Tab1 (TGF-beta activated kinase 1 (MAP3K7) binding protein 1) - Rat Genome Database

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Gene: Tab1 (TGF-beta activated kinase 1 (MAP3K7) binding protein 1) Ictidomys tridecemlineatus
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Symbol: Tab1
Name: TGF-beta activated kinase 1 (MAP3K7) binding protein 1
RGD ID: 12610725
Description: ENCODES a protein that exhibits MAP kinase kinase kinase activity (ortholog); mitogen-activated protein kinase p38 binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN aorta development (ortholog); cardiac septum development (ortholog); coronary vasculature development (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; interleukin-1 signaling pathway; nuclear factor kappa B signaling pathway; ASSOCIATED WITH adenylosuccinase lyase deficiency (ortholog); genetic disease (ortholog); polycystic ovary syndrome (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: TGF-beta activated kinase 1 (MAP3K7) binding protein 1, transcript variant X1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1, transcript variant X2; TGF-beta activated kinase 1 (MAP3K7) binding protein 1, transcript variant X4; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049459,196,563 - 9,224,198 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364922,210,197 - 2,234,489 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364922,207,147 - 2,234,573 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Tab1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049459,196,563 - 9,224,198 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364922,210,197 - 2,234,489 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364922,207,147 - 2,234,573 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TAB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382239,399,780 - 39,437,132 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2239,399,778 - 39,437,060 (+)EnsemblGRCh38hg38GRCh38
GRCh372239,795,785 - 39,833,137 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362238,125,705 - 38,163,078 (+)NCBINCBI36Build 36hg18NCBI36
Build 342238,120,258 - 38,157,632NCBI
Celera2223,597,809 - 23,635,185 (+)NCBICelera
Cytogenetic Map22q13.1NCBI
HuRef2222,760,425 - 22,797,733 (+)NCBIHuRef
CHM1_12239,754,498 - 39,791,875 (+)NCBICHM1_1
T2T-CHM13v2.02239,870,398 - 39,907,761 (+)NCBIT2T-CHM13v2.0
Tab1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391580,017,333 - 80,045,908 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1580,017,328 - 80,045,908 (+)EnsemblGRCm39 Ensembl
GRCm381580,133,127 - 80,161,707 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1580,133,127 - 80,161,707 (+)EnsemblGRCm38mm10GRCm38
MGSCv371579,963,584 - 79,992,132 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361579,960,409 - 79,988,957 (+)NCBIMGSCv36mm8
Celera1582,249,914 - 82,278,414 (+)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.85NCBI
Tab1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87113,556,157 - 113,587,351 (+)NCBIGRCr8
mRatBN7.27111,675,829 - 111,707,058 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7111,686,371 - 111,707,058 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7113,430,333 - 113,461,541 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07115,653,881 - 115,685,092 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07115,623,239 - 115,654,452 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07121,350,953 - 121,382,100 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7121,350,965 - 121,382,088 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07121,340,948 - 121,371,923 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47118,368,997 - 118,402,928 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17118,403,087 - 118,435,710 (+)NCBI
Celera7108,004,014 - 108,035,121 (+)NCBICelera
Cytogenetic Map7q34NCBI
Tab1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541325,290,828 - 25,313,969 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541325,290,733 - 25,315,267 (+)NCBIChiLan1.0ChiLan1.0
TAB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22349,244,509 - 49,279,097 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12251,935,877 - 51,970,474 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02220,303,547 - 20,343,314 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12238,122,835 - 38,158,015 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2238,122,835 - 38,162,705 (+)Ensemblpanpan1.1panPan2
TAB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11025,623,381 - 25,657,630 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1025,623,940 - 25,657,543 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1025,559,053 - 25,593,235 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01026,375,000 - 26,409,197 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1026,375,011 - 26,409,213 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11026,089,607 - 26,123,813 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01026,409,038 - 26,443,015 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01026,584,751 - 26,618,730 (-)NCBIUU_Cfam_GSD_1.0
TAB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl58,826,840 - 8,852,776 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.158,827,363 - 8,852,814 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.256,122,718 - 6,146,897 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TAB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11921,971,362 - 22,004,289 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666045103,706,687 - 103,740,657 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tab1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247528,913,900 - 8,937,329 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247528,912,467 - 8,937,313 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000002355   ⟹   ENSSTOP00000002106
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364922,210,197 - 2,234,489 (-)Ensembl
RefSeq Acc Id: XM_013357257   ⟹   XP_013212711
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049459,196,563 - 9,224,198 (-)NCBI
SpeTri2.0NW_0049364922,207,147 - 2,234,573 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021724409   ⟹   XP_021580084
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049459,196,563 - 9,220,727 (-)NCBI
SpeTri2.0NW_0049364922,207,147 - 2,231,082 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021724410   ⟹   XP_021580085
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049459,196,563 - 9,220,726 (-)NCBI
SpeTri2.0NW_0049364922,207,350 - 2,231,082 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002483632
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049459,196,563 - 9,220,727 (-)NCBI
SpeTri2.0NW_0049364922,207,582 - 2,231,082 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_013212711   ⟸   XM_013357257
- Peptide Label: isoform X3
- UniProtKB: I3M090 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021580084   ⟸   XM_021724409
- Peptide Label: isoform X1
- UniProtKB: I3M090 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021580085   ⟸   XM_021724410
- Peptide Label: isoform X2
- UniProtKB: I3M090 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000002106   ⟸   ENSSTOT00000002355
Protein Domains
PPM-type phosphatase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000002357 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000002355.3 UniProtKB/TrEMBL
Gene3D-CATH 3.60.40.10 UniProtKB/TrEMBL
InterPro PP2C UniProtKB/TrEMBL
  PPM-type_dom_sf UniProtKB/TrEMBL
  PPM-type_phosphatase_dom UniProtKB/TrEMBL
NCBI Gene Tab1 ENTREZGENE
PANTHER PTHR13832 UniProtKB/TrEMBL
  TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1 UniProtKB/TrEMBL
Pfam PP2C UniProtKB/TrEMBL
PROSITE PPM_2 UniProtKB/TrEMBL
SMART PP2Cc UniProtKB/TrEMBL
Superfamily-SCOP SSF81606 UniProtKB/TrEMBL
UniProt I3M090 ENTREZGENE, UniProtKB/TrEMBL