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Expanding role of ubiquitination in NF-kappaB signaling.

Authors: Liu, S  Chen, ZJ 
Citation: Liu S and Chen ZJ, Cell Res. 2011 Jan;21(1):6-21. Epub 2010 Dec 7.
Pubmed: (View Article at PubMed) PMID:21135871
DOI: Full-text: DOI:10.1038/cr.2010.170

Best known for its role in targeting protein degradation by the proteasome, ubiquitin modification has also emerged as an important mechanism that regulates cell signaling through proteasome-independent mechanisms. The role of ubiquitin as a versatile signaling tag is characteristically illustrated in the NF-kappaB pathways, which regulate a variety of physiological and pathological processes in response to diverse stimuli. Here, we review the role of ubiquitination in different steps of the NF-kappaB signaling cascades, focusing on recent advances in understanding the mechanisms of protein kinase activation by polyubiquitin chains in different pathways that converge on NF-kappaB.


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RGD Object Information
RGD ID: 5490225
Created: 2011-09-08
Species: All species
Last Modified: 2011-09-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.