PMID:25336585RGDPMID:25336585
Mirlet7iRatRISC complex part_ofISOMirlet7i (Mus musculus)1624291 PMID:23185045RGDPMID:23185045

Molecular Function

  


#
Reference Title
Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:14691248   PMID:15345052   PMID:16381832   PMID:16766679   PMID:17604727   PMID:17805466   PMID:20403161   PMID:20439489   PMID:20548288   PMID:21742974   PMID:22352906   PMID:23185045  
PMID:24205035   PMID:25751060   PMID:25858512   PMID:26755202   PMID:27384999   PMID:38429909  



Mirlet7i
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8760,527,877 - 60,527,961 (-)NCBIGRCr8
mRatBN7.2758,642,485 - 58,642,569 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl758,642,480 - 58,642,571 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx760,514,724 - 60,514,808 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0762,717,359 - 62,717,443 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0762,494,683 - 62,494,767 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0766,802,731 - 66,802,815 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl766,802,732 - 66,802,821 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0767,000,236 - 67,000,320 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera755,814,162 - 55,814,246 (-)NCBICelera
Cytogenetic Map7q22NCBI
MIRLET7I
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381262,603,686 - 62,603,769 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1262,603,686 - 62,603,769 (+)EnsemblGRCh38hg38GRCh38
GRCh371262,997,466 - 62,997,549 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361261,283,732 - 61,283,815 (+)NCBINCBI36Build 36hg18NCBI36
Celera1262,666,013 - 62,666,096 (+)NCBICelera
Cytogenetic Map12q14.1NCBI
HuRef1260,047,889 - 60,047,972 (+)NCBIHuRef
CHM1_11262,965,189 - 62,965,272 (+)NCBICHM1_1
T2T-CHM13v2.01262,582,504 - 62,582,587 (+)NCBIT2T-CHM13v2.0
Mirlet7i
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910122,821,545 - 122,821,629 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10122,821,545 - 122,821,629 (-)EnsemblGRCm39 Ensembl
GRCm3810122,985,640 - 122,985,724 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10122,985,640 - 122,985,724 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710122,422,696 - 122,422,780 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera10125,366,173 - 125,366,257 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1072.1NCBI
MIRLET7I
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl527,252,787 - 27,252,894 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1527,252,802 - 27,252,886 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2530,021,224 - 30,021,308 (+)NCBISscrofa10.2Sscrofa10.2susScr3

.

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Vimrno-let-7i-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830

Predicted Targets
Summary Value
Count of predictions:14385
Count of gene targets:7635
Count of transcripts:8182
Interacting mature miRNAs:rno-let-7i-3p, rno-let-7i-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 36 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat

1 to 10 of 36 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
1 6 31 83 38 43 20 21 20 6 108 60 70 21 42 23


RefSeq Transcripts NR_031808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000053765
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl758,642,480 - 58,642,571 (-)Ensembl
Rnor_6.0 Ensembl766,802,732 - 66,802,821 (+)Ensembl
RefSeq Acc Id: NR_031808
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,527,877 - 60,527,961 (-)NCBI
mRatBN7.2758,642,485 - 58,642,569 (-)NCBI
Rnor_6.0766,802,731 - 66,802,815 (+)NCBI
Rnor_5.0767,000,236 - 67,000,320 (+)NCBI
Celera755,814,162 - 55,814,246 (-)NCBI
Sequence:

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 10 of 10 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-33847 BioCyc
Ensembl Genes ENSRNOG00000035642 Ensembl
miRBase MI0000835 ENTREZGENE
NCBI Gene 100313993 ENTREZGENE
PhenoGen Mirlet7i PhenoGen
RatGTEx ENSRNOG00000035642 RatGTEx
RNAcentral URS0000237CBD RNACentral
  URS00004023EA RNACentral
  URS000075E0BA RNACentral
  URS0000D50063 RNACentral
1 to 10 of 10 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-06-02 Mirlet7i  microRNA let-7i      Symbol and Name status set to provisional 70820 PROVISIONAL