Thap2 (THAP domain containing 2) - Rat Genome Database

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Gene: Thap2 (THAP domain containing 2) Rattus norvegicus
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Symbol: Thap2
Name: THAP domain containing 2
RGD ID: 1593643
Description: Predicted to be located in nucleolus. Predicted to be active in nucleus. Orthologous to human THAP2 (THAP domain containing 2); INTERACTS WITH amphetamine; bisphenol A; endosulfan.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: LOC688019; similar to THAP domain containing, apoptosis associated protein 2; THAP domain containing, apoptosis associated protein 2; THAP domain-containing protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Genome Annotation Status: not in current annotation release
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
UTH_Rnor_SHR_Utx752,899,683 - 52,914,352 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0755,102,766 - 55,117,437 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0754,880,756 - 54,895,421 (-)NCBIRnor_WKY
Rnor_6.0758,350,744 - 58,365,812 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl758,354,582 - 58,365,313 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0758,359,646 - 58,374,231 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4754,644,248 - 54,655,301 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera747,784,948 - 47,800,212 (-)NCBICelera
Cytogenetic Map7q22NCBI


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleolus  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Thap2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
UTH_Rnor_SHR_Utx752,899,683 - 52,914,352 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0755,102,766 - 55,117,437 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0754,880,756 - 54,895,421 (-)NCBIRnor_WKY
Rnor_6.0758,350,744 - 58,365,812 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl758,354,582 - 58,365,313 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0758,359,646 - 58,374,231 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4754,644,248 - 54,655,301 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera747,784,948 - 47,800,212 (-)NCBICelera
Cytogenetic Map7q22NCBI
THAP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381271,664,301 - 71,680,644 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1271,664,301 - 71,680,644 (+)EnsemblGRCh38hg38GRCh38
GRCh371272,058,081 - 72,074,424 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361270,344,051 - 70,360,686 (+)NCBINCBI36Build 36hg18NCBI36
Celera1271,720,131 - 71,736,767 (+)NCBICelera
Cytogenetic Map12q21.1NCBI
HuRef1269,106,790 - 69,123,547 (+)NCBIHuRef
CHM1_11272,024,918 - 72,041,669 (+)NCBICHM1_1
T2T-CHM13v2.01271,641,810 - 71,658,153 (+)NCBIT2T-CHM13v2.0
Thap2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910115,204,303 - 115,220,340 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10115,204,309 - 115,220,348 (-)EnsemblGRCm39 Ensembl
GRCm3810115,368,398 - 115,384,435 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10115,368,404 - 115,384,443 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710114,807,022 - 114,821,491 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610114,774,076 - 114,788,545 (-)NCBIMGSCv36mm8
Celera10117,299,363 - 117,313,938 (-)NCBICelera
Cytogenetic Map10D2NCBI
Thap2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540511,647,989 - 11,665,110 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540511,647,989 - 11,665,110 (+)NCBIChiLan1.0ChiLan1.0
THAP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11272,046,980 - 72,063,734 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1272,046,980 - 72,063,734 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01269,187,221 - 69,204,095 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
THAP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11013,216,886 - 13,231,548 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1013,155,478 - 13,170,350 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01013,351,032 - 13,365,909 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1013,351,264 - 13,363,007 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11013,214,624 - 13,229,485 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01013,462,189 - 13,477,047 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01013,585,921 - 13,600,811 (+)NCBIUU_Cfam_GSD_1.0
THAP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl535,671,280 - 35,687,288 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1535,671,280 - 35,687,298 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2538,373,033 - 38,388,509 (+)NCBISscrofa10.2Sscrofa10.2susScr3
THAP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11167,279,973 - 67,296,919 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1167,280,586 - 67,296,919 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037178,357,736 - 178,374,585 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Thap2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475026,085,638 - 26,097,815 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475026,086,472 - 26,098,303 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
RH143299  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2751,007,257 - 51,007,472 (+)MAPPERmRatBN7.2
Rnor_6.0758,365,131 - 58,365,345NCBIRnor6.0
Rnor_5.0758,374,033 - 58,374,247UniSTSRnor5.0
RGSC_v3.4754,655,119 - 54,655,333UniSTSRGSC3.4
Celera747,799,528 - 47,799,742UniSTS
RH 3.4 Map7477.51UniSTS
Cytogenetic Map7q22UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:89
Count of miRNA genes:74
Interacting mature miRNAs:79
Transcripts:ENSRNOT00000005443
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 6 10 4 8 4 62 18 28
Low 2 36 47 37 11 37 8 10 12 17 13 11 8
Below cutoff 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000005443   ⟹   ENSRNOP00000005443
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl758,354,582 - 58,365,313 (-)Ensembl
RefSeq Acc Id: XM_001080899   ⟹   XP_001080899
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera747,784,948 - 47,800,212 (-)NCBI
Sequence:
RefSeq Acc Id: XM_002729786   ⟹   XP_002729832
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0758,350,744 - 58,365,812 (-)NCBI
Rnor_5.0758,359,646 - 58,374,231 (-)NCBI
RGSC_v3.4754,644,248 - 54,655,301 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001381922 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_001080899   ⟸   XM_001080899
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_002729832   ⟸   XM_002729786
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000005443   ⟸   ENSRNOT00000005443

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZAX9-F1-model_v2 AlphaFold D3ZAX9 1-217 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695202
Promoter ID:EPDNEW_R5724
Type:single initiation site
Name:Thap2_1
Description:THAP domain containing 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0758,365,377 - 58,365,437EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1593643 AgrOrtholog
Ensembl Genes ENSRNOG00000003993 Ensembl
NCBI Gene 688019 ENTREZGENE
PhenoGen Thap2 PhenoGen
UniProt D3ZAX9 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-03 Thap2  THAP domain containing 2  Thap2  THAP domain containing, apoptosis associated protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-02 Thap2  THAP domain containing, apoptosis associated protein 2  LOC688019  similar to THAP domain containing, apoptosis associated protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC688019  similar to THAP domain containing, apoptosis associated protein 2      Symbol and Name status set to provisional 70820 PROVISIONAL