Mirlet7i (microRNA let-7i) - Rat Genome Database

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Gene: Mirlet7i (microRNA let-7i) Rattus norvegicus
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Symbol: Mirlet7i
Name: microRNA let-7i
RGD ID: 2325604
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Predicted to be involved in miRNA-mediated gene silencing by inhibition of translation. Predicted to act upstream of or within several processes, including cellular response to amino acid stimulus; cellular response to leukemia inhibitory factor; and long-term synaptic potentiation. Predicted to be located in cytoplasm. Predicted to be part of RISC complex. Orthologous to human MIRLET7I (microRNA let-7i); INTERACTS WITH 2,5-hexanedione; 2-acetamidofluorene; atrazine.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: rno-let-7i
RGD Orthologs
Human
Mouse
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8760,527,877 - 60,527,961 (-)NCBIGRCr8
mRatBN7.2758,642,485 - 58,642,569 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl758,642,480 - 58,642,571 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx760,514,724 - 60,514,808 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0762,717,359 - 62,717,443 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0762,494,683 - 62,494,767 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0766,802,731 - 66,802,815 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl766,802,732 - 66,802,821 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0767,000,236 - 67,000,320 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera755,814,162 - 55,814,246 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
RISC complex  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14691248   PMID:15345052   PMID:16381832   PMID:16766679   PMID:17604727   PMID:17805466   PMID:20403161   PMID:20439489   PMID:20548288   PMID:21742974   PMID:22352906   PMID:23185045  
PMID:24205035   PMID:25751060   PMID:25858512   PMID:26755202   PMID:27384999   PMID:38429909  


Genomics

Comparative Map Data
Mirlet7i
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8760,527,877 - 60,527,961 (-)NCBIGRCr8
mRatBN7.2758,642,485 - 58,642,569 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl758,642,480 - 58,642,571 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx760,514,724 - 60,514,808 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0762,717,359 - 62,717,443 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0762,494,683 - 62,494,767 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0766,802,731 - 66,802,815 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl766,802,732 - 66,802,821 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0767,000,236 - 67,000,320 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera755,814,162 - 55,814,246 (-)NCBICelera
Cytogenetic Map7q22NCBI
MIRLET7I
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381262,603,686 - 62,603,769 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1262,603,686 - 62,603,769 (+)EnsemblGRCh38hg38GRCh38
GRCh371262,997,466 - 62,997,549 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361261,283,732 - 61,283,815 (+)NCBINCBI36Build 36hg18NCBI36
Celera1262,666,013 - 62,666,096 (+)NCBICelera
Cytogenetic Map12q14.1NCBI
HuRef1260,047,889 - 60,047,972 (+)NCBIHuRef
CHM1_11262,965,189 - 62,965,272 (+)NCBICHM1_1
T2T-CHM13v2.01262,582,504 - 62,582,587 (+)NCBIT2T-CHM13v2.0
Mirlet7i
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910122,821,545 - 122,821,629 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10122,821,545 - 122,821,629 (-)EnsemblGRCm39 Ensembl
GRCm3810122,985,640 - 122,985,724 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10122,985,640 - 122,985,724 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710122,422,696 - 122,422,780 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera10125,366,173 - 125,366,257 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1072.1NCBI
MIRLET7I
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl527,252,787 - 27,252,894 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1527,252,802 - 27,252,886 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2530,021,224 - 30,021,308 (+)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Vimrno-let-7i-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830

Predicted Targets
Summary Value
Count of predictions:14385
Count of gene targets:7635
Count of transcripts:8182
Interacting mature miRNAs:rno-let-7i-3p, rno-let-7i-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat
61435Cia4Collagen induced arthritis QTL 45.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)75811322462004598Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
1 6 31 83 38 43 20 21 20 6 108 60 70 21 42 23

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000053765
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl758,642,480 - 58,642,571 (-)Ensembl
Rnor_6.0 Ensembl766,802,732 - 66,802,821 (+)Ensembl
RefSeq Acc Id: NR_031808
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,527,877 - 60,527,961 (-)NCBI
mRatBN7.2758,642,485 - 58,642,569 (-)NCBI
Rnor_6.0766,802,731 - 66,802,815 (+)NCBI
Rnor_5.0767,000,236 - 67,000,320 (+)NCBI
Celera755,814,162 - 55,814,246 (-)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325604 AgrOrtholog
BioCyc Gene G2FUF-33847 BioCyc
Ensembl Genes ENSRNOG00000035642 Ensembl
miRBase MI0000835 ENTREZGENE
NCBI Gene 100313993 ENTREZGENE
PhenoGen Mirlet7i PhenoGen
RatGTEx ENSRNOG00000035642 RatGTEx
RNAcentral URS0000237CBD RNACentral
  URS00004023EA RNACentral
  URS000075E0BA RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-06-02 Mirlet7i  microRNA let-7i      Symbol and Name status set to provisional 70820 PROVISIONAL