F11r (F11 receptor) - Rat Genome Database

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Gene: F11r (F11 receptor) Rattus norvegicus
Analyze
Symbol: F11r
Name: F11 receptor
RGD ID: 621842
Description: Predicted to enable PDZ domain binding activity; integrin binding activity; and protein homodimerization activity. Involved in cell differentiation and positive regulation of blood pressure. Located in slit diaphragm. Biomarker of hypertension; peptic esophagitis; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human F11R (F11 receptor); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: JAM-1; JAM-A; Jam1; junctional adhesion molecule 1; junctional adhesion molecule A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81386,406,229 - 86,429,819 (+)NCBIGRCr8
mRatBN7.21383,873,797 - 83,897,388 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,873,797 - 83,897,402 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1386,379,556 - 86,403,149 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,777,772 - 87,801,365 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01385,013,286 - 85,036,855 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,826,272 - 89,850,151 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,826,254 - 89,850,612 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01394,453,478 - 94,477,357 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41387,369,918 - 87,393,508 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11387,558,801 - 87,582,389 (+)NCBI
Celera1383,504,334 - 83,527,924 (+)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,3-bis(4-hydroxyphenyl)propionitrile  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbonyl sulfide  (EXP)
CGP 52608  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenthion  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
inulin  (ISO)
ivermectin  (ISO)
luteolin  (EXP)
LY294002  (ISO)
methamphetamine  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (ISO)
N-nitrosodiethylamine  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-cresol  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
poly(I:C)  (ISO)
potassium iodide  (EXP)
quercitrin  (ISO)
rac-lactic acid  (ISO)
riddelliine  (EXP)
rotenone  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
tetrachloromethane  (ISO)
topotecan  (EXP)
tributylstannane  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tyrphostin AG 1478  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A dynamic in vivo model of epithelial-to-mesenchymal transitions in circulating tumor cells and metastases of breast cancer. Bonnomet A, etal., Oncogene. 2012 Aug 16;31(33):3741-53. doi: 10.1038/onc.2011.540. Epub 2011 Nov 28.
2. Biphasic cytoarchitecture and functional changes in the BBB induced by chronic inflammatory pain. Brooks TA, etal., Brain Res. 2006 Nov 20;1120(1):172-82. Epub 2006 Sep 27.
3. Increased DC trafficking to lymph nodes and contact hypersensitivity in junctional adhesion molecule-A-deficient mice. Cera MR, etal., J Clin Invest. 2004 Sep;114(5):729-38.
4. The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM). Ebnet K, etal., EMBO J. 2001 Jul 16;20(14):3738-48.
5. Junctional adhesion molecule interacts with the PDZ domain-containing proteins AF-6 and ZO-1. Ebnet K, etal., J Biol Chem. 2000 Sep 8;275(36):27979-88.
6. Slit diaphragms contain tight junction proteins. Fukasawa H, etal., J Am Soc Nephrol. 2009 Jul;20(7):1491-503. doi: 10.1681/ASN.2008101117. Epub 2009 May 28.
7. [Microwave radiation decreases the expressions of occludin and JAM-1 in rats]. Gao XF, etal., Zhonghua Nan Ke Xue. 2010 Jan;16(1):10-3.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Junctional adhesion molecule-A is abnormally expressed in diffuse cutaneous systemic sclerosis skin and mediates myeloid cell adhesion. Hou Y, etal., Ann Rheum Dis. 2010 Jan;69(1):249-54. doi: 10.1136/ard.2008.102624. Epub .
10. Cerebralcare Granule(R) attenuates blood-brain barrier disruption after middle cerebral artery occlusion in rats. Huang P, etal., Exp Neurol. 2012 Oct;237(2):453-63. doi: 10.1016/j.expneurol.2012.07.017. Epub 2012 Jul 31.
11. The INAD scaffold is a dynamic, redox-regulated modulator of signaling in the Drosophila eye. Liu W, etal., Cell. 2011 Jun 24;145(7):1088-101. doi: 10.1016/j.cell.2011.05.015.
12. Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration. Martin-Padura I, etal., J Cell Biol 1998 Jul 13;142(1):117-27.
13. JAM-A expression positively correlates with poor prognosis in breast cancer patients. McSherry EA, etal., Int J Cancer. 2009 Sep 15;125(6):1343-51. doi: 10.1002/ijc.24498.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Abrogation of junctional adhesion molecule-A expression induces cell apoptosis and reduces breast cancer progression. Murakami M, etal., PLoS One. 2011;6(6):e21242. doi: 10.1371/journal.pone.0021242. Epub 2011 Jun 17.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Association of F11 receptor gene polymorphisms with central obesity and blood pressure. Ong KL, etal., J Intern Med. 2008 Mar;263(3):322-32. Epub 2007 Dec 6.
18. Involvement of JAM-A in mononuclear cell recruitment on inflamed or atherosclerotic endothelium: inhibition by soluble JAM-A. Ostermann G, etal., Arterioscler Thromb Vasc Biol. 2005 Apr;25(4):729-35. Epub 2005 Jan 27.
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
21. Junctional adhesion molecule-1 is upregulated in spontaneously hypertensive rats: evidence for a prohypertensive role within the brain stem. Waki H, etal., Hypertension. 2007 Jun;49(6):1321-7. Epub 2007 Apr 9.
22. Differential interactions between transforming growth factor-beta3/TbetaR1, TAB1, and CD2AP disrupt blood-testis barrier and Sertoli-germ cell adhesion. Xia W, etal., J Biol Chem. 2006 Jun 16;281(24):16799-813. Epub 2006 Apr 13.
23. Up-regulation of JAM-1 in AR42J cells treated with activin A and betacellulin and the diabetic regenerating islets. Yoshikumi Y, etal., Endocr J. 2008 Aug;55(4):757-65. Epub 2008 May 28.
Additional References at PubMed
PMID:11812992   PMID:14749337   PMID:15344881   PMID:15489334   PMID:15494378   PMID:16396499   PMID:18357461   PMID:18514073   PMID:19199708   PMID:20458337   PMID:22918977   PMID:23376485  
PMID:23885123   PMID:25438062   PMID:25468996   PMID:25753039   PMID:25916097   PMID:26985018  


Genomics

Comparative Map Data
F11r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81386,406,229 - 86,429,819 (+)NCBIGRCr8
mRatBN7.21383,873,797 - 83,897,388 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,873,797 - 83,897,402 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1386,379,556 - 86,403,149 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,777,772 - 87,801,365 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01385,013,286 - 85,036,855 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,826,272 - 89,850,151 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,826,254 - 89,850,612 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01394,453,478 - 94,477,357 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41387,369,918 - 87,393,508 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11387,558,801 - 87,582,389 (+)NCBI
Celera1383,504,334 - 83,527,924 (+)NCBICelera
Cytogenetic Map13q24NCBI
F11R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381160,995,211 - 161,021,152 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1160,995,211 - 161,021,175 (-)EnsemblGRCh38hg38GRCh38
GRCh371160,965,001 - 160,990,942 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,232,608 - 159,275,358 (-)NCBINCBI36Build 36hg18NCBI36
Build 341157,779,056 - 157,821,784NCBI
Celera1134,032,809 - 134,058,962 (-)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1132,321,150 - 132,348,030 (-)NCBIHuRef
CHM1_11162,360,724 - 162,386,856 (-)NCBICHM1_1
T2T-CHM13v2.01160,132,277 - 160,158,230 (-)NCBIT2T-CHM13v2.0
F11r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391171,265,129 - 171,292,161 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1171,265,103 - 171,292,171 (+)EnsemblGRCm39 Ensembl
GRCm381171,437,561 - 171,464,593 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,437,535 - 171,464,603 (+)EnsemblGRCm38mm10GRCm38
MGSCv371173,367,692 - 173,394,724 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361173,274,236 - 173,301,268 (+)NCBIMGSCv36mm8
Celera1173,888,870 - 173,917,464 (+)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.43NCBI
F11r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546812,765,874 - 12,785,929 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546812,764,968 - 12,785,956 (-)NCBIChiLan1.0ChiLan1.0
F11R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2188,839,533 - 88,864,710 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1188,521,319 - 88,546,095 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01136,399,766 - 136,424,722 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11140,322,264 - 140,347,158 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1140,324,943 - 140,346,890 (-)Ensemblpanpan1.1panPan2
F11R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13821,433,819 - 21,456,722 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3821,451,952 - 21,454,959 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3821,506,583 - 21,530,426 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03821,549,642 - 21,573,725 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3821,549,649 - 21,573,720 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13821,437,767 - 21,461,771 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03821,851,653 - 21,875,546 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03822,261,259 - 22,285,444 (+)NCBIUU_Cfam_GSD_1.0
F11r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050587,109,320 - 7,130,236 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936903315,716 - 338,932 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936903317,975 - 338,892 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
F11R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl489,425,018 - 89,449,599 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1489,425,101 - 89,447,889 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2497,325,385 - 97,348,465 (-)NCBISscrofa10.2Sscrofa10.2susScr3
F11R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1202,966,019 - 2,986,177 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl202,966,164 - 2,984,269 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660382,004,876 - 2,027,811 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
F11r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624794346,387 - 367,428 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624794346,281 - 367,132 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in F11r
118 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:341
Count of miRNA genes:216
Interacting mature miRNAs:245
Transcripts:ENSRNOT00000006141
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)137486211785581182Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat

Markers in Region
AU048745  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q32UniSTS
Cytogenetic Map13q24UniSTS
Cytogenetic Map6q32UniSTS
Cytogenetic Map17p12UniSTS
Cytogenetic Map16p14UniSTS
Cytogenetic Map13q26UniSTS
Cytogenetic Map10q22UniSTS
Cytogenetic Map7q11UniSTS
Cytogenetic Map8q24UniSTS
Cytogenetic Map5q21UniSTS
Cytogenetic Map4q24UniSTS
Cytogenetic Map2q11UniSTS
Cytogenetic Map1q54UniSTS
Cytogenetic Map1q36UniSTS
Cytogenetic Map18p11UniSTS
Cytogenetic Map13q13UniSTS
Cytogenetic Map10q24UniSTS
Cytogenetic Map8q31UniSTS
Cytogenetic Map3q21UniSTS
Cytogenetic Map13p13UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map11q23UniSTS
Cytogenetic Map10q31UniSTS
Cytogenetic Map16q12.2UniSTS
Cytogenetic Map3q24UniSTS
Cytogenetic Map5q36UniSTS
Cytogenetic Map3p13UniSTS
F11r  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21383,894,264 - 83,894,602 (+)MAPPERmRatBN7.2
mRatBN7.21202,535,636 - 202,535,731 (+)MAPPERmRatBN7.2
Rnor_6.01220,610,946 - 220,611,040NCBIRnor6.0
Rnor_6.01389,847,009 - 89,847,346NCBIRnor6.0
Rnor_5.01394,474,215 - 94,474,552UniSTSRnor5.0
Rnor_5.01227,541,910 - 227,542,004UniSTSRnor5.0
RGSC_v3.41207,868,018 - 207,868,112UniSTSRGSC3.4
RGSC_v3.41387,390,385 - 87,390,722UniSTSRGSC3.4
Celera1383,524,801 - 83,525,138UniSTS
Celera1200,074,132 - 200,074,226UniSTS
Cytogenetic Map1q43UniSTS
Cytogenetic Map13q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 37 53 41 15 41 1 1 6 35 40 11 1
Low 6 4 4 7 10 68 1 7
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000006141   ⟹   ENSRNOP00000006141
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1383,873,797 - 83,897,383 (+)Ensembl
Rnor_6.0 Ensembl1389,826,254 - 89,850,612 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094139   ⟹   ENSRNOP00000093065
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1383,893,341 - 83,897,383 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108868   ⟹   ENSRNOP00000093956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1383,873,797 - 83,897,402 (+)Ensembl
RefSeq Acc Id: NM_053796   ⟹   NP_446248
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,406,229 - 86,429,819 (+)NCBI
mRatBN7.21383,873,797 - 83,897,388 (+)NCBI
Rnor_6.01389,826,272 - 89,850,151 (+)NCBI
Rnor_5.01394,453,478 - 94,477,357 (+)NCBI
RGSC_v3.41387,369,918 - 87,393,508 (+)RGD
Celera1383,504,334 - 83,527,924 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446248 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF61729 (Get FASTA)   NCBI Sequence Viewer  
  AAF78250 (Get FASTA)   NCBI Sequence Viewer  
  AAH65309 (Get FASTA)   NCBI Sequence Viewer  
  EDL94656 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006141.3
  ENSRNOP00000093065.1
  ENSRNOP00000093956
  ENSRNOP00000093956.1
GenBank Protein Q9JHY1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446248   ⟸   NM_053796
- Peptide Label: precursor
- UniProtKB: Q9JHY1 (UniProtKB/Swiss-Prot),   A0A8L2Q2H4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006141   ⟸   ENSRNOT00000006141
RefSeq Acc Id: ENSRNOP00000093065   ⟸   ENSRNOT00000094139
RefSeq Acc Id: ENSRNOP00000093956   ⟸   ENSRNOT00000108868
Protein Domains
Ig-like   Ig-like V-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JHY1-F1-model_v2 AlphaFold Q9JHY1 1-300 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699008
Promoter ID:EPDNEW_R9533
Type:multiple initiation site
Name:F11r_1
Description:F11 receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01389,826,279 - 89,826,339EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621842 AgrOrtholog
BioCyc Gene G2FUF-17366 BioCyc
Ensembl Genes ENSRNOG00000004414 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006141.6 UniProtKB/TrEMBL
  ENSRNOT00000094139.1 UniProtKB/TrEMBL
  ENSRNOT00000108868 ENTREZGENE
  ENSRNOT00000108868.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5599898 IMAGE-MGC_LOAD
InterPro F11R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116479 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72346 IMAGE-MGC_LOAD
NCBI Gene 116479 ENTREZGENE
PANTHER JUNCTIONAL ADHESION MOLECULE A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ig_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen F11r PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004414 RatGTEx
SMART IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGv UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AIY6_RAT UniProtKB/TrEMBL
  A0A8I6ALF6_RAT UniProtKB/TrEMBL
  A0A8L2Q2H4 ENTREZGENE, UniProtKB/TrEMBL
  A6JG00_RAT UniProtKB/TrEMBL
  JAM1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 F11r  F11 receptor    junctional adhesion molecule 1  Name updated 1299863 APPROVED
2004-09-10 F11r  junctional adhesion molecule 1  Jam1    Symbol and Name updated 1299863 APPROVED
2002-08-07 Jam1  junctional adhesion molecule 1      Symbol and Name status set to provisional 70820 PROVISIONAL