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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306216
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tab1
Name: TGF-beta activated kinase 1/MAP3K7 binding protein 1
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:13147076480464CTDSimvastatin results in decreased activity of [MAP3K7 protein co-treated with TAB1 protein]

PMID:17277159
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.