TAB1 (TGF-beta activated kinase 1 (MAP3K7) binding protein 1) - Rat Genome Database

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Gene: TAB1 (TGF-beta activated kinase 1 (MAP3K7) binding protein 1) Canis lupus familiaris
Analyze
Symbol: TAB1
Name: TGF-beta activated kinase 1 (MAP3K7) binding protein 1
RGD ID: 12391022
Description: ENCODES a protein that exhibits MAP kinase kinase kinase activity (ortholog); mitogen-activated protein kinase p38 binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN aorta development (ortholog); cardiac septum development (ortholog); coronary vasculature development (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; interleukin-1 signaling pathway; nuclear factor kappa B signaling pathway; ASSOCIATED WITH adenylosuccinase lyase deficiency (ortholog); polycystic ovary syndrome (ortholog); Rubinstein-Taybi syndrome (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: MAP3K7IP1; mitogen-activated protein kinase kinase kinase 7 interacting protein 1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11025,623,381 - 25,657,630 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1025,623,940 - 25,657,543 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1025,559,053 - 25,593,235 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01026,375,000 - 26,409,197 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1026,375,011 - 26,409,213 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11026,089,607 - 26,123,813 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01026,409,038 - 26,443,015 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01026,584,751 - 26,618,730 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
TAB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11025,623,381 - 25,657,630 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1025,623,940 - 25,657,543 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1025,559,053 - 25,593,235 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01026,375,000 - 26,409,197 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1026,375,011 - 26,409,213 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11026,089,607 - 26,123,813 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01026,409,038 - 26,443,015 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01026,584,751 - 26,618,730 (-)NCBIUU_Cfam_GSD_1.0
TAB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382239,399,780 - 39,437,132 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2239,399,778 - 39,437,060 (+)EnsemblGRCh38hg38GRCh38
GRCh372239,795,785 - 39,833,137 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362238,125,705 - 38,163,078 (+)NCBINCBI36Build 36hg18NCBI36
Build 342238,120,258 - 38,157,632NCBI
Celera2223,597,809 - 23,635,185 (+)NCBICelera
Cytogenetic Map22q13.1NCBI
HuRef2222,760,425 - 22,797,733 (+)NCBIHuRef
CHM1_12239,754,498 - 39,791,875 (+)NCBICHM1_1
T2T-CHM13v2.02239,870,398 - 39,907,761 (+)NCBIT2T-CHM13v2.0
Tab1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391580,017,333 - 80,045,908 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1580,017,328 - 80,045,908 (+)EnsemblGRCm39 Ensembl
GRCm381580,133,127 - 80,161,707 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1580,133,127 - 80,161,707 (+)EnsemblGRCm38mm10GRCm38
MGSCv371579,963,584 - 79,992,132 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361579,960,409 - 79,988,957 (+)NCBIMGSCv36mm8
Celera1582,249,914 - 82,278,414 (+)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.85NCBI
Tab1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87113,556,157 - 113,587,351 (+)NCBIGRCr8
mRatBN7.27111,675,829 - 111,707,058 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7111,686,371 - 111,707,058 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7113,430,333 - 113,461,541 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07115,653,881 - 115,685,092 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07115,623,239 - 115,654,452 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07121,350,953 - 121,382,100 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7121,350,965 - 121,382,088 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07121,340,948 - 121,371,923 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47118,368,997 - 118,402,928 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17118,403,087 - 118,435,710 (+)NCBI
Celera7108,004,014 - 108,035,121 (+)NCBICelera
Cytogenetic Map7q34NCBI
Tab1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541325,290,828 - 25,313,969 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541325,290,733 - 25,315,267 (+)NCBIChiLan1.0ChiLan1.0
TAB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22349,244,509 - 49,279,097 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12251,935,877 - 51,970,474 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02220,303,547 - 20,343,314 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12238,122,835 - 38,158,015 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2238,122,835 - 38,162,705 (+)Ensemblpanpan1.1panPan2
Tab1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049459,196,563 - 9,224,198 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364922,210,197 - 2,234,489 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364922,207,147 - 2,234,573 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TAB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl58,826,840 - 8,852,776 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.158,827,363 - 8,852,814 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.256,122,718 - 6,146,897 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TAB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11921,971,362 - 22,004,289 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666045103,706,687 - 103,740,657 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tab1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247528,913,900 - 8,937,329 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247528,912,467 - 8,937,313 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TAB1
260 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005625866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005625867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_014117350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038488576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038488577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038488578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038550518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038550519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038550520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038614475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038614476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038614477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038679822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038679823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038679824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCAFT00000002071   ⟹   ENSCAFP00000001917
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1025,623,940 - 25,657,543 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845038132   ⟹   ENSCAFP00845029872
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1026,375,011 - 26,409,213 (-)Ensembl
RefSeq Acc Id: XM_005625866   ⟹   XP_005625923
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11025,623,381 - 25,657,630 (-)NCBI
Dog10K_Boxer_Tasha1025,559,053 - 25,593,235 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005625867   ⟹   XP_005625924
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11025,623,381 - 25,657,585 (-)NCBI
Dog10K_Boxer_Tasha1025,559,053 - 25,593,197 (-)NCBI
Sequence:
RefSeq Acc Id: XM_014117350   ⟹   XP_013972825
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11025,623,381 - 25,657,618 (-)NCBI
Dog10K_Boxer_Tasha1025,559,053 - 25,593,189 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038488576   ⟹   XP_038344504
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11026,089,607 - 26,123,813 (-)NCBI
RefSeq Acc Id: XM_038488577   ⟹   XP_038344505
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11026,089,607 - 26,123,767 (-)NCBI
RefSeq Acc Id: XM_038488578   ⟹   XP_038344506
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11026,089,607 - 26,123,775 (-)NCBI
RefSeq Acc Id: XM_038550518   ⟹   XP_038406446
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01026,584,751 - 26,618,730 (-)NCBI
RefSeq Acc Id: XM_038550519   ⟹   XP_038406447
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01026,584,751 - 26,618,684 (-)NCBI
RefSeq Acc Id: XM_038550520   ⟹   XP_038406448
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01026,584,751 - 26,618,692 (-)NCBI
RefSeq Acc Id: XM_038614475   ⟹   XP_038470403
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01026,409,038 - 26,443,015 (-)NCBI
RefSeq Acc Id: XM_038614476   ⟹   XP_038470404
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01026,409,038 - 26,442,969 (-)NCBI
RefSeq Acc Id: XM_038614477   ⟹   XP_038470405
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01026,409,038 - 26,442,977 (-)NCBI
RefSeq Acc Id: XM_038679822   ⟹   XP_038535750
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01026,375,000 - 26,409,197 (-)NCBI
RefSeq Acc Id: XM_038679823   ⟹   XP_038535751
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01026,375,000 - 26,409,151 (-)NCBI
RefSeq Acc Id: XM_038679824   ⟹   XP_038535752
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01026,375,000 - 26,409,159 (-)NCBI
RefSeq Acc Id: XP_005625923   ⟸   XM_005625866
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JMM3 (UniProtKB/TrEMBL),   A0A8C0NMV3 (UniProtKB/TrEMBL),   A0A8I3PLL0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013972825   ⟸   XM_014117350
- Peptide Label: isoform X2
- UniProtKB: A0A8C0NMV3 (UniProtKB/TrEMBL),   A0A8I3PLL0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005625924   ⟸   XM_005625867
- Peptide Label: isoform X2
- UniProtKB: A0A8C0NMV3 (UniProtKB/TrEMBL),   A0A8I3PLL0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000001917   ⟸   ENSCAFT00000002071
RefSeq Acc Id: XP_038344504   ⟸   XM_038488576
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038344506   ⟸   XM_038488578
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038344505   ⟸   XM_038488577
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038470403   ⟸   XM_038614475
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038470405   ⟸   XM_038614477
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038470404   ⟸   XM_038614476
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038535750   ⟸   XM_038679822
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JMM3 (UniProtKB/TrEMBL),   A0A8C0NMV3 (UniProtKB/TrEMBL),   A0A8I3PLL0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038535752   ⟸   XM_038679824
- Peptide Label: isoform X2
- UniProtKB: A0A8C0NMV3 (UniProtKB/TrEMBL),   A0A8I3PLL0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038535751   ⟸   XM_038679823
- Peptide Label: isoform X2
- UniProtKB: A0A8C0NMV3 (UniProtKB/TrEMBL),   A0A8I3PLL0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038406446   ⟸   XM_038550518
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JMM3 (UniProtKB/TrEMBL),   A0A8C0NMV3 (UniProtKB/TrEMBL),   A0A8I3PLL0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038406448   ⟸   XM_038550520
- Peptide Label: isoform X2
- UniProtKB: A0A8C0NMV3 (UniProtKB/TrEMBL),   A0A8I3PLL0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038406447   ⟸   XM_038550519
- Peptide Label: isoform X2
- UniProtKB: A0A8C0NMV3 (UniProtKB/TrEMBL),   A0A8I3PLL0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845029872   ⟸   ENSCAFT00845038132
Protein Domains
PPM-type phosphatase

Promoters
RGD ID:13684962
Promoter ID:EPDNEW_C3029
Type:single initiation site
Name:TAB1_1
Description:TGF-beta activated kinase 1 binding protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11025,657,554 - 25,657,614EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001332 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030017826 UniProtKB/TrEMBL
  ENSCAFG00040005892 UniProtKB/TrEMBL
  ENSCAFG00845021610 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000002071.5 UniProtKB/TrEMBL
  ENSCAFT00030032943.1 UniProtKB/TrEMBL
  ENSCAFT00040011045.1 UniProtKB/TrEMBL
  ENSCAFT00845038132 ENTREZGENE
  ENSCAFT00845038132.1 UniProtKB/TrEMBL
Gene3D-CATH 3.60.40.10 UniProtKB/TrEMBL
InterPro PP2C UniProtKB/TrEMBL
  PPM-type_dom_sf UniProtKB/TrEMBL
  PPM-type_phosphatase_dom UniProtKB/TrEMBL
NCBI Gene TAB1 ENTREZGENE
PANTHER PTHR13832 UniProtKB/TrEMBL
  TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1 UniProtKB/TrEMBL
Pfam PP2C UniProtKB/TrEMBL
PROSITE PPM_2 UniProtKB/TrEMBL
SMART PP2Cc UniProtKB/TrEMBL
Superfamily-SCOP SSF81606 UniProtKB/TrEMBL
UniProt A0A8C0JMM3 ENTREZGENE
  A0A8C0NMV3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PLL0 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:54550 ENTREZGENE