Mtch1 (mitochondrial carrier 1) - Rat Genome Database

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Gene: Mtch1 (mitochondrial carrier 1) Rattus norvegicus
Analyze
Symbol: Mtch1
Name: mitochondrial carrier 1
RGD ID: 1309262
Description: Predicted to enable membrane insertase activity. Predicted to be involved in positive regulation of apoptotic process and protein insertion into mitochondrial outer membrane. Predicted to be located in mitochondrial outer membrane. Predicted to be active in membrane and mitochondrion. Orthologous to human MTCH1 (mitochondrial carrier 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; diazinon.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC294313; mitochondrial carrier homolog 1; mitochondrial carrier homolog 1 (C. elegans)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8207,391,558 - 7,415,291 (-)NCBIGRCr8
mRatBN7.2207,389,942 - 7,413,426 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl207,389,949 - 7,413,426 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx208,100,918 - 8,116,465 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0207,462,777 - 7,478,324 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0207,934,718 - 7,950,248 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0206,937,341 - 6,961,165 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl206,937,347 - 6,961,162 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0209,177,057 - 9,200,881 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4207,649,782 - 7,673,289 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1207,650,009 - 7,673,543 (-)NCBI
Celera208,935,505 - 8,956,541 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12377771   PMID:12477932   PMID:18614015  


Genomics

Comparative Map Data
Mtch1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8207,391,558 - 7,415,291 (-)NCBIGRCr8
mRatBN7.2207,389,942 - 7,413,426 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl207,389,949 - 7,413,426 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx208,100,918 - 8,116,465 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0207,462,777 - 7,478,324 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0207,934,718 - 7,950,248 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0206,937,341 - 6,961,165 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl206,937,347 - 6,961,162 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0209,177,057 - 9,200,881 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4207,649,782 - 7,673,289 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1207,650,009 - 7,673,543 (-)NCBI
Celera208,935,505 - 8,956,541 (-)NCBICelera
Cytogenetic Map20p12NCBI
MTCH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38636,968,135 - 36,986,551 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl636,965,807 - 36,986,298 (-)EnsemblGRCh38hg38GRCh38
GRCh37636,935,911 - 36,954,327 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36637,043,895 - 37,061,927 (-)NCBINCBI36Build 36hg18NCBI36
Build 34637,043,895 - 37,061,927NCBI
Celera638,490,892 - 38,508,924 (-)NCBICelera
Cytogenetic Map6p21.2ENTREZGENE
HuRef636,654,248 - 36,672,674 (-)NCBIHuRef
CHM1_1636,937,712 - 36,956,128 (-)NCBICHM1_1
T2T-CHM13v2.0636,791,204 - 36,809,630 (-)NCBIT2T-CHM13v2.0
Mtch1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391729,551,050 - 29,566,921 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1729,551,046 - 29,566,908 (-)EnsemblGRCm39 Ensembl
GRCm381729,332,076 - 29,347,947 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1729,332,072 - 29,347,934 (-)EnsemblGRCm38mm10GRCm38
MGSCv371729,469,021 - 29,484,849 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361729,059,088 - 29,074,916 (-)NCBIMGSCv36mm8
Celera1729,874,292 - 29,890,013 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1715.23NCBI
Mtch1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554376,045,321 - 6,061,086 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554376,046,033 - 6,061,086 (+)NCBIChiLan1.0ChiLan1.0
MTCH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2551,436,924 - 51,457,552 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1647,306,697 - 47,327,324 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0636,530,002 - 36,548,412 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1637,725,121 - 37,743,030 (-)NCBIpanpan1.1PanPan1.1panPan2
MTCH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1126,033,915 - 6,047,881 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl126,033,921 - 6,050,993 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha126,051,738 - 6,070,611 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0126,382,004 - 6,400,870 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl126,377,729 - 6,402,305 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1126,036,687 - 6,055,534 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0126,116,127 - 6,134,986 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0126,214,525 - 6,233,383 (-)NCBIUU_Cfam_GSD_1.0
Mtch1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494641,490,083 - 41,507,560 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647622,452,954 - 22,470,881 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647622,452,670 - 22,470,147 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTCH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl732,617,426 - 32,635,575 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1732,617,426 - 32,635,575 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2737,520,860 - 37,539,012 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MTCH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11735,156,085 - 35,174,480 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1735,156,285 - 35,175,980 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604436,905,806 - 36,924,210 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mtch1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475420,900,443 - 20,915,302 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475420,900,723 - 20,914,894 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mtch1
104 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:207
Count of miRNA genes:148
Interacting mature miRNAs:168
Transcripts:ENSRNOT00000000635
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20669170617489458Rat

Markers in Region
RH128600  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2207,390,001 - 7,390,569 (+)MAPPERmRatBN7.2
mRatBN7.25162,662,613 - 162,663,181 (+)MAPPERmRatBN7.2
Rnor_6.05169,333,521 - 169,334,088NCBIRnor6.0
Rnor_6.0206,937,401 - 6,937,968NCBIRnor6.0
Rnor_5.0209,177,117 - 9,177,684UniSTSRnor5.0
Rnor_5.05172,888,035 - 172,888,602UniSTSRnor5.0
RGSC_v3.45169,384,655 - 169,385,222UniSTSRGSC3.4
RGSC_v3.4207,649,836 - 7,650,403UniSTSRGSC3.4
Celera208,935,559 - 8,936,126UniSTS
Celera5160,894,614 - 160,895,181UniSTS
Cytogenetic Map20p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000000635   ⟹   ENSRNOP00000000635
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl207,389,949 - 7,413,426 (-)Ensembl
Rnor_6.0 Ensembl206,937,347 - 6,961,162 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093164
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl206,944,152 - 6,957,146 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093172   ⟹   ENSRNOP00000076246
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl207,389,949 - 7,413,426 (-)Ensembl
Rnor_6.0 Ensembl206,937,961 - 6,960,481 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093697
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl206,941,794 - 6,957,095 (-)Ensembl
RefSeq Acc Id: NM_001100833   ⟹   NP_001094303
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8207,391,564 - 7,415,042 (-)NCBI
mRatBN7.2207,389,948 - 7,413,426 (-)NCBI
Rnor_6.0206,937,347 - 6,961,143 (-)NCBI
Rnor_5.0209,177,057 - 9,200,881 (-)NCBI
RGSC_v3.4207,649,782 - 7,673,289 (-)RGD
Celera208,935,505 - 8,956,541 (-)RGD
Sequence:
RefSeq Acc Id: XM_006256184   ⟹   XP_006256246
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8207,391,558 - 7,415,291 (-)NCBI
mRatBN7.2207,389,942 - 7,413,418 (-)NCBI
Rnor_6.0206,937,341 - 6,961,165 (-)NCBI
Rnor_5.0209,177,057 - 9,200,881 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001094303   ⟸   NM_001100833
- UniProtKB: B0BN30 (UniProtKB/TrEMBL),   A0A1W2Q6G8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256246   ⟸   XM_006256184
- Peptide Label: isoform X1
- UniProtKB: A0A1W2Q6G8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000000635   ⟸   ENSRNOT00000000635
RefSeq Acc Id: ENSRNOP00000076246   ⟸   ENSRNOT00000093172

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B0BN30-F1-model_v2 AlphaFold B0BN30 1-389 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701447
Promoter ID:EPDNEW_R11969
Type:initiation region
Name:Mtch1_1
Description:mitochondrial carrier 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0206,961,109 - 6,961,169EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309262 AgrOrtholog
BioCyc Gene G2FUF-4377 BioCyc
Ensembl Genes ENSRNOG00000000527 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000635 ENTREZGENE
  ENSRNOT00000000635.7 UniProtKB/TrEMBL
  ENSRNOT00000093172.2 UniProtKB/TrEMBL
Gene3D-CATH 1.50.40.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7377090 IMAGE-MGC_LOAD
  IMAGE:8369713 IMAGE-MGC_LOAD
InterPro Mitochondrial_sb/sol_carrier UniProtKB/TrEMBL
  Mt_carrier_dom UniProtKB/TrEMBL
KEGG Report rno:294313 UniProtKB/TrEMBL
MGC_CLONE MGC:112857 IMAGE-MGC_LOAD
  MGC:187651 IMAGE-MGC_LOAD
NCBI Gene 294313 ENTREZGENE
PANTHER MITOCHONDRIAL CARRIER HOMOLOG UniProtKB/TrEMBL
  MITOCHONDRIAL CARRIER HOMOLOG 1 UniProtKB/TrEMBL
Pfam Mito_carr UniProtKB/TrEMBL
PhenoGen Mtch1 PhenoGen
PROSITE SOLCAR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000527 RatGTEx
Superfamily-SCOP Mitoch_carrier UniProtKB/TrEMBL
UniProt A0A1W2Q6G8 ENTREZGENE, UniProtKB/TrEMBL
  A6JJU7_RAT UniProtKB/TrEMBL
  A6JJU8_RAT UniProtKB/TrEMBL
  B0BN30 ENTREZGENE, UniProtKB/TrEMBL
  Q4G025_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Mtch1  mitochondrial carrier 1  Mtch1  mitochondrial carrier homolog 1 (C. elegans)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Mtch1  mitochondrial carrier homolog 1 (C. elegans)  Mtch1_predicted  mitochondrial carrier homolog 1 (C. elegans) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Mtch1_predicted  mitochondrial carrier homolog 1 (C. elegans) (predicted)      Symbol and Name status set to approved 70820 APPROVED